Cited by 779Cholesterol and Lipid MetabolismAutophagy in Disease and TherapyLipid metabolism and biosynthesis

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

Open access

Ouimet, Mireille, Franklin, Vivian, Mak, Esther, Liao, Xianghai, Tabas, Ira, Marcel, Yves L.·2011·Cell Metabolism

DOI 10.1016/j.cmet.2011.03.023PMC PMC3257518

Open this paper in CoChat — free account Open PDF

Abstract

The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis. Cholesterol, stored as cholesteryl esters (CEs), is liberated from this organelle and delivered to cholesterol acceptors. The current paradigm attributes all cytoplasmic CE hydrolysis to the action of neutral CE hydrolases. Here, we demonstrate an important role for lysosomes in LD CE hydrolysis in cholesterol-loaded macrophages, in addition to that mediated by neutral hydrolases. Furthermore, we demonstrate that LDs are delivered to lysosomes via autophagy, where lysosomal acid lipase (LAL) acts to hydrolyze LD CE to generate free cholesterol mainly for ABCA1-dependent efflux; this process is specifically induced upon macrophage cholesterol loading. We conclude that, in macrophage foam cells, lysosomal hydrolysis contributes to the mobilization of LD-associated cholesterol for reverse cholesterol transport.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2011.03.023

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.333 · Cited by 2,447
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science · doi:10.1126/science.1189862 · Cited by 1,260
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108 · cited 1×
“A further increase in LC3-II protein upon lysosomal inhibition was observed, indicative of a functional autophagic flux in these cells, as cellular LC3 levels per se are not a good marker for autophagy (Tanida et al., 2005).”
Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
Farese, R. V., & Walther, T. C. (2009) · Cell · doi:10.1016/j.cell.2009.11.005 · Cited by 1,047
Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.
Basu, S. K., Goldstein, J. L., Anderson, G. W., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.9.3178 · Cited by 1,019
The molecular machinery of autophagy: unanswered questions
Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 960
Autophagy regulates adipose mass and differentiation in mice
Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 765

Flagged first, then by citations

Show all 57 references

Sorted by citations

Items 101–200 of 779

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins
Winkler, M., Kidmose, R. T., Szomek, M., Thaysen, K., Rawson, S., Muench, S. P., Wüstner, D., & Pedersen, B. P. (2019) · Cell · doi:10.1016/j.cell.2019.08.038 · Cited by 137
Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis
Cui, W., Sathyanarayan, A., Lopresti, M. W., Aghajan, M., Chen, C., & Mashek, D. G. (2020) · Autophagy · doi:10.1080/15548627.2020.1728097 · Cited by 136
Astrocytes in stress accumulate lipid droplets
Smolič, T., Tavčar, P., Horvat, A., Černe, U., Halužan Vasle, A., Tratnjek, L., Kreft, M. E., Scholz, N., Matis, M., Petan, T., et al. (2021) · Glia · doi:10.1002/glia.23978 · Cited by 127
Intact endothelial autophagy is required to maintain vascular lipid homeostasis
Torisu, K., Singh, K. K., Torisu, T., Lovren, F., Liu, J., Pan, Y., Quan, A., Ramadan, A., Al-Omran, M. A., Pankova, N., et al. (2015) · Aging Cell · doi:10.1111/acel.12423 · Cited by 135
Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome
Ahamad, J., Toufeeq, I., Khan, M. A., Ameen, M. S. M., Anwer, E. T., Uthirapathy, S., Mir, S. R., & Ahmad, J. (2019) · Phytotherapy Research · doi:10.1002/ptr.6511 · Cited by 140
The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System
Du, Q., Liao, Q., Chen, C., Yang, X., Xie, R., & Xu, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01064 · Cited by 127
TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells
Li, B.-H., Yin, Y.-W., Liu, Y., Pi, Y., Guo, L., Cao, X.-J., Gao, C.-Y., Zhang, L.-L., & Li, J.-C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.146 · Cited by 129
Macrophages and Cardiovascular Health
Frodermann, V., & Nahrendorf, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00068.2017 · Cited by 128
Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis
Zhang, X., Ramírez, C. M., Aryal, B., Madrigal‐Matute, J., Liu, X., Díaz, A., Torrecilla-Parra, M., Suárez, Y., Cuervo, A. M., Sessa, W. C., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314291 · Cited by 130
Exposure to polystyrene nanoplastics impairs lipid metabolism in human and murine macrophages in vitro
Florance, I., Chandrasekaran, N., Gopinath, P. M., & Mukherjee, A. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113612 · Cited by 133
Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids
Swiader, A., Nahapetyan, H., Faccini, J., D’Angelo, R., Mucher, E., Elbaz, M., Boya, P., & Vindis, C. (2016) · Oncotarget · doi:10.18632/oncotarget.8936 · Cited by 129
SIRT 6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox‐ LDL condition
He, J., Zhang, G., Pang, Q., Yu, C., Xiong, J., Zhu, J., & Chen, F. (2017) · FEBS Journal · doi:10.1111/febs.14055 · Cited by 124
Adipose Tissue Foam Cells Are Present in Human Obesity
Shapiro, H., Pecht, T., Shaco‐Levy, R., Harman‐Boehm, I., Kirshtein, B., Kuperman, Y., Chen, A., Blüher, M., Shai, I., & Rudich, A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2745 · Cited by 126
Coordination of Triacylglycerol and Cholesterol Homeostasis by DHR96 and the Drosophila LipA Homolog magro
Sieber, M., & Thummel, C. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.011 · Cited by 120
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy
Han, Y., Xiong, S., Zhao, H., Yang, S., Yang, M., Zhu, X., Jiang, N., Xiong, X., Gao, P., Wei, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04326-y · Cited by 121
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis
Robichaud, S., Rasheed, A., Pietrangelo, A., Kim, A. D., Boucher, D. M., Emerton, C., Vijithakumar, V., Gharibeh, L., Fairman, G., Mak, E., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.320047 · Cited by 118
Self-citation
Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease
Ryter, S. W., Bhatia, D., & Choi, M. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7518 · Cited by 117
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
Yang, D.-S., Stavrides, P., Saito, M., Kumar, A., Rodriguez-Navarro, J. A., Pawlik, M., Huo, C., Walkley, S. U., Saito, M., Cuervo, A. M., et al. (2014) · Brain · doi:10.1093/brain/awu278 · Cited by 114
Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies
Zhang, H. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000507 · Cited by 118
Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool
Romero-Molina, C., Garretti, F., Andrews, S. J., Marcora, E., & Goate, A. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.015 · Cited by 111
Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis
Sergin, I., & Razani, B. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.010 · Cited by 111
Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
Zhang, Y., Whaley‐Connell, A. T., Sowers, J. R., & Ren, J. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.004 · Cited by 109
The Role of Lipids and Lipoproteins in Atherosclerosis
Linton, M. F., Yancey, P. G., Davies, S. S., Jerome, W. G., Linton, E. F., Song, W., Doran, A. C., & Vickers, K. C. (2015) · Europe PMC (PubMed Central) · Cited by 108
Potential therapeutic effects of mTOR inhibition in atherosclerosis
Kurdi, A., Meyer, G. R. Y. D., & Martinet, W. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12820 · Cited by 111
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis
Sergin, I., Bhattacharya, S., Emanuel, R., Esen, E., Stokes, C. J., Evans, T. D., Arif, B., Curci, J. A., & Razani, B. (2016) · Science Signaling · doi:10.1126/scisignal.aad5614 · Cited by 108
Implications of autophagy for vascular smooth muscle cell function and plasticity
Salabei, J. K., & Hill, B. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.003 · Cited by 108
Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux
Jeong, S., Kim, S., Park, J., Jung, I., Lee, M.-N., Jeon, S., Kweon, H. Y., Yu, D., Lee, S., Jang, Y., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1327942 · Cited by 105
Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages
Zhang, H., Song, G., Ni, B., He, K., Zhu, P., Wu, X., & Shao, Y. (2021) · Autophagy · doi:10.1080/15548627.2021.1909833 · Cited by 108
MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway
Tang, F., & Yang, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.001 · Cited by 104
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Tian, Y., Yang, B., Qiu, W., Hao, Y., Zhang, Z., Yang, B., Li, N., Cheng, S., Lin, Z., Rui, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11274-x · Cited by 105
Protective role of chaperone-mediated autophagy against atherosclerosis
Madrigal-Matute, J., de Bruijn, J., van Kuijk, K., Riascos-Bernal, D. F., Diaz, A., Tasset, I., Martín-Segura, A., Gijbels, M. J. J., Sander, B., Kaushik, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121133119 · Cited by 107
Lipid Droplets as Organelles
Cohen, S. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2017.12.007 · Cited by 102
Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy
Michiels, C. F., Kurdi, A., Timmermans, J., Meyer, G. R. Y. D., & Martinet, W. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.07.899 · Cited by 102
Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases
Sözen, E., Karademir-Yilmaz, B., & Özer, N. K. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.031 · Cited by 104
Exploring autophagy with Gene Ontology
Denny, P., Feuermann, M., Hill, D. P., Lovering, R. C., Plun‐Favreau, H., & Roncaglia, P. (2018) · Autophagy · doi:10.1080/15548627.2017.1415189 · Cited by 95
Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro
Florance, I., Seenivasan, R., Mukherjee, A., & Chandrasekaran, N. (2021) · Toxicology · doi:10.1016/j.tox.2021.152850 · Cited by 102
Crosstalk between reverse cholesterol transport and innate immunity
Azzam, K. M., & Fessler, M. B. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.02.001 · Cited by 96
Changes in transcriptome of macrophages in atherosclerosis
Chistiakov, D. A., Bobryshev, Y. V., & Orekhov, A. N. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12591 · Cited by 103
The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis
Buckley, M. L., & Ramji, D. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.04.011 · Cited by 98
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy
Shen, L., Yang, Y., Ou, T., Key, C.-C. C., Tong, S. H., Sequeira, R. C., Nelson, J. M., Nie, Y., Wang, Z., Boudyguina, E. Y., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m075879 · Cited by 98
Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage
Kou, J., Li, Y., Zhong, Z., Jiang, Y., Li, X. S., Han, X. B., Liu, Z. N., Tian, Y., & Yang, L. M. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.354 · Cited by 95
Tanshinone IIA harmonizes the crosstalk of autophagy and polarization in macrophages via miR-375/KLF4 pathway to attenuate atherosclerosis
Chen, W., Li, X., Guo, S., Song, N., Wang, J., Jia, L., & Zhu, A. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.02.054 · Cited by 94
Autophagy and Immune Senescence
Zhang, H., Puleston, D. J., & Simon, A. K. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.001 · Cited by 95
Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis
Litvinov, D. Y., Savushkin, E. V., & Dergunov, A. D. (2018) · Journal of Lipids · doi:10.1155/2018/3965054 · Cited by 99
A role for lipophagy in atherosclerosis
Laval, T., & Ouimet, M. I. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00885-z · Cited by 93
Self-citation
Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease
Geltinger, F., Schartel, L., Wiederstein, M., Tevini, J., Aigner, E. S., Felder, T. K., & Rinnerthaler, M. (2020) · Molecules · doi:10.3390/molecules25215053 · Cited by 96
Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK
Dai, S., Dulcey, A. E., Hu, X., Wassif, C. A., Porter, F. D., Austin, C. P., Ory, D. S., Marugán, J., & Zheng, W. (2017) · Autophagy · doi:10.1080/15548627.2017.1329081 · Cited by 95
Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells
Ji, J. X., Petropavlovskaia, M., Khatchadourian, A., Patapas, J. M., Makhlin, J., Rosenberg, L. C., & Maysinger, D. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14172 · Cited by 91
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the presymptomatic stage
Shibuya, Y., Niu, Z., Bryleva, E. Y., Harris, B. T., Murphy, S. R., Kheirollah, A., Bowen, Z. D., Chang, C. C. Y., & Chang, T.-Y. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.002 · Cited by 87
Autophagosomes contribute to intracellular lipid distribution in enterocytes
Khaldoun, S. A., Emond-Boisjoly, M.-A., Château, D., Carrière, V., Lacasa, M., Rousset, M., Demignot, S., & Morel, É. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-06-0324 · Cited by 96
DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity
Soussi, H., Reggio, S., Alili, R., Prado, C., Mutel, S., Pini, M., Rouault, C., Clément, K., & Dugail, I. (2015) · Diabetes · doi:10.2337/db14-1933 · Cited by 93
MicroRNA Control of High-Density Lipoprotein Metabolism and Function
Rayner, K. J., & Moore, K. J. (2014) · Circulation Research · doi:10.1161/circresaha.114.300645 · Cited by 91
Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells
Qiao, L., Zhang, X., Liu, M., Liu, X., Dong, M., Cheng, J., Zhang, X., Zhai, C., Song, Y., Lu, H., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00727 · Cited by 91
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation
Zhong, S., Li, L., Zhang, Y., Zhang, L., Lu, J., Guo, S., Liang, N., Ge, J., Zhu, M., Tao, Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122064 · Cited by 89
Reactive Oxygen Species and Thiol Redox Signaling in the Macrophage Biology of Atherosclerosis
Tavakoli, S., & Asmis, R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4638 · Cited by 91
Classical and alternative roles for autophagy in lipid metabolism
Zhang, X., Evans, T. D., Jeong, S., & Razani, B. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000509 · Cited by 89
Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis
Gibson, M. S., Domingues, N. S., & Vieira, O. V. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00654 · Cited by 82
Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma
Zhang, C.-J., Zhu, N., Long, J., Wu, H.-T., Wang, Y., Liu, B.-Y., Liao, D., & Li, Q. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00572-6 · Cited by 86
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction
Sun, H. L., Krauss, R. M., Chang, J. T., & Teng, B. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m078360 · Cited by 94
Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems
Ouimet, M. I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.03.007 · Cited by 86
Self-citation
Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes
Dahik, V. D., Frisdal, É., & Goff, W. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155505 · Cited by 88
Lipid metabolism, remodelling and intercellular transfer in the CNS
Vanherle, S., Loix, M., Miron, V. E., Hendriks, J. J. A., & Bogie, J. F. J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00908-3 · Cited by 96
Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function
Galle-Treger, L., Hurrell, B. P., Lewis, G. M., Howard, E. D., Shafiei-Jahani, P., Banie, H., Razani, B., Soroosh, P., & Akbari, O. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.10.035 · Cited by 86
IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability
Fang, S., Sun, S. Y., Cai, H., Zou, X., Wang, S., Hao, X., Wan, X. H., Tian, J., Li, Z., He, Z., et al. (2021) · Theranostics · doi:10.7150/thno.62797 · Cited by 85
Effect of lysosomotropic molecules on cellular homeostasis
Kuzu, O. F., Toprak, M., Noory, M. A., & Robertson, G. P. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.021 · Cited by 83
Cardiovascular disease in lupus
Knight, J. S., & Kaplan, M. J. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328363eba3 · Cited by 84
Targeting cholesterol homeostasis in lung diseases
Sallese, A., Suzuki, T., McCarthy, C., Bridges, J. P., Filuta, A. L., Arumugam, P. I., Shima, K., Ma, Y., Wessendarp, M., Black, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10879-w · Cited by 82
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells
Miceli, C., Roccio, F., Penalva-Mousset, L., Burtin, M., Leroy, C., Nemazanyy, I., Kuperwasser, N., Pontoglio, M., Friedlander, G., Morel, É., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0566-0 · Cited by 87
Luteolin Attenuates Foam Cell Formation and Apoptosis in Ox-LDL-Stimulated Macrophages by Enhancing Autophagy
Zhang, B., Zhang, C.-W., Wang, C., Pan, D.-F., Xu, T.-D., & Li, D.-Y. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000447902 · Cited by 80
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets
Chung, J., Park, J., Lai, Z. W., Lambert, T. J., Richards, R. C., Zhang, J., Walther, T. C., & Farese, R. V. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01178-w · Cited by 83
Mild Renal Dysfunction and Metabolites Tied to Low HDL Cholesterol Are Associated With Monocytosis and Atherosclerosis
Ganda, A., Magnusson, M., Yvan‐Charvet, L., Hedblad, B., Engström, G., Ai, D., Wang, T. J., Gerszten, R. E., Melander, O., & Tall, A. R. (2013) · Circulation · doi:10.1161/circulationaha.112.000682 · Cited by 80
Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB
Li, X., Zhang, X., Zheng, L., Kou, J., Zhong, Z., Jiang, Y., Wang, W., Dong, Z., Liu, Z., Han, X. B., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.433 · Cited by 79
Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation
Minami, S., Yamamoto, T., Takabatake, Y., Takahashi, A., Namba‐Hamano, T., Matsuda, J., Kimura, T., Kaimori, J.-Y., Matsui, I., Hamano, T., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1341464 · Cited by 79
Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression
Zhang, X., Rotllan, N., Canfrán-Duque, A., Sun, J., Toczek, J., Moshnikova, A., Malik, S., Price, N. L., Araldi, E., Zhong, W., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.320296 · Cited by 75
Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation
Kumar, S. R., Nanduri, R., Bhagyaraj, E., Kalra, R., Ahuja, N., Chacko, A. P., Tiwari, D., Sethi, K., Saini, A., Chandra, V., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1822088 · Cited by 78
An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread
Tan, J. M. J., Mellouk, N., Osborne, S. E., Ammendolia, D. A., Dyer, D. N., Li, R., Brunen, D., van Rijn, J. M., Huang, J., Czuczman, M. A., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0293-5 · Cited by 76
Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes
Bovo, S., Mazzoni, G., Bertolini, F., Schiavo, G., Galimberti, G., Gallo, M., Dall’Olio, S., & Fontanesi, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-43297-1 · Cited by 78
A Review of the Relationship Between CTRP Family and Coronary Artery Disease
Si, Y., Fan, W., & Sun, L. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00840-0 · Cited by 76
Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis
Tao, H., Yancey, P. G., Blakemore, J. L., Zhang, Y., Ding, L., Jerome, W. G., Brown, J. D., Vickers, K. C., & Linton, M. F. (2021) · Journal of Clinical Investigation · doi:10.1172/jci94229 · Cited by 78
Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport
Kuzu, O. F., Gowda, R., Sharma, A. K., & Robertson, G. P. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0868 · Cited by 80
Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis
Li, W., Sultana, N., Siraj, N., Ward, L. J., Pawlik, M., Levy, E., Jovinge, S. V., Bengtsson, E., & Yuan, X. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12859 · Cited by 76
Metabolic reprogramming & inflammation: Fuelling the host response to pathogens
Gleeson, L. E., & Sheedy, F. J. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.007 · Cited by 78
Macrophage Autophagy in Atherosclerosis
Maiuri, M. C., Grassia, G., Platt, A. M., Carnuccio, R., Ialenti, A., & Maffia, P. (2013) · Mediators of Inflammation · doi:10.1155/2013/584715 · Cited by 72
Target acquired: Selective autophagy in cardiometabolic disease
Evans, T. D., Sergin, I., Zhang, X., & Razani, B. (2017) · Science Signaling · doi:10.1126/scisignal.aag2298 · Cited by 74
Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance
Kim, S., Kim, N., Park, S., Jeon, Y., Lee, J., Yoo, S., Lee, J., Moon, C., Yu, S., & Kim, E. (2019) · Autophagy · doi:10.1080/15548627.2019.1659616 · Cited by 75
Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System
Zhang, W., Xu, L., Zhu, L., Liu, Y., Yang, S., & Zhao, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746749 · Cited by 77
Lipophagy Contributes to Testosterone Biosynthesis in Male Rat Leydig Cells
Ma, Y., Zhou, Y., Zhu, Y., Wang, S., Ping, P., & Chen, X. (2018) · Endocrinology · doi:10.1210/en.2017-03020 · Cited by 77
The Molecular Brakes of Adipose Tissue Lipolysis
Li, Y., Li, Z., Ngandiri, D. A., Perez, M. L., Wolf, A., & Wang, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.826314 · Cited by 82
Lipophagy at a glance
Schott, M. B., Rozeveld, C. N., Weller, S. G., & McNiven, M. A. (2022) · Journal of Cell Science · doi:10.1242/jcs.259402 · Cited by 72
Recent insights into lysosomal acid lipase deficiency
Korbelius, M., Kuentzel, K. B., Bradić, I., Vujić, N., & Kratky, D. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.03.001 · Cited by 76
Autophagy: an emerging therapeutic target in vascular diseases
Vindis, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13052 · Cited by 75
Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis
Wang, Y., Ding, W., & Li, T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.04.005 · Cited by 76
Autophagy activation contributes to lipid accumulation in tubular epithelial cells during kidney fibrosis
Yan, Q., Song, Y., Zhang, L., Chen, Z., Yang, C., Liu, S., Yuan, X., Gao, H., Ding, G., & Wang, H. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0065-2 · Cited by 72
Lipid droplet-associated proteins in atherosclerosis (Review)
Ayyappan, J. P., Paul, A., & Goo, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5099 · Cited by 71
Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis
Rasheed, A., Robichaud, S., Nguyen, M.-A., Geoffrion, M., Wyatt, H., Cottee, M. L., Dennison, T., Pietrangelo, A., Lee, R. G., Lagace, T. A., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313640 · Cited by 76
Self-citation
Autophagy Protects Cells From HCV-Induced Defects in Lipid Metabolism
Vescovo, T., Romagnoli, A., Perdomo, A. B., Corazzari, M., Ciccosanti, F., Alonzi, T., Nardacci, R., Ippolito, G., Tripodi, M., Garcia–Monzon, C., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.11.033 · Cited by 69
CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells
Zahid, M. K., Rogowski, M. P., Ponce, C., Choudhury, M., Moustaïd‐Moussa, N., & Rahman, S. M. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03642-4 · Cited by 69
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover
Pu, M., Zheng, W., Zhang, H., Wan, W., Peng, C., Chen, X., Liu, X., Xu, Z., Zhou, T., Sun, Q., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac063 · Cited by 76
p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy
Mei, S., Gu, H., Ward, A. R., Yang, X., Guo, H., He, K., Liu, Z., & Cao, W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333575 · Cited by 70
Akt Inhibition Promotes ABCA1-Mediated Cholesterol Efflux to ApoA-I through Suppressing mTORC1
Dong, F., Mo, Z., Eid, W., Courtney, K. C., & Zha, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113789 · Cited by 71

Authors: Ouimet, M., Franklin, V., Mak, E., Liao, X., Tabas, I., & Marcel, Y. L.
Affiliations: University of Ottawa (CA)
Ottawa Heart Institute (CA)
Columbia University (US)
Corresponding author: Marcel, Yves L.
ORCID: Ouimet, Mireille
Mak, Esther
Tabas, Ira
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2011-06
Volume: 13
Issue: 6
Pages: 655-667
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2011.03.023
PMC: PMC3257518
OpenAlex: W1983619827
Cited by: 774
References: 57
Citations by year: 2026: 49 · 2025: 57 · 2024: 42 · 2023: 61 · 2022: 61 · 2021: 69 · 2020: 62 · 2019: 48 · 2018: 66 · 2017: 52 · 2016: 51 · 2015: 48 · 2014: 35 · 2013: 28 · 2012: 37
FWCI: 34.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 813 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes of Health Research
Heart and Stroke Foundation of Canada
National Institutes of Health (HL057560)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: autophagy, lysosomal acid lipase, foam cells, cholesterol efflux, lipid droplets, cholesterol ester hydrolysis, lysosomes, ABCA1, reverse cholesterol transport, atherosclerosis, free cholesterol
MeSH terms: Autophagy-Related Protein 5, Animals, Autophagy, Bone Marrow Cells, Cells, Cultured, Chloroquine, Cholesterol, Sterol Esterase, Foam Cells, Lipolysis, Lipoproteins, LDL, Lysosomes, Mice, Inbred C57BL, Microtubule-Associated Proteins, Paraoxon, Mice, Knockout, Atherosclerosis, Lipid Metabolism, Mice, Gene Knockout Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks