Metabolism as an integral cog in the mammalian circadian clockwork
Open accessAbstract
Circadian rhythms are an integral part of life. These rhythms are apparent in virtually all biological processes studies to date, ranging from the individual cell (e.g. DNA synthesis) to the whole organism (e.g. behaviors such as physical activity). Oscillations in metabolism have been characterized extensively in various organisms, including mammals. These metabolic rhythms often parallel behaviors such as sleep/wake and fasting/feeding cycles that occur on a daily basis. What has become increasingly clear over the past several decades is that many metabolic oscillations are driven by cell-autonomous circadian clocks, which orchestrate metabolic processes in a temporally appropriate manner. During the process of identifying the mechanisms by which clocks influence metabolism, molecular-based studies have revealed that metabolism should be considered an integral circadian clock component. The implications of such an interrelationship include the establishment of a vicious cycle during cardiometabolic disease states, wherein metabolism-induced perturbations in the circadian clock exacerbate metabolic dysfunction. The purpose of this review is therefore to highlight recent insights gained regarding links between cell-autonomous circadian clocks and metabolism and the implications of clock dysfunction in the pathogenesis of cardiometabolic diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · see citing works
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 1× · see citing works
“The satiety hormone leptin is an attractive candidate to explain this relationship between sleep and metabolism because peak leptin levels normally reached during the night are blunted in a dosedependent manner to the amount of sleep restriction (Taheri et al., 2004).”
BackgroundDibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Quantity and Quality of Sleep and Incidence of Type 2 Diabetes
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Diabetes Care · doi:10.2337/dc09-1124 · Cited by 1,670 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426 · see citing works
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works
Molecular cloning and expression of glycogen synthase kinase‐3/factor A.
Woodgett, J. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07419.x · Cited by 1,362 · see citing works
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216 · see citing works
Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175 · see citing works
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD <sup>+</sup> Biosynthesis
Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059 · see citing works
Physiological significance of a peripheral tissue circadian clock
Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036 · see citing works
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958 · see citing works
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932 · see citing works
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921 · see citing works
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · cited 1× · see citing works
“Similar to humans, rodents exhibit marked diurnal variations in metabolic parameters, at the whole body, organ and cellular levels (Green et al., 2008; Rutter et al., 2002; Wijnen & Young, 2006).”
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works
Circadian clocks in human red blood cells
O'Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 830 · see citing works
GSK3 signalling in neural development
Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 828 · see citing works
Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792 · see citing works
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765 · see citing works
Aschoff, J. (1965) · Science · doi:10.1126/science.148.3676.1427 · Cited by 752 · see citing works
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707 · see citing works
Frame, S., Cohen, P., & Biondi, R. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00253-2 · Cited by 703 · see citing works
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-05 · Cited by 682 · see citing works
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works
Putative contributors to the secular increase in obesity: exploring the roads less traveled
Keith, S. W., Redden, D. T., Katzmarzyk, P. T., Boggiano, M. M., Hanlon, E. C., Benca, R. M., Ruden, D. M., Pietrobelli, A., Barger, J. L., Fontaine, K. R., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803326 · Cited by 633 · see citing works
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 611 · see citing works
Hermida, R. C., Ayala, D. E., Mojón, A., & Fernández, J. R. (2010) · Chronobiology International · doi:10.3109/07420528.2010.510230 · Cited by 608 · see citing works
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567 · see citing works
The human circadian metabolome
Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114410109 · Cited by 566 · see citing works
Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536 · see citing works
Bradley, T. D., & Floras, J. S. (2003) · Circulation · doi:10.1161/01.cir.0000061758.05044.64 · Cited by 518 · see citing works
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 513 · see citing works
Self-citationChaput, J., Després, J., Bouchard, C., & Tremblay, A. (2007) · Obesity · doi:10.1038/oby.2007.512 · Cited by 498 · see citing works
Ravussin, É. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.3.566 · Cited by 482 · see citing works
Linking neural activity and molecular oscillations in the SCN
Colwell, C. S. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3086 · Cited by 474 · see citing works
Obesity in mice with adipocyte-specific deletion of clock component Arntl
Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465 · see citing works
Increased risk of ischaemic heart disease in shift workers
Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91619-3 · Cited by 459 · see citing works
Ripperger, J. A., Shearman, L. P., Reppert, S. M., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.14.6.679 · Cited by 429 · see citing works
Clinical Relevance of Nighttime Blood Pressure and of Daytime Blood Pressure Variability
Palatini, P. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400210081013 · Cited by 424 · see citing works
Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanismPreprint
Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., & Okamura, H. (2001) · Genes & Development · doi:10.1101/gad.873501 · Cited by 403 · see citing works
Metabolism and the Control of Circadian Rhythms
Rutter, J. P., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 401 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
The Circadian<i>Clock</i>Mutation Alters Sleep Homeostasis in the Mouse
Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08138.2000 · Cited by 367 · see citing works
Diurnal Variations of Blood Pressure and Microalbuminuria in Essential Hypertension
Bianchi, S., Bigazzi, R., Baldari, G., Sgherri, G., & Campese, V. M. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.1.23 · Cited by 366 · see citing works
Suprachiasmatic Nucleus: Use of <sup>14</sup> C-Labeled Deoxyglucose Uptake as a Functional Marker
Schwartz, W. J., & Gainer, H. (1977) · Science · doi:10.1126/science.887940 · Cited by 358 · cited 1× · see citing works
“…utilization (uptake of 2-deoxyglucose) within the suprachiasmatic nucleus (SCN) of animals were observed, independent of the lighting conditions (Schwartz & Gainer, 1977); and 20 years later, these rhythms were shown to persist at the single cell level in immortalized rat SCN cells (Earnest et…”
BackgroundSleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351 · see citing works
The Clocks That Time Us: Physiology of the Circadian Timing System
(1983) · Journal of Gerontology · doi:10.1093/geronj/38.2.246a · Cited by 349 · see citing works
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 344 · see citing works
Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
Kaasik, K., & Lee, C. C. (2004) · Nature · doi:10.1038/nature02724 · Cited by 341 · see citing works
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340 · see citing works
A Daily Rhythm in Glucose Tolerance
la Fleur, S. E., Kalsbeek, A., Wortel, J., Fekkes, M. L., & Buijs, R. M. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1237 · Cited by 337 · see citing works
Interplay of Circadian Clocks and Metabolic Rhythms
Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 335 · see citing works
Self-citationCircadian Clock Control by SUMOylation of BMAL1
Cardone, L., Hirayama, J., Giordano, F., Tamaru, T., Palvimo, J. J., & Sassone‐Corsi, P. (2005) · Science · doi:10.1126/science.1110689 · Cited by 329 · see citing works
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323 · see citing works
Jung, C. M., Melanson, E. L., Frydendall, E. J., Perreault, L., Eckel, R. H., & Wright, K. P. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.197517 · Cited by 318 · see citing works
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters
Martino, T. A., Oudit, G. Y., Herzenberg, A. M., Tata, N., Koletar, M. M., Kabir, G. M., Belsham, D. D., Backx, P. H., Ralph, M. R., & Sole, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00829.2007 · Cited by 317 · see citing works
Neurons and networks in daily rhythms
Herzog, E. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2215 · Cited by 316 · see citing works
Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ
Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works
Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila
Xu, K., Zheng, X., & Sehgal, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.006 · Cited by 306 · see citing works
The Suprachiasmatic Nucleus Generates the Diurnal Changes in Plasma Leptin Levels
Kalsbeek, A., Fliers, E., Romijn, J. A., la Fleur, S. E., Wortel, J., Bakker, O., Endert, E., & Buijs, R. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8197 · Cited by 305 · see citing works
Bodosi, B., Gardi, J., Hajdu, I., Szentirmai, É., Obál, F., & Krueger, J. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00294.2004 · Cited by 304 · see citing works
Farshchi, H. R., Taylor, M. A., & Macdonald, I. A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.388 · Cited by 302 · see citing works
Incidence of metabolic syndrome among night-shift healthcare workers
Pietroiusti, A., Neri, A., Somma, G., Coppeta, L., Iavicoli, I., BERGAMASCHI, A., & Magrini, A. (2009) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.046797 · Cited by 301 · see citing works
Glycogen Synthase Kinase 3α-Specific Regulation of Murine Hepatic Glycogen Metabolism
MacAulay, K., Doble, B. W., Patel, S., Hansotia, T., Sinclair, E. M., Drucker, D. J., Nagy, A., & Woodgett, J. R. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.013 · Cited by 296 · see citing works
Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation
Sahar, S., Zocchi, L., Kinoshita, C., Borrelli, E., & Sassone‐Corsi, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008561 · Cited by 291 · see citing works
Glycogen Synthase Kinase-3 - An Overview of An Over-Achieving Protein Kinase
Kockeritz, L. K., Doble, B. W., Patel, S., & Woodgett, J. R. (2006) · Current Drug Targets · doi:10.2174/1389450110607011377 · Cited by 285 · see citing works
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 284 · see citing works
Hirota, T., Lewis, W. G., Liu, A. C., Lee, J. W., Schultz, P. G., & Kay, S. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811410106 · Cited by 283 · see citing works
The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease
Durgan, D. J., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209957 · Cited by 277 · see citing works
Self-citationYagita, K., Tamanini, F., Yasuda, M., Hoeijmakers, J. H. J., van der Horst, G. T. J., & Okamura, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1301 · Cited by 271 · see citing works
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262 · see citing works
A Suprachiasmatic Nucleus Generated Rhythm In Basal Glucose Concentrations
Fleur, L., Kalsbeek, Wortel, & Buijs (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00373.x · Cited by 256 · see citing works
Durgan, D. J., Pulinilkunnil, T., Villegas-Montoya, C., Garvey, M. E., Frangogiannis, N. G., Michael, L. H., Chow, C.-W., Dyck, J. R. B., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209346 · Cited by 254 · see citing works
Self-citationCoomans, C. P., van den Berg, S. A. A., Houben, T., van Klinken, J., van den Berg, R., Pronk, A. C. M., Havekes, L. M., Romijn, J. A., van Dijk, K. W., Biermasz, N. R., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-210898 · Cited by 252 · see citing works
Young, M. E., Razeghi, P., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh1101.091190 · Cited by 251 · see citing works
Self-citationUm, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700070200 · Cited by 244 · see citing works
Foster, F., & Wulff, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1670 · Cited by 243 · see citing works
Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men.
Degaute, J. P., van de Borne, P., Linkowski, P., & Van Cauter, E. (1991) · Hypertension · doi:10.1161/01.hyp.18.2.199 · Cited by 243 · see citing works
Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm
Van Cauter, E., Shapiro, E. T., Tillil, H., & Polonsky, K. S. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.4.e467 · Cited by 240 · see citing works
Boden, G., Chen, X., & Urbain, J. L. (1996) · Diabetes · doi:10.2337/diab.45.8.1044 · Cited by 228 · cited 2× · see citing works
“Although insulin sensitivity is relatively low during the night in healthy people, subjects with diabetes show increased sensitivity to insulin at this phase (Boden et al., 1996).”
BackgroundClock is important for food and circadian regulation of macronutrient absorption in mice
Pan, X., & Hussain, M. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900085-jlr200 · Cited by 226 · see citing works
Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
Wang, T. A., Yu, Y. V., Govindaiah, G., Ye, X., Artinian, L. R., Coleman, T. P., Sweedler, J. V., Cox, C. L., & Gillette, M. U. (2012) · Science · doi:10.1126/science.1222826 · Cited by 221 · see citing works
Work characteristics and incidence of type 2 diabetes in women.
Kroenke, C. H., Spiegelman, D., Manson, J., Schernhammer, E. S., Colditz, G. A., & Kawachi, I. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj355 · Cited by 220 · see citing works
Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake
Nagai, K., Nishio, T., Nakagawa, H., Nakamura, S., & Fukuda, Y. (1978) · Brain Research · doi:10.1016/0006-8993(78)90648-0 · Cited by 217 · see citing works
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215 · see citing works
Boivin, D. B., Tremblay, G. M., & James, F. O. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.015 · Cited by 214 · see citing works
High-fat feeding alters the clock synchronization to light
Mendoza, J., Pévet, P., & Challet, E. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159566 · Cited by 213 · see citing works
Young, M. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00582.2005 · Cited by 212 · see citing works
Self-citationProgressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus
Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207 · see citing works
Postprandial hormone and metabolic responses amongst shift workers in Antarctica
Lund, J., Arendt, J., Hampton, S., English, J., & Morgan, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710557 · Cited by 206 · see citing works
Sack, R. L., Hughes, R. J., Edgar, D. M., & Lewy, A. J. (1997) · SLEEP · doi:10.1093/sleep/20.10.908 · Cited by 205 · see citing works
Circadian Adaptation to Night-Shift Work by Judicious Light and Darkness Exposure
Boivin, D. B., & James, F. O. (2002) · Journal of Biological Rhythms · doi:10.1177/0748730402238238 · Cited by 205 · see citing works
The clocks that time us. Physiology of the circadian timing system
Aschoff, J. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90088-3 · Cited by 203 · see citing works
Altered sleep regulation in leptin-deficient mice
Laposky, A. D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., & Turek, F. W. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2005 · Cited by 203 · see citing works
Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice
Bray, M. S., Ratcliffe, W. F., Grenett, M. H., Brewer, R. A., Gamble, K. L., & Young, M. E. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.137 · Cited by 202 · see citing works
Self-citationHigh-fat diet acutely affects circadian organisation and eating behavior
Pendergast, J. S., Branecky, K. L., Yang, W., Ellacott, K. L. J., Niswender, K. D., & Yamazaki, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12133 · Cited by 198 · see citing works
Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191 · see citing works
Jéquier, E., & Felber, J.-P. (1987) · Baillière's Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(87)80011-3 · Cited by 191 · see citing works
Health risks related to shift work
Koller, M. (1983) · International Archives of Occupational and Environmental Health · doi:10.1007/bf00406178 · Cited by 191 · see citing works
Edgar, D. M., Martin, C. E., & Dement, W. C. (1991) · Journal of Biological Rhythms · doi:10.1177/074873049100600301 · Cited by 187 · see citing works
Shift Work in Nurses: Contribution of Phenotypes and Genotypes to Adaptation
Gamble, K. L., Motsinger‐Reif, A. A., Hida, A., Borsetti, H., Servick, S. V., Ciarleglio, C. M., Robbins, S., Hicks, J., Carver, K., Hamilton, N. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018395 · Cited by 185 · see citing works
Self-citationThe Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity
Coomans, C. P., van den Berg, S. A. A., Lucassen, E. A., Houben, T., Pronk, A. C. M., van der Spek, R. D., Kalsbeek, A., Biermasz, N. R., Willems van Dijk, K., Romijn, J. A., et al. (2013) · Diabetes · doi:10.2337/db12-0507 · Cited by 173 · see citing works
Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork
Li, J., Lu, W., Beesley, S., Loudon, A. S. I., & Meng, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033292 · Cited by 169 · see citing works
The clock gene, brain and muscle Arnt‐like 1, regulates adipogenesis via Wnt signaling pathway
Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., Yechoor, V. K., Minze, L. J., Hsueh, W. A., & Ma, K. (2012) · The FASEB Journal · doi:10.1096/fj.12-205781 · Cited by 168 · see citing works
Alterations of the Circadian Clock in the Heart by Streptozotocin-induced Diabetes
Young, M. E., Wilson, C. R., Razeghi, P., Guthrie, P. H., & Taegtmeyer, H. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1504 · Cited by 165 · see citing works
Self-citationImpairment of Peripheral Circadian Clocks Precedes Metabolic Abnormalities in ob/ob Mice
Ando, H., Kumazaki, M., Motosugi, Y., Ushijima, K., Maekawa, T., Ishikawa, E., & Fujimura, A. (2011) · Endocrinology · doi:10.1210/en.2010-1068 · Cited by 164 · see citing works
Development of dilated cardiomyopathy in<i>Bmal1</i>-deficient mice
Lefta, M., Campbell, K. S., Feng, H.-Z., Jin, J.-P., & Esser, K. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00238.2012 · Cited by 158 · see citing works
Koban, M., & Swinson, K. L. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00543.2004 · Cited by 152 · see citing works
Fonjallaz, P., Ossipow, V., Wanner, G., & Schibler, U. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00365.x · Cited by 151 · see citing works
Sanada, K., Okano, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107850200 · Cited by 151 · see citing works
Schlierf, G., & Dorow, E. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107235 · Cited by 148 · see citing works
Kräuchi, K., Cajochen, C., Werth, E., & Wirz‐Justice, A. (2002) · Journal of Biological Rhythms · doi:10.1177/074873040201700409 · Cited by 146 · see citing works
Entrainment and phase shifting of circadian rhythms in mice by forced treadmill running
Marchant, E. G., & Mistlberger, R. E. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)80045-x · Cited by 145 · see citing works
Durgan, D. J., Pat, B., Laczy, B., Bradley, J. A., Tsai, J.-Y., Grenett, M. H., Ratcliffe, W. F., Brewer, R. A., Nagendran, J., Villegas‐Montoya, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278903 · Cited by 144 · see citing works
Self-citationDemonstration of a dawn phenomenon in normal human volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diabetes.33.12.1150 · Cited by 142 · see citing works
Schroeder, A., Truong, D. A., Loh, D. H., Jordan, M. C., Roos, K. P., & Colwell, C. S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.233676 · Cited by 135 · see citing works
Kurabayashi, N., Hirota, T., Sakai, M., Sanada, K., & Fukada, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01047-09 · Cited by 134 · see citing works
Working for Food Shifts Nocturnal Mouse Activity into the Day
Hut, R. A., Pilorz, V., Boerema, A. S., Strijkstra, A. M., & Daan, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017527 · Cited by 133 · see citing works
Horowitz, T. S., Cade, B. E., Wolfe, J. M., & Czeisler, C. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e384 · Cited by 133 · see citing works
CK2α phosphorylates BMAL1 to regulate the mammalian clock
Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S., Takamatsu, K., & Sassone‐Corsi, P. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1578 · Cited by 131 · see citing works
Biological clocks and the digestive system
Scheving, L. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.9305 · Cited by 130 · see citing works
Demonstration of a Dawn Phenomenon in Normal Human Volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P. J., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diab.33.12.1150 · Cited by 129 · see citing works
Immortal Time: Circadian Clock Properties of Rat Suprachiasmatic Cell Lines
Earnest, D. J., Liang, F.-Q., Ratcliff, M., & Cassone, V. M. (1999) · Science · doi:10.1126/science.283.5402.693 · Cited by 129 · see citing works
Circadian Aspects of Postprandial Metabolism
Morgan, L., Hampton, S. M., Gibbs, M. A., & Arendt, J. (2003) · Chronobiology International · doi:10.1081/cbi-120024218 · Cited by 129 · see citing works
Cellular Senescence Impairs Circadian Expression of Clock Genes In Vitro and In Vivo
Kunieda, T., Minamino, T., Katsuno, T., Tateno, K., Nishi, J.-I., Miyauchi, H., Orimo, M., Okada, S., & Komuro, I. (2006) · Circulation Research · doi:10.1161/01.res.0000204504.25798.a8 · Cited by 129 · see citing works
Changes in cortisol secretion during shiftwork: implications for tolerance to shiftwork?
Hennig, J., KIEFERDORF, P., MORITZ, C., Huwe, S., & Netter, P. (1998) · Ergonomics · doi:10.1080/001401398186784 · Cited by 128 · see citing works
Direct Regulation of Myocardial Triglyceride Metabolism by the Cardiomyocyte Circadian Clock
Tsai, J.-Y., Kienesberger, P. C., Pulinilkunnil, T., Sailors, M. H., Durgan, D. J., Villegas‐Montoya, C., Jahoor, A., Gonzalez, R., Garvey, M. E., Boland, B. B., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077800 · Cited by 125 · see citing works
Self-citationEdgar, D. M., Kilduff, T. S., Martin, C. E., & Dement, W. C. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90080-8 · Cited by 125 · see citing works
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes
Ando, H., Takamura, T., Nagata, N., Shima, K. R., Eto, T., Misu, H., Shiramoto, M., Tsuru, T., Irie, S., Fujimura, A., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1194-6 · Cited by 124 · see citing works
Crowley, S. J., Lee, C., Tseng, C. Y., Fogg, L., & Eastman, C. I. (2004) · SLEEP · doi:10.1093/sleep/27.6.1077 · Cited by 122 · see citing works
Towards the 24-hour society - new approaches for aging shift workers?
Härmä, M., & Ilmarinen, J. (1999) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.488 · Cited by 118 · see citing works
DIURNAL VARIATION IN INSULIN SENSITIVITY
Gibson, T. C., & Jarrett, R. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92472-5 · Cited by 117 · see citing works
Durgan, D. J., Tsai, J.-Y., Grenett, M. H., Pat, B., Ratcliffe, W. F., Villegas‐Montoya, C., Garvey, M. E., Nagendran, J., Dyck, J. R. B., Bray, M. S., et al. (2011) · Chronobiology International · doi:10.3109/07420528.2010.550406 · Cited by 114 · see citing works
Self-citationPhysiologic Versus Pathologic Hypertrophy and the Pressure-Overloaded Myocardium
Weber, K. T., Clark, W. A., Janicki, J. S., et al. (1987) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198700106-00006 · Cited by 113 · see citing works
Kudo, T., Akiyama, M., Kuriyama, K., Sudo, M., Moriya, T., & Shibata, S. (2004) · Diabetologia · doi:10.1007/s00125-004-1461-0 · Cited by 110 · see citing works
Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids
Stavinoha, M. A., RaySpellicy, J. W., Hart-Sailors, M. L., Mersmann, H. J., Bray, M. S., & Young, M. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2004 · Cited by 109 · see citing works
Self-citationSmith, M. R., Fogg, L., & Eastman, C. I. (2009) · SLEEP · doi:10.1093/sleep/32.11.1481 · Cited by 108 · see citing works
Hsieh, M.-C., Yang, S.-C., Tseng, H.-L., Hwang, L.-L., Chen, C.-T., & Shieh, K.-R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.228 · Cited by 108 · see citing works
The role of cell‐specific circadian clocks in metabolism and disease
Bray, M. S., & Young, M. E. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00684.x · Cited by 106 · see citing works
Self-citationFalvey, E., Fleury-Olela, F., & Schibler, U. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00105.x · Cited by 105 · see citing works
Meal frequency patterns determine the phase of mouse peripheral circadian clocks
Kuroda, H., Tahara, Y., Saito, K., Ohnishi, N., Kubo, Y., Seo, Y., Otsuka, M., Fuse, Y., Ohura, Y., Hirao, A., et al. (2012) · Scientific Reports · doi:10.1038/srep00711 · Cited by 105 · see citing works
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
Bellet, M. M., Nakahata, Y., Boudjelal, M., Watts, E. F., Mossakowska, D. E., Edwards, K. A., Cervantes, M., Astarita, G., Loh, C., Ellis, J. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214266110 · Cited by 105 · see citing works
OBESITY AND HIGH BLOOD PRESSURE OF 12-HOUR NIGHT SHIFT FEMALE CLEAN-ROOM WORKERS
Chen, J., Lin, Y.-C., & Hsiao, S.-T. (2010) · Chronobiology International · doi:10.3109/07420520903502242 · Cited by 105 · see citing works
Kario, K. (2009) · Hypertension Research · doi:10.1038/hr.2009.73 · Cited by 99 · see citing works
Lithium- and Valproate-Induced Alterations in Circadian Locomotor Behavior in Drosophila
Dokucu, M. E., Yu, L., & Taghert, P. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300764 · Cited by 96 · see citing works
Schiavo‐Cardozo, D., Lima, M. M. O., Pareja, J. C., & Geloneze, B. (2013) · Clinical Endocrinology · doi:10.1111/cen.12114 · Cited by 96 · see citing works
Circadian feeding rhythm after hypothalamic knife-cut isolating suprachiasmatic nucleus
Nishio, T., Shiosaka, S., Nakagawa, H., Sakumoto, T., & Satoh, K. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90172-0 · Cited by 92 · see citing works
Circadian rhythms in disaccharidases of rat small intestine and its relation to food intake
Saito, M., Murakami, E., & Suda, M. (1976) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(76)90181-1 · Cited by 90 · see citing works
Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock
Edgar, D. M., Reid, M. S., & Dement, W. C. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.1.r265 · Cited by 90 · see citing works
Reznick, J., Preston, E., Wilks, D. L., Beale, S. M., Turner, N., & Cooney, G. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.08.010 · Cited by 86 · cited 2× · see citing works
“Recent studies have shown that this food-induced dyssynchrony extends beyond the central versus peripheral clock relationship, but causes dyssynchrony between peripheral clocks (Bray et al., 2012; Reznick et al., 2013).”
BackgroundKoban, M., Le, W. W., & Hoffman, G. E. (2006) · Endocrinology · doi:10.1210/en.2005-0695 · Cited by 85 · cited 1× · see citing works
“At the CNS level, sleep deprivation also increases hypothalamic expression of neuropeptide y (orexigenic) and decreases expression of proopiomelanocortin (anorectic; Koban et al., 2006).”
BackgroundTwenty-four-hour melatonin and core body temperature rhythms: their adaptation in night workers
Weibel, L., Spiegel, K., Gronfier, C., FOLLENIUS, M., & BRANDENBERGER, G. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.3.r948 · Cited by 81 · see citing works
Clock genes, intestinal transport and plasma lipid homeostasis
Hussain, M. M., & Pan, X. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.001 · Cited by 77 · see citing works
Clock gene dysfunction in patients with obstructive sleep apnoea syndrome
Burioka, N., Koyanagi, S., Endo, M., Takata, M., Fukuoka, Y., Miyata, M., Takeda, K., Chikumi, H., Ohdo, S., & Shimizu, E. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138207 · Cited by 77 · see citing works
Essential and expendable features of the circadian timekeeping mechanism
Hardin, P. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.001 · Cited by 76 · see citing works
The Nutritional Status and Eating Habits of Shift Workers: A Chronobiological Approach
Pasqua, I. C., & Moreno, C. R. C. (2004) · Chronobiology International · doi:10.1081/cbi-200040310 · Cited by 75 · see citing works
Diurnal Variation in Response to Intravenous Glucose
Whichelow, M. J., Sturge, R. A., KEEN, H., et al. (1974) · BMJ · doi:10.1136/bmj.1.5906.488 · Cited by 75 · see citing works
Wang, Q., Maillard, M. P., Schibler, U., Burnier, M., & Gachon, F. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00241.2010 · Cited by 70 · see citing works
Barter, P. J., Carroll, K. F., & Nestel, P. J. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106528 · Cited by 66 · see citing works
Smith, M. R., & Eastman, C. I. (2008) · SLEEP · doi:10.1093/sleep/31.12.1639 · Cited by 64 · see citing works
Heme-Based Sensing by the Mammalian Circadian Protein CLOCK
Lukat-Rodgers, G. S., Correia, C., Botuyan, M. V., Mer, G., & Rodgers, K. R. (2010) · Inorganic Chemistry · doi:10.1021/ic902388q · Cited by 63 · see citing works
Kung, T. A., Egbejimi, O., Cui, J., Ha, N. P., Durgan, D. J., Essop, M. F., Bray, M. S., Shaw, C. A., Hardin, P. E., Stanley, W. C., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.018 · Cited by 62 · see citing works
Self-citationOxygen Consumption and Body Temperatures During the Night
Kreider, M. B., BUSKIRK, E. R., & Bass, D. E. (1958) · Journal of Applied Physiology · doi:10.1152/jappl.1958.12.3.361 · Cited by 61 · see citing works
Reinberg, A., Migraine, C., Apfelbaum, M., et al. (1979) · PubMed · Cited by 61 · see citing works
Durgan, D. J., Moore, M. W., Ha, N. P., Egbejimi, O., Fields, A., Mbawuike, U., Egbejimi, A., Shaw, C. A., Bray, M. S., Nannegari, V., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01361.2006 · Cited by 60 · see citing works
Self-citationIshikawa, K., & Shimazu, T. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90119-3 · Cited by 59 · see citing works
Circadian rhythm and sudden death in heart failure
Carson, P. E., O’Connor, C. M., Miller, A. B., Anderson, S., Belkin, R. N., Neuberg, G. W., WERTHEIMER, J. H., Frid, D. J., Cropp, A., & Packer, M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00728-2 · Cited by 57 · see citing works
The suprachiasmatic nucleus participates in food entrainment: a lesion study
Castellanos, A., Salgado‐Delgado, R., Rodríguez, K., Buijs, R. M., & Escobar, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.061 · Cited by 57 · see citing works
Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells
Osland, T. M., Fernø, J., Håvik, B., Heuch, I., Ruoff, P., Lærum, O. D., & Steen, V. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110379508 · Cited by 56 · see citing works
Protein Kinase G Type II Is Required for Night-to-Day Progression of the Mammalian Circadian Clock
Tischkau, S. A., Mitchell, J. W., Pace, L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.027 · Cited by 55 · see citing works
Escobar, C., Martínez-Merlos, T., Castellanos, A., Miñana-Solis, M. D. C., & Buijs, R. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05893.x · Cited by 54 · see citing works
Salgado‐Delgado, R., Saderi, N., Castellanos, A., Buijs, R. M., & Escobar, C. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410383403 · Cited by 52 · see citing works
Paul, J. R., Johnson, R. L., Jope, R. S., & Gamble, K. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.047 · Cited by 51 · see citing works
Self-citationSaito, M., Murakami, E., Nishida, T., et al. (1976) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131312 · Cited by 49 · see citing works
Effect of meal timing on diurnal rhythm of human cholesterol synthesis
Cella, L. K., Cauter, E. V., & Schoeller, D. A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.5.e878 · Cited by 47 · see citing works
Circadian rhythm in sensitivity of glucose metabolism to insulin in rat soleus muscle
Leighton, B., Kowalchuk, J. M., Challiss, R. A. J., & Newsholme, E. A. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.1.e41 · Cited by 43 · see citing works
Marquez, S., Crespo, P. M., Carlini, V. P., Garbarino‐Pico, E., Baler, R., Caputto, B. L., & Guido, M. E. (2004) · The FASEB Journal · doi:10.1096/fj.03-0417fje · Cited by 41 · see citing works
Trümper, B., Reschke, K., & Molling, J. (1995) · Hormone and Metabolic Research · doi:10.1055/s-2007-979926 · Cited by 39 · see citing works
Mechanism controlling sleep organization of the obese Zucker rats
Megirian, D., Dmochowski, J., & Farkas, G. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.1.253 · Cited by 37 · see citing works
Anticipating anticipation: pursuing identification of cardiomyocyte circadian clock function
Young, M. E. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00473.2009 · Cited by 35 · see citing works
Self-citationLight responses of the circadian system in leptin deficient mice
Sans-Fuentes, M. A., Dı́ez-Noguera, A., & Cambras, T. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.023 · Cited by 35 · see citing works
Diurnal Variations in Cardiovascular Function and Glucose Regulation in Normotensive Humans
Biston, P., Cauter, E. V., Ofek, G., Linkowski, P., Polonsky, K. S., & Degaute, J.-P. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.863 · Cited by 34 · see citing works
Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport
Altamirano, A. A., Breitwieser, G. E., & Russell, J. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.4.c878 · Cited by 34 · see citing works
Castillo, C., Molyneux, P. C., Carlson, R. H., & Harrington, M. E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.003 · Cited by 30 · see citing works
Sleep patterns in the genetically obese Zucker rat: effect of acarbose treatment
Danguir, J. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.1.r281 · Cited by 30 · see citing works
Circadian rhythm of intestinal disaccharidases of rats fed with adiurnal periodicity
Saito, M., Kato, H., & Suda, M. (1980) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1980.238.2.g97 · Cited by 29 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Knutsson A Akerstedt T Jonsson B Orth-Gomer K Increased risk of ischaemic heart disease in shift workers Lancet 1986b 2 89 92 2873389
- Young ME Razeghi P Taegtmeyer H Clock genes in the heart: characterization and attenuation with hypertrophy Circ Res 2001b 88 1142 1150 11397780
Cited by
Sorted by citations
Timing of food intake: identifying contributing factors to design effective interventions
Dashti, H. S., Scheer, F. A. J. L., Saxena, R., & Garaulet, M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy131 · Cited by 121 · see citing works
Meal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72 · see citing works
“More precisely, in humans and animals, food intake has been proven to entrain the peripheral clocks of liver, heart, and pancreatic tissue (31 – 33).”
Background
- Authors
- Gamble, K. L., & Young, M. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Young, Martin E.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2013-04-17
- Volume
- 48
- Issue
- 4
- Pages
- 317-331
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC3862897
- OpenAlex
- W2007270297
- Cited by
- 18
- References
- 208
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000165)
- Center for Clinical and Translational Science, University of Alabama at Birmingham
- National Heart, Lung, and Blood Institute (HL-074259, HL‑106199, R21HL106199, R21HL107709, HL-107709, R01HL074259)
- National Institute of General Medical Sciences (GM086683, R00GM086683, K99GM086683)
- National Institute of Neurological Disorders and Stroke (R01NS082413, NS082413)
- National Center for Research Resources
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, metabolic rhythms, metabolism, cardiometabolic disease, sleep-wake cycle, circadian metabolism
- MeSH terms
- Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Mammals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review