Cited by 18Circadian rhythm and melatoninDietary Effects on HealthSleep and Work-Related Fatigue

Metabolism as an integral cog in the mammalian circadian clockwork

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Gamble, Karen L., Young, Martin E.·2013·Critical Reviews in Biochemistry and Molecular Biology

Abstract

Circadian rhythms are an integral part of life. These rhythms are apparent in virtually all biological processes studies to date, ranging from the individual cell (e.g. DNA synthesis) to the whole organism (e.g. behaviors such as physical activity). Oscillations in metabolism have been characterized extensively in various organisms, including mammals. These metabolic rhythms often parallel behaviors such as sleep/wake and fasting/feeding cycles that occur on a daily basis. What has become increasingly clear over the past several decades is that many metabolic oscillations are driven by cell-autonomous circadian clocks, which orchestrate metabolic processes in a temporally appropriate manner. During the process of identifying the mechanisms by which clocks influence metabolism, molecular-based studies have revealed that metabolism should be considered an integral circadian clock component. The implications of such an interrelationship include the establishment of a vicious cycle during cardiometabolic disease states, wherein metabolism-induced perturbations in the circadian clock exacerbate metabolic dysfunction. The purpose of this review is therefore to highlight recent insights gained regarding links between cell-autonomous circadian clocks and metabolism and the implications of clock dysfunction in the pathogenesis of cardiometabolic diseases.

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Crossref · 10.3109/10409238.2013.786672

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  1. Knutsson A Akerstedt T Jonsson B Orth-Gomer K Increased risk of ischaemic heart disease in shift workers Lancet 1986b 2 89 92 2873389
  2. Young ME Razeghi P Taegtmeyer H Clock genes in the heart: characterization and attenuation with hypertrophy Circ Res 2001b 88 1142 1150 11397780

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Authors
Gamble, K. L., & Young, M. E.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Young, Martin E.
Venue
Critical Reviews in Biochemistry and Molecular Biology
Published
2013-04-17
Volume
48
Issue
4
Pages
317-331
ISSN
  • 0045-6411 (ISSN-L)
  • 1040-9238
  • 1549-7798
OpenAlex
W2007270297
Cited by
18
References
208
Citations by year
2026: 1 · 2024: 1 · 2022: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1
FWCI
0.32
Type
journal article
Language
en
Open access
Locations
  • Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000165)
  • Center for Clinical and Translational Science, University of Alabama at Birmingham
  • National Heart, Lung, and Blood Institute (HL-074259, HL‑106199, R21HL106199, R21HL107709, HL-107709, R01HL074259)
  • National Institute of General Medical Sciences (GM086683, R00GM086683, K99GM086683)
  • National Institute of Neurological Disorders and Stroke (R01NS082413, NS082413)
  • National Center for Research Resources
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian clock, metabolic rhythms, metabolism, cardiometabolic disease, sleep-wake cycle, circadian metabolism
MeSH terms
Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Mammals

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