Circadian autophagy drives iTRF-mediated longevity

NIH Image to ImageJ: 25 years of image analysis

Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Effects of intermittent fasting on health, aging, and disease

de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works

Circadian physiology of metabolism

Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092 · see citing works

JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087 · see citing works

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013 · see citing works

Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions

Claesson, M. J., Wang, Q., O’Sullivan, Ó., Greene-Diniz, R., Cole, J. R., Ross, R. P., & O’Toole, P. W. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq873 · Cited by 981 · see citing works

Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body

Scott, R. C., Schuldiner, O., & Neufeld, T. P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.009 · Cited by 963 · see citing works

Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges

Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956 · see citing works

Autophagy as a promoter of longevity: insights from model organisms

Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754 · see citing works

Prandiology of Drosophila and the CAFE assay

Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., & Benzer, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702726104 · Cited by 702 · see citing works

Independent Photoreceptive Circadian Clocks Throughout Drosophila

Plautz, J. D., Kaneko, M. A. N., Hall, J. C., & Kay, S. A. (1997) · Science · doi:10.1126/science.278.5343.1632 · Cited by 640 · see citing works

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

Rera, M., Clark, R. I., & Walker, D. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215849110 · Cited by 619 · see citing works

Circadian clock genes and the transcriptional architecture of the clock mechanism

Cox, K. H., & Takahashi, J. S. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0153 · Cited by 481 · see citing works

Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog

Rera, M., Bahadorani, S., Cho, J., Koehler, C. L., Ulgherait, M., Hur, J. H., Ansari, W. S., Lo, T., Jones, D. L., & Walker, D. W. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.013 · Cited by 472 · see citing works

Circadian Organization of Behavior and Physiology in Drosophila

Allada, R., & Chung, B. Y. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135815 · Cited by 456 · see citing works

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works

Aging and circadian rhythms

Duffy, J. F., Zitting, K.-M., & Chinoy, E. D. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.002 · Cited by 367 · see citing works

A Molecular Mechanism for Circadian Clock Negative Feedback

Duong, H. A., Robles, M. S., Knutti, D., & Weitz, C. J. (2011) · Science · doi:10.1126/science.1196766 · Cited by 362 · see citing works

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

Rana, A., Rera, M., & Walker, D. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216197110 · Cited by 335 · see citing works

Circadian rhythms, time-restricted feeding, and healthy aging

Manoogian, E. N. C., & Panda, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.006 · Cited by 330 · see citing works

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Partridge, L., Alic, N., Bjedov, I., & Piper, M. D. W. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.003 · Cited by 318 · see citing works

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

Ulgherait, M., Rana, A., Rera, M., Graniel, J. V., & Walker, D. W. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.006 · Cited by 307 · see citing works

Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila

Xu, K., Zheng, X., & Sehgal, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.006 · Cited by 306 · see citing works

Time-restricted feeding attenuates age-related cardiac decline in <i>Drosophila</i>

Gill, S., Le, H. D., Melkani, G. C., & Panda, S. (2015) · Science · doi:10.1126/science.1256682 · Cited by 272 · see citing works

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

Chang, J. T., Kumsta, C., Hellman, A. B., Adams, L. M., & Hansen, M. (2017) · eLife · doi:10.7554/elife.18459 · Cited by 241 · see citing works

Making Time: Conservation of Biological Clocks from Fungi to Animals

Dunlap, J., & Loros, J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0039-2016 · Cited by 163 · see citing works

Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption

Villanueva, J. E., Livelo, C., Trujillo, A. S., Chandran, S., Woodworth, B., Andrade, L., Le, H. D., Manor, U., Panda, S., & Melkani, G. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10563-9 · Cited by 158 · see citing works

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

Catterson, J. H., Khericha, M., Dyson, M. C., Vincent, A. J., Callard, R., Haveron, S. M., Rajasingam, A., Ahmad, M., & Partridge, L. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.015 · Cited by 154 · see citing works

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner

Tricoire, H., Battisti, V., Trannoy, S., Lasbleiz, C., Pret, A., & Monnier, V. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.05.004 · Cited by 147 · see citing works

Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells ofDrosophila cause abnormal behavioral rhythms

Kaneko, M. A. N., Park, J. H., Cheng, Y., Hardin, P. E., & Hall, J. C. (2000) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(20000605)43:3 · Cited by 138 · see citing works

Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle

Kinouchi, K., Magnan, C., Ceglia, N., Liu, Y., Cervantes, M., Pastore, N., Huynh, T., Ballabio, A., Baldi, P., Masri, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.077 · Cited by 130 · see citing works

Postprandial sleep mechanics in Drosophila

Murphy, K. R., Deshpande, S. A., Yurgel, M. E., Quinn, J. P., Weissbach, J. L., Keene, A. C., Dawson-Scully, K. D., Huber, R., Tomchik, S. M., & Ja, W. W. (2016) · eLife · doi:10.7554/elife.19334 · Cited by 105 · see citing works

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

Wang, H., Spyk, E. N. V., Liu, Q., Geyfman, M., Salmans, M., Kumar, V., Ihler, A., Li, N., Takahashi, J. S., & D, B. A. M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.022 · Cited by 104 · see citing works

Circadian autophagy rhythm: a link between clock and metabolism?

Ma, D., Li, S., Molusky, M. M., & Lin, J. D. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.03.004 · Cited by 103 · see citing works

Circadian regulation of mitochondrial uncoupling and lifespan

Ulgherait, M., Chen, A., McAllister, S. F., Kim, H. X., Delventhal, R., Wayne, C. R., Garcia, C., Recinos, Y., Oliva, M. K., Canman, J. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15617-x · Cited by 89 · see citing works

Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth

Barcelo, H., & Stewart, M. J. (2002) · Genesis · doi:10.1002/gene.10132 · Cited by 78 · see citing works

Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

Delventhal, R., Pantalia, M., O'Connor, R. M., Ulgherait, M., Kim, H. X., Basturk, M. K., Canman, J. C., & Shirasu‐Hiza, M. (2019) · eLife · doi:10.7554/elife.48308 · Cited by 62 · see citing works

Crosstalk of clock gene expression and autophagy in aging

Kalfalah, F. M., Janke, L., Schiavi, A., Tigges, J., Ix, A., Ventura, N., Boege, F., & Reinke, H. (2016) · Aging · doi:10.18632/aging.101018 · Cited by 56 · see citing works

Simultaneous measurement of sleep and feeding in individual Drosophila

Murphy, K. R., Park, S. J., Huber, R., & Ja, W. W. (2017) · Nature Protocols · doi:10.1038/nprot.2017.096 · Cited by 53 · see citing works

Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding

Yamamuro, D., Takahashi, M., Nagashima, S., Wakabayashi, T., Yamazaki, H., Takei, A., Takei, S., Sakai, K., Ebihara, K., Iwasaki, Y., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234439 · Cited by 45 · see citing works

Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction

García-Gaytán, A. C., Miranda‐Anaya, M., Turrubiate, I., Portugal, L. L.-D., Bocanegra-Botello, G. N., López-Islas, A., Díaz‐Muñoz, M., & Méndez, I. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-66538-0 · Cited by 30 · see citing works

Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per

Ulgherait, M., Chen, A., Oliva, M. K., Kim, H. X., Canman, J. C., Ja, W. W., & Shirasu‐Hiza, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.002 · Cited by 23 · see citing works

Monitoring Autophagy in Drosophila Using Fluorescent Reporters in the UAS-GAL4 SystemPreprint

DeVorkin, L., & Gorski, S. M. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot080341 · Cited by 22 · see citing works

Time-restricted feeding prolongs lifespan in Drosophila in a peripheral clock-dependent mannerPreprint

Cabrera, D., Young, M. W., & Axelrod, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.14.296368 · Cited by 8 · see citing works

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Izumo, M., Xu, P., Wight‐Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 361 · see citing works

Nutrition, longevity and disease: From molecular mechanisms to interventions

Longo, V. D., & Anderson, R. M. (2022) · Cell · doi:10.1016/j.cell.2022.04.002 · Cited by 342 · see citing works

Dietary regulation in health and disease

Wu, Q., Gao, Z., Yu, X., & Wang, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01104-w · Cited by 182 · see citing works

Spermidine is essential for fasting-mediated autophagy and longevity

Hofer, S. J., Daskalaki, I., Bergmann, M., Friščić, J., Zimmermann, A., Mueller, M. I., Abdellatif, M., Nicastro, R., Masser, S., Durand, S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01468-x · Cited by 183 · see citing works

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Ji, S., Xiong, M., Chen, H., Liu, Y., Zhou, L., Hong, Y., Wang, M., Wang, C., Fu, X., & Sun, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01343-5 · Cited by 166 · see citing works

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Wolff, C. A., Gutierrez‐Monreal, M. A., Meng, L., Zhang, X., Douma, L. G., Costello, H. M., Douglas, C. M., Ebrahimi, E., Pham, A. T., Oliveira, A. C. D. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2022.111982 · Cited by 153 · see citing works

Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals

Deota, S., Lin, T. C., Chaix, A., Williams, A. E., Le, H. D., Calligaro, H., Ramasamy, R., Huang, L., & Panda, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.006 · Cited by 139 · see citing works

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.

Gallage, S., Ali, A., Avila, J. E. B., Seymen, N., Ramadori, P., Joerke, V., Zizmare, L., Aicher, D., Gopalsamy, I. K., Fong, W., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.015 · Cited by 122 · see citing works

Effects of exercise on circadian rhythms in humans

Shen, B., Ma, C., Wu, G., Liu, H., Chen, L., & Yang, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1282357 · Cited by 125 · see citing works

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial

He, M., Wang, J., Liang, Q., Li, M., Guo, H., Wang, Y., Deji, C., Sui, J., Wang, Y.-W., Liu, Y., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100777 · Cited by 111 · see citing works

Intermittent fasting protects against Alzheimer’s disease in mice by altering metabolism through remodeling of the gut microbiota

Pan, R.-Y., Zhang, J., Wang, J., Wang, Y., Li, Z., Liao, Y., Liao, Y., Zhang, C., Liu, Z., Song, L., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00311-y · Cited by 107 · see citing works

When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging

Mihaylova, M. M., Chaix, A., Delibegović, M., Ramsey, J. J., Bass, J. T., Melkani, G. C., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.008 · Cited by 91 · see citing works

Complex physiology and clinical implications of time-restricted eating

Petersen, M. C., Gallop, M. R., Ramos, S. F., Zarrinpar, A., Broussard, J. L., Chondronikola, M., Chaix, A., & Klein, S. (2022) · Physiological Reviews · doi:10.1152/physrev.00006.2022 · Cited by 91 · see citing works

Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation

Lu, J. Y., Simon, M. A., Zhao, Y., Ablaeva, J., Corson, N., Choi, Y., Yamada, K. Y. H., Schork, N. J., Hood, W. R., Hill, G. E., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.011 · Cited by 82 · see citing works

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Zhao, Y., Jia, M., Chen, W., & Liu, Z. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.021 · Cited by 86 · see citing works

The microbiome stabilizes circadian rhythms in the gut

Zhang, Y., Li, Y., Barber, A. F., Noya, S. B., Williams, J. A., Li, F., Daniel, S. G., Bittinger, K. L., Fang, J., & Sehgal, A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217532120 · Cited by 73 · see citing works

Fasting: From Physiology to Pathology

Tang, D., Tang, Q., Huang, W., Zhang, Y., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202204487 · Cited by 71 · see citing works

Intermittent fasting and cardiovascular health: a circadian rhythm-based approach

Zhang, J., Chen, Y., Zhong, Y., Wang, Y., Huang, H., Xu, W. L., Pan, W., Chen, L., Zhu, Y., Bischof, E. Y., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.05.017 · Cited by 60 · see citing works

Circadian clock communication during homeostasis and ageing

Mortimer, T., Smith, J. G., Muñoz‐Cánoves, P., & Benitah, S. A. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00802-3 · Cited by 54 · see citing works

Interorgan rhythmicity as a feature of healthful metabolism

Bass, J. T. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.009 · Cited by 49 · see citing works

Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

Vaughen, J. P., Theisen, E. K., Rivas‐Serna, I. M., Berger, A. B., Kalakuntla, P. R., Anreiter, I., Mazurak, V. C., Rodriguez, T. P., Mast, J. D., Hartl, T. A., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.016 · Cited by 46 · see citing works

Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding

Williams, A. S., Crown, S. B., Lyons, S. P., Koves, T. R., Wilson, R. J., Johnson, J. M., Slentz, D. H., Kelly, D. P., Grimsrud, P. A., Zhang, G., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.007 · Cited by 50 · see citing works

Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging

Fu, Y., Jiang, F., Zhang, X., Pan, Y., Xu, R., Liang, X. H., Wu, X., Li, X., Lin, K., Shi, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49796-8 · Cited by 45 · see citing works

Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration

Na, D., Zhang, Z., Meng, M., Li, M., Gao, J., Kong, J., Zhang, G., & Guo, Y. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01555-z · Cited by 42 · see citing works

The hunger strikes back: an epigenetic memory for autophagy

González-Rodríguez, P., Füllgrabe, J., & Joseph, B. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01159-4 · Cited by 41 · see citing works

Six-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism

Shi, D., Fang, G., Chen, Q., Li, J., Ruan, X. Z., & Lian, X. (2023) · BMC Medicine · doi:10.1186/s12916-023-03131-y · Cited by 40 · see citing works

Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer

Fellows, R. C., Chun, S. K., Larson, N., Fortin, B. M., Mahieu, A. L., Song, W. A., Seldin, M. M., Pannunzio, N. R., & Masri, S. (2024) · Science Advances · doi:10.1126/sciadv.ado1458 · Cited by 41 · see citing works

Obesity, cancer risk, and time-restricted eating

Das, M., & Webster, N. J. G. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10061-3 · Cited by 42 · see citing works

Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process

Salminen, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101928 · Cited by 38 · see citing works

Effects of time-restricted feeding and walking exercise on the physical health of female college students with hidden obesity: a randomized trial

Liu, H., Chen, S.-Y., Ji, H., & Dai, Z. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1020887 · Cited by 36 · see citing works

Gender-specific effects of pro-longevity interventions in Drosophila

Lushchak, O. V., Strilbytska, O. M., & Storey, K. B. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111754 · Cited by 38 · see citing works

Pharmacological modulation of vascular ageing: A review from VascAgeNet

Roth, L., Doğan, S., Tuna, B. G., Arányi, T., Benı́tez, S., Borrell-Pagés, M., Bozaykut, P., Meyer, G. R. Y. D., Duca, L., Durmuş, N., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102122 · Cited by 36 · see citing works

Circadian mechanisms in adipose tissue bioenergetics and plasticityPreprint

Hepler, C., & Bass, J. T. (2023) · Genes & Development · doi:10.1101/gad.350759.123 · Cited by 33 · see citing works

Intermittent time-restricted feeding promotes longevity through circadian autophagy

Yin, Z., & Klionsky, D. J. (2022) · Autophagy · doi:10.1080/15548627.2022.2039524 · Cited by 32 · see citing works

Circadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding

Roth, J. R., Varshney, S., de Moraes, R. C. M., & Melkani, G. C. (2023) · Obesity · doi:10.1002/oby.23664 · Cited by 33 · see citing works

Autophagy, Clock Genes, and Cardiovascular Disease

Rabinovich-Nikitin, I., Kirshenbaum, E., & Kirshenbaum, L. A. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.08.022 · Cited by 31 · see citing works

Circadian disruption in cancer hallmarks: Novel insight into the molecular mechanisms of tumorigenesis and cancer treatment

Zhou, Z., Zhang, R., Zhang, Y., Xu, Y., Wang, R., Chen, S., Lv, Y., Chen, Y., Ren, Y., Luo, P., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217273 · Cited by 29 · see citing works

Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities

Vacca, A., Wang, R., Nambiar, N., Capone, F., Farrelly, C., Mostafa, A., Sechi, L. A., & Schiattarella, G. G. (2024) · Heart Failure Reviews · doi:10.1007/s10741-024-10439-1 · Cited by 27 · see citing works

Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation

Song, S., Chen, L., Bai, M., Wang, S., Ye, X., Lin, Y., Luo, X., Li, Z., Zhang, L., Zhu, X., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1043783 · Cited by 27 · see citing works

Intermittent fasting protects against food allergy in a murine model via regulating gut microbiota

Ma, R.-X., Hu, J., Fu, W., Zhong, J. Q., Cao, C., Wang, C., Qi, S.-Q., Zhang, X., Liu, G., & Gao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1167562 · Cited by 27 · see citing works

Roles of Stress Response in Autophagy Processes and Aging-Related Diseases

Watanabe, Y., Taguchi, K., & Tanaka, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813804 · Cited by 26 · see citing works

The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO

Yang, M., Zhu, X., Chen, C., Guo, X., Xu, S., Xu, Y., Du, S., Xiao, S., Mueller‐Roeber, B., Huang, W., et al. (2022) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13343 · Cited by 25 · see citing works

The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease

Ezzati, A., & Pak, V. M. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112033 · Cited by 26 · see citing works

Quercetin activates autophagy to protect rats ovarian granulosa cells from H2O2-induced aging and injury

Cai, M., Li, Q., Cao, Y., Huang, Y., Yao, H., Zhao, C., Wang, J., & Zhu, H. F. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176339 · Cited by 24 · see citing works

Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging

Jiao, J., Curley, M., Graça, F. A., Robles‐Murguia, M., Shirinifard, A., Finkelstein, D., Xu, B., Fan, Y., & Demontis, F. (2023) · Cell Reports · doi:10.1016/j.celrep.2022.111970 · Cited by 24 · see citing works

Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Godos, J., Currenti, W., Ferri, R., Lanza, G., Caraci, F., Frias-Toral, E., Guglielmetti, M., Ferraris, C., Lipari, V., Carvajal Altamiranda, S., et al. (2025) · Nutrients · doi:10.3390/nu17030529 · Cited by 22 · see citing works

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health

Kim, E., Yoo, S. H., & Chen, Z. (2022) · F1000Research · doi:10.12688/f1000research.126364.1 · Cited by 21 · see citing works

Autophagy takes it all – autophagy inducers target immune aging

Zinecker, H., & Simon, A. K. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049345 · Cited by 22 · see citing works

Time-Restricted Feeding Studies and Possible Human Benefit

Boyd, P., O’Connor, S. G., Heckman‐Stoddard, B. M., & Sauter, E. R. (2022) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkac032 · Cited by 23 · see citing works

A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan

Hu, X., Peng, J., Tang, W., Xia, Y., & Song, P. (2023) · BioScience Trends · doi:10.5582/bst.2023.01221 · Cited by 19 · see citing works

Circadian rhythm disruption-mediated downregulation of Bmal1 exacerbates DSS-induced colitis by impairing intestinal barrier

Zhang, Z., Li, W., Han, X., Tian, D., Yan, W., Liu, M., & Li, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1402395 · Cited by 19 · see citing works

Trajectories of cardiovascular ageing—from molecular mechanisms to clinical implementation

Ministrini, S., Wenzl, F. A., Lüscher, T. F., & Camici, G. G. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae178 · Cited by 21 · see citing works

Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?

Parrotta, M. E., Colangeli, L., Scipione, V., Vitale, C., Sbraccia, P., & Guglielmi, V. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00609-z · Cited by 19 · see citing works

The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites

Dong, Y., Lam, S. M., Li, Y., Li, M., & Shui, G. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.04.014 · Cited by 18 · see citing works

Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia

Kelu, J. J., & Hughes, S. M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422446122 · Cited by 19 · see citing works

A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila

Huang, S., Piao, C., Beuschel, C. B., Zhao, Z., & Sigrist, S. J. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001730 · Cited by 18 · see citing works

Intermittent time‐restricted eating may increase autophagic flux in humans: an exploratory analysis

Bensalem, J., Teong, X. T., Hattersley, K. J., Hein, L. K., Fourrier, C., Dang, L. V. P., Singh, S., Liu, K., Wittert, G., Hutchison, A. T., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287938 · Cited by 18 · see citing works

Understanding and improving vaccine efficacy in older adults

Hofer, S. J., Rapp, S., Klenerman, P., & Simon, A. K. (2025) · Nature Aging · doi:10.1038/s43587-025-00939-6 · Cited by 21 · see citing works

Circadian and Immunity Cycle Talk in Cancer Destination: From Biological Aspects to In Silico Analysis

Mirian, M., Hariri, A., Yadollahi, M., & Kohandel, M. (2022) · Cancers · doi:10.3390/cancers14061578 · Cited by 17 · see citing works

Intermittent fasting and Alzheimer's disease—Targeting ketone bodies as a potential strategy for brain energy rescue

Ye, Y., Chai, S.-F., Li, X.-R., Wu, M., Cai, H.-Y., & Wang, Z.-J. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01288-2 · Cited by 17 · see citing works

The potential impacts of circadian rhythm disturbances on male fertility

Li, T., Bai, Y., Jiang, Y., Jiang, K., Tian, Y., Gu, J., & Sun, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1001316 · Cited by 18 · see citing works

Time-restricted feeding and circadian autophagy for long life

Long, H., & Panda, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00600-3 · Cited by 17 · see citing works

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

Li, J., Peitao, X., Wenhui, Y., Ye, G., Feng, Y., Xu, X., Su, Z., Lin, J., Yunshu, C., Zhaoqiang, Z., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.02.014 · Cited by 16 · see citing works

Sea cucumber (Acaudina leucoprocta) peptides exhibit anti-aging effect in Drosophila melanogaster via regulation of microbiota dysbiosis and metabolic disorder

Wang, Q., Zhang, J., Shen, F., Du, J., & Feng, F. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104476 · Cited by 16 · see citing works

Separation of reproductive decline from lifespan extension during methionine restriction

Wei, F., Liu, S., Liu, J., Sun, Y., Allen, A. E., Reid, M. A., & Locasale, J. W. (2024) · Nature Aging · doi:10.1038/s43587-024-00674-4 · Cited by 16 · see citing works

Dietary urbanization destabilizes host-gut microbiome homeostasis and informs precision nutrition for human health

Zhang, F., Zhou, G., Schewe, M., Kulling, S. E., Ding, Y., Mozaffarian, D., & Zuo, T. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.013 · Cited by 15 · see citing works

Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder

Tener, S. J., Lin, Z., Park, S. J., Oraedu, K., Ulgherait, M., van Beek, E., Martínez-Muñiz, A., Pantalia, M., Gatto, J. A., Volpi, J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-51657-9 · Cited by 15 · see citing works

Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands

Dissel, S., Klose, M. K., van Swinderen, B., Cao, L., Ford, M., Periandri, E. M., Jones, J. D., Li, Z., & Shaw, P. J. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001797 · Cited by 15 · see citing works

OsATG1 and OsATG8 exhibit autophagy-independent functions to oppositely regulate ROP GTPase-mediated plant immunity in rice

He, F., Tao, H., Wang, R., Liu, J., Hao, Z., Wang, D., Shi, X., Zhang, F., Long, J., Zhang, H., et al. (2025) · Molecular Plant · doi:10.1016/j.molp.2025.07.006 · Cited by 14 · see citing works

A Bibliometric and Visualization Analysis of Intermittent Fasting

Chen, S., Han, R., & Liu, H. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.946795 · Cited by 14 · see citing works

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

Chen, H., Sun, L., Feng, L., Han⊗, X., Zhang, Y., Zhai, W., Zhang, Z., Mulholland, M. T., Zhang, W., & Yin, Y. (2023) · eLife · doi:10.7554/elife.91060 · Cited by 17 · see citing works

Unraveling the Health Benefits and Mechanisms of Time-Restricted Feeding: Beyond Caloric Restriction

Wang, R., Liao, Y., Deng, Y., & Rong, S. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae074 · Cited by 14 · see citing works

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies

Nunkoo, V. S., Cristian, A., Jurcău, A., Diaconu, R. G., & Jurcău, M. C. (2024) · Biomedicines · doi:10.3390/biomedicines12112540 · Cited by 15 · see citing works

Glia: the cellular glue that binds circadian rhythms and sleep

Carvalhas-Almeida, C., & Sehgal, A. (2025) · SLEEP · doi:10.1093/sleep/zsae314 · Cited by 14 · see citing works

Early Time-Restricted Eating Improves Weight Loss While Preserving Muscle: An 8-Week Trial in Young Women

Yu, Z., & Ueda, T. (2025) · Nutrients · doi:10.3390/nu17061022 · Cited by 16 · see citing works

The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans

Ching, T., & Hsu, A. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01188-w · Cited by 15 · see citing works

c-Jun N-terminal kinase signaling in aging

Li, Y., You, L., Nepovimová, E., Adam, V., Heger, Z., Jomová, K., Valko, M., Wu, Q., & Kuča, K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1453710 · Cited by 13 · see citing works

Metabolic dysregulation of trained immunity in immune aging and the impact of dietary patterns

Grigorescu, A., Riza, A., Streață, I., & Netea, M. G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00153.2025 · Cited by 13 · see citing works

d-Glucosamine induces circadian phase delay by promoting BMAL1 degradation through AMPK/mTOR pathway

Li, Z., Fu, B., Wei, A., Wu, Y., Huang, M., Zhang, E., Cui, B., Wang, B. J., & Peng, H. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121765 · Cited by 12 · see citing works

Aging and diet alter the protein ubiquitylation landscape in the mouse brain

Marino, A., Fraia, D. D., Panfilova, D., Sahu, A. K., Minetti, A., Omrani, O., Cirri, E., & Ori‬‬, A. (2025) · Nature Communications · doi:10.1038/s41467-025-60542-6 · Cited by 14 · see citing works

Late-life shift in caloric intake affects fly metabolism and longevity

Li, M., Macro, J., Meadows, K., Mishra, D., Martin, D., Olson, S., Huggins, B., Graveley, B. R., Li, J. Y. H., & Rogina, B. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311019120 · Cited by 11 · see citing works

Obesity-Related Glomerulopathy: Epidemiology, Pathogenesis, and Current Treatments

Yang, X., Bayliss, G. P., & Zhuang, S. (2024) · Integrative Medicine in Nephrology and Andrology · doi:10.1097/imna-d-24-00011 · Cited by 11 · see citing works

A detective story of intermittent fasting effect on immunity

Ma, R. (2024) · Immunology · doi:10.1111/imm.13829 · Cited by 13 · see citing works

The Estrogen–Autophagy Axis: Insights into Cytoprotection and Therapeutic Potential in Cancer and Infection

Zhao, Y., Klionsky, D. J., Wang, X., Huang, Q., Deng, Z., & Xiang, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312576 · Cited by 10 · see citing works

A 2‐week time‐restricted feeding attenuates psoriasis‐like lesions with reduced inflammatory cytokines and immunosenescence in mice

Chen, Y., Li, X., Yang, M., Wang, L., Lv, X., Shen, K., Wu, H., & Lu, Q. (2023) · Experimental Dermatology · doi:10.1111/exd.14932 · Cited by 11 · see citing works

Age mosaic of gut epithelial cells prevents aging

Qin, P., Wang, Q., Wu, Y., You, Q., Li, M., & Guo, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-62043-y · Cited by 10 · see citing works

The clock gene Cryptochrome 1 is involved in the photoresponse of embryonic hatching behavior in Bombyx mori

Yuan, X., Luo, C., Zhao, Q., Zhong, S., Hang, Q.-Q., Dai, T., Pan, Z., Sima, Y., Qiu, J., & Xu, S. (2023) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.22046 · Cited by 9 · see citing works

Time‐Restricted Feeding Promotes Longevity and Gut Health Without Fitness Trade‐Offs

Hofacker, A.-C., Knop, M., Krauss‐Etschmann, S., & Roeder, T. (2025) · The FASEB Journal · doi:10.1096/fj.202500875r · Cited by 9 · see citing works

Molecular mechanisms underlying the beneficial effects of exercise and dietary interventions in the prevention of cardiometabolic diseases

Forte, M., Rodolico, D., Ameri, P., Catalucci, D., Chimenti, C., Crotti, L., Schirone, L., Pingitore, A., Torella, D., Iacovone, G., et al. (2022) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001397 · Cited by 9 · see citing works

Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes

Wang, Y., Feng, C., Yu, B., Wang, J., Chen, W., Song, C., Ji, X., Guo, R., Cheng, G., Chen, H., et al. (2024) · Research · doi:10.34133/research.0468 · Cited by 9 · see citing works

Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting

Wei, F., Gong, L., Lu, S., Zhou, Y., Liu, L., Duan, Z., Xiang, R., Gonzalez, F. J., & Li, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111547 · Cited by 9 · see citing works

Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation.

Jiao, X., Li, Y., Chen, Z., Zhang, Q., He, R., Huang, Y., & Zuo, Z.-X. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk0636 · Cited by 9 · see citing works

Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

Liu, Z., Zhang, J., Jiang, F., Liu, C., Shao, Y., & Le, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70392 · Cited by 8 · see citing works

Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction

Ebeigbe, O. P., Mezhnina, V., Astaf’ev, A. A., Velingkaar, N., Kodger, J. V., Poe, A., Fritz, J., Williams, K. Z., Trokhimenko, E., Rom, J.-M. B., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116141 · Cited by 7 · see citing works

The metabolic basis of regulated cell death

Liu, J., Wang, J., Kang, R., Kroemer, G., & Tang, D. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.06.001 · Cited by 8 · see citing works

Autophagy-inducing nutritional interventions in experimental and clinical oncology

Hofer, S. J., Kroemer, G., & Kepp, O. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.08.003 · Cited by 8 · see citing works

A nexus of dietary restriction and gut microbiota: Recent insights into metabolic health

Wang, L., Wang, F., Xiong, L. H., Song, H., Ren, B., & Shen, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2202750 · Cited by 9 · see citing works

Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February – 2 March, 2024 (2024Pdm3)

Zampieri, S., Bersch, I., Smeriglio, P., Barbieri, E., Boncompagni, S., Maccarone, M. C., & Carraro, U. (2024) · European Journal of Translational Myology · doi:10.4081/ejtm.2024.12346 · Cited by 8 · see citing works

Time-restricted feeding and circadian autophagy for long life

Long, H., & Panda, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00600-3 · Cited by 17 · see citing works

Intermittent time-restricted feeding promotes longevity through circadian autophagy

Yin, Z., & Klionsky, D. J. (2022) · Autophagy · doi:10.1080/15548627.2022.2039524 · Cited by 32 · see citing works

Time-restricted feeding prolongs lifespan in Drosophila in a peripheral clock-dependent mannerPreprint

Cabrera, D., Young, M. W., & Axelrod, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.14.296368 · Cited by 8 · see citing works

Sleep Hungry for Cellular Cleanup!

Huh, J. Y. (2022) · Molecules and Cells · doi:10.14348/molcells.2021.5038 · Cited by 1 · see citing works

Time-Restricted Feeding Extends Longevity in Drosophila Melanogaster

Cabrera, D. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/eg2f-1e53