The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila
Open accessAbstract
SUMMARY Studies in mammals have indicated a connection between circadian clocks and feeding behavior, but the nature of the interaction, and its relationship to nutrient metabolism, are not understood. In Drosophila clock proteins are expressed in many metabolically important tissues, but have not been linked to metabolic processes. Here we demonstrate that Drosophila feeding behavior displays a 24-hour circadian rhythm which is regulated by clocks in digestive/metabolic tissues. Flies lacking clocks in these tissues, in particular in the fat body, also display increased food consumption, but have decreased levels of glycogen and a higher sensitivity to starvation. Interestingly, glycogen levels and starvation sensitivity are also affected by clocks in neuronal cells but the effects of neuronal clocks generally oppose those of the fat body. We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis.
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Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059
Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus
Hara, R., Wan, K., Wakamatsu, H., Aida, R., Moriya, T., Akiyama, M., & Shibata, S. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00419.x · Cited by 569 · cited 5×
“In mammals, the central pacemaker is in the suprachiasmatic nuclei (SCN) of the hypothalamus (Aton and Herzog, 2005; Liu et al., 2007) and peripheral clocks are located in multiple organs including the liver (Shibata, 2004), heart (Young, 2006), pineal gland (Fukada and Okano, 2002), and adipose tissue (Zvonic et al.,…”
BackgroundInfluentialShimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536
Colles, S. L., Dixon, J. B., & O'Brien, P. E. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803664 · Cited by 324
Young, M. E., & Bray, M. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.010 · Cited by 129
Cited by
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656
Hulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D., Takemura, S.-Y., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2021) · eLife · doi:10.7554/elife.66039 · Cited by 392
Circadian autophagy drives iTRF-mediated longevity
Ulgherait, M., Midoun, A. M., Park, S. J., Gatto, J. A., Tener, S. J., Siewert, J., Klickstein, N., Canman, J. C., Ja, W. W., & Shirasu-Hiza, M. (2021) · Nature · doi:10.1038/s41586-021-03934-0 · Cited by 226
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58
“(Hutton et al., 1998) (Spillantini et al., 1998) (Spillantini and Goedert, 2013) D is ea se M o d el s & M ec h an is m s fat body (see Glossary, Box 1) (Xu et al., 2008).”
BackgroundHulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D. B., Takemura, S., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2020) · doi:10.1101/2020.12.08.413955 · Cited by 392
“Similarly, both sleep and feeding are known to be under circadian control (Dubowy and Sehgal, 2017; Murphy et al., 2016; Xu et al., 2008), biasing their occurrence to appropriate times of day.”
BackgroundMetabolism as an integral cog in the mammalian circadian clockwork
Gamble, K. L., & Young, M. E. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.786672 · Cited by 18
Metadata
- Authors
- Xu, K., Zheng, X., & Sehgal, A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 8
- Issue
- 4
- Pages
- 289-300
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2007299852
- Cited by
- 306
- References
- 6
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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