The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?
Open accessAbstract
Summary Epigenetics is defined as heritable changes to the transcriptome that are independent on changes in the genome. The biochemical principles that govern epigenetic modifications are DNA methylation and posttranslational modifications of histones, amongst which acetylation/deacetylation and methylation/demethylation of lysine residues are the most widely studied. Such epigenetic changes are involved in many physiological and pathological processes. This essay will focus on the biology of histone methylation and demethylation reactions, highlighting how these reactions depend on “metabolic” cofactors like S-Adenosylmethionine, Flavin Adenine Dinucleotide and α-ketoglutarate. Furthermore, we will illustrate that the absence of lysine methyltranferases and demethylases can lead to altered metabolic homeostasis. Altogether, this provides preliminary evidence that lysine methyltranferases and demethylases could act as molecular transducers of metabolic signals to chromatin, and sets the stage for further research into this area to consolidate these enticing initial observations.
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Cites
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Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920
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Metadata
- Authors
- Teperino, R., Schoonjans, K., & Auwerx, J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 12
- Issue
- 4
- Pages
- 321-327
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2042336817
- Cited by
- 271
- References
- 21
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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