Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy regulates lipid metabolism

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Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

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MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

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Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

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Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

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Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

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The molecular machinery of autophagy: unanswered questions

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Autophagy regulates adipose mass and differentiation in mice

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Transcriptome Analysis of Genes Regulated by Cholesterol Loading in Two Strains of Mouse Macrophages Associates Lysosome Pathway and ER Stress Response with Atherosclerosis Susceptibility

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Interferon-stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR-17-5p/Beclin-1 pathway in THP-1 macrophage-derived foam cells

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Vanadium(IV)-chlorodipicolinate alleviates hepatic lipid accumulation by inducing autophagy via the LKB1/AMPK signaling pathway in vitro and in vivo

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New insights into foam cells in atherosclerosis

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Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

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The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis

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Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis

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Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses

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Autophagy and its regulation by ginseng components

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Inhibited autophagy impairs systemic nutrient metabolism in Nile tilapia

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Caveolin-1 in autophagy: A potential therapeutic target in atherosclerosis

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Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production

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Genome-wide studies of gene expression relevant to coronary artery disease

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Autophagy regulates lipid production and contributes to the sebosuppressive effect of retinoic acid in human SZ95 sebocytes

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Capitalizing on the Autophagic Response for Treatment of Liver Disease Caused by Alpha-1-Antitrypsin Deficiency and Other Genetic Diseases

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Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein

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Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/β-catenin pathway in atherosclerosis

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Translation Inhibitors Induce Formation of Cholesterol Ester-Rich Lipid Droplets

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Autophagy and cardiometabolic risk factors

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TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse

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Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease

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Eicosapentaenoic acid membrane incorporation impairs cholesterol efflux from cholesterol-loaded human macrophages by reducing the cholesteryl ester mobilization from lipid droplets

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Autophagy as an emerging therapeutic target for age-related vascular pathologies

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Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis

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Atorvastatin Enhances Foam Cell Lipophagy and Promotes Cholesterol Efflux Through the AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway

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Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

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Recent insights into atherosclerotic plaque cell autophagy

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Silencing of IGF2BP1 restrains ox‐LDL‐induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

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Cholesterol homeostasis and autophagic flux in perifosine-treated human hepatoblastoma HepG2 and glioblastoma U-87 MG cell lines

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Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease

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Effect of high-fat diet on cholesterol metabolism in rats and its association with Na+/K+-ATPase/Src/pERK signaling pathway

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Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation

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Inflammasomes: a preclinical assessment of targeting in atherosclerosis

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Traditional Chinese Medication Tongxinluo Attenuates Lipidosis in Ox-LDL-Stimulated Macrophages by Enhancing Beclin-1-Induced Autophagy

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Essential Roles of PPARs in Lipid Metabolism during Mycobacterial Infection

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Effects of VO2 nanoparticles on human liver HepG2 cells: Cytotoxicity, genotoxicity, and glucose and lipid metabolism disorders

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The effect of trehalose administration on vascular inflammation in patients with coronary artery disease

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Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue

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The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy

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Regulation of Benzo[a]pyrene-Induced Hepatic Lipid Accumulation through CYP1B1-Induced mTOR-Mediated Lipophagy

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T cell metabolism in metabolic disease-associated autoimmunity

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Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology

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Lanatoside C Promotes Foam Cell Formation and Atherosclerosis

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Foam cells: tracing the diverse cellular origins and their linked signaling pathways

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A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

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Elucidating the crosstalk between endothelial-to-mesenchymal transition (EndoMT) and endothelial autophagy in the pathogenesis of atherosclerosis

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Cell death in atherosclerosis

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First-Generation Antipsychotic Haloperidol Alters the Functionality of the Late Endosomal/Lysosomal Compartment in Vitro

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Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion

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Advances in metal-organic frameworks for cardiovascular therapy: from structural design to preclinical applications

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Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation

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Autophagy: A new target for the treatment of atherosclerosis

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Lipid Droplet—a New Target in Ischemic Heart Disease

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A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux

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The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and treatment options

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Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1 / TFEB / ABCA1‐SCARB1 signal axis

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Effects of Toxicologically Relevant Xenobiotics and the Lipid-Derived Electrophile 4-Hydroxynonenal on Macrophage Cholesterol Efflux: Silencing Carboxylesterase 1 Has Paradoxical Effects on Cholesterol Uptake and Efflux

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The role of C/EBP-α expression in human liver and liver fibrosis and its relationship with autophagy.

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Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

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The effect of trehalose administration on vascular inflammation in patients with coronary artery disease

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NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

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Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

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PCSK9 inhibitors suppress oxidative stress and inflammation in atherosclerotic development by promoting macrophage autophagy.

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Tanshinone IIA Regulates MAPK/mTOR Signal-Mediated Autophagy to Alleviate Atherosclerosis through the miR-214-3p/ATG16L1 Axis

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Multi-faceted roles of C1q/TNF-related proteins family in atherosclerosis

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TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity

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Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis

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PCSK9: A new participant in lipophagy in regulating atherosclerosis?

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Macrophage apoptosis using alendronate in targeted nanoarchaeosomes

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Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study

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UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor α Dependent Pathway

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Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells

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Lysosomal Acid Lipase Activity Deficiency in Children with Liver Disease:a potential biomarker?

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Emerging Roles of Lipophagy in Cancer Metastasis

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FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy

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Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration

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The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization

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