Cited by 779Cholesterol and Lipid MetabolismAutophagy in Disease and TherapyLipid metabolism and biosynthesis

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

Open access

Ouimet, Mireille, Franklin, Vivian, Mak, Esther, Liao, Xianghai, Tabas, Ira, Marcel, Yves L.·2011·Cell Metabolism

DOI 10.1016/j.cmet.2011.03.023PMC PMC3257518

Open this paper in CoChat — free account Open PDF

Abstract

The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis. Cholesterol, stored as cholesteryl esters (CEs), is liberated from this organelle and delivered to cholesterol acceptors. The current paradigm attributes all cytoplasmic CE hydrolysis to the action of neutral CE hydrolases. Here, we demonstrate an important role for lysosomes in LD CE hydrolysis in cholesterol-loaded macrophages, in addition to that mediated by neutral hydrolases. Furthermore, we demonstrate that LDs are delivered to lysosomes via autophagy, where lysosomal acid lipase (LAL) acts to hydrolyze LD CE to generate free cholesterol mainly for ABCA1-dependent efflux; this process is specifically induced upon macrophage cholesterol loading. We conclude that, in macrophage foam cells, lysosomal hydrolysis contributes to the mobilization of LD-associated cholesterol for reverse cholesterol transport.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2011.03.023

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.333 · Cited by 2,447
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science · doi:10.1126/science.1189862 · Cited by 1,260
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108 · cited 1×
“A further increase in LC3-II protein upon lysosomal inhibition was observed, indicative of a functional autophagic flux in these cells, as cellular LC3 levels per se are not a good marker for autophagy (Tanida et al., 2005).”
Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
Farese, R. V., & Walther, T. C. (2009) · Cell · doi:10.1016/j.cell.2009.11.005 · Cited by 1,047
Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.
Basu, S. K., Goldstein, J. L., Anderson, G. W., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.9.3178 · Cited by 1,019
The molecular machinery of autophagy: unanswered questions
Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 960
Autophagy regulates adipose mass and differentiation in mice
Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 765

Show all 57 references

Sorted by citations

Items 501–600 of 779

Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver
Lian, J., van der Veen, J. N., Watts, R., Jacobs, R. L., & Lehner, R. S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100093 · Cited by 13
The emerging crosstalk between atherosclerosis-related microRNAs and Bermuda triangle of foam cells: Cholesterol influx, trafficking, and efflux
Achmad, H., Almajidi, Y. Q., Adel, H., Obaid, R. F., Romero‐Parra, R. M., Kadhum, W. R., Almulla, A. F., Alhachami, F. R., Gabr, G. A., Mustafa, Y. F., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110632 · Cited by 13
Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis
Gulshan, K. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-21547-6_13 · Cited by 12
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
Zhong, Y., Maruf, A., Qu, K., Milewska, M., Wandzik, I., Mou, N., Cao, Y., & Wu, W. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02248-9 · Cited by 12
Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation
Gao, W., Yang, T., Wang, B., Liu, Q., Li, Q., Zhou, X., Zheng, C., & Chen, P. (2024) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13845 · Cited by 12
TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection
Venkatasubramanian, S., Plumlee, C. R., Dill‐McFarland, K. A., Cohen, S. B., Gern, B. H., Rane, D. A., Meyer, M., Saha, A., Hinderstein, S. A., Pearson, G. L., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01641-w · Cited by 15
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy
Wang, B., Du, A., Chen, X., Huang, T., Mamun, A. A., Li, P., Du, S., Feng, Y.-Z., Jiang, L.-Y., Xu, J., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01463-w · Cited by 13
Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in advanced glycation end‐product low‐density lipoprotein–induced macrophages
Li, S., Gao, G., Wu, F., Liu, D., Zhao, H., Ke, J., Liu, Y., Li, F., Li, J., Chen, Z., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28043 · Cited by 12
The Oncogene Transcription Factor EB Regulates Vascular Functions
Doronzo, G., Astanina, E., & Bussolino, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.640061 · Cited by 12
Beclin1 circulating level as predictor of carotid intima-media thickness in patients with type 2 diabetes mellitus
Naguib, M., Tarabay, A., ElSaraf, N., Rashed, L., & Meligy, A. E. (2021) · Medicine · doi:10.1097/md.0000000000026630 · Cited by 12
TMT-based quantitative proteomic profiling of human monocyte-derived macrophages and foam cells
Zhang, Y., Fu, Y., Jia, L., Zhang, C., Cao, W., Alam, N., Wang, R., Wang, W., Bai, L., Zhao, S., et al. (2022) · Proteome Science · doi:10.1186/s12953-021-00183-x · Cited by 12
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism
Cavounidis, A., Pandey, S., Capitani, M., Friedrich, M., Cross, A. R., Gartner, L., Aschenbrenner, D., Kim‐Schulze, S., Lam, Y. K., Berridge, G., et al. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00572-1 · Cited by 12
Protoporphyrin IX-mediated sonodynamic therapy promotes autophagy in vascular smooth muscle cells
Li, Q., Kang, J., Xiong, X., Liu, Y., Cao, W., Liu, Y., & Li, Y. (2017) · Oncology Letters · doi:10.3892/ol.2017.6394 · Cited by 12
Oxidized low‑density lipoprotein‑induced p62/SQSTM1 accumulation in THP‑1‑derived macrophages promotes IL‑18 secretion and cell death
Ning, H., Liu, D., Yu, X., & Guan, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5221 · Cited by 12
[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs
Ding, Y., Feng, Y., Zou, Y., Wang, F., Liu, H., Liu, C., & Zhang, Y. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.07.022 · Cited by 12
Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies
Короленко, Т. А., Johnston, T. P., & Větvička, V. (2020) · Molecules · doi:10.3390/molecules25215052 · Cited by 13
Anti-Inflammatory Strategies for Plaque Stabilization after Acute Coronary Syndromes
Baruch, A., van Bruggen, N., Kim, J. B., & Lehrer‐Graiwer, J. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0327-7 · Cited by 12
Roles of Autophagy and Oxidative Stress in Cardiovascular Disease
Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Kim, S. S., & Kang, I. (2025) · Antioxidants · doi:10.3390/antiox14101263 · Cited by 13
CES1 Releases Oxylipins from Oxidized Triacylglycerol (oxTAG) and Regulates Macrophage oxTAG/TAG Accumulation and PGE2/IL-1β Production
Phillips, M. E., Adekanye, O., Borazjani, A., Crow, J. A., & Ross, M. K. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00194 · Cited by 11
CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
Lin, Y., Liang, Z., Weng, Z., Liu, X., Zhang, F., & Chong, Y. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03329-3 · Cited by 12
Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis
Lan, T., Li, Q., Yu, M., Duan, X., Ming, T., Li, S., Wang, C., Zhu, Y., Shen, Z., Kong, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61965-x · Cited by 11
The multifaceted role of autophagy and mitophagy in cardiovascular health and disease
Nàger, M., Calvoli, M., Larsen, K. B., & Birgisdottir, Å. B. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2572511 · Cited by 11
Altered expression of lysosomal hydrolase, acid α-glucosidase, gene in coronary artery disease
Zhang, J., Ma, L., Zhang, J., Huang, J. A., Wei, G., Liu, L., Zhang, J., & Yan, B. (2015) · Coronary Artery Disease · doi:10.1097/mca.0000000000000322 · Cited by 11
Quantifying Cellular Cholesterol Efflux
Robichaud, S., & Ouimet, M. I. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9130-3_9 · Cited by 11
Self-citation
Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection
Wang, Z., Sequeira, R. C., Zabalawi, M., Madenspacher, J. H., Boudyguina, E. Y., Ou, T., Nelson, J. M., Nie, Y., Zhao, Q., Fessler, M. B., et al. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.01.004 · Cited by 10
A Novel Anticancer Therapeutic Strategy to Target Autophagy Accelerates Radiation-Associated Atherosclerosis
Yuan, R., Sun, Z., Cai, J., Yang, X., Zhang, W., Wu, C., Shen, Y., Yin, A., Wang, X., Cai, X., et al. (2020) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2020.09.007 · Cited by 11
Lipid-associated macrophages and metabolic inflammatory diseases
Zheng, Y., Tu, D., Dong, C., Zhao, H., & Wang, H. (2026) · Cell Insight · doi:10.1016/j.cellin.2026.100312 · Cited by 12
Epigenetic Regulation of Key Enzymes CYP7a1 and HMGCR Affect Hepatic Cholesterol Metabolism in Different Breeds of Piglets
Li, X., Xiao, H., Jian, X., Zhang, X., Zhang, H., Mu, Y., Wang, H., Chen, S., & Cong, R. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00231 · Cited by 10
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
Ye, Z., Li, Y., Yang, X., Li, C., Yu, R., Zheng, G., & Su, Z. (2025) · Cell Proliferation · doi:10.1111/cpr.70012 · Cited by 10
Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis
Yeh, Y., Evans, T. D., Iwase, M., Jeong, S., Zhang, X., Liu, Z., Park, A. C., Ghasemian, A., Dianati, B., Javaheri, A., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci185340 · Cited by 11
The combined characteristics of cholesterol metabolism and the immune microenvironment may serve as valuable biomarkers for both the prognosis and treatment of hepatocellular carcinoma
Bai, W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22885 · Cited by 10
Antisense Oligonucleotides, microRNAs, and Antibodies
Dávalos, A., & Chroni, A. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_22 · Cited by 10
Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins
Demine, S., Michel, S., Vannuvel, K., Wanet, A., Renard, P., & Arnould, T. (2012) · Cells · doi:10.3390/cells1020168 · Cited by 11
San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages
Ye, H., Wang, G., Wang, X., Wang, X., Ni, W., Chen, L., Zhu, Y., Zhao, L., Xiong, Z., Wang, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116444 · Cited by 9
Dickkopf‐1 promotes vascular smooth muscle cell foam cell formation and atherosclerosis development through CYP4A11 / SREBP2 / ABCA1
Li, X., Zheng, T., Zhang, Y., Zhao, Y., Liu, F., Dai, S., Liu, X., & Zhang, M. (2023) · The FASEB Journal · doi:10.1096/fj.202300295r · Cited by 9
Cathelicidin LL-37-ApoB-100 interaction promotes LDL clearance and attenuates cholesterol accumulation in the liver
Fang, Y., Zhang, Z., Cao, Q., Gan, W., Duan, Z., Meng, P., Zhou, S., Fei, S., Tadese, D. A., Mwangi, J., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3006-2 · Cited by 9
AICAR upregulates ABCA1/ABCG1 expression in the retinal pigment epithelium and reduces Bruch's membrane lipid deposit in ApoE deficient mice
Kim, Y., Hong, H. K., Yoo, H. S., Park, S. P., & Park, K. H. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108854 · Cited by 9
Impavido Attenuates Inflammation, Reduces Atherosclerosis, and Alters Gut Microbiota in Hyperlipidemic Mice
Traughber, C. A., Iacano, A. J., Neupane, K., Khan, M. R., Opoku, E., Nunn, T., Prince, A., Sangwan, N., Hazen, S. L., Smith, J. D., et al. (2022) · iScience · doi:10.1016/j.isci.2023.106453 · Cited by 9
Unbalanced Redox With Autophagy in Cardiovascular Disease
Jeong, S.-J., & Oh, G. (2023) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2023.12.2.132 · Cited by 10
Vascular Electrical Stimulation with Wireless, Battery‐Free, and Fully Implantable Features Reduces Atherosclerotic Plaque Formation Through Sirt1‐Mediated Autophagy
Wang, P., Li, M., Gao, T., Fan, J., Zhang, D., Zhao, Y., Zhao, Y., Wang, Y., Guo, T., Gao, X., et al. (2023) · Small · doi:10.1002/smll.202300584 · Cited by 9
WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics
Pfisterer, S. G., Bakula, D., Cezanne, A., Robenek, H., & Proikas‐Cezanne, T. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140152 · Cited by 9
Overview of Autophagy
Hayat, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00001-9 · Cited by 10
Autophagy differentially regulates macrophage lipid handling depending on the lipid substrate (oleic acid vs. acetylated-LDL) and inflammatory activation state
Bechor, S., Haim, Y., Pecht, T., Gat, R., Tarnovscki, T., Gericke, M. T., & Rudich, A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158527 · Cited by 9
Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis
LeBlond, N. D., Nunes, J. R. C., Smith, T. K. T., O’Dwyer, C., Robichaud, S., Gadde, S., Côté, M., Kemp, B. E., Ouimet, M. I., & Fullerton, M. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239033 · Cited by 9
Self-citation
Probucol treatment is associated with an ABCA1-independent mechanism of cholesterol efflux to lipid poor apolipoproteins from foam cell macrophages
Hafiane, A., Pisaturo, A., Ronca, A., Incerti, M., Kiss, R. S., & Favari, E. (2021) · BBA Advances · doi:10.1016/j.bbadva.2021.100003 · Cited by 9
A bibliometric analysis of autophagy in atherosclerosis from 2012 to 2021
Zhang, F., Wang, R., Liu, B., & Zhang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.977870 · Cited by 10
High-Density Lipoproteins
Francis, G. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-444-63438-2.00015-8 · Cited by 12
LOX-1 and mitochondria: an inflammatory relationship
Christ, A., & Latz, E. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu187 · Cited by 9
Bisdemethoxycurcumin suppresses the progression of atherosclerosis and VSMC-derived foam cell formation by promoting lipophagy
Zuo, J., Guo, S., & Qin, X. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02558-7 · Cited by 9
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Guan, X., Hu, Y., Hao, J., Lu, M., Zhang, Z., Hu, W., Li, D., & Li, C. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01220-8 · Cited by 11
Vitamin D and Atherosclerosis: Unraveling the Impact on Macrophage Function
Wang, D., Sun, Z., Yin, Y., Xiang, J., Wei, Y., Ma, Y., Wang, L., & Liu, G. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300867 · Cited by 8
MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice
Ma, H., Ou, Z., Alaeiilkhchi, N., Cheng, Y., Chen, K., Chen, J., Guo, R.-Q., He, M.-Y., Tang, S.-Y., Zhang, X., et al. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02185-y · Cited by 12
Global deletion of COX-2 attenuates hepatic inflammation but impairs metabolic homeostasis in diet-induced obesity
Balakrishnan, J., Desouza, C. V., Thakare, R., Alnouti, Y., & Saraswathi, V. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100823 · Cited by 8
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy
Huang, T., Tang, Y., Chen, S., Chen, S., Wang, J., Fu, L., & Tang, Y. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08157-z · Cited by 8
Exploring the common mechanisms and biomarker ST8SIA4 of atherosclerosis and ankylosing spondylitis through bioinformatics analysis and machine learning
Ma, Y., Lai, J., Wan, Q., Liqiang, S., Wang, Y., Li, X., Zhang, Q., & Wu, J. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1421071 · Cited by 8
Modeling Niemann Pick type C1 using human embryonic and induced pluripotent stem cells
Ordonez, M. P., & Steele, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.007 · Cited by 9
Impact of Dysfunctional Protein Catabolism on Macrophage Cholesterol Handling
Miyazaki, T., & Miyazaki, A. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180326165234 · Cited by 8
The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson’s Disease
Wu, J., Yu, X., Xue, K., Wu, J., Wang, R., Xie, X., Li, K., Yang, Z., & Yue, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8735249 · Cited by 8
Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages
Tlili, M., Ospina, H. A., Descoteaux, A., Germain, M., & Heinonen, K. M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102193 · Cited by 9
Genetic Markers Predisposing to Nonalcoholic Steatohepatitis
Sohal, A., Chaudhry, H., & Kowdley, K. V. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.01.006 · Cited by 9
Role of histone post-translational modifications in atherosclerosis and the therapeutic potential of targeting epigenetic modifiers
Wu, L., Li, W., & Ye, W. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1705966 · Cited by 7
Nrf2 Connects Cellular Autophagy and Vascular Senescence in Atherosclerosis: A Mini-Review
Wai, K. W., Low, L. E., Goh, B. H., & Yap, W. H. (2024) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2024.13.3.292 · Cited by 7
Trehalose alleviated hepatic cholesterol accumulation via inhibiting transformation from glucose-derived acyl-CoA to cholesterol synthesis in Nile tilapia
Li, R., Chen, L., Yao, B., Rahimnejad, S., Ren, J., Luo, Y., Qiao, F., Zhang, M., & Du, Z. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738600 · Cited by 7
Role of thyroid hormone in an experimental model of atherosclerosis: the potential mediating role of immune response and autophagy
Ohba, K., & Iwaki, T. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej22-0177 · Cited by 9
TCDD induced lipid accumulation by impairment of autophagic flux in THP-1 macrophages
Lu, J., Liu, M., Fan, Y., Zheng, H., & Guan, S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13258-1 · Cited by 7
Autophagy in Atherosclerosis: Not All Foam Cells Are Created Equal
Francis, G. A., & Razani, B. (2022) · Circulation Research · doi:10.1161/circresaha.122.320857 · Cited by 7
Copper oxide nanoparticles disrupt lysosomal function and promote foam cell formation in RAW264.7 macrophages
Luo, Y., Zhang, K., Mao, L., Tan, M., Dong, X., Li, N., Zhou, Y., Chen, C., Zou, Z., & Zhang, J. (2025) · Toxicology · doi:10.1016/j.tox.2025.154101 · Cited by 6
Steroid Signaling in Autophagy
Bradic, I., & Rewitz, K. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169134 · Cited by 6
Enhancing the efficacy of sonodynamic therapy through modulation of autophagy
Wang, M., Deng, X.-N., Dong, H., Feng, X.-Y., Zhu, F., Yin, D., Hong, C., Chen, Z., Wang, L., & Zhu, X. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107527 · Cited by 6
Fatty acid metabolism and lipid channeling in macrophages: mechanisms of inflammation, resolution, and lipotoxicity
Bamgbose, T. T., Igiehon, O. O., Fieira, J. N., Palmer, C., Andriichuk, A., & Woolard, M. D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1839069 · Cited by 8
Rubicon siRNA-encapsulated liver-targeting nanoliposome is a promising therapeutic for non-alcoholic fatty liver disease
Zhang, Y., Wang, H., Xu, C., Ye, X., Nan, Y., Hu, X., Fan, J., Wang, X., & Ju, D. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125291 · Cited by 7
A Solvatochromic and Photosensitized Lipid Droplet Probe Detects Local Polarity Heterogeneity and Labels Interacting Proteins in Human Liver Disease Tissue
Wang, Y., Guo, H., Wan, W., Jing, B., Bai, Y., Sun, J., Zhang, X., Gao, Z., Liu, Y., & Dong, X. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404713 · Cited by 6
Discussion on the comparison of Raman spectroscopy and cardiovascular disease-related imaging techniques and the future applications of Raman technology: a systematic review
Xie, S., Zhu, X., Han, F., Wang, S., Cui, K., Xue, J., Xi, X., Shi, C., Li, S., Wang, F., et al. (2025) · Lasers in Medical Science · doi:10.1007/s10103-025-04315-z · Cited by 6
Lipid droplet biogenesis
Salo, V. T., Ohsaki, Y., & Ikonen, E. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834d1729 · Cited by 6
Emerging investigator series: long-term exposure of amorphous silica nanoparticles disrupts the lysosomal and cholesterol homeostasis in macrophages
Ma, R., Cai, X., Zhou, Y., Liu, X., Wu, D., Zheng, H., Pan, Y., Jiang, J., Xu, S., Xie, Q., et al. (2021) · Environmental Science Nano · doi:10.1039/d1en00696g · Cited by 6
New Method for Quantitation of Lipid Droplet Volume From Light Microscopic Images With an Application to Determination of PAT Protein Density on the Droplet Surface
Dejgaard, S. Y., & Presley, J. F. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417753573 · Cited by 6
A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastomaPreprint
Shojaei, S., Basso, J., Amereh, M., Alizadeh, J., Dehesh, T., Rosa, S. C. D. S., Clark, C. J., Hassan, M., Tomczyk, M., Cole, L., et al. (2022) · Research Square · doi:10.1101/2022.10.29.514383 · Cited by 7
Animal models and lysosomal pathogenesis of atherosclerosis
Wang, Z., Li, X., Moura, A. K., Hu, J. Z., Wang, Y., & Zhang, Y. (2025) · Animal Advances · doi:10.48130/animadv-0025-0003 · Cited by 5
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy
Guo, R., Chen, M., Lin, Q.-H., Qi, H.-M., Wang, X., Li, B., Wang, S., Xu, S., Zhang, Y., & Liu, W. (2025) · Inflammation · doi:10.1007/s10753-025-02313-5 · Cited by 6
Quantum sensing of free radicals in macrophages reveals early autophagy-lysosome regulation in an atherosclerosis cell model
Fan, S., Gao, H. J., Nieuwhof, W., Mulder, T., Ribeiro, B. F. M., Li, R., Sharmin, R., Νιώρα, Μ., Machado‐Santelli, G. M., Sorensen, K. B., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103825 · Cited by 7
Mammalian lipophagy: process and function
Zhao, R., Dai, E., Kang, R., Liu, J., Klionsky, D. J., Tang, D., Qu, Y., 林元强, & Zhang, X. (2026) · Autophagy · doi:10.1080/15548627.2026.2632256 · Cited by 5
Mitophagy in Macrophages: A Metabolic Checkpoint in Inflammation‐to‐Repair Transition in Atherosclerosis
Zhou, J. H., Liu, H., Ma, S., Wang, H., He, N., Zhang, X., & Liu, Z. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.048103 · Cited by 5
Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities
Seo, J., Park, S., Lee, D. C., Yoo, W., Yang, Y. R., Seo, H. W., Park, J. L., Joo, J., Park, K. C., & Byun, S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02688-3 · Cited by 5
From lipid overload to autophagy collapse: how lipid dysregulation drives chronic inflammation and metabolic disease
Fomin, M., Zapf, K., Schieffer, E., Freitag, J., Bange, G., & Schieffer, B. (2026) · Inflammation Research · doi:10.1007/s00011-026-02283-w · Cited by 5
M1 linear ubiquitination of LKB1 inhibits vascular endothelial cell injury in atherosclerosis through activation of AMPK
Haiquan, H., Huang, Z., Liao, W., Zou, T., Shang, X., & Yu, H. (2023) · Human Cell · doi:10.1007/s13577-023-00950-2 · Cited by 5
Cholesterol depletion inhibits rabies virus infection by restricting viral adsorption and fusion
Hou, Q., Wang, C., Xiong, J., Wang, H., Wang, Z., Zhao, J., Wu, Q., Wu, Q. D., Zhao, L., & Zhou, M. (2023) · Veterinary Microbiology · doi:10.1016/j.vetmic.2023.109952 · Cited by 5
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy
Wang, Y., Liao, Q., Mei, X., Han, X., Luo, L., Huang, R., Tang, Y., & Zhou, C. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326687 · Cited by 6
A Case Study of Single‐Pill Combination Therapy: The Ezetimibe/Simvastatin Combination for Treatment of Hyperlipidemia
Huang, X., & Chen, D. Y. ‐. (2012) · ChemMedChem · doi:10.1002/cmdc.201200287 · Cited by 5
Role of Chaperone-Mediated Autophagy in Ageing Biology and Rejuvenation of Stem Cells
Vitale, E., Perveen, S., Rossin, D., Iacono, M. L., Rastaldo, R., & Giachino, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.912470 · Cited by 6
Autophagy in Atherosclerosis
Grootaert, M. O. J., Kurdi, A., Munck, D. G. D., Martinet, W., & Meyer, G. R. Y. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805421-5.00013-6 · Cited by 5
Genetic Variants and Functional Analyses of the ATG16L1 Gene Promoter in Acute Myocardial Infarction
Han, F., Pang, S., Sun, Z., Cui, Y., & Yan, B. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.591954 · Cited by 5
Overview of Autophagy
Hayat, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802936-7.00001-5 · Cited by 5
Lipolytic proteomics
Schittmayer, M., & Birner‐Gruenberger, R. (2012) · Mass Spectrometry Reviews · doi:10.1002/mas.20355 · Cited by 5
Dysregulated Lipid Metabolism as a Central Driver of Atherosclerotic Plaque Pathology
Steinbeck, J. E., Iannotti, R. A., & Rasheed, A. (2025) · Lipidology · doi:10.3390/lipidology2040017 · Cited by 5
The signaling and regulatory functions of dying cells and cell corpses
Zhang, G., Liu, J. Q., Li, W., Wang, B., Feng, H., Cui, T., Pan, T., Chen, D.-P., & Xiong, Y. (2026) · Communications Biology · doi:10.1038/s42003-026-10428-0 · Cited by 4
Tianxiangdan suppresses foam cell formation by enhancing lipophagy and reduces the progression of atherosclerosis
Zhang, Y., He, H., Sawuer, G., Ma, X.-K., Ainiwaer, Z., Wu, D., Zhang, X., & Dong-qing, A. (2025) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-024-01004-z · Cited by 4
Redefining Macrophage Heterogeneity in Atherosclerosis: A Focus on Possible Therapeutic Implications
Kanuri, B., Maremanda, K. P., Chattopadhyay, D., Essop, M. F., Lee, M. K. S., Murphy, A. J., & Nagareddy, P. R. (2025) · Comprehensive physiology · doi:10.1002/cph4.70008 · Cited by 6
The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment
Wang, L., Zhang, Y., Yue, J., & Zhou, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094260 · Cited by 4
The role of lipophagy in liver cancer: mechanisms and targeted therapeutic interventions
Han, P., Wang, H., Chen, Y., Ge, Y., Xu, H., Ren, H., & Meng, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1562542 · Cited by 4
MicroRNA-146a inhibits autophagy to maintain the intracellular survival of Burkholderia pseudomallei by targeting LIPA
Hu, Z., Li, Q., Hu, Z., Liu, H.-C., Rao, C., Zhang, M., Xia, Y., Deng, L., Mao, X., & Fang, Y. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104969 · Cited by 4

Authors: Ouimet, M., Franklin, V., Mak, E., Liao, X., Tabas, I., & Marcel, Y. L.
Affiliations: University of Ottawa (CA)
Ottawa Heart Institute (CA)
Columbia University (US)
Corresponding author: Marcel, Yves L.
ORCID: Ouimet, Mireille
Mak, Esther
Tabas, Ira
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2011-06
Volume: 13
Issue: 6
Pages: 655-667
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2011.03.023
PMC: PMC3257518
OpenAlex: W1983619827
Cited by: 774
References: 57
Citations by year: 2026: 49 · 2025: 57 · 2024: 42 · 2023: 61 · 2022: 61 · 2021: 69 · 2020: 62 · 2019: 48 · 2018: 66 · 2017: 52 · 2016: 51 · 2015: 48 · 2014: 35 · 2013: 28 · 2012: 37
FWCI: 34.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 813 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes of Health Research
Heart and Stroke Foundation of Canada
National Institutes of Health (HL057560)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: autophagy, lysosomal acid lipase, foam cells, cholesterol efflux, lipid droplets, cholesterol ester hydrolysis, lysosomes, ABCA1, reverse cholesterol transport, atherosclerosis, free cholesterol
MeSH terms: Autophagy-Related Protein 5, Animals, Autophagy, Bone Marrow Cells, Cells, Cultured, Chloroquine, Cholesterol, Sterol Esterase, Foam Cells, Lipolysis, Lipoproteins, LDL, Lysosomes, Mice, Inbred C57BL, Microtubule-Associated Proteins, Paraoxon, Mice, Knockout, Atherosclerosis, Lipid Metabolism, Mice, Gene Knockout Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks