PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677 · see citing works

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works

Regulation of protein kinase cascades by protein phosphatase 2A

Millward, T. A., Zołnierowicz, S., & Hemmings, B. A. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01375-4 · Cited by 793 · see citing works

Nutrient-Dependent Expression of Insulin-like Peptides from Neuroendocrine Cells in the CNS Contributes to Growth Regulation in Drosophila

Ikeya, T., Galic, M., Belawat, P., Nairz, K., & Hafen, E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01043-6 · Cited by 765 · see citing works

Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathwayPreprint

Puig, Ó., Marr, M. T., Ruhf, M.-L., & Tjian, R. (2003) · Genes & Development · doi:10.1101/gad.1098703 · Cited by 612 · see citing works

mTOR, translation initiation and cancer

Mamane, Y., Petroulakis, E., LeBacquer, O., & Sonenberg, N. (2006) · Oncogene · doi:10.1038/sj.onc.1209888 · Cited by 607 · see citing works

Ends-out, or replacement, gene targeting in Drosophila

Gong, W. J., & Golic, K. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0535280100 · Cited by 363 · see citing works

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

Taguchi, A., & White, M. F. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100533 · Cited by 309 · see citing works

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

Kozma, S. C., & Thomas, G. (2002) · Bioessays · doi:10.1002/bies.10031 · Cited by 308 · see citing works

PP2A: Unveiling a Reluctant Tumor Suppressor

Mumby, M. (2007) · Cell · doi:10.1016/j.cell.2007.06.034 · Cited by 295 · see citing works

Insulin/TOR signaling in growth and homeostasis: A view from the fly world

Grewal, S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.10.010 · Cited by 279 · see citing works

4E-BP functions as a metabolic brake used under stress conditions but not during normal growthPreprint

Teleman, A. A., Chen, Y., & Cohen, S. M. (2005) · Genes & Development · doi:10.1101/gad.341505 · Cited by 262 · see citing works

Nutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila

Teleman, A. A., Hietakangas, V., Sayadian, A.-C., & Cohen, S. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.010 · Cited by 253 · see citing works

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

Jastrzebski, K., Hannan, K. M., Tchoubrieva, E. B., Hannan, R. D., & Pearson, R. B. (2007) · Growth Factors · doi:10.1080/08977190701779101 · Cited by 240 · see citing works

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

Götz, J., Probst, A., Ehler, E., Hemmings, B., & Kues, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12370 · Cited by 220 · see citing works

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

Radimerski, T., Montagne, J., Rintelen, F., Stocker, H., KAAY, J. V. D., Downes, C. P., Hafen, E., & Thomas, G. (2002) · Nature Cell Biology · doi:10.1038/ncb763 · Cited by 190 · see citing works

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G. J., Czech, M., & Tissenbaum, H. A. (2009) · Cell · doi:10.1016/j.cell.2009.01.025 · Cited by 170 · see citing works

The Drosophila insulin/IGF receptor controls growth and size by modulating PtdIns P 3 levels

Oldham, S., Stocker, H., Laffargue, M., Wittwer, F., Wymann, M. P., & Hafen, E. (2002) · Development · doi:10.1242/dev.129.17.4103 · Cited by 169 · see citing works

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

Ballou, L. M., Jenö, P., & Thomas, G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57284-2 · Cited by 152 · see citing works

The functions of insulin signaling: size isn't everything, even in Drosophila

Goberdhan, D. C. I., & WILSON, C. G. (2003) · Differentiation · doi:10.1046/j.1432-0436.2003.7107001.x · Cited by 128 · see citing works

Cancer, type 2 diabetes, and ageing: news from flies and worms

Hafen, E. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.09885 · Cited by 71 · see citing works

The protein phosphatase PP2A-B′ subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism inDrosophila

Vereshchagina, N., Ramel, M., Bitoun, E., & WILSON, C. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.035220 · Cited by 57 · see citing works

The B′ Protein Phosphatase 2A Regulatory Subunit well-rounded Regulates Synaptic Growth and Cytoskeletal Stability at the Drosophila Neuromuscular Junction

Viquez, N. M., Li, C. R., Wairkar, Y. P., & DiAntonio, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1740-06.2006 · Cited by 53 · see citing works

Regulation of ribosomal protein S6 kinases by ubiquitination

Wang, M., Panasyuk, G., Gwalter, J., Nemazanyy, I., Fenton, T. R., Filonenko, V. V., & Gout, I. T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.032 · Cited by 41 · see citing works

Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase

Bielinski, V. A., & Mumby, M. C. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.05.008 · Cited by 38 · see citing works

Ultrafine Mapping of SNPs From Mouse Strains C57BL/6J, DBA/2J, and C57BLKS/J for Loci Contributing to Diabetes and Atherosclerosis Susceptibility

Davis, R. C., Schadt, E. E., Cervino, A., Péterfy, M., & Lusis, A. J. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1191 · Cited by 37 · see citing works

The protein phosphatase 2A subunit Bγ gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization

Deichmann, M., Polychronidis, M., Wacker, J., Thome, M., & Näher, H. (2001) · Melanoma Research · doi:10.1097/00008390-200112000-00004 · Cited by 30 · see citing works

Gene–Environment Interaction and the Metabolic Syndrome

Adamo, K. B., & Tesson, F. (2008) · Novartis Foundation symposium · doi:10.1002/9780470696781.ch8 · Cited by 20 · see citing works

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

Magnuson, B., Ekim, B., & Fingar, D. C. (2012) · Biochemical Journal · doi:10.1042/bj20110892 · Cited by 1,015 · see citing works

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

Demetriades, C., Doumpas, N., & Teleman, A. A. (2014) · Cell · doi:10.1016/j.cell.2014.01.024 · Cited by 412 · see citing works

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

Gutierrez, A., Pan, L., Groen, R. W. J., Baleydier, F., Kentsis, A., Marineau, J., Grebliunaite, R., Kozakewich, E., Reed, C., Pflumio, F., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci65093 · Cited by 220 · see citing works

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Hales, E. C., Taub, J. W., & Matherly, L. H. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.09.021 · Cited by 183 · see citing works

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

Moraru, A., Wiederstein, J. L., Pfaff, D. H., Fleming, T. H., Miller, A. K., Nawroth, P. P., & Teleman, A. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.003 · Cited by 170 · see citing works

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP

Straßburger, K., Tiebe, M., Pinna, F., Breuhahn, K., & Teleman, A. A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.05.008 · Cited by 141 · see citing works

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

Katewa, S. D., & Kapahi, P. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.11.036 · Cited by 134 · see citing works

Recurrent <i>PPP2R1A</i> Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth

Haesen, D., Abbasi Asbagh, L., Derua, R., Hubert, A., Schrauwen, S., Hoorne, Y., Amant, F., Waelkens, E., Sablina, A., & Janssens, V. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3342 · Cited by 124 · see citing works

RNA polymerase III limits longevity downstream of TORC1

Filer, D., Thompson, M. A., Takhaveev, V., Dobson, A. J., Kotronaki, I., Green, J. W. M., Heinemann, M., Tullet, J. M. A., & Alic, N. (2017) · Nature · doi:10.1038/nature25007 · Cited by 116 · see citing works

Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification

Meeusen, B., & Janssens, V. (2018) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2017.10.002 · Cited by 96 · see citing works

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

Tiebe, M., Lutz, M., Garza, A. D. L., Buechling, T., Boutros, M., & Teleman, A. A. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.03.013 · Cited by 95 · see citing works

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93 · see citing works

PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth

Liu, J., Stevens, P. D., Li, X., Schmidt, M. D., & Gao, T. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05799-11 · Cited by 93 · see citing works

Beyond controlling cell size: functional analyses of S6K in tumorigenesis

Wu, X., Xie, W., Xie, W.-X., Wei, W.-Y., & Guo, J.-P. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05081-4 · Cited by 77 · see citing works

Insulin Signaling Regulates Fatty Acid Catabolism at the Level of CoA Activation

Xu, X., Gopalacharyulu, P. V., Seppänen‐Laakso, T., Ruskeepää, A., Aye, C. C., Carson, B. P., Mora, S., Orešič, M., & Teleman, A. A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002478 · Cited by 90 · see citing works

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling

Apostolidis, S. A., Rauen, T., Hedrich, C. M., Tsokos, G. C., & Crispín, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.483743 · Cited by 91 · see citing works

Control of mTORC1 signaling by the Opitz syndrome protein MID1

Liu, E., Knutzen, C. A., Krauß, S., Schweiger, S., & Chiang, G. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100131108 · Cited by 91 · see citing works

Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State

Sacco, F., Silvestri, A., Posca, D., Pirro, S., Gherardini, P. F., Castagnoli, L., Mann, M., & Cesareni, G. (2016) · Cell Systems · doi:10.1016/j.cels.2016.02.005 · Cited by 85 · see citing works

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling

Vinayagam, A., Kulkarni, M. M., Sopko, R., Sun, X., Hu, Y., Nand, A., Villalta, C., Moghimi, A. M., Yang, X., Mohr, S. E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.029 · Cited by 81 · see citing works

Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis

Zhang, T., Zhou, Q., Ogmundsdottir, M. H., Möller, K., Siddaway, R., Larue, L., Hsing, M., Kong, S. W., Goding, C. R., Pálsson, A., et al. (2015) · Journal of Cell Science · doi:10.1242/jcs.173807 · Cited by 75 · see citing works

Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting

Jouandin, P., Marelja, Z., Shih, Y.-H., Parkhitko, A. A., Dambowsky, M., Asara, J. M., Nemazanyy, I., Dibble, C. C., Simons, M., & Perrimon, N. (2022) · Science · doi:10.1126/science.abc4203 · Cited by 73 · see citing works

TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

Wei, Y.-H., Reveal, B. S., Reich, J., Laursen, W. J., Senger, S., Akbar, T., Iida-Jones, T., Cai, W.-L., Jarnik, M., & Lilly, M. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1419156112 · Cited by 59 · see citing works

The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function

Cai, W., Wei, Y., Jarnik, M., Reich, J., & Lilly, M. A. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006036 · Cited by 61 · see citing works

An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease

Besse‐Patin, A., & Estall, J. L. (2014) · International Journal of Cell Biology · doi:10.1155/2014/519153 · Cited by 58 · see citing works

Tissue-Specific Coupling between Insulin/IGF and TORC1 Signaling via PRAS40 in Drosophila

Pallares-Cartes, C., Cakan‐Akdogan, G., & Teleman, A. A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.10.029 · Cited by 57 · see citing works

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

Bao, Y., Oguz, G., Lee, W. C., Lee, P. L., Ghosh, K., Li, J., Wang, P., Lobie, P. E., Ehmsen, S., Ditzel, H. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19704-x · Cited by 56 · see citing works

PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury

Chen, S., Chen, L., Ye, L., Jiang, Y., Li, Q., Zhang, H., Zhang, R., Li, H., Yu, D., Zhang, R., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127624 · Cited by 54 · see citing works

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

Kim, B., Kim, H. Y., Yoon, B. R., Yeo, J., Jung, J. I., Yu, K., Kim, H. C., Yoo, S., Park, J. K., Kang, S. W., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abi7400 · Cited by 55 · see citing works

PP2A regulates autophagy in two alternative ways in Drosophila

Banreti, A. R., Lukácsovich, T., Csikós, G., Erdélyi, M., & Sass, M. (2012) · Autophagy · doi:10.4161/auto.19081 · Cited by 55 · see citing works

The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila

Wei, Y.-H., & Lilly, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.63 · Cited by 52 · see citing works

Notch-1 signaling activates NF-κB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent AKT pathway

Li, L., Zhang, J., Xiong, N., Li, S., Chen, Y., Yang, H., Wu, C., Zeng, H., & Liu, Y. (2016) · Medical Oncology · doi:10.1007/s12032-016-0747-7 · Cited by 51 · see citing works

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling

Merhi, A., Delrée, P., & Marini, A. M. (2017) · Scientific Reports · doi:10.1038/srep44602 · Cited by 51 · see citing works

Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo

Lambrecht, C., Libbrecht, L., Sagaert, X., Pauwels, P., Hoorne, Y., Crowther, J., Louis, J. V., Sents, W., Sablina, A., & Janssens, V (2018) · Oncogene · doi:10.1038/onc.2017.350 · Cited by 50 · see citing works

Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options

Grech, G., Baldacchino, S., Saliba, C., Grixti, M. P., Gauci, R., Magri, V. P., Fenech, A. G., & Scerri, C. A. (2016) · Tumor Biology · doi:10.1007/s13277-016-5145-4 · Cited by 48 · see citing works

Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

Hales, E. C., Orr, S. M., Gedman, A. L., Taub, J. W., & Matherly, L. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.451625 · Cited by 46 · see citing works

PPP2R5C couples hepatic glucose and lipid homeostasis

Cheng, Y.-S., Seibert, O., Klöting, N., Dietrich, A., Straßburger, K., Fernández-Veledo, S., Vendrell, J. J., Zorzano, A., Blüher, M., Herzig, S., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005561 · Cited by 43 · see citing works

Microcystin-LR promotes proliferation by activating Akt/S6K1 pathway and disordering apoptosis and cell cycle associated proteins phosphorylation in HL7702 cells

Liu, J., Wang, H., Wang, B., Chen, T., Wang, X., Huang, P., Xu, L., & Guo, Z. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.015 · Cited by 43 · see citing works

Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction

Zhu, G., Briz, V., Seinfeld, J., Liu, Y., Bi, X., & Baudry, M. (2017) · Scientific Reports · doi:10.1038/srep42788 · Cited by 43 · see citing works

Microcystin-LR promotes cell proliferation in the mice liver by activating Akt and p38/ERK/JNK cascades

Liu, J., Wang, B., Huang, P., Wang, H., Xu, K., Wang, X., Xu, L., & Guo, Z. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.08.002 · Cited by 42 · see citing works

Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye

Kim, W., Jang, Y., Yang, J., & Chung, J. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.07.020 · Cited by 36 · see citing works

TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1

Plescher, M., Teleman, A. A., & Demetriades, C. (2015) · Scientific Reports · doi:10.1038/srep13828 · Cited by 33 · see citing works

MicroRNA-652 induces NED in LNCaP and EMT in PC3 prostate cancer cells

Nam, R. K., Benatar, T., Amemiya, Y., Wallis, C. J. D., Romero, J. M., Tsagaris, M., Sherman, C., Sugar, L., & Seth, A. K. (2018) · Oncotarget · doi:10.18632/oncotarget.24937 · Cited by 37 · see citing works

An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer

Elshazly, A. M., & Gewirtz, D. A. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2022.09 · Cited by 36 · see citing works

Conservation of gene and tissue networks regulating insulin signalling in flies and vertebrates

Das, R., & Dobens, L. L. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150078 · Cited by 35 · see citing works

How it all Started: Tau and Protein Phosphatase 2A

Liu, C., & Götz, J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130503 · Cited by 35 · see citing works

The protein phosphatase 2A B56γ regulatory subunit is required for heart development

Varadkar, P., Despres, D., Kraman, M., Lozier, J., Phadke, A., Nagaraju, K., & Mccright, B. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24111 · Cited by 34 · see citing works

G protein‐dependent signaling triggers a β‐arrestin‐scaffolded p70S6K/ rpS6 module that controls 5'TOP mRNA translation

Trefier, A., Musnier, A., Landomiel, F., Bourquard, T., Boulo, T., Ayoub, M. A., Leon, K. E., Bruneau, G., Chevalier, M., Durand, G., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700763r · Cited by 33 · see citing works

Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism

Straßburger, K., Lutz, M., Müller, S., & Teleman, A. A. (2021) · Nature Communications · doi:10.1038/s41467-021-26780-0 · Cited by 33 · see citing works

TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

Wainszelbaum, M. J., Liu, J., Chen, K., Srikanth, P., Samovski, D., Su, X., & Stahl, P. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031225 · Cited by 32 · see citing works

eIF4A inactivates TORC1 in response to amino acid starvation

Tsokanos, F.-F., Albert, M., Demetriades, C., Spirohn, K., Boutros, M., & Teleman, A. A. (2016) · EMBO Journal · doi:10.15252/embj.201593118 · Cited by 25 · see citing works

The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in<i>Drosophila melanogaster</i>

Wei, Y., Reveal, B., Cai, W., & Lilly, M. A. (2016) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.116.035337 · Cited by 31 · see citing works

Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models

Zonari, A. A. C., Brace, L. E., Al-Katib, K., Porto, W. F., Foyt, D. A., Guiang, M., Cruz, E. A. O., Marshall, B., Salgueiro, W. G., Inan, M. D., et al. (2023) · npj Aging · doi:10.1038/s41514-023-00109-1 · Cited by 40 · see citing works

Amino acid-induced impairment of insulin sensitivity in healthy and obese rats is reversible

Jeganathan, S., Abdullahi, A., Zargar, S., Maeda, N., Riddell, M. C., & Adegoke, O. A. J. (2014) · Physiological Reports · doi:10.14814/phy2.12067 · Cited by 29 · see citing works

Divergent functions for eIF4E and S6 kinase by sonic hedgehog mitogenic signaling in the developing cerebellum

Mainwaring, L. A., & Kenney, A. M. (2011) · Oncogene · doi:10.1038/onc.2010.564 · Cited by 30 · see citing works

Phosphoprotein Phosphatase PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling

Mandavia, C. H., & Sowers, J. R. (2012) · Cardiorenal Medicine · doi:10.1159/000343889 · Cited by 30 · see citing works

TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes

Vázquez‐Carballo, A., Ceperuelo‐Mallafré, V., Chacón, M. R., Maymó‐Masip, E., Lorenzo, M., Porrás, A., Vendrell, J. J., & Fernández‐Veledo, S. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00589.2012 · Cited by 29 · see citing works

Network‐regulated organ allometry: The developmental regulation of morphological scaling

Vea, I. M., & Shingleton, A. W. (2020) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.391 · Cited by 28 · see citing works

Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity

Umberger, N. L., Caspary, T., & Bettencourt‐Dias, M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0952 · Cited by 28 · see citing works

Regulation and role of the PP2A-B56 holoenzyme family in cancer

Peris, I., Romero-Murillo, S., Vicente, C., Narla, G., & Odero, M. D. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188953 · Cited by 29 · see citing works

REPTOR and CREBRF encode key regulators of muscle energy metabolism

Saavedra, P., Dumesic, P. A., Hu, Y., Filine, E., Jouandin, P., Binari, R. C., Wilensky, S. E., Rodiger, J., Wang, H., Chen, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40595-1 · Cited by 26 · see citing works

The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

Wei, Y.-H., Bettedi, L., Ting, C.-Y., Kim, K., Zhang, Y.-B., Cai, J.-D., & Lilly, M. (2018) · bioRxiv · doi:10.7554/elife.42149 · Cited by 25 · see citing works

Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest

Salamango, D. J., & Harris, R. S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.622012 · Cited by 24 · see citing works

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Zhao, Q., Liu, Y., Zhang, S., Zhao, Y., Wang, C., Li, K., Jin, Z., Qiao, J., & Liu, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.870326 · Cited by 23 · see citing works

The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma

Enjoji, S., Yabe, R., Fujiwara, N., Tsuji, S., Vitek, M. P., Mizuno, T., Nakagawa, T., Usui, T., Ohama, T., & Sato, K. (2015) · Journal of Veterinary Medical Science · doi:10.1292/jvms.15-0193 · Cited by 23 · see citing works

Has gene duplication impacted the evolution of Eutherian longevity?

Doherty, A., & de Magalhães, J. P. (2016) · Aging Cell · doi:10.1111/acel.12503 · Cited by 22 · see citing works

Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation

Chen, K., Lange, J. J., Samovski, D., Su, X., Liu, J., Sundaresan, S., & Stahl, P. D. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.001 · Cited by 21 · see citing works

Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP

Ruoff, R., Katsara, O., & KOLUPAEVA, V. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605451113 · Cited by 21 · see citing works

Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila

Fischer, P., Rosa, M. K. L., Schulz, A., Preiss, A., & Nagel, A. C. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005440 · Cited by 20 · see citing works

Ubiquitination and Degradation of the Hominoid-Specific Oncoprotein TBC1D3 Is Mediated by CUL7 E3 Ligase

Chen, K., Samovski, D., Srikanth, P., Wainszelbaum, M. J., Charron, A. J., Liu, J., Lange, J. J., Chen, P.-I., Pan, Z., Su, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046485 · Cited by 20 · see citing works

Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle

Moorwood, C., Philippou, Α., Spinazzola, J. M., Keyser, B., Macarak, E. J., & Barton, E. R. (2014) · Skeletal Muscle · doi:10.1186/2044-5040-4-13 · Cited by 20 · see citing works

Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation

Gollowitzer, A., Pein, H., Rao, Z., Waltl, L., Bereuter, L., Loeser, K., Meyer, T., Jafari, V., Witt, F., Winkler, R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56711-2 · Cited by 19 · see citing works

Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs

Straßburger, K., Lorbeer, F. K., Lutz, M., Graf, F., Boutros, M., & Teleman, A. A. (2017) · Development · doi:10.1242/dev.147538 · Cited by 19 · see citing works

SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma

Luk, I. S. U., Bridgwater, C. M., Yu, A. Y. C., Boila, L. D., Yáñez-Bartolomé, M., Lampano, A., Hulahan, T. S., Boukhali, M., Kathiresan, M., Macarulla, T. M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj7685 · Cited by 18 · see citing works

Multiple pools of PP2A regulate spindle assembly, kinetochore attachments and cohesion in Drosophila oocytes

Jang, J. K., Gladstein, A. C., Das, A., Shapiro, J. G., Sisco, Z., & McKim, K. S. (2021) · Journal of Cell Science · doi:10.1242/jcs.254037 · Cited by 18 · see citing works

Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila

Sun, D., & Buttitta, L. (2015) · Development · doi:10.1242/dev.120824 · Cited by 18 · see citing works

Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance

Rasool, R. U., O’Connor, C. M., Das, C. K., Alhusayan, M., Verma, B. K., Islam, S., Frohner, I. E., Deng, Q., Mitchell-Velasquez, E., Sangodkar, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40760-6 · Cited by 17 · see citing works

Serine-threonine protein phosphatases: Lost in translation

KOLUPAEVA, V. G. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.08.006 · Cited by 17 · see citing works

Protein Phosphatase 2A: Role in T Cells and Diseases

Roy, S., & Batra, L. (2023) · Journal of Immunology Research · doi:10.1155/2023/4522053 · Cited by 16 · see citing works

GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila

Frappaolo, A., Karimpour-Ghahnavieh, A., Cesare, G., Sechi, S., Fraschini, R., Vaccari, T., & Giansanti, M. G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05438-9 · Cited by 16 · see citing works

Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways

Sacco, F., Boldt, K., Calderone, A., Panni, S., Paoluzi, S., Castagnoli, L., Ueffing, M., & Cesareni, G. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00115 · Cited by 14 · see citing works

A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism inDrosophila

Fischer, P., Preiss, A., & Nagel, A. C. (2016) · Fly · doi:10.1080/19336934.2016.1162362 · Cited by 14 · see citing works

ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer

Zhao, L., Wang, Y., Sun, X., Zhang, X., Simone, N. L., & He, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042382 · Cited by 13 · see citing works

Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae

Rodríguez-Vázquez, M., Falconi, J., Héron‐Milhavet, L., Lassus, P., Géminard, C., & Djiane, A. (2024) · EMBO Reports · doi:10.1038/s44319-024-00241-3 · Cited by 13 · see citing works

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts

Jäger, K., Mensch, J., Grimmig, M., Neuner, B., Gorzelniak, K., Türkmen, S., Demuth, I., Hartmann, A., Hartmann, C., Wittig, F., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk2814 · Cited by 13 · see citing works

The role of SET/I2PP2A in canine mammary tumors

Kake, S., Tsuji, S., Enjoji, S., Hanasaki, S., Hayase, H., Yabe, R., Tanaka, Y., Nakagawa, T., Liu, H., Chang, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04291-7 · Cited by 13 · see citing works

Correction: TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

Wainszelbaum, M. J., Liu, J., Chen, K., Srikanth, P., Samovski, D., Su, X., & Stahl, P. D. (2012) · PLoS ONE · doi:10.1371/annotation/6ef317b6-c9eb-44a4-8e4d-556d064ce987 · Cited by 13 · see citing works

Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling

Jeong, E. B., Jeong, S. S., Cho, E., & Kim, E. Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215688 · Cited by 12 · see citing works

Maternal starvation primes progeny response to nutritional stress

Voo, K., Hui, J. C. W., Lim, J. W. H., Chan, S. N., Ng, A. Y. E., Heng, J. Y. Y., Lim, S. S., & Pek, J. W. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009932 · Cited by 11 · see citing works

The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

Hsiao, K.-C., Ruan, S.-Y., Chen, S.-M., Lai, T.-Y., Chan, R., Zhang, Y., Chu, C., Cheng, H., Tsai, H., Tu, Y., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01182-5 · Cited by 9 · see citing works

Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells

Roy, S., Goel, R., Aggarwal, S., Asthana, S., Yadav, A. K., & Awasthi, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-67845-2 · Cited by 9 · see citing works

Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster

Venugopal, P., Veyssière, H., Couderc, J., Richard, G., Vachias, C., & Mirouse, V. (2020) · BMC Developmental Biology · doi:10.1186/s12861-020-00218-0 · Cited by 9 · see citing works

PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma

Akaike, K., Suehara, Y., Kohsaka, S., Hayashi, T., Tanabe, Y., Kazuno, S., Mukaihara, K., Ishii, M., Kurihara, T., Kim, Y., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25392 · Cited by 8 · see citing works

Finding new edges: systems approaches to MTOR signaling

Heberle, A. M., Rehbein, U., Rodríguez-Peiris, M., & Thedieck, K. (2021) · Biochemical Society Transactions · doi:10.1042/bst20190730 · Cited by 8 · see citing works

HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity

Dobersch, S., Yamamoto, N., Schutter, A., Cavender, S. M., Robertson, T. M., Kartha, N., Samraj, A. N., Doron, B., Poole, L. A., Wladyka, C. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60129-1 · Cited by 8 · see citing works

Wdr59 promotes or inhibits TORC1 activity depending on cellular context

Zhang, Y.-B., Ting, C.-Y., Yang, S., Reich, J., Fru, K. N., & Lilly, M. (2022) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2212330120 · Cited by 9 · see citing works

Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP

Zhan, X., Asmara, H., Pfaffinger, P. J., & Turner, R. W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0136-24.2024 · Cited by 7 · see citing works

Phenotypic characterization of SETD3 knockout Drosophila

Tiebe, M., Lutz, M., Levy, D., & Teleman, A. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201609 · Cited by 7 · see citing works

PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites

Zhao, M., Yang, Y., Shi, Y., Chen, X., Yang, Y., Pan, L., Du, Z., Sun, H., Yao, C., Ma, G., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00104-23 · Cited by 7 · see citing works

Pathogenic de novo variants in PPP2R5C cause a neurodevelopmental disorder within the Houge-Janssens syndrome spectrum

Verbinnen, I., Douzgou, S., Hsieh, T., Lesmann, H., Kirchhoff, A., Geneviève, D., Brimble, E., Lenaerts, L., Haesen, D., Levy, R. J., et al. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2025.01.021 · Cited by 6 · see citing works

Microcystin‐LR exposure disrupts the insulin signaling pathway in C2C12 mice muscle cell line

Ma, T., Cao, N., Chen, K., Wang, H., Xu, L., Xu, C., & Huang, P. (2019) · Environmental Toxicology · doi:10.1002/tox.22856 · Cited by 6 · see citing works

InAKTivation of insulin/IGF-1 signaling by dephosphorylation

Narasimhan, S. D., Mukhopadhyay, A., & Tissenbaum, H. A. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10072 · Cited by 19 · see citing works

Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase

Bielinski, V. A., & Mumby, M. C. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.05.008 · Cited by 38 · see citing works

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G. J., Czech, M., & Tissenbaum, H. A. (2009) · Cell · doi:10.1016/j.cell.2009.01.025 · Cited by 170 · see citing works

ACCELERATED PUBLICATION Insulin-induced Drosophila S6 kinase activation requires phosphoinositide

(2015)

Phosphatase PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis

Cheng, Y.-S. (2015) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00018759