Calorie restriction prevents diet‐induced insulin resistance independently of PGC‐1‐driven mitochondrial biogenesis in white adipose tissue
Open accessAbstract
Calorie restriction (CR) exerts remarkable, beneficial effects on glucose homeostasis by mechanisms that are not fully understood. Given the relevance of white adipose tissue (WAT) in glucose homeostasis, we aimed at identifying the main cellular processes regulated in WAT in response to CR in a pathologic context of obesity. For this, a gene‐expression profiling study was first conducted in mice fed ad libitum or subjected to 40% CR. We found that the gene network related to mitochondria was the most highly upregulated in WAT by CR. To study the role that increased mitochondrial biogenesis plays on glucose homeostasis following CR, we generated a mouse model devoid of the coactivators peroxisome proliferator‐activated receptor ³ coactivator 1 (PGC‐1)α and PGC‐1β specifically in adipocytes. Our results show that mice lacking PGC‐1s in adipocytes are unable to increase mitochondrial biogenesis in WAT upon CR. Despite a blunted induction of mitochondrial biogenesis in response to calorie deprivation, mice lacking adipose PGC‐1s still respond to CR by improving their glucose homeostasis. Our study demonstrates that PGC‐1 coactivators are major regulators of CR‐induced mitochondrial biogenesis in WAT and that increased mitochondrial biogenesis and oxidative function in adipose tissue are not required for the improvement of glucose homeostasis mediated by CR.—Pardo, R., Vila, M., Cervela, L., de Marco, M., Gama‐Pérez, P., González‐Franquesa, A., Statuto, L., Vilallonga, R., Simó, R., Garcia‐Roves, P. M., Villena, J. A. Calorie restriction prevents diet‐induced insulin resistance independently of PGC‐1‐driven mitochondrial biogenesis in white adipose tissue. FASEB J. 33, 2343–2358 (2019). www.fasebj.org
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Calorie restriction stimulates mitochondrial turnover by increasing mitochondrial biogenesis and clearance of damaged mitochondria via mitophagy.
“Moreover, calorie restriction stimulates mitochondrial turnover by boosting mitochondrial biogenesis and the clearance of damaged mitochondria via mitophagy221,222.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [222]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Macrophage-mediated inflammation in metabolic disease
Chawla, A., Nguyen, K. D., & Goh, Y. P. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3071 · Cited by 1,314 · see citing works
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works
Adapting to obesity with adipose tissue inflammation
Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204 · see citing works
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Calorie restriction, SIRT1 and metabolism: understanding longevity
Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,021 · see citing works
Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790 · see citing works
Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719 · see citing works
Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., & Lee, C.-H. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.002 · Cited by 699 · see citing works
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699 · see citing works
Uldry, M., Yang, W., St‐Pierre, J., Lin, J. D., Seale, P., & Spiegelman, B. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.002 · Cited by 644 · see citing works
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works
Transcriptional Control of Adipose Lipid Handling by IRF4
Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 607 · see citing works
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo
Bogacka, I., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1392 · Cited by 467 · see citing works
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016) · Diabetologia · doi:10.1007/s00125-016-3933-4 · Cited by 432 · see citing works
Villena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 404 · see citing works
Self-citationEndotrophin triggers adipose tissue fibrosis and metabolic dysfunction
Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4485 · Cited by 364 · see citing works
Adipose Tissue Collagen VI in Obesity
Pasarica, M., Gawrońska‐Kozak, B., Burk, D. H., Remedios, I., Hymel, D., Gimble, J., Ravussin, É., Bray, G. A., & Smith, S. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0947 · Cited by 338 · see citing works
Rong, J. X., Qiu, Y., Hansen, M. K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Mattie, M. D., Higashiyama, H., Asano, S., et al. (2007) · Diabetes · doi:10.2337/db06-1135 · Cited by 335 · see citing works
Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling
Fabbiano, S., Suárez-Zamorano, N., Rigo, D., Veyrat‐Durebex, C., Đokić, A., Colin, D., & Trajkovski, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.023 · Cited by 291 · see citing works
UCP1 mRNA does not produce heat
Nedergaard, J., & Cannon, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.009 · Cited by 264 · see citing works
Muscle Oxidative Capacity Is a Better Predictor of Insulin Sensitivity than Lipid Status
Bruce, C. R., Anderson, M. J., Carey, A. L., Newman, D. G., Bonen, A., Kriketos, A. D., Cooney, G. J., & Hawley, J. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030791 · Cited by 234 · see citing works
Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis
Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., & Kralli, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607696104 · Cited by 215 · see citing works
Self-citationHamann, A., Flier, J. S., & Lowell, B. B. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536614 · Cited by 205 · see citing works
Effect of Age and Diet on Insulin Secretion and Insulin Action in the Rat
REAVEN, E. P., Wright, D. W., Mondon, C. E., Solomon, R., Ho, H., & Reaven, G. M. (1983) · Diabetes · doi:10.2337/diab.32.2.175 · Cited by 178 · see citing works
Higami, Y., Pugh, T. D., Page, G. P., Allison, D. B., Prolla, T. A., & Weindruch, R. (2004) · The FASEB Journal · doi:10.1096/fj.03-0678fje · Cited by 173 · see citing works
Does calorie restriction induce mitochondrial biogenesis? A reevaluation
Hancock, C. R., Han, D., Higashida, K., Kim, S. H., & Holloszy, J. O. (2011) · The FASEB Journal · doi:10.1096/fj.10-170415 · Cited by 131 · see citing works
GCN5-mediated Transcriptional Control of the Metabolic Coactivator PGC-1β through Lysine Acetylation
Kelly, T. J., Lerín, C., Haas, W., Gygi, S. P., & Puigserver, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.015164 · Cited by 130 · see citing works
Boden, G., Homko, C., Mozzoli, M., Showe, L. C., Nichols, C., & Cheung, P. (2005) · Diabetes · doi:10.2337/diabetes.54.3.880 · Cited by 129 · see citing works
Microenvironmental Control of Adipocyte Fate and Function
Pope, B. D., Warren, C. R., Parker, K. K., & Cowan, C. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.005 · Cited by 117 · see citing works
Finley, L. W. S., Lee, J., Souza, A., Desquiret-Dumas, V., Bullock, K., Rowe, G. C., Procaccio, V., Clish, C. B., Arany, Z., & Haigis, M. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115813109 · Cited by 102 · see citing works
Rothwell, N. J., & Stock, M. J. (1982) · Bioscience Reports · doi:10.1007/bf01314214 · Cited by 96 · see citing works
Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026989 · Cited by 85 · see citing works
Self-citationBarquissau, V., Léger, B., Beuzelin, D., Martins, F., Amri, E., Pisani, D. F., Saris, W. H. M., Astrup, A. V., Maoret, J.-J., Iacovoni, J. S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.102 · Cited by 83 · see citing works
Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats
Wetter, T. J., Gazdag, A. C., Dean, D. J., & Cartee, G. D. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e728 · Cited by 65 · see citing works
High‐Resolution Respirometry for Mitochondrial Characterization of Ex Vivo Mouse Tissues
Cantó, C., & García-Rovés, P. M. (2015) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo140061 · Cited by 56 · see citing works
Enguix, N., Pardo, R., González-Vicens, A., López-Álvarez, V. M., Simó, R., Kralli, A., & Villena, J. A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.05.004 · Cited by 51 · see citing works
Self-citationBarger, J. L., Vann, J. M., Cray, N., Pugh, T. D., Mastaloudis, A., Hester, S. N., Wood, S. M., Newton, M. A., Weindruch, R. H., & Prolla, T. A. (2017) · Aging Cell · doi:10.1111/acel.12608 · Cited by 49 · see citing works
Hamann, A. (1996) · Endocrinology · doi:10.1210/en.137.1.21 · Cited by 45 · see citing works
Defective brown adipose tissue thermogenesis in obese mice.
Himms‐Hagen, J. (1985) · PubMed · Cited by 42 · see citing works
Effects of mild calorie restriction on lipid metabolism and inflammation in liver and adipose tissue
Park, C. Y., Park, S., Kim, M. S., Kim, H., & Han, S. N. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.090 · Cited by 42 · see citing works
Targeting Mitochondrial Biogenesis to Treat Insulin Resistance
Zamora, M., & Villena, J. A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140306102514 · Cited by 39 · see citing works
Self-citationWang, Q., Perrard, X. D., Perrard, J. L., Mansoori, A., Raya, J. L., Hoogeveen, R. C., Smith, C. W., Ballantyne, C. M., & Wu, H. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.07.025 · Cited by 38 · see citing works
Lasheras, J., Vilà, M., Zamora, M., Riu, E., Pardo, R., Poncelas, M., Cases, I., Ruiz‐Meana, M., Hernández, C., Felíu, J. E., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.004 · Cited by 15 · see citing works
Self-citationBrown adipose tissue activity in hypocaloric-diet fed lactating rats
Villarroya, F., Felipe, A., & Mampel, T. (1986) · Bioscience Reports · doi:10.1007/bf01114762 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
Díaz‐Vegas, A., Sánchez-Aguilera, P., Krycer, J. R., Morales, P. E., Monsalves‐Álvarez, M., Cifuentes, M., Rothermel, B. A., & Lavandero, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa005 · Cited by 174 · see citing works
Perivascular adipose tissue–derived extracellular vesicle miR‐221‐3p mediates vascular remodeling
Li, X., Ballantyne, L. L., Yu, Y., & Funk, C. D. (2019) · The FASEB Journal · doi:10.1096/fj.201901548r · Cited by 133 · see citing works
Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy
Davinelli, S., De Stefani, D., De Vivo, I., & Scapagnini, G. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.02.011 · Cited by 117 · see citing works
Rakshe, P. S., Dutta, B. J., Chib, S., Maurya, N., & Singh, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102255 · Cited by 103 · see citing works
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
Mishra, A. K., Mirzaei, H., Guidi, N., Vinciguerra, M., Mouton, A., Linardić, M., Rappa, F., Barone, R., Navarrete, G., Wei, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00469-6 · Cited by 77 · see citing works
Kobayashi, M., Deguchi, Y., Nozaki, Y., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116025 · Cited by 60 · see citing works
Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production
Beltran, C., Pardo, R., Bou‐Teen, D., Ruiz‐Meana, M., Villena, J. A., González, I. F., & Barba, I. (2020) · Metabolites · doi:10.3390/metabo10040132 · Cited by 45 · see citing works
Self-citationDietary protein and amino acid restriction: Roles in metabolic health and aging-related diseases
Wang, D., Ye, J., Shi, R., Zhao, B., Liu, Z., Lin, W. J., & Liu, X. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.009 · Cited by 44 · see citing works
Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full Losses
Yuan, Q., Zeng, Z., Yang, S., Li, A., Zu, X., & Liu, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8803404 · Cited by 43 · see citing works
Mooli, R. G. R., Mukhi, D., Watt, M., Edmunds, L. R., Xie, B., Capooci, J., Reslink, M. C., Eze, C., Mills, A. M., Stolz, D. B., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154225 · Cited by 35 · see citing works
Intermittent fasting: What questions should we be asking?
Liu, K., Liu, B., & Heilbronn, L. K. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112827 · Cited by 29 · see citing works
Insulin resistance in bariatric surgery
Stenberg, E., & Thorell, A. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000657 · Cited by 21 · see citing works
AlZaim, I., Eid, A. H., Abd‐Elrahman, K. S., & EL‐Yazbi, A. F. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115337 · Cited by 16 · see citing works
Pardo, R., Velilla, M., Herrero, L., Cervela‐Cardona, L., Ribeiro, M. L., Simó, R., & Villena, J. A. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000672 · Cited by 15 · see citing works
Self-citationThorell, A. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.03.044 · Cited by 8 · see citing works
Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8 · see citing works
An Insight into the Exploration of Antibiotic Resistance Genes in Calorie Restricted Diet Fed Mice
Fan, X., Lu, Y., Zhao, Y., Miao, H., Qi, K., & Wang, R. (2023) · Nutrients · doi:10.3390/nu15143198 · Cited by 6 · see citing works
Gudiksen, A., Zhou, E., Pedersen, L., Zaia, C. A., Wille, C. E., Eliesen, E. V., & Pilegaard, H. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102034 · Cited by 3 · see citing works
Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys
Clark, J. P., Rhoads, T. W., McIlwain, S. J., Polewski, M. A., Pavelec, D. M., Colman, R. J., & Anderson, R. M. (2025) · Aging Cell · doi:10.1111/acel.70254 · Cited by 3 · see citing works
Nascimento, R. H. D. O., Pejon, T. M. M., & Beck, W. R. (2025) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2025.04.002 · Cited by 1 · see citing works
Ishimatsu, M., Taki, K., Hayami, A., Kato, K., Nozaki, Y., Mizunoe, Y., Narita, T., Mori, R., Higami, Y., & Kobayashi, M. (2025) · FEBS Open Bio · doi:10.1002/2211-5463.70077 · Cited by 1 · see citing works
Mehrtash, M., Salesi, M., Daryanoosh, F., Tanideh, N., & Jamhiri, I. (2026) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/6888340 · Cited by 1 · see citing works
Effect of caloric restriction on aging and neurodegenerative diseases
Анатольевна, Ф. Ю., & Мурашев, Б. Ю. (2022) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2022.03.166-176
Neuroprotection and antiaging effects of caloric restriction
Dias, R. A., Mendes, C., Raimundo, N., & Domingues, N. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33841-0.00023-3
Das, J. K., Banskota, N., Donegà, S., Shehadeh, N., Piao, Y., Price, N., Mattison, J. A., Candia, J., de Cabo, R., & Ferrucci, L. (2026) · Skeletal Muscle · doi:10.1186/s13395-026-00422-9
Borzooei, R., Parastouei, K., Taghdir, M., Sepandi, M., & Heris, M. A. A. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72228
- Authors
- Pardo, R., Vilà, M., Cervela, L., de Marco, M., Gama-Pérez, P., González-Franquesa, A., Statuto, L., Vilallonga, R., Simó, R., Garcia-Roves, P. M., & Villena, J. A.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Laboratory of Metabolism and Obesity Universitat Autónoma de Barcelona Barcelona Spain
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Department of Physiological Sciences Institut d'Investigació Biomèdica de Bellvitge Universitat de Barcelona L'Hospitalet de Llobregat Barcelona Spain
- Corresponding author
- Villena, Josep A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2018-10-02
- Volume
- 33
- Issue
- 2
- Pages
- 2343-2358
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2894680188
- Cited by
- 27
- References
- 53
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- ddd.uab.cat
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Ministerio de Economía y Competitividad (SAF2011-23886, SAF2012-39484)
- Instituto de Salud Carlos III (PI15/00701)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- caloric restriction, insulin resistance, white adipose tissue, PGC-1α, PGC-1β, mitochondrial biogenesis, glucose homeostasis, obesity, adipocytes, gene expression profiling
- MeSH terms
- Animals, Organelle Biogenesis, Diet, Homeostasis, Insulin Resistance, Male, Mice, Inbred C57BL, Transcription Factors, Glucose Intolerance, Mice, Knockout, Gene Expression Profiling, Caloric Restriction, Mice, Adipose Tissue, White
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
