The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding
Open accessAbstract
The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA) and other components of the mesolimbic dopamine (DA) system to control motivation, including the incentive to feed. The anorexigenic hormone leptin modulates the mesolimbic DA system, although the mechanisms underlying this control have remained incompletely understood. We show that leptin directly regulates a population of leptin receptor (LepRb)-expressing inhibitory neurons in the LHA and that leptin action via these LHA LepRb neurons decreases feeding and body weight. Furthermore, these LHA LepRb neurons innervate the VTA, and leptin action on these neurons restores VTA expression of the rate-limiting enzyme in DA production along with mesolimbic DA content in leptin-deficient animals. Thus, these findings reveal that LHA LepRb neurons link anorexic leptin action to the mesolimbic DA system.
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“But clearly, leptin receptors are located in other hypothalamic areas such as the ventromedial, dorsomedial, and premammillary nuclei, as well as the lateral and perifornical areas where they likely contribute to leptin's effects on food intake and energy expenditure”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [101]
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“Recent investigations show that lateral hypothalamic neurons expressing orexin ([77](#B77), [199](#B199)) and other transmitters such as neurotensin ([101](#B101), [107](#B107)) provide modulatory input to midbrain dopamine neurons”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [101]
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Central nervous system control of food intake
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Self-citationA simplified system for generating recombinant adenoviruses
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Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
Is there a common molecular pathway for addiction?
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A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320
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Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-I., Sugiyama, F., Goto, K., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00331-3 · Cited by 958
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
Self-citationLeptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902
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Perrin‐Terrin, A. (2018) · theses.fr (ABES) · doi:10.70675/e19e922bz4ab1z4df2z8e00z839db7c46630
Triglyceride-sensing in the mesocorticolimbic system and reward-driven behaviour control
Berland, C. (2018) · theses.fr (ABES) · doi:10.70675/3a1dc076z7d5az413czbc66z525614a40de5
Balland, É. (2012) · theses.fr (ABES) · doi:10.70675/d7f779cdz4102z40e1z8a5azf9f1f5543314
Etude de la contribution de l'hormone adipocytaire leptine dans la pathogenèse du syndrome de Rett
Belaïdouni, Y. (2022) · theses.fr (ABES) · doi:10.70675/f69d2875zfa9fz4465z917eza8e7b93935c6
Vringer, M., Mahfouz, A. E., Huijbers, M. G. M., Lammers, G. J., Berkhout, J. B., Koning, F., Fronczek, R., & Schinkelshoek, M. S. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.578936 · Cited by 1
Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network
Papavoine, N., Veendijk, M., Nijman, J., Luijendijk, M. C. M., Wolterink‐Donselaar, I. G., Meye, F. J., & Adan, R. A. H. (2026) · European Eating Disorders Review · doi:10.1002/erv.70119
Woo, Y. S., & Kwon, Y. (2026) · Springer eBooks · doi:10.1007/978-981-92-1331-3_10
Huang, Y., Fan, W., Knuth, O., Jackson, A. C., & Sciolino, N. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.13.744663
Metadata
- Authors
- Leinninger, G. M., Jo, Y.-H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., Wilson, H., Opland, D. M., Faouzi, M. A., Gong, Y., Jones, J. C., Rhodes, C. J., Chua, S., Diano, S., Horvath, T. L., Seeley, R. J., Becker, J. B., Münzberg, H., & Myers, M. G.
- Affiliations
- University of Michigan (US)
- Albert Einstein College of Medicine (US)
- University of Cincinnati (US)
- University of Chicago (US)
- Yale University (US)
- Corresponding author
- Myers, Martin G.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 10
- Issue
- 2
- Pages
- 89-98
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2723060
- OpenAlex
- W2001980298
- Cited by
- 412
- References
- 47
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 22 · 2022: 16 · 2021: 27 · 2020: 18 · 2019: 19 · 2018: 32 · 2017: 32 · 2016: 30 · 2015: 30 · 2014: 25 · 2013: 33 · 2012: 27
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1446 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Diabetes Research and Training Center
- American Diabetes Association
- American Heart Association
- National Institutes of Health
- Obesity Society
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, leptin receptor, lateral hypothalamus, ventral tegmental area, mesolimbic dopamine system, feeding behavior, anorexia, inhibitory neurons, dopamine synthesis, body weight regulation, leptin deficiency
- MeSH terms
- Animals, Body Weight, Dopamine, Eating, Hypothalamic Area, Lateral, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Ventral Tegmental Area, Leptin, Mice, Receptors, Leptin, Gene Knock-In Techniques
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