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Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity
Open accessAbstract
Evidence is emerging that the PGC-1 coactivators serve a critical role in skeletal muscle metabolism, function, and disease. Mice with total PGC-1 deficiency in skeletal muscle (PGC-1α(-/-)β(f/f/MLC-Cre) mice) were generated and characterized. PGC-1α(-/-)β(f/f/MLC-Cre) mice exhibit a dramatic reduction in exercise performance compared to single PGC-1α- or PGC-1β-deficient mice and wild-type controls. The exercise phenotype of the PGC-1α(-/-)β(f/f/MLC-Cre) mice was associated with a marked diminution in muscle oxidative capacity, together with rapid depletion of muscle glycogen stores. In addition, the PGC-1α/β-deficient muscle exhibited mitochondrial structural derangements consistent with fusion/fission and biogenic defects. Surprisingly, the proportion of oxidative muscle fiber types (I, IIa) was not reduced in the PGC-1α(-/-)β(f/f/MLC-Cre) mice. Moreover, insulin sensitivity and glucose tolerance were not altered in the PGC-1α(-/-)β(f/f/MLC-Cre) mice. Taken together, we conclude that PGC-1 coactivators are necessary for the oxidative and mitochondrial programs of skeletal muscle but are dispensable for fundamental fiber type determination and insulin sensitivity.
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“Along the same line, insulin-stimulated glucose sensitivity is increased in some mouse models of mitochondrial dysfunction (Wredenberg et al, 2006; Pospisilik et al, 2007; Zechner et al, 2010).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Zechner et al, 2010
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Metadata
- Authors
- Zechner, C., Lai, L., Zechner, J. F., Geng, T., Yan, Z., Rumsey, J. W., Collia, D., Chen, Z., Wozniak, D. F., Leone, T. C., & Kelly, D. P.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- University of Virginia Medical Center (US)
- Washington University in St. Louis (US)
- Corresponding author
- Kelly, Daniel P.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 12
- Issue
- 6
- Pages
- 633-642
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2999961
- OpenAlex
- W2064754499
- Cited by
- 274
- References
- 45
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 13 · 2020: 13 · 2019: 19 · 2018: 19 · 2017: 21 · 2016: 23 · 2015: 22 · 2014: 12 · 2013: 31 · 2012: 16
- FWCI
- 14.73
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- journal article
- Language
- en
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- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK45416, HL58427, P30 NS057105)
- American Diabetes Association (AR050429)
- Washington University School of Medicine in St. Louis
- Deutsche Forschungsgemeinschaft (ZE 796/2-1)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- PGC-1α, PGC-1β, skeletal muscle, mitochondrial dysfunction, mitochondrial fission and fusion, oxidative capacity, muscle glycogen depletion, exercise performance, insulin sensitivity, glucose tolerance, muscle metabolism
- MeSH terms
- Analysis of Variance, Animals, Glucose Tolerance Test, Insulin Resistance, Microscopy, Electron, Mitochondria, Oxygen Consumption, Physical Conditioning, Animal, Transcription Factors, Polymerase Chain Reaction, Mice, Knockout, Muscle, Skeletal, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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