Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice
Open accessAbstract
Emerging evidence has demonstrated that saturated fatty acids prime pro-IL-1β production and inflammasome-mediated IL-1β activation is critical in obesity-associated insulin resistance (IR). Nonetheless, IL-1 receptor I-deficient (IL-1RI−/−) mice develop mature-onset obesity despite consuming a low-fat diet (LFD). With this apparent contradiction, the present study evaluated whether IL-1RI−/− mice were protected against long-term (6 mo) high-fat diet (HFD)-induced IR. Male wild-type and IL-1RI−/− mice were fed LFD or HFD for 3 or 6 mo, and glucose and insulin tolerance tests were performed. Adipose insulin sensitivity, cytokine profiles, and adipocyte morphology were assessed. The adipogenic potential of stromal vascular fraction was determined. Hepatic lipid accumulation and insulin sensitivity were characterized. IL-1RI−/− mice developed glucose intolerance and IR after 6 mo HFD compared with 3 mo HFD, coincident with enhanced weight gain, hyperinsulinemia, and hyperleptinemia. The aggravated IR phenotype was associated with loss of adipose functionality, switch from adipocyte hyperplasia to hypertrophy and hepatosteatosis. Induction of adipogenic genes was reduced in IL-1RI−/− preadipocytes after 6 mo HFD compared with 3 mo HFD. Obese LFD-IL-1RI−/− mice exhibited preserved metabolic health. IL-1RI−/− mice develop glucose intolerance and IR after 6 mo HFD intervention. While mature-onset obesity is evident in LFD-IL-1RI−/− mice, the additional metabolic insult of HFD was required to drive adipose inflammation and systemic IR. These findings indicate an important interaction between dietary fat and IL-1, relevant to optimal metabolic health.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pro-inflammatory cytokines such as interleukin (IL)-1β inhibit adipogenesis, or the ability of pre-adipocytes to mature into functional lipid-enriched adipocytes.
“Pro‐inflammatory cytokines such as interleukin (IL)‐1β inhibit adipogenesis, or the ability of pre‐adipocytes to mature into functional lipid‐enriched adipocytes.[ 33 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works
The cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551 · see citing works
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works
Interleukin-6-deficient mice develop mature-onset obesity
Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Lumeng, C. N., DeYoung, S. M., Bodzin, J. L., & Saltiel, A. R. (2007) · Diabetes · doi:10.2337/db06-1076 · Cited by 1,016 · see citing works
Selective versus Total Insulin Resistance: A Pathogenic Paradox
Brown, M. S., & Goldstein, J. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.009 · Cited by 959 · see citing works
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works
Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals
Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.015 · Cited by 804 · see citing works
Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692 · see citing works
Stienstra, R., Joosten, L. A. B., Koenen, T. B., van Tits, B. L. J. H., van Diepen, J. A., van den Berg, S. A. A., Rensen, P. C. N., Voshol, P. J., Fantuzzi, G., Hijmans, A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.011 · Cited by 681 · see citing works
Csak, T., Ganz, M., Pespisa, J., Kodys, K., Dolganiuc, A., & Szabo, G. (2011) · Hepatology · doi:10.1002/hep.24341 · Cited by 645 · see citing works
Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
Netea, M. G., Joosten, L. A. B., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J., van Krieken, H., Kim, S.-H., Stalenhoef, A. F., et al. (2006) · Nature Medicine · doi:10.1038/nm1415 · Cited by 424 · see citing works
Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385 · see citing works
Poggi, M., Bastelica, D., Gual, P., Iglesias, M. A., Grémeaux, T., Knauf, C., Peiretti, F., Verdier, M., Juhan-Vague, I., Tanti, J., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0654-8 · Cited by 355 · see citing works
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
Semple, R. K., Sleigh, A., Murgatroyd, P. R., Adams, C. A., Bluck, L. J. C., Jackson, S. J., Vottero, A., Kanabar, D. J., Charlton-Menys, V., Durrington, P. N., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37432 · Cited by 347 · see citing works
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1865-y · Cited by 334 · see citing works
Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes
Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 323 · see citing works
Harford, K. A., Reynolds, C. M., McGillicuddy, F. C., & Roche, H. M. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111000565 · Cited by 299 · see citing works
Self-citationMatsuki, T., Horai, R., Sudo, K., & Iwakura, Y. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030299 · Cited by 229 · see citing works
McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Oliver, E., Claessens, M., Mills, K. H. G., & Roche, H. M. (2011) · Diabetes · doi:10.2337/db10-1278 · Cited by 199 · see citing works
Self-citationLipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
Lelliott, C. J., & Vidal‐Puig, A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802854 · Cited by 183 · see citing works
Altered expression of C/EBP family members results in decreased adipogenesis with aging
Karagiannides, I., Tchkonia, T., Dobson, D. E., Steppan, C. M., Cummins, P., Chan, G., Salvatori, K., Hadzopoulou‐Cladaras, M., & Kirkland, J. L. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1772 · Cited by 182 · see citing works
Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
García, M. C., Asterholm, I. W., Berndtsson, A., Enge, M., Bell, M. I., Hultgren, O., Horn, M., Åhrén, B., Enerbäck, S., Ohlsson, C., et al. (2006) · Diabetes · doi:10.2337/db05-1304 · Cited by 174 · see citing works
Reynolds, C. M., McGillicuddy, F. C., Harford, K. A., Finucane, O. M., Mills, K. H. G., & Roche, H. M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200058 · Cited by 168 · see citing works
Self-citationKozak, W., Zheng, H., Conn, C. A., Soszyński, D., der Ploeg, L. H. T. V., & Kluger, M. J. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.5.r969 · Cited by 160 · see citing works
Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice
Somm, E., Henrichot, E., Pernin, A., Juge-Aubry, C. E., Muzzin, P., Dayer, J.-M., Nicklin, M. J. H., & Meier, C. A. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3503 · Cited by 114 · see citing works
Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice
Chida, D., Osaka, T., Hashimoto, O., & Iwakura, Y. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1250 · Cited by 89 · see citing works
Immune modulation: IL-1, master mediator or initiator of inflammation
Mills, K. H. G., & Dunne, A. (2009) · Nature Medicine · doi:10.1038/nm1209-1363 · Cited by 74 · see citing works
Self-citationImpacts of transcriptional regulation on aging and senescence
Roy, A. K., Oh, T., Rivera, O., Mubiru, J., Song, C. S., & Chatterjee, B. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00006-5 · Cited by 72 · see citing works
Is Interleukin-6 Receptor Blockade the Holy Grail for Inflammatory Diseases?
Febbraio, M. A., Rose‐John, S., & Pedersen, B. K. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.1 · Cited by 55 · see citing works
Hotta, K., Bodkin, N. L., Gustafson, T. A., Yoshioka, S., Ortmeyer, H. K., & Hansen, B. C. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.5.b183 · Cited by 51 · see citing works
Yoshimoto, M., Kikuchi, K., Yamamoto, N., Somiya, H., & Ito, H. (1999) · Brain Behavior and Evolution · doi:10.1159/000006623 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626 · see citing works
Fatty Acids and NLRP3 Inflammasome–Mediated Inflammation in Metabolic Tissues
Ralston, J. C., Lyons, C. L., Kennedy, E. B., Kirwan, A. M., & Roche, H. M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064836 · Cited by 229 · see citing works
Self-citationIL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects
Feng, X., Guan, D., Auen, T., Choi, J. W., Hernández, M. A. S., Lee, J., Chun, H., Faruk, F., Kaplun, E., Herbert, Z. T., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0358-x · Cited by 134 · see citing works
Adipose tissue inflammation in glucose metabolism
Kammoun, H. L., Kraakman, M. J., & Febbraio, M. A. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9274-4 · Cited by 99 · see citing works
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
Liu, J., Ibi, D., Taniguchi, K., Lee, J., Herrema, H., Akosman, B., Mucka, P., Hernández, M. A. S., Uyar, M. F., Park, S. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.015 · Cited by 93 · see citing works
NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: Friend or foe?
Chen, X., Zhang, D., Li, Y., Wang, W., Bei, W., & Guo, J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105885 · Cited by 84 · see citing works
Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications
Fonseka, T. M., Müller, D. J., & Kennedy, S. H. (2016) · Complex Psychiatry · doi:10.1159/000441521 · Cited by 64 · see citing works
The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis
Wang, M. G., Seale, P., & Furman, D. (2024) · npj Aging · doi:10.1038/s41514-024-00159-z · Cited by 64 · see citing works
Komaki, A., Karimi, S. A., Salehi, I., Sarihi, A., Shahidi, S., & Zarei, M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.02.008 · Cited by 52 · see citing works
Inflammation and metabolism: the role of adiposity in sarcopenic obesity
Lynch, G. M., Murphy, C. H., Castro, E. D. M., & Roche, H. M. (2020) · Proceedings of the Nutrition Society · doi:10.1017/s0029665120007119 · Cited by 41 · see citing works
Self-citationEleazu, C. O., Suleiman, J. B., Othman, Z. A., Zakaria, Z., Nna, V. U., Hussain, N. H. N., & Mohamed, M. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1752258 · Cited by 36 · see citing works
Tsuzuki, T., Shinozaki, S., Nakamoto, H., Kaneki, M., Goto, S., Shimokado, K., Kobayashi, H., & Naıto, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132029 · Cited by 35 · see citing works
IL-1β promotes adipogenesis by directly targeting adipocyte precursors
Hofwimmer, K., Souza, J. D. P., Subramanian, N., Vujičić, M., Rachid, L., Méreau, H., Zhao, C., Dror, E., Barreby, E., Björkström, N. K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51938-x · Cited by 33 · see citing works
Tsuchiya, M., Sekiai, S., Hatakeyama, H., Koide, M., Chaweewannakorn, C., Yaoita, F., Tan–No, K., Sasaki, K., Watanabe, M., Sugawara, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.067 · Cited by 33 · see citing works
Fonseka, T. M., Tiwari, A. K., Gonçalves, V. F., Lieberman, J. A., Meltzer, H. Y., Goldstein, B. I., Kennedy, J. L., Kennedy, S. H., & Müller, D. J. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.984631 · Cited by 33 · see citing works
Non-Alcoholic Steatohepatitis: From Pathophysiology to Novel Therapies
Jahn, D., Rau, M., Wohlfahrt, J., Hermanns, H. M., & Geier, A. (2016) · Digestive Diseases · doi:10.1159/000444547 · Cited by 32 · see citing works
Zhang, K., Yang, C. C., Zhou, X. M., Liang, J. H., Guo, J., Li, M., Zhang, Y., Shao, S., Sun, P. G., Li, K., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04820-w · Cited by 23 · see citing works
Dietary modulation of energy homoeostasis and metabolic-inflammation
Roche, H. M. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002872 · Cited by 22 · see citing works
Self-citationNeurotensin receptor 1 agonist provides neuroprotection in pre-diabetic rats
Saiyasit, N., Chunchai, T., Jaiwongkam, T., Kerdphoo, S., Apaijai, N., Pratchayasakul, W., Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0439 · Cited by 20 · see citing works
Molina-Ayala, M., Rodríguez-Amador, V., Suárez‐Sánchez, R., León-Solís, L. E., Gómez-Zamudio, J. H., Mendoza‐Zubieta, V., Cruz, M., & Suárez‐Sánchez, F. (2022) · Gene · doi:10.1016/j.gene.2021.146181 · Cited by 20 · see citing works
Obesity and Diastolic Heart Failure: Is Inflammation the Link?
Carbone, S. (2013) · Translational Medicine · doi:10.4172/2161-1025.1000e124 · Cited by 14 · see citing works
Inflammation in human adipose tissues–Shades of gray, rather than white and brown
Rakotoarivelo, V., Variya, B. C., Ilangumaran, S., Langlois, M., & Ramanathan, S. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.001 · Cited by 14 · see citing works
Ramirez‐Perez, F. I., Schenewerk, A. L., Coffman, K. L., Foote, C. A., Ji, T., Rivera, R. M., & Martinez‐Lemus, L. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112651 · Cited by 11 · see citing works
Lee, S. R., Khamoui, A. V., Jo, E., Zourdos, M. C., Panton, L. B., Ormsbee, M. J., & Kim, J. (2017) · Experimental Physiology · doi:10.1113/ep086317 · Cited by 9 · see citing works
Ralston, J. C., Mitchelson, K. A. J., Lynch, G. M., Tran, T. T. T., Wang, H., Strain, C., Lenighan, Y. M., Kennedy, E. B., Stanton, C., McGillicuddy, F. C., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000202 · Cited by 6 · see citing works
Self-citationBridge-Comer, P. E., Plows, J. F., Ramzan, F., Patel, R., Ganapathy, T. P., Stanley, J. L., Vickers, M. H., & Reynolds, C. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00601 · Cited by 5 · see citing works
Self-citationPlows, J. F., Vickers, M. H., Ganapathy, T. P., Bridge-Comer, P. E., Stanley, J. L., & Reynolds, C. M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900770 · Cited by 4 · see citing works
Self-citationMachado, M. S. G., Rodrigues, V. F., Barbosa, S. C., Elias‐Oliveira, J., Pereira, Í., Pereira, J., Pacheco, T., & Carlos, D. (2024) · Microorganisms · doi:10.3390/microorganisms12081717 · Cited by 2 · see citing works
Rønningen, T., Zeng, Y., Dahl, M. B., Wang, J., Visnovska, T., Tannæs, T. M., Poulsen, L. L. C., Çayır, A., Svensson, S. I. A., Svanevik, M., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00857-0 · Cited by 1 · see citing works
Bridge-Comer, P. E., Vickers, M. H., & Reynolds, C. M. (2021) · Preprints.org · doi:10.20944/preprints202106.0239.v1 · Cited by 1 · see citing works
Self-citationMitchelson, K. A. J., Ralston, J. C., Strain, C., Lenighan, Y. M., Kennedy, E. B., Lynch, G., McGillicuddy, F. C., O’Toole, P. W., & Roche, H. M. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002409
Self-citationAvaliação do eixo IL-1/IL-1R na comorbidade obesidade e tuberculose
de Oliveira, R. S. (2019) · doi:10.11606/d.17.2019.tde-15102018-113326
Phachonpai, W., Riyamongkol, P., Mann, D., & Kamkaew, N. (2024) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2024.182575
Dimeji, I. Y., Jabba, H. L., Murtala, N., & Ayodeji, A. S. (2025) · Asian Science Bulletin · doi:10.3923/asb.2025.205.223
Gmoshinski, I. V., Вячеславович, Т. Н., Александрович, Ш. В., & Nikityuk, D. B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177808
- Authors
- McGillicuddy, F. C., Reynolds, C. M., Finucane, O., Coleman, E., Harford, K. A., Grant, C., Sergi, D., Williams, L. M., Mills, K. H. G., & Roche, H. M.
- Affiliations
- University College Dublin (IE)
- University of Aberdeen (GB)
- Trinity College Dublin (IE)
- Corresponding author
- Roche, Helen M.
- ORCID
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2013-10-01
- Volume
- 305
- Issue
- 7
- Pages
- E834-E844
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC3798700
- OpenAlex
- W2026796986
- Cited by
- 36
- References
- 48
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (097311/Z/11/Z)
- Science Foundation Ireland
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- high-fat diet, insulin resistance, impaired glucose tolerance, obesity, adipose tissue inflammation, adipocyte hypertrophy, adipocyte hyperplasia, hepatic steatosis, hepatic lipid accumulation, adipogenesis, pro-IL-1β, inflammasome, leptin, hyperinsulinemia, dietary fat
- MeSH terms
- Adipose Tissue, Animals, Dietary Fats, Fatty Liver, Glucose Tolerance Test, Inflammation, Insulin, Insulin Resistance, Male, Glucose Intolerance, Mice, Knockout, Leptin, Adiposity, Mice, Receptors, Interleukin-1 Type I, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
