Capturing the multifaceted function of adipose tissue macrophages
Open accessAbstract
Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabolism, extracellular remodeling, and supporting angiogenesis and adipogenesis. Thus, high-resolution methods are needed to capture macrophages’ dynamic and multifaceted functions in adipose tissue. Herein, we review current knowledge on regulatory networks critical to macrophage plasticity and their multifaceted response in the complex adipose tissue microenvironment.
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Our whole-body mapping approach adds a comprehensive spatial view of obesity-induced inflammation, revealing tissue-specific patterns of macrophage accumulations, which can reflect both inflammatory and remodelling states in our HFD-induced obesity model.
“Our whole-body mapping approach adds a comprehensive spatial view of obesity-induced inflammation, revealing tissue-specific patterns of macrophage accumulations, which can reflect both inflammatory and remodelling states39 in our HFD-induced obesity model.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [39]
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Effect of Targeting Inflammation With Salsalate
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Flagged first, then by citations
Cited by
Sorted by citations
A deep-learning framework reveals whole-body perturbations at cell level
Kaltenecker, D., Horvath, I., Al-Maskari, R., Chen, Y., Kolabas, Z. I., Hoeher, L., Todorov, M., Minde, D.-P., Kapoor, S., Turhan, S. G., et al. (2026) · Nature · doi:10.1038/s41586-026-10535-2 · Cited by 5 · see citing works
- Authors
- Matz, A. J., Qu, L., Karlinsey, K., Vella, A. T., & Zhou, B.
- Affiliations
- University of Connecticut (US)
- Corresponding author
- Zhou, Beiyan
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2023-02-16
- Volume
- 14
- Pages
- 1148188-1148188
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC9977801
- OpenAlex
- W4321103281
- Cited by
- 16
- References
- 106
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 2 · 2023: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Heart Association (19TPA34910079, R01DK121805, 23PRE1023282, 23PRE1023195)
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK121805)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- adipose tissue macrophages, obesity, metabolic dysfunction, macrophage plasticity, adipose tissue microenvironment, lipid metabolism, extracellular matrix remodeling, angiogenesis, adipogenesis, regulatory networks
- MeSH terms
- Adipose Tissue, Humans, Macrophages, Obesity, Adipocytes, Adipogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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