Metabolic switching and fuel choice during T‐cell differentiation and memory development

van der Windt, Gerritje J. W.; Pearce, Erika L.

doi:10.1111/j.1600-065x.2012.01150.x

Cited by 566T-cell and B-cell ImmunologyImmune cells in cancerCancer, Hypoxia, and Metabolism

Metabolic switching and fuel choice during T‐cell differentiation and memory development

Open access

van der Windt, Gerritje J. W., Pearce, Erika L.·2012·Immunological Reviews

DOI 10.1111/j.1600-065x.2012.01150.xPMC PMC3645891

Open this paper in CoChat — free account Open PDF

Abstract

Summary: Clearance or control of pathogens or tumors usually requires T‐cell‐mediated immunity. As such, understanding the mechanisms that govern the function, maintenance, and persistence of T cells will likely lead to new treatments for controlling disease. During an immune response, T‐cell development is marked by striking changes in metabolism. There is a growing appreciation that these metabolic changes underlie the capacity of T cells to perform particular functions, and this has led to a recent focus on the idea that the manipulation of cellular metabolism can be used to shape adaptive immune responses. Although interest in this area has grown in the last few years, a full understanding of the metabolic control of T‐cell functions, particularly during an immune response in vivo , is still lacking. In this review, we first provide a basic overview of metabolism in T cells, and then we focus on recent studies providing new or updated insights into the regulation of metabolic pathways and how they underpin T‐cell differentiation and memory T‐cell development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1600-065x.2012.01150.x

Cites

157 of 157 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

T cell activation upregulates glucose transporter 1 through T cell receptor, CD28 and PI3K-Akt-mTOR signalling, increasing aerobic glycolysis.
“signalling pathways involving the T cell receptor (TCR), CD28 and the PI3K–Akt–mTOR axis upregulate the expression of glucose transporter 1 (GLUT1), increasing the rate of aerobic glycolysis71,72”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [71]
The “Glucose and proliferating T cells” section says TCR stimulation moves Glut1 to the cell surface, while CD28 signals increase its expression and surface localization. The “Conventional view of T-cell metabolism” section links CD28–PI3K–AKT and mTOR signaling to increased glycolysis. It does not say that TCR signaling increases Glut1 expression, or specifically that mTOR increases Glut1 expression; page numbers were not supplied. (LLM, conf=0.85)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Kim, D.-H., Sarbassov, D., Ali, S. M., King, J. E., Latek, R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,135 · see citing works
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341 · see citing works
mTOR signaling at a glance
Laplante, M., & Sabatini, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.051011 · Cited by 2,317 · see citing works
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 22× · see citing works
“Despite its quick induction, HIF-1a appeared dispensable for the initiation of metabolic changes and activation-associated proliferation in these T cells (21).”
BackgroundResultInfluential
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091 · see citing works
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081 · see citing works
Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor
Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861 · see citing works
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 1× · see citing works
“Accordingly, it has been shown that cells generated during the peak of infection that have not terminally differentiated, express IL-7R and persist as long-lived memory T cells (123).”
Background
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797 · see citing works
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works
A serine/threonine kinase gene defective in Peutz–Jeghers syndrome
Hemminki, A., Markie, D., Tomlinson, I. P. M., Avizienyte, E., Roth, S., Loukola, A., Bignell, G. R., Warren, W., Aminoff, M., Höglund, P., et al. (1998) · Nature · doi:10.1038/34432 · Cited by 1,652 · see citing works
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650 · see citing works
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Schluns, K. S., Kieper, W. C., Jameson, S. C., & Lefrançois, L. (2000) · Nature Immunology · doi:10.1038/80868 · Cited by 1,619 · see citing works
mTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559 · see citing works
Self-citation
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545 · see citing works
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540 · see citing works
Self-citation
daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
Cunningham, J. T., Rodgers, J. T., Arlow, D. H., Vazquez, F., Mootha, V. K., & Puigserver, P. (2007) · Nature · doi:10.1038/nature06322 · Cited by 1,488 · see citing works
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487 · see citing works
The CD28 Signaling Pathway Regulates Glucose Metabolism
Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00323-0 · Cited by 1,475 · see citing works
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2904 · Cited by 1,454 · see citing works
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works
mTOR differentially regulates effector and regulatory T cell lineage commitment
Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293 · see citing works
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281 · see citing works
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,257 · see citing works
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193 · see citing works
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,111 · see citing works
Oncogenic alterations of metabolism
Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106 · see citing works
The LKB1 tumor suppressor negatively regulates mTOR signaling
Shaw, R. J., Bardeesy, N. M., Manning, B. D., Lopez, L. V., Kosmatka, M., DePinho, R. A., & Cantley, L. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.007 · Cited by 1,067 · see citing works
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018 · see citing works
Function of Mitochondrial Stat3 in Cellular Respiration
Wegrzyn, J., Potla, R., Chwae, Y.-J., Sepuri, N. B. V., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., et al. (2009) · Science · doi:10.1126/science.1164551 · Cited by 1,014 · see citing works
IL-7 is critical for homeostatic proliferation and survival of naïve T cells
Tan, J. T., Dudl, E. P., LeRoy, E., Murray, R. M., Sprent, J., Weinberg, K. I., & Surh, C. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161126098 · Cited by 966 · see citing works
Synergism of nutrition, infection, and immunity: an overview
Scrimshaw, N. S., & SanGiovanni, J. P. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.464s · Cited by 946 · see citing works
Lipotoxicity: when tissues overeat
Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 914 · see citing works
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works
Fuel feeds function: energy metabolism and the T-cell response
Fox, C. J., Hammerman, P. S., & Thompson, C. B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1710 · Cited by 854 · see citing works
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
Jacobs, S. R., Herman, C. E., MacIver, N. J., Wofford, J. A., Wieman, H. L., Hammen, J. J., & Rathmell, J. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4476 · Cited by 853 · see citing works
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
Chang, J. T., Palanivel, V., Kinjyo, I., Schambach, F., Intlekofer, A. M., Banerjee, A., Longworth, S. A., Vinup, K. E., Mrass, P., Oliaro, J., et al. (2007) · Science · doi:10.1126/science.1139393 · Cited by 845 · see citing works
A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span
Lehtinen, M. K., Yuan, Z., Boag, P. R., Yang, Y., Villén, J., Becker, E. B. E., DiBacco, S., de la Iglesia, N., Gygi, S. P., Blackwell, T. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.046 · Cited by 842 · see citing works
Regulation of Immune Responses by mTOR
Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Carr, E. L., Kelman, A., Wu, G. S., Gopaul, R., Senkevitch, E., Aghvanyan, A., Turay, A. M., & Frauwirth, K. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903586 · Cited by 830 · see citing works
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
Gordan, J. D., Thompson, C. B., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.006 · Cited by 806 · see citing works
Fatty acid import into mitochondria
Kerner, J., & Hoppel, C. L. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00044-5 · Cited by 805 · see citing works
LKB1-Dependent Signaling Pathways
Alessi, D. R., Sakamoto, K., & Bayascas, J. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142702 · Cited by 789 · see citing works
Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., & Levy, D. E. (2009) · Science · doi:10.1126/science.1171721 · Cited by 716 · see citing works
Interdependence of hypoxic and innate immune responses
Nizet, V., & Johnson, R. S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2607 · Cited by 708 · see citing works
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682 · see citing works
The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
Rao, R. R., Li, Q., Odunsi, K., & Shrikant, P. A. (2010) · Immunity · doi:10.1016/j.immuni.2009.10.010 · Cited by 656 · see citing works
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
Li, F., Wang, Y., Zeller, K. I., Potter, J. J., Wonsey, D. R., O’Donnell, K. A., Kim, J., Yustein, J. T., Lee, L. A., & Dang, C. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6225-6234.2005 · Cited by 615 · see citing works
Kruppel-like factor 2 regulates thymocyte and T-cell migration
Carlson, C. M., Endrizzi, B. T., Wu, J., Ding, X., Weinreich, M. A., Walsh, E. R., Wani, M. A., Lingrel, J. B., Hogquist, K. A., & Jameson, S. C. (2006) · Nature · doi:10.1038/nature04882 · Cited by 593 · see citing works
Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking
Wieman, H. L., Wofford, J. A., & Rathmell, J. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0593 · Cited by 593 · see citing works
Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake
Edinger, A. L., & Thompson, C. B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0584 · Cited by 589 · see citing works
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 584 · see citing works
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillón, D. H., DePinho, R. A., & Hedrick, S. Μ. (2009) · Nature Immunology · doi:10.1038/ni.1689 · Cited by 541 · see citing works
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524 · see citing works
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108024 · Cited by 501 · see citing works
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stressPreprint
Zaugg, K., Yao, Y., Reilly, P. T., Kannan, K., Kiarash, R., Mason, J. M., Huang, P., Sawyer, S. K., Fuerth, B. J., Faubert, B., et al. (2011) · Genes & Development · doi:10.1101/gad.1987211 · Cited by 493 · see citing works
Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
Wellen, K. E., & Thompson, C. B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.004 · Cited by 486 · see citing works
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
Rera, M., Bahadorani, S., Cho, J., Koehler, C. L., Ulgherait, M., Hur, J. H., Ansari, W. S., Lo, T., Jones, D. L., & Walker, D. W. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.013 · Cited by 472 · see citing works
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
Rathmell, J. C., Heiden, M. G. V., Harris, M. H., Frauwirth, K. A., & Thompson, C. B. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00066-6 · Cited by 467 · see citing works
GLUTAMINE METABOLISM IN LYMPHOCYTES: ITS BIOCHEMICAL, PHYSIOLOGICAL AND CLINICAL IMPORTANCE
Newsholme, E. A., Crabtree, B., & Ardawi, M. S. M. (1985) · Quarterly Journal of Experimental Physiology · doi:10.1113/expphysiol.1985.sp002935 · Cited by 465 · see citing works
Advances in measuring cellular bioenergetics using extracellular flux
Ferrick, D. A., Neilson, A., & Beeson, C. C. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.12.008 · Cited by 455 · see citing works
The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway
Ogg, S., & Ruvkun, G. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80303-2 · Cited by 454 · see citing works
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
Gan, B., HU, J. L., Jiang, S., Liu, Y., Sahin, E., Li, Z., Fletcher-Sananikone, E., Colla, S., Wang, Y., Chin, L., et al. (2010) · Nature · doi:10.1038/nature09595 · Cited by 437 · see citing works
AGEMAP: A Gene Expression Database for Aging in Mice
Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030201 · Cited by 431 · see citing works
Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche
Banerjee, A., Gordon, S. M., Intlekofer, A. M., Paley, M., Mooney, E. C., Lindsten, T., Wherry, E. J., & Reiner, S. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002042 · Cited by 429 · see citing works
Foxo Transcription Factors Control Regulatory T Cell Development and Function
Kerdiles, Y. M., Stone, E. L., Beisner, D. R., McGargill, M. A., Ch’en, I. L., Stockmann, C., Katayama, C. D., & Hedrick, S. Μ. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.002 · Cited by 419 · see citing works
Energy-dependent regulation of cell structure by AMP-activated protein kinase
Lee, J. H., Koh, H., Kim, M.-J., Kim, Y., Lee, S. Y., Karess, R. E., Lee, S. H., Shong, M., Kim, J., Kim, J., et al. (2007) · Nature · doi:10.1038/nature05828 · Cited by 418 · see citing works
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells
Cui, W., Liu, Y., Weinstein, J. S., Craft, J., & Kaech, S. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.017 · Cited by 410 · see citing works
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
Wang, M. C., O’Rourke, E. J., & Ruvkun, G. (2008) · Science · doi:10.1126/science.1162011 · Cited by 402 · see citing works
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
Sinclair, L. V., Finlay, D. K., Feijóo, C. G., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H., & Cantrell, D. A. (2008) · Nature Immunology · doi:10.1038/ni.1603 · Cited by 391 · see citing works
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Gurumurthy, S., Xie, S. Z.-J., Alagesan, B., Kim, J., Yusuf, R. Z., Sáez, B., Tzatsos, A., Ozsolak, F., Milos, P. M., Ferrari, F., et al. (2010) · Nature · doi:10.1038/nature09572 · Cited by 391 · see citing works
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
Cham, C. M., Driessens, G., O'Keefe, J. P., & Gajewski, T. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200838289 · Cited by 388 · see citing works
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B. (2010) · Genes & Development · doi:10.1101/gad.1985910 · Cited by 377 · see citing works
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
Angelini, G., Gardella, S., Ardy, M., Ciriolo, M. R., Filomeni, G., Trapani, G. D., Clarke, F. M., Sitia, R., & Rubartelli, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022630299 · Cited by 372 · see citing works
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
Newsholme, E. A., Crabtree, B., & Ardawi, M. S. (1985) · Bioscience Reports · doi:10.1007/bf01116556 · Cited by 364 · see citing works
Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells
Cham, C. M., & Gajewski, T. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4670 · Cited by 359 · see citing works
The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid
Eagle, H., Oyama, V. I., Levy, M., Horton, C. L., & Fleischman, R. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65826-0 · Cited by 354 · see citing works
Revving the Engine: Signal Transduction Fuels T Cell Activation
Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works
The TOR pathway comes of age
Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 339 · see citing works
Critical phosphorylation sites for acetyl-CoA carboxylase activity.
Ha, J., Daniel, S., Broyles, S. S., & Kim, K. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31770-2 · Cited by 328 · see citing works
Positive correlation between mammalian life span and cellular resistance to stress
Kapahi, P., Boulton, M. E., & Kirkwood, T. B. L. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00323-2 · Cited by 326 · see citing works
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
Furuyama, T., Kitayama, K., Yamashita, H., & Mori, N. (2003) · Biochemical Journal · doi:10.1042/bj20030022 · Cited by 326 · see citing works
Metabolism in T cell activation and differentiation
Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314 · see citing works
Self-citation
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
Pellegrini, M., Calzascia, T., Toe, J. G., Preston, S., Lin, A. E., Elford, A. R., Shahinian, A., Lang, P. A., Lang, K. S., Morre, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.011 · Cited by 309 · see citing works
Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production.
Greiner, E. F., Guppy, M., & Brand, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31720-4 · Cited by 307 · see citing works
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
Yang, K., Neale, G. A. M., Green, D. R., He, W., & Chi, H. (2011) · Nature Immunology · doi:10.1038/ni.2068 · Cited by 294 · see citing works
Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
Rao, R. R., Li, Q., Bupp, M. G., & Shrikant, P. A. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.015 · Cited by 293 · see citing works
The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth
Tennessen, J. M., Baker, K. D., Lam, G., Evans, J. M., & Thummel, C. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.005 · Cited by 290 · see citing works
Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells
Barata, J. T., da Silva, A. B. G., Brandão, J. G., Nadler, L. M., Cardoso, A. A., & Boussiotis, V. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040789 · Cited by 283 · see citing works
Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
Anderson, R. M., Barger, J. L., Edwards, M. G., Braun, K. H., O’Connor, C. E., Prolla, T. A., & Weindruch, R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00357.x · Cited by 283 · cited 1× · see citing works
“The decline in mitochondrial function with aging is opposed by caloric restriction by the induction of nuclear encoded genes that promote mitochondrial function (149).”
Background
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival
Nehme, N. T., Schmid, J. P., Debeurme, F., André‐Schmutz, I., Lim, A., Nitschké, P., Rieux‐Laucat, F., Lutz, P., Pïcard, C., Mahlaoui, N., et al. (2011) · Blood · doi:10.1182/blood-2011-09-378364 · Cited by 281 · see citing works
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
Siegel, A., Heimall, J., Freeman, A., Hsu, A. P., Brittain, E., Brenchley, J., Douek, D., Fahle, G., Cohen, J. I., Holland, S., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.016 · Cited by 277 · see citing works
Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism
Macintyre, A. N., Finlay, D. K., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijóo, C. G., Okkenhaug, K., & Cantrell, D. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.012 · Cited by 274 · see citing works
Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone
Yadava, N., & Nicholls, D. G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0212-07.2007 · Cited by 272 · see citing works
Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells
Ichii, H., Sakamoto, A., Hatano, M., Okada, S., Toyama, H., Taki, S., Arima, M., 嘉和, 黒., & Tokuhisa, T. (2002) · Nature Immunology · doi:10.1038/ni802 · Cited by 258 · see citing works
ERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · cited 1× · see citing works
“Another important regulator of transcription of metabolic genes is the nuclear hormone receptor, estrogen-related receptor-a (ERR-a) (91, 92) (Fig.”
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
MacIver, N. J., Blagih, J., Saucillo, D. C., Tonelli, L., Griss, T., Rathmell, J. C., & Jones, R. G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100367 · Cited by 235 · see citing works
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
Hand, T. W., Cui, W., Jung, Y. W., Sefik, E., Joshi, N. S., Chandele, A., Liu, Y., & Kaech, S. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003457107 · Cited by 229 · see citing works
Phosphatidylinositol 3-Kinase-dependent Modulation of Carnitine Palmitoyltransferase 1A Expression Regulates Lipid Metabolism during Hematopoietic Cell Growth
DeBerardinis, R. J., Lum, J. J., & Thompson, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608372200 · Cited by 221 · see citing works
Metabolism, migration and memory in cytotoxic T cells
Finlay, D. K., & Cantrell, D. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri2888 · Cited by 220 · see citing works
Regulation of quiescence in lymphocytes
Yusuf, I., & Fruman, D. A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00141-8 · Cited by 217 · see citing works
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216 · see citing works
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure
Choi, S. W., Gerencser, A. A., & Nicholls, D. G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06055.x · Cited by 204 · see citing works
Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma
Rathmell, J. C., Elstrom, R., Cinalli, R. M., & Thompson, C. B. (2003) · European Journal of Immunology · doi:10.1002/eji.200324048 · Cited by 197 · see citing works
Role for Bcl-6 in the generation and maintenance of memory CD8[+] T cells
市井, 啓. (2002) · Kobe University Repository Kernel (Kobe University) · Cited by 192 · see citing works
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells
Feng, X., Wang, H., Takata, H., Day, T. J., Willen, J., & Hu, H. (2011) · Nature Immunology · doi:10.1038/ni.2034 · Cited by 191 · see citing works
Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease
Newsholme, P., Curi, R., Pithon‐Curi, T. C., Murphy, C., Garcia, C. R. S., & de Melo, M. P. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00022-4 · Cited by 190 · see citing works
Bioenergetic Profile Experiment using C2C12 Myoblast Cells
Nicholls, D. G., Darley-Usmar, V. M., Wu, M., Jensen, P. B., Rogers, G. W., & Ferrick, D. A. (2010) · Journal of Visualized Experiments · doi:10.3791/2511 · Cited by 186 · see citing works
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes
Roos, D., & Loos, J. A. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90561-2 · Cited by 182 · see citing works
Differential regulation of T-cell growth by IL-2 and IL-15
Cornish, G. H., Sinclair, L. V., & Cantrell, D. A. (2006) · Blood · doi:10.1182/blood-2005-12-4827 · Cited by 175 · see citing works
Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease
Gatza, E., Wahl, D. R., Opipari, A. W., Sundberg, T. B., Reddy, P., Liu, C., Glick, G. D., & Ferrara, J. L. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001975 · Cited by 168 · see citing works
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease
Wong, A., Howie, J., Petrie, J. R., & Lang, C. C. (2009) · Clinical Science · doi:10.1042/cs20080066 · Cited by 164 · see citing works
Spare respiratory capacity, oxidative stress and excitotoxicity
Nicholls, D. G. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371385 · Cited by 161 · see citing works
The transcription factor ELF4 controls proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2
Yamada, T., Park, C., Mamonkin, M., & Lacorazza, D. (2009) · Nature Immunology · doi:10.1038/ni.1730 · Cited by 154 · see citing works
Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children
Savy, M., Edmond, K. M., Fine, P., Hall, A., Hennig, B. J., Moore, S. E., Mulholland, K., Schaible, U. E., & Prentice, A. M. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105312 · Cited by 154 · see citing works
Carnitine acyltransferases and their influence on CoA pools in health and disease
RAMSAY, R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.06.002 · Cited by 153 · see citing works
Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8+ T Cells
Ichii, H., Sakamoto, A., Kuroda, Y., & Tokuhisa, T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.883 · Cited by 152 · see citing works
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Brown, N. F., Stefanović-Račić, M., SIPULA, I. J., & Perdomo, G. (2007) · Metabolism · doi:10.1016/j.metabol.2007.06.016 · Cited by 152 · see citing works
Signaling Takes a Breath – New Quantitative Perspectives on Bioenergetics and Signal Transduction
Krauss, S., Brand, M. D., & Buttgereit, F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00205-9 · Cited by 147 · see citing works
AMP‐activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction–induced Longevity
Greer, E. L., Banko, M. R., & Brunet, A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04019.x · Cited by 146 · see citing works
Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation.
Stonier, S. W., Ma, L. J., Castillo, E. F., & Schluns, K. (2008) · Blood · doi:10.1182/blood-2008-05-156307 · Cited by 133 · see citing works
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection
McGill, J. L., van Rooijen, N., & Legge, K. L. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091711 · Cited by 133 · see citing works
Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors
Ao, A. S., Wang, H., Kamarajugadda, S., & Lu, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711677105 · Cited by 131 · see citing works
Stable Activation of Phosphatidylinositol 3-Kinase in the T Cell Immunological Synapse Stimulates Akt Signaling to FoxO1 Nuclear Exclusion and Cell Growth Control
Fabre, S., Lang, V., Harriague, J., Jobart‐Malfait, A., Unterman, T. G., Trautmann, A., & Bismuth, G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4161 · Cited by 126 · see citing works
CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARδ/β-mediated Adaptation to Metabolic Stress
Nahlé, Z., Hsieh, M., Pietka, T., Coburn, C. T., Grimaldi, P. A., Zhang, M. Q., Das, D., & Abumrad, N. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706478200 · Cited by 122 · see citing works
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
SIPULA, I. J., Brown, N. F., & Perdomo, G. (2006) · Metabolism · doi:10.1016/j.metabol.2006.08.002 · Cited by 118 · see citing works
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
Finley, L. W. S., Lee, J., Souza, A., Desquiret-Dumas, V., Bullock, K., Rowe, G. C., Procaccio, V., Clish, C. B., Arany, Z., & Haigis, M. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115813109 · Cited by 102 · see citing works
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation
D’Souza, A. D., Parikh, N. S., Kaech, S. M., & Shadel, G. S. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.08.001 · Cited by 99 · see citing works
Insulin and longevity: antidiabetic biguanides as geroprotectors
Anisimov, V. N., Semenchenko, A. V., & Yashin, A. I. (2003) · Biogerontology · doi:10.1023/a:1026299318315 · Cited by 97 · see citing works
LKB1 is essential for the proliferation of T‐cell progenitors and mature peripheral T cells
Tamás, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo‐Carnero, C., Ashworth, A., & Cantrell, D. (2010) · European Journal of Immunology · doi:10.1002/eji.200939677 · Cited by 94 · see citing works
Protein Energy Malnutrition Impairs Homeostatic Proliferation of Memory CD8 T Cells
Iyer, S. S., Chatraw, J. H., Tan, W. G., Wherry, E. J., Becker, T. C., Ahmed, R., & Kapasi, Z. F. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004027 · Cited by 89 · see citing works
Cutting Edge: The Role of IFN-α Receptor and MyD88 Signaling in Induction of IL-15 Expression In Vivo
Colpitts, S. L., Stoklasek, T. A., Plumlee, C. R., Obar, J. J., Guo, C., & Lefrançois, L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103609 · Cited by 86 · see citing works
Regulation of T‐cell survival and mitochondrial homeostasis by TSC1
O'Brien, T. F., Gorentla, B. K., Xie, D., Srivatsan, S., McLeod, I. X., He, Y.-W., & Zhong, X. (2011) · European Journal of Immunology · doi:10.1002/eji.201141411 · Cited by 86 · see citing works
TOR Pathway: Linking Nutrient Sensing to Life Span
Kapahi, P., & Zid, B. M. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.36.pe34 · Cited by 83 · see citing works
The Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
Wu, Q., Liu, Y., Chen, C., Ikenoue, T., Qiao, Y., Li, C.-S., Li, W., Guan, K., Liu, Y., & Zheng, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003968 · Cited by 82 · see citing works
Kruppel-Like Factor 2 Is Required for Trafficking but Not Quiescence in Postactivated T Cells
Takada, K., Wang, X., Hart, G. T., Odumade, O. A., Weinreich, M. A., Hogquist, K. A., & Jameson, S. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000094 · Cited by 77 · see citing works
Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation
Waugh, C. M., Sinclair, L. V., Finlay, D. K., Bayascas, J. R., & Cantrell, D. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00585-09 · Cited by 77 · see citing works
The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
Cao, Y., Li, H., Liu, H., Zheng, C., Ji, H., & Liu, X. (2009) · Cell Research · doi:10.1038/cr.2009.141 · Cited by 75 · see citing works
Bioenergetic Profile Experiment using C2C12 Myoblast Cells
Nicholls, D. G., Darley-Usmar, V. M., Wu, M., Jensen, P. B., Rogers, G. W., & Ferrick, D. A. (2010) · Journal of Visualized Experiments · doi:10.3791/2511-v · Cited by 72 · see citing works
Antigen-presenting cells control T cell proliferation by regulating amino acid availability
Edinger, A. L., & Thompson, C. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042707999 · Cited by 69 · see citing works
TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice
Zhang, L., Zhang, H., Li, L., Xiao, Y., Rao, E., Miao, Z., Chen, H., Sun, L., Li, H., Liu, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030592 · Cited by 54 · see citing works
Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice
Asami, D. K., McDonald, R. B., Hagopian, K., Horwitz, B. A., Warman, D. B., Hsiao, A., Warden, C. H., & Ramsey, J. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.010 · Cited by 39 · see citing works
Cutting Edge: Expression of the Transcription Factor E74-Like Factor 4 Is Regulated by the Mammalian Target of Rapamycin Pathway in CD8+ T Cells
Yamada, T., Gierach, K., Lee, P., Wang, X., & Lacorazza, H. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000718 · Cited by 26 · see citing works

Flagged first, then by citations

Sorted by citations

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204 · see citing works
Self-citation
Metabolic Pathways in Immune Cell Activation and Quiescence
Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692 · see citing works
Self-citation
T Cell Dysfunction in Cancer
Thommen, D. S., & Schumacher, T. N. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.012 · Cited by 1,304 · see citing works
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Patsoukis, N., Bardhan, K., Chatterjee, P., Sari, D., Liu, B., Bell, L. N., Karoly, E. D., Freeman, G. J., Petkova, V., Seth, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms7692 · Cited by 1,210 · see citing works
T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,190 · see citing works
Self-citation
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Sukumar, M., Liu, J., Ji, Y., Subramanian, M., Crompton, J. G., Yu, Z., Roychoudhuri, R., Palmer, D. C., Muranski, P., Karoly, E. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69589 · Cited by 952 · see citing works
Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
Nakaya, M., Xiao, Y., Zhou, X., Chang, J., Chang, M., Cheng, X., Blonska, M., Lin, X., & Sun, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.007 · Cited by 870 · see citing works
Regulation and metabolic functions of mTORC1 and mTORC2.
Szwed, A., Kim, E., & Jacinto, E. (2021) · Physiological Reviews · doi:10.1152/physrev.00026.2020 · Cited by 723 · see citing works
Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.005 · Cited by 790 · see citing works
Self-citation
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy
Golubovskaya, V., & Wu, L. (2016) · Cancers · doi:10.3390/cancers8030036 · Cited by 581 · see citing works
Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells
Caro‐Maldonado, A., Wang, R., Nichols, A., Kuraoka, M., Milasta, S., Sun, L., Gavin, A. L., Abel, E. D., Kelsoe, G. H., Green, D. R., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302062 · Cited by 553 · see citing works
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
van der Windt, G. J. W., O’Sullivan, D., Everts, B., Huang, S. C.-C., Buck, M. D., Curtis, J. D., Chang, C.-H., Smith, A. M., Ai, T., Faubert, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221740110 · Cited by 523 · see citing works
Self-citation
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Klysz, D., Tai, X., Robert, P. A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M. I., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aab2610 · Cited by 522 · see citing works
Redox regulation of immunometabolism
Muri, J., & Köpf, M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00478-8 · Cited by 501 · see citing works
Metabolic pathways in T cell activation and lineage differentiation
Almeida, L., Lochner, M., Berod, L., & Sparwasser, T. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.009 · Cited by 475 · see citing works
A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
Kramer, P. A., Ravi, S., Chacko, B., Johnson, M. S., & Darley-Usmar, V. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.026 · Cited by 389 · see citing works
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Pollizzi, K. N., Patel, C. H., Sun, I., Oh, M. H., Waickman, A. T., Wen, J., Delgoffe, G. M., & Powell, J. D. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77746 · Cited by 409 · see citing works
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
Man, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2710 · Cited by 407 · see citing works
The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells
Kurachi, M., Barnitz, R. A., Yosef, N., Odorizzi, P. M., DiIorio, M. A., Lemieux, M. E., Yates, K. B., Godec, J., Klatt, M. G., Regev, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2834 · Cited by 384 · see citing works
The Bioenergetic Health Index: a new concept in mitochondrial translational research
Chacko, B., Kramer, P. A., Ravi, S., Benavides, G., Mitchell, T., Dranka, B. P., Ferrick, D., Singal, A., Ballinger, S., Bailey, S., et al. (2014) · Clinical science · doi:10.1042/cs20140101 · Cited by 342 · see citing works
Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
Renner, K., Singer, K., Koehl, G. E., Geissler, E. K., Peter, K., Siska, P. J., & Kreutz, M. P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00248 · Cited by 378 · see citing works
Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Quinn, W. J., Jiao, J., TeSlaa, T. A., Stadanlick, J. E., Wang, Z., Wang, L., Akimova, T., Angelin, A., Schäfer, P. M., Cully, M. D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108500 · Cited by 370 · see citing works
STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
Zhang, C.-Y., Yue, C., Herrmann, A., Song, J., Egelston, C., Wang, T., Zhang, Z.-F., Li, W.-Z., Lee, H., Aftabizadeh, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.013 · Cited by 345 · see citing works
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
Rambold, A. S., & Pearce, E. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.006 · Cited by 341 · see citing works
Self-citation
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
Renner, K., Bruß, C., Schnell, A., Koehl, G. E., Becker, H. M., Fante, M. A., Menevse, A. N., Babl, N., Blazquez, R., Hacker, L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.068 · Cited by 309 · see citing works
Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function
Notarangelo, G., Spinelli, J. B., Perez, E. M., Baker, G. J., Kurmi, K., Elia, I., Stopka, S. A., Baquer, G., Lin, J., Golby, A. J., et al. (2022) · Science · doi:10.1126/science.abj5104 · Cited by 292 · see citing works
Arginase 1 is an innate lymphoid cell-intrinsic metabolic checkpoint controlling type 2 inflammation
Monticelli, L., Buck, M., Flamar, A., Saenz, S., Wojno, E. T., Yudanin, N., Osborne, L., Hepworth, M., Tran, S. V., Rodewald, H., et al. (2016) · Nature Immunology · doi:10.1038/ni.3421 · Cited by 275 · see citing works
Self-citation
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification.
Oburoglu, L., Tardito, S., Fritz, V., de Barros, S. D., Merida, P., Craveiro, M., Mamede, J., Cretenet, G., Mongellaz, C., An, X., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.002 · Cited by 266 · see citing works
Sorting Through Subsets
Klebanoff, C. A., Gattinoni, L., & Restifo, N. P. (2012) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31827806e6 · Cited by 276 · see citing works
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
Verbist, K., Guy, C. S., Milasta, S., Liedmann, S., Kamiński, M. M., Wang, R., & Green, D. R. (2016) · Nature · doi:10.1038/nature17442 · Cited by 273 · see citing works
Essential role of mitochondrial energy metabolism in Foxp3 + T‐regulatory cell function and allograft survival
Beier, U. H., Angelin, A., Akimova, T., Wang, L., Liu, Y., Xiao, H., Koike, M. A., Hancock, S. A., Bhatti, T. R., Han, R., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-268409 · Cited by 275 · see citing works
Complement and the Regulation of T Cell Responses
West, E. E., Kolev, M. V., & Kemper, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053245 · Cited by 271 · see citing works
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, S., Daenthanasanmak, A., Chakraborty, P., Wyatt, M. W., Dhar, P., Selvam, S. P., Fu, J., Zhang, J., Nguyen, H., Kang, I., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.006 · Cited by 270 · see citing works
Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production
McMaster, S. R., Wilson, J. J., Wang, H., & Kohlmeier, J. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402975 · Cited by 260 · see citing works
Targeting T cell metabolism for therapy
O’Sullivan, D., & Pearce, E. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.004 · Cited by 251 · see citing works
Self-citation
Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes
Moro‐García, M. A., Mayo, J. C., Sainz, R. M., & Alonso‐Arias, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00339 · Cited by 232 · see citing works
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Ma, L., Hostetler, A., Morgan, D. M., Maiorino, L., Sulkaj, I., Whittaker, C. A., Neeser, A., Pires, I. S., Yousefpour, P., Gregory, J. R., et al. (2023) · Cell · doi:10.1016/j.cell.2023.06.002 · Cited by 225 · see citing works
Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits
Heise, N., Silva, N. S. D., Silva, K., Carette, A., Simonetti, G., Pasparakis, M., & Klein, U. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20132613 · Cited by 220 · see citing works
High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells
Malinarich, F., Duan, K., Hamid, R. A., Bijin, A., Lin, W. X., Poidinger, M., Fairhurst, A., & Connolly, J. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1303316 · Cited by 216 · see citing works
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
O’Connor, R. S., Guo, L., Ghassemi, S., Snyder, N. W., Worth, A. J., Weng, L., Kam, Y., Philipson, B. I., Trefely, S., Nuñez-Cruz, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24676-6 · Cited by 207 · see citing works
mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
Hwang, S. S., Lim, J., Yu, Z., Kong, P. L., Sefik, E., Xu, H. Y., Harman, C. C. D., Kim, L. K., Lee, G. R., Li, H., et al. (2020) · Science · doi:10.1126/science.aax0194 · Cited by 207 · see citing works
Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity
Shi, H., & Chi, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02716 · Cited by 204 · see citing works
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts
Kerdidani, D., Aerakis, E., Verrou, K., Angelidis, I., Douka, K., Maniou, M.-A., Stamoulis, P., Goudevenou, K., Prados, A., Tzaferis, C., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210815 · Cited by 205 · see citing works
Metabolic Reprogramming in Immune Response and Tissue Inflammation
Sun, L., Yang, X., Yuan, Z., & Wang, H. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314037 · Cited by 198 · see citing works
Activation or exhaustion of CD8+ T cells in patients with COVID-19
Rha, M., & Shin, E. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00750-4 · Cited by 193 · see citing works
Bcl-6 directly represses the gene program of the glycolysis pathway
Oestreich, K. J., Read, K. A., Gilbertson, S. E., Hough, K. P., McDonald, P. W., Krishnamoorthy, V., & Weinmann, A. S. (2014) · Nature Immunology · doi:10.1038/ni.2985 · Cited by 189 · see citing works
Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
Cassim, S., & Pouysségur, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010157 · Cited by 189 · see citing works
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
Gómez‐Rodríguez, J., Wohlfert, E. A., Handon, R., Meylan, F., Wu, J. Z., Anderson, S. M., Kirby, M., Belkaid, Y., & Schwartzberg, P. L. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131459 · Cited by 182 · see citing works
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options
Kabacaoğlu, D., Ciecielski, K. J., Ruess, D. A., & Algül, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01878 · Cited by 175 · see citing works
Reinforce the antitumor activity of CD 8 + T cells via glutamine restriction
Nabe, S., Yamada, T., Suzuki, J., Toriyama, K., Yasuoka, T., Kuwahara, M., Shiraishi, A., Takenaka, K., Yasukawa, M., & Yamashita, M. (2018) · Cancer Science · doi:10.1111/cas.13827 · Cited by 175 · see citing works
Mitochondrial function, ornamentation, and immunocompetence
Koch, R. E., Josefson, C. C., & Hill, G. E. (2016) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12291 · Cited by 172 · see citing works
Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations
Ahl, P. J., Hopkins, R. A., Xiang, W. W., Au, B. V., Kaliaperumal, N., Fairhurst, A., & Connolly, J. E. (2020) · Communications Biology · doi:10.1038/s42003-020-1027-9 · Cited by 170 · see citing works
Amino-acid transporters in T-cell activation and differentiation
Ren, W., Liu, G., Yin, J., Tan, B., Wu, G., Bazer, F. W., Peng, Y., & Yin, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.222 · Cited by 165 · see citing works
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
Wang, L., Liang, Y., Zhao, C., Ma, P., Zeng, S., Ju, D., Zhao, M., Yu, M., & Shi, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02326-4 · Cited by 177 · see citing works
Mechanisms underlying immunosuppression by regulatory cells
Goldmann, O., Nwofor, O. V., Chen, Q., & Medina, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1328193 · Cited by 154 · see citing works
Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer
Luz-Crawford, P., Hernandez, J., Djouad, F., Luque-Campos, N., Caicedo, A., Carrère-Kremer, S., Brondello, J.-M., Vignais, M.-L., Pène, J., & Jorgensen, C. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1307-9 · Cited by 152 · see citing works
Immune Response Regulation in the Tumor Microenvironment by Hypoxia
Labiano, S., Palazón, A., & Melero, I. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.02.009 · Cited by 151 · see citing works
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
Gao, Z., Li, Y., Wang, F., Huang, T., Fan, K.-Q., Zhang, Y., Zhong, J.-Y., Cao, Q., Tong, C., Jia, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01919-0 · Cited by 147 · see citing works
Metabolic control of dendritic cell activation and function: recent advances and clinical implications
Everts, B., & Pearce, E. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00203 · Cited by 140 · see citing works
Self-citation
Co-Stimulatory Receptor Signaling in CAR-T Cells
Honikel, M. M., & Olejniczak, S. H. (2022) · Biomolecules · doi:10.3390/biom12091303 · Cited by 143 · see citing works
Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
Kouidhi, S., Elgaaïed, A. B., & Chouaı̈b, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00270 · Cited by 138 · see citing works
Role of Polyamines in Immune Cell Functions
Hesterberg, R. S., Cleveland, J. L., & Epling‐Burnette, P. K. (2018) · Medical Sciences · doi:10.3390/medsci6010022 · Cited by 137 · see citing works
Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration
Kolb, D., Kolishetti, N., Surnar, B., Sarkar, S., Guin, S., Shah, A. S., & Dhar, S. (2020) · ACS Nano · doi:10.1021/acsnano.9b10037 · Cited by 137 · see citing works
Cancer metabolism and tumor microenvironment: fostering each other?
Yuan, Y., Li, H., Wang, P., Chen, L., Guo, D. S., Jiang, H., He, B., Qin, S., Wang, K., Li, N., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-1999-2 · Cited by 138 · see citing works
Erratum: Amino-acid transporters in T-cell activation and differentiation
Ren, W., Liu, G., Yin, J., Tan, B., Wu, G., Bazer, F. W., Peng, Y., & Yin, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.207 · Cited by 128 · see citing works
Adipose Tissue Remodeling in Pathophysiology
Auger, C., & Kajimura, S. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042220-023633 · Cited by 123 · see citing works
The Emerging Facets of Non-Cancerous Warburg Effect
Abdel‐Haleem, A. M., Lewis, N. E., Jamshidi, N., Mineta, K., Gao, X., & Gojobori, T. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00279 · Cited by 121 · see citing works
Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches
Klein, K., He, K., Younes, A. I. A., Barsoumian, H. B., Chen, D., Ozgen, T., Mosaffa, S., Patel, R. R., Gu, M., Novaes, J. A. M. D. O., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573326 · Cited by 120 · see citing works
Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
Lian, X., Yang, K., Li, R., Li, M., Zuo, J., Zheng, B., Wang, W., Wang, P., & Zhou, S. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01486-5 · Cited by 120 · see citing works
Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease
Patel, C. H., & Powell, J. D. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.04.006 · Cited by 114 · see citing works
Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model
Ando, Y., Siegler, E. L., Ta, H. P., Cinay, G. E., Zhou, H., Gorrell, K. A., Au, H., Jarvis, B. M., Wang, P., & Shen, K. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900001 · Cited by 114 · see citing works
CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria
Almeida, L., Dhillon-LaBrooy, A., Carriche, G. M., Berod, L., & Sparwasser, T. D. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.03.033 · Cited by 112 · see citing works
MCJ/DnaJC15, an Endogenous Mitochondrial Repressor of the Respiratory Chain That Controls Metabolic Alterations
Hatle, K. M., Gummadidala, P. M., Navasa, N., Bernardo, E., Dodge, J. T., Silverstrim, B., Fortner, K. A., Burg, E., Suratt, B. T., Hammer, J., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00189-13 · Cited by 116 · see citing works
Metabolic Reprogramming Commits Differentiation of Human CD27+IgD+ B Cells to Plasmablasts or CD27−IgD− Cells
Torigoe, M., Iwata, S., Nakayamada, S., Sakata, K., Zhang, M., Hajime, M., Miyazaki, Y., Narisawa, M., Ishii, K., Shibata, H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601908 · Cited by 113 · see citing works
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections
Panagioti, E., Klenerman, P., Lee, L. N., van der Burg, S. H., & Arens, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00276 · Cited by 106 · see citing works
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells
Kolev, M. V., West, E. E., Kunz, N., Chauss, D., Moseman, E. A., Rahman, J., Freiwald, T., Balmer, M. L., Lötscher, J., Dimeloe, S., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.006 · Cited by 111 · see citing works
HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells
Hegedus, A., Williamson, M. K., & Huthoff, H. T. (2014) · Retrovirology · doi:10.1186/s12977-014-0098-4 · Cited by 109 · see citing works
Immunometabolism and HIV-1 pathogenesis: food for thought
Sáez‐Cirión, A., & Sereti, I. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0381-7 · Cited by 104 · see citing works
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans
Link, V. M., Subramanian, P., Cheung, F., Han, K. L., Stacy, A., Chi, L., Sellers, B. A., Koroleva, G., Courville, A. B., Mistry, S., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02761-2 · Cited by 109 · see citing works
Immunometabolism in Tuberculosis
Shi, L., Eugenín, E. A., & Subbian, S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00150 · Cited by 105 · see citing works
Vitamin D endocrinology on the cross-road between immunity and metabolism
Vanherwegen, A.-S., Gysemans, C. A., & Mathieu, C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.018 · Cited by 105 · see citing works
Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia
Tao, J.-H., Barbi, J. J., & Pan, F. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00204.2015 · Cited by 103 · see citing works
Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection
Angin, M., Volant, S., Passaes, C., Lécuroux, C., Monceaux, V., Dillies, M., Valle‐Casuso, J. C., Pancino, G., Vaslin, B., Grand, R. L., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0081-4 · Cited by 103 · see citing works
Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8+ T Cells
Hurst, K. E., Lawrence, K. A., Essman, M. T., Walton, Z. J., Leddy, L. R., & Thaxton, J. E. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0182 · Cited by 102 · see citing works
Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvironment Prevent Tumor Progression
Zhang, Y., & Ertl, H. C. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00032 · Cited by 100 · see citing works
Mitochondrial Dysfunction in Peripheral Blood Mononuclear Cells in Pediatric Septic Shock*
Weiss, S. L., Selak, M. A., Tuluc, F., Villarroel, J. P. P., Nadkarni, V., Deutschman, C. S., & Becker, L. B. (2014) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000277 · Cited by 101 · see citing works
Mitochondrial Reactive Oxygen Species and Type 1 Diabetes
Chen, J., Stimpson, S. E., Fernandez‐Bueno, G. A., & Mathews, C. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7346 · Cited by 100 · see citing works
Imaging of T-cells and their responses during anti-cancer immunotherapy
Krekorian, M., Fruhwirth, G. O., Srinivas, M., Figdor, C. G., Heskamp, S., Witney, T. H., & Aarntzen, E. H. J. G. (2019) · Theranostics · doi:10.7150/thno.37924 · Cited by 98 · see citing works
The Intercellular Metabolic Interplay between Tumor and Immune Cells
Wang, T., Liu, G., & Wang, R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00358 · Cited by 95 · see citing works
GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism
Na, Y. R., Gu, G., Jung, D., Kim, Y. W., Na, J., Woo, J. S., Cho, J., Youn, H., & Seok, S. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600745 · Cited by 94 · see citing works
c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells
Chou, C., Pinto, A. K., Curtis, J. D., Persaud, S. P., Cella, M., Lin, C., Edelson, B. T., Allen, P. M., Colonna, M., Pearce, E. L., et al. (2014) · Nature Immunology · doi:10.1038/ni.2943 · Cited by 95 · see citing works
Self-citation
Immunobiology of T Cells in Sjögren’s Syndrome
Yao, Y., Ma, J.-F., Chang, C. C.-C., Xu, T., Gao, C., Gershwin, M. E., & Lian, Z. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08793-7 · Cited by 95 · see citing works
4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation
Choi, B. K., Lee, D. Y., Lee, D. G., Kim, Y. H., Kim, S.-H., Oh, H. S., Han, C., & Kwon, B. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.02 · Cited by 91 · see citing works
Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2‐deoxy‐glucose affects effector functions
Renner, K., Geiselhöringer, A.-L., Fante, M. A., Bruß, C., Färber, S., Schoenhammer, G., Peter, K., Singer, K., Andreesen, R., Hoffmann, P., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545473 · Cited by 90 · see citing works
Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
Hu, Z., Qu, G., Yu, X., Jiang, H., Teng, X.-L., Ding, L., Hu, Q., Guo, X., Zhou, Y., Wang, F., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.016 · Cited by 87 · see citing works
Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
Zhang, M., Jin, X. K., Sun, R., Xiong, X., Wang, J., Xie, D., & Zhao, M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03165-x · Cited by 87 · see citing works
Enhancement of Antitumor Immunity in Lung Cancer by Targeting Myeloid-Derived Suppressor Cell Pathways
Sawant, A., Schafer, C. C., Jin, T. H., Zmijewski, J. W., Tse, H. M., Roth, J. C., Sun, Z., Siegal, G. P., Thannickal, V. J., Grant, S. C., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0987 · Cited by 87 · see citing works
Metabolic Reprogramming of Non-Hodgkin's B-Cell Lymphomas and Potential Therapeutic Strategies
Ricci, J., & Chiche, J. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00556 · Cited by 82 · see citing works
Powering the Immune System: Mitochondria in Immune Function and Deficiency
Walker, M. A., Volpi, S., Sims, K. B., Walter, J. E., & Traggiai, E. (2014) · Journal of Immunology Research · doi:10.1155/2014/164309 · Cited by 83 · see citing works

Authors: van der Windt, G. J. W., & Pearce, E. L.
Affiliations: Department of Pathology & Immunology Washington University School of Medicine St. Louis MO USA
Washington University in St. Louis (US)
Corresponding author: Pearce, Erika L.
ORCID: Pearce, Erika L.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2012-08-14
Volume: 249
Issue: 1
Pages: 27-42
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2012.01150.x
PMC: PMC3645891
OpenAlex: W1999195849
Cited by: 563
References: 157
Citations by year: 2026: 38 · 2025: 52 · 2024: 44 · 2023: 55 · 2022: 58 · 2021: 53 · 2020: 54 · 2019: 44 · 2018: 41 · 2017: 35 · 2016: 22 · 2015: 26 · 2014: 23 · 2013: 14 · 2012: 3
FWCI: 1.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Emerald Foundation
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
National Institutes of Health
National Cancer Institute (R21CA158823)
National Institute of Allergy and Infectious Diseases (R01AI091965)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: T cell metabolism, metabolic switch, fuel selection, T cell differentiation, memory T cells, metabolic reprogramming, adaptive immune response, T cell immunity
MeSH terms: Animals, Cell Differentiation, Energy Metabolism, Humans, Immunity, Cellular, Immunologic Memory, Lymphocyte Activation, Mitochondria, T-Lymphocytes, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Metabolic switching and fuel choice during T‐cell differentiation and memory development

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks