Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy regulates lipid metabolism

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MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

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Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

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Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

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The molecular machinery of autophagy: unanswered questions

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Autophagy regulates adipose mass and differentiation in mice

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Autophagy-activating strategies to promote innate defense against mycobacteria

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Targeting lipophagy in macrophages improves repair in multiple sclerosis

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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

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Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages

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Role of cholesterol homeostasis and its efflux pathways in cancer progression

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Eating the dead to keep atherosclerosis at bay

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Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy

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Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation

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Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages

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Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway

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Adverse outcome pathway of fine particulate matter leading to increased cardiovascular morbidity and mortality: An integrated perspective from toxicology and epidemiology

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Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype

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Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

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Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression

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Emerging roles of autophagy in metabolism and metabolic disorders

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Mapping Autophagy on to Your Metabolic Radar

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Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice

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The Role of Macrophage Lipophagy in Reverse Cholesterol Transport

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The expanding organelle lipidomes: current knowledge and challenges

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Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023

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ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover

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Non-lethal sonodynamic therapy facilitates the M1-to-M2 transition in advanced atherosclerotic plaques via activating the ROS–AMPK–mTORC1–autophagy pathway

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Nicotinate-Curcumin Impedes Foam Cell Formation from THP-1 Cells through Restoring Autophagy Flux

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Role of AMPK in atherosclerosis via autophagy regulation

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mTOR Enhances Foam Cell Formation by Suppressing the Autophagy Pathway

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Identification of certain Panax species to be potential substitutes for Panax notoginseng in hemostatic treatments

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Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress

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Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene‐deleted mice

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Lipid metabolism disorder promotes the development of intervertebral disc degeneration

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Mitochondria orchestrate macrophage effector functions in atherosclerosis

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Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging

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Ursolic acid enhances macrophage autophagy and attenuates atherogenesis

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Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target

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Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages

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Macrophage-based therapeutic approaches for cardiovascular diseases

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Lipids in autophagy: Constituents, signaling molecules and cargo with relevance to disease

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Novel insights: Dynamic foam cells derived from the macrophage in atherosclerosis

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Complex Relations Between Phospholipids, Autophagy, and Neutral Lipids

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Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis

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Circular RNAs: Rising stars in lipid metabolism and lipid disorders

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Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle

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Novel Lipid Droplet–Associated Serine Hydrolase Regulates Macrophage Cholesterol Mobilization

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Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

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Foam cell formation by particulate matter (PM) exposure: a review

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Cysteine proteases in atherosclerosis

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Links between autophagy and lipid droplet dynamics

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Phosphatidylcholine: Greasing the Cholesterol Transport Machinery

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Monocytes and macrophages in atherogenesis

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Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis

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The use of electron microscopy for the detection of autophagy in human atherosclerosis

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Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins

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Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules

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Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy

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Promising Anti-atherosclerotic Effect of Berberine: Evidence from In Vitro, In Vivo, and Clinical Studies

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From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport

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Drug-induced macrophage autophagy in atherosclerosis: for better or worse?

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Rab proteins implicated in lipid storage and mobilization

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H 2 O 2 -responsive and plaque-penetrating nanoplatform for mTOR gene silencing with robust anti-atherosclerosis efficacy

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Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis

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Sterol Metabolism and Transport in Atherosclerosis and Cancer

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Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages

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Exploring the Dynamic Changes of Brain Lipids, Lipid Rafts, and Lipid Droplets in Aging and Alzheimer’s Disease

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A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux

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Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

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Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

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Autophagy in Metabolic Age-Related Human Diseases

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Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination

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Impaired Autophagy in CD11b + Dendritic Cells Expands CD4 + Regulatory T Cells and Limits Atherosclerosis in Mice

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Deficient Chaperone-Mediated Autophagy Promotes Lipid Accumulation in Macrophage

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Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue

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Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance

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Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome

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Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue

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Small but smart: MicroRNAs orchestrate atherosclerosis development and progression

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Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1

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Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages

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Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: Potential role in atherosclerosis

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Lipid droplet autophagy during energy mobilization lipid homeostasis and protein quality control

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CTRP13 inhibits atherosclerosis via autophagy‐lysosome‐dependent degradation of CD36

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Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction

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FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation

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Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK‐FoxO1‐TFEB signalling axis

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Lysosome/lipid droplet interplay in metabolic diseases

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ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability

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Early steps in reverse cholesterol transport

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LncRNA DYNLRB2-2 inhibits THP-1 macrophage foam cell formation by enhancing autophagy

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Immune metabolism in allergies, does it matter?—A review of immune metabolic basics and adaptations associated with the activation of innate immune cells in allergy

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Lipid droplets, autophagy, and ageing: A cell-specific tale

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An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis

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Differential effects of GLP-1 receptor agonist on foam cell formation in monocytes between non-obese and obese subjects

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ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading–induced autophagy

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Rab18: new insights into the function of an essential protein

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SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL‐treated human vascular smooth muscle cells

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The role of TRPV1 channels in atherosclerosis

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GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway

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Unmasking the janus faces of autophagy in obesity‐associated insulin resistance and cardiac dysfunction

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Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity

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Coronary Artery Disease–Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes

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Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab

Ouimet, M., Franklin, V., Mak, E., Liao, X., Tabas, I. A., & Yves, L. (2011)

Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells

Ouimet, M. I., & Marcel, Y. L. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.240705 · Cited by 229

Regulation of Lipid Droplet Cholesterol Efflux from Macrophage Foam Cells: a Role for Oxysterols and Autophagy

Ouimet, M. I. (2011) · uO Research (University of Ottawa) · doi:10.20381/ruor-3440

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport

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Autophagy is not required for abca1-mediated cholesterol efflux in cholesterol loaded human monocyte-derived macrophages

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