Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471

The Emergence of the Metabolic Syndrome with Menopause

Carr, M. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030242 · Cited by 1,449

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174

Regulation of Kiss1 gene expression in the brain of the female mouse

Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791

Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility

Wintermantel, T. M., Campbell, R. E., Porteous, R. W., Bock, D., Gröne, H., Todman, M. G., Korach, K. S., Greiner, E. F., Pérez, C. A., Schütz, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.023 · Cited by 598

Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin

Clegg, D. J., Brown, L. M., Woods, S. C., & Benoit, S. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1339 · Cited by 552

Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones

Shivers, B. D., Harlan, R. E., Morrell, J. I., & Pfaff, D. W. (1983) · Nature · doi:10.1038/304345a0 · Cited by 531

Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction

Rašić-Marković, A., Djuric, E., Škrijelj, D., Bjekić-Macut, J., Ignjatović, Đ., Šutulović, N., Hrnčić, D., Mladenović, D. R., Rašić-Marković, A., Radenković, S., et al. (2024) · Endocrine · doi:10.1007/s12020-024-03755-x · Cited by 10

Estrogen receptor inhibition enhances cold-induced adipocyte beiging and glucose tolerance

Lapid, K., Lim, A., Berglund, E. D., & Graff, J. M. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s190752 · Cited by 10

SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis

Yu, M., Bean, J. C., Liu, H., He, Y., Yang, Y., Cai, X., Yu, K., Pei, Z., Liu, H., Tu, L., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00907-2 · Cited by 10

Estrogen-dependent post-translational change in the nitric oxide system may mediate the leptin action on LH and prolactin secretion

Borges, B. D. B., & Franci, C. R. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.001 · Cited by 10

Absence of Endothelial ERα Results in Arterial Remodeling and Decreased Stiffness in Western Diet–Fed Male Mice

Manrique‐Acevedo, C., Ramirez‐Perez, F. I., Padilla, J., Vieira‐Potter, V. J., Aroor, A. R., Barron, B. J., Chen, D., Haertling, D., DeClue, C. E., Sowers, J. R., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1831 · Cited by 10

Neotomodon alstoni mice present sex differences between lean and obese in daily hypothalamic leptin signaling

Pérez-Mendoza, M., Luna-Moreno, D., Carmona-Castro, A., Rodríguez-Guadarrama, H. A., GÓMEZ, L. M. M., Díaz‐Muñoz, M., & Miranda‐Anaya, M. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1331354 · Cited by 10

Dietary Supplementation with 20-Hydroxyecdysone Ameliorates Hepatic Steatosis and Reduces White Adipose Tissue Mass in Ovariectomized Rats Fed a High-Fat, High-Fructose Diet

Buniam, J., Chansela, P., Weerachayaphorn, J., & Saengsirisuwan, V. (2023) · Biomedicines · doi:10.3390/biomedicines11072071 · Cited by 9

Sexual differentiation of estrogen receptor alpha subpopulations in the ventromedial nucleus of the hypothalamus

Cortes, L. R., Sturgeon, H., & Forger, N. G. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105348 · Cited by 9

Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins

Lee, T. H., Nicolas, J.-C., & Quarta, C. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02411-5 · Cited by 12

Estrogen synthesized in the central nervous system enhances MC 4 R expression and reduces food intake

Hayashi, T., Kumamoto, K., Kobayashi, T., Hou, X., Nagao, S., Harada, N., Honda, S., Shimono, Y., & Nishio, E. (2025) · FEBS Journal · doi:10.1111/febs.17426 · Cited by 9

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Yang, Y., van der Klaauw, A. A., Zhu, L.-L., Cacciottolo, T. M., He, Y., Stadler, L. K. J., Wang, C., Xu, P., Saito, K., Hinton Jr, A., et al. (2019) · Yearbook of pediatric endocrinology · doi:10.1530/ey.16.11.3 · Cited by 9

The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis

Le, N., Sayers, S., Mata‐Pacheco, V., & Wagner, E. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.877647 · Cited by 10

Role of Estrogen Receptor α in Aging and Chronic Disease

Isola, J. V. V., Ko, S.-H., Ocañas, S. R., & Stout, M. B. (2023) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20230005 · Cited by 13

Tibolone regulates systemic metabolism and the expression of sex hormone receptors in the central nervous system of ovariectomised rats fed with high-fat and high-fructose diet

Coyoy-Salgado, A., Segura-Uribe, J. J., Gallardo, J. M., Estrada-Cruz, N. A., Camacho‐Arroyo, I., & Guerra‐Araiza, C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147096 · Cited by 10

Estradiol Priming Potentiates the Kisspeptin-Induced Release of LH in Ovariectomized Cows

Macedo, G. G., Batista, E. O. S., dos Santos, G. M. G., D’Occhio, M. J., & Baruselli, P. S. (2021) · Animals · doi:10.3390/ani11051236 · Cited by 9

Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension‐Induced Hypertensive Response Sensitization Elicited by Postweaning High‐Fat Diet in Female Offspring

Xue, B., Yu, Y., Beltz, T. G., Guo, F., Wei, S., & Johnson, A. K. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023685 · Cited by 9

Estradiol and appetite: To eat or not to eat

Dragano, N. R. V., Milbank, E., & López, M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101061 · Cited by 9

Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner

Steiner, B. M., Benvie, A. M., Lee, D., Jiang, Y., & Berry, D. C. (2024) · Nature Communications · doi:10.1038/s41467-024-50985-8 · Cited by 8

Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation

Oh, E.-Y., Park, B. S., Yang, H. R., Lee, H. G., Tu, T. H., Yang, S., Han, M.-R., & Kim, J. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043204 · Cited by 8

Brain Estrogens and Feeding Behavior

Xu, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_16 · Cited by 8

Magel2knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity

Choi, Y., Min, H.-Y., Hwang, J., & Jo, Y. (2022) · Life Science Alliance · doi:10.26508/lsa.202201502 · Cited by 8

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Zhou, P., He, Y., Bean, J. C., Yang, Y., Liu, H., Yu, M., Yu, K., Hyseni, I., Cai, X., Liu, H., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889122 · Cited by 8

Exposure to endocrine disrupters and cardiometabolic health effects in preschool children: Urinary parabens are associated with wider retinal venular vessels

Reimann, B., Sleurs, H., Dockx, Y., Rasking, L., Boever, P. D., Pirard, C., Charlier, C., Nawrot, T. S., & Plusquin, M. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138570 · Cited by 9

Phosphorylation site S122 in estrogen receptor α has a tissue‐dependent role in female mice

Ohlsson, C., Gustafsson, K. L., Farman, H. H., Henning, P., Lionikaite, V., Movérare‐Skrtic, S., Sjögren, K., Törnqvist, A. E., Andersson, A., Islander, U., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901376rr · Cited by 9

JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin–Estrogen Feedback Loop and Reproductive Function

Song, A., Jiang, S., Wang, Q., Zou, J., Lin, Z., & Gao, X. (2017) · Endocrinology · doi:10.1210/en.2016-1750 · Cited by 8

Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study

Baretić, M. (2019) · Acta Clinica Croatica · doi:10.20471/acc.2019.58.02.06 · Cited by 8

Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat

Sapkota, S., Roy, S. C., Shrestha, R., & Briski, K. P. (2024) · ASN NEURO · doi:10.1080/17590914.2024.2368382 · Cited by 7

The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice

Ouldibbat, L., Rocks, D., Sampson, B., & Kundaković, M. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105693 · Cited by 7

New Insights Into Metabolic Regulation via Bifurcated Function of Estrogen Receptor α

Wada, T., Tsuneki, H., & Sasaoka, T. (2013) · Diabetes · doi:10.2337/db13-1325 · Cited by 7

Nutrient-sensing mechanisms in hypothalamic cell models: neuropeptide regulation and neuroinflammation in male- and female-derived cell lines

Loganathan, N., & Belsham, D. D. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00168.2016 · Cited by 9

3.01 – Membrane-Initiated Effects of Estradiol in the Central Nervous System

Rønnekleiv, O., & Kelly, M. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00043-2 · Cited by 4

Generation and characterization of an estrogen receptor alpha‐iCre knock‐in mouse

Park, C. J., Chen, G., Koo, Y., Lin, P.-C. P., Cacioppo, J. A., Prohaska, H., & Ko, C. J. (2017) · genesis · doi:10.1002/dvg.23084 · Cited by 7

Estrogen – serotonin interaction and its implication on insulin resistance

Ulhaq, Z. S. (2019) · Alexandria Journal of Medicine · doi:10.1080/20905068.2019.1670413 · Cited by 7

From Reductionism Toward Integration: Understanding How Social Behavior Emerges From Integrated Circuits

Dickinson, S. Y., Kelly, D. A., Padilla, S. L., & Bergan, J. F. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.862437 · Cited by 7

A review: Effects of estrogen and estrogen receptor modulators on leptin resistance: Mechanisms and pathway

Farhadi, Z., Azizian, H., Haji‐Seyed‐Javadi, R., & Khaksari, M. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100446 · Cited by 7

Developmental changes in hypothalamic SF-1, POMC, and ERα mRNA expression and their sensitivity to fasting in male and female rats

Iwasa, T., Matsuzaki, T., Mayila, Y., Yano, K., & Irahara, M. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej17-0140 · Cited by 7

Impaired metabolic and hepatic functions following subcutaneous lipectomy in adult obese rats

El-Kafoury, B. M. A., Bahgat, N. M., Abdel‐Hady, E. A., Samad, A. A. A. E., Shawky, M., & Mohamed, F. A. (2019) · Experimental Physiology · doi:10.1113/ep087670 · Cited by 7

Ovarian Hormonal Change-Related Energy Metabolism and Obesity in Menopausal Women

Zhu, J., Ji, M., Xing, L., Yu, Z., Guo, X., Chen, X., & Shu, J. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89336 · Cited by 7

Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy

Yu, H. M., Thompson, Z., Kiran, S., Jones, G. L., Mundada, L. V., Surbhi, Rubinstein, M., & Low, M. J. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0576 · Cited by 7

Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats

Nishimura, Y., Mabuchi, K., Omura, N., Igarashi, A., Miura, M., Mima, N., Negishi, H., Morimoto, K., & Takamata, A. (2020) · Nutrients · doi:10.3390/nu12030849 · Cited by 7

Estrogenic and androgenic activity of tert-butyl phenolic antioxidants assessed by in vitro receptor transcriptional activation and their association with in silico molecular docking analysis

Hoang, N. M.-H., & Park, K. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117344 · Cited by 6

JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism

Fernández-González, I., Freire-Agulleiro, Ó., Ferreira, V., Silveira-Loureiro, M., Rial‐Pensado, E., Garrido‐Gil, P., Martinez, G. M., Rada, P., Labandeira-García, J. L., Mittag, J., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102170 · Cited by 6

High-Fat Diet Induces Unexpected Fatal Uterine Infections in Mice with aP2-Cre-mediated Deletion of Estrogen Receptor Alpha

Bán, Z., Maurischat, P., Benz, V., Brix, S., Sonnenburg, A., Schuler, G. C., Klopfleisch, R., Rothe, M., Gustafsson, J.-Α., Foryst‐Ludwig, A., et al. (2017) · Scientific Reports · doi:10.1038/srep43269 · Cited by 6

Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes

Tokgöz, S., Boss, M., Jansen, T. J. P., Meijer, R. I., Frielink, C., van Bon, A. C., Tack, C. J., de Galan, B. E., & Gotthardt, M. (2024) · Diabetes · doi:10.2337/db24-0463 · Cited by 6

TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis

Zizzari, P., Castellanos-Jankiewicz, A., Yagoub, S., Simon, V., Clark, S., Maître, M., Dupuy, N., Lesté-Lasserre, T., Gonzales, D., Schoonjans, K., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102071 · Cited by 6

The ARCCRABP1 neurons play a crucial role in the regulation of energy homeostasis

Yan, L., Zhang, X., Jin, L., Li, Y., Chen, Y., Zhang, J., Sun, Z., Qi, J., Qu, C., Dong, G., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57411-7 · Cited by 8

Loss of CTRP10 results in female obesity with preserved metabolic health

Chen, F., Sarver, D. C., Saqib, M., Vélez, L. M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2024) · eLife · doi:10.7554/elife.93373.3 · Cited by 8

Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice

Yu, M., Feng, B. C., Bean, J. C., Zhao, Q., Yang, Y., Liu, H., Li, Y., Eappen, B. P., Liu, H., Tu, L., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01268-z · Cited by 6

Changes in Appetite Regulation-Related Signaling Pathways in the Brain of Mice Supplemented with Non-nutritive Sweeteners

Contreras-Chávez, G. G., Estrada, J. A., & Contreras, I. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01737-y · Cited by 6

Sex Differences in Glucose Homeostasis

Arioglu‐Inan, E., & Kayki‐Mutlu, G. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_664 · Cited by 7

Sex differences in obesity development in pair-fed neuronal lipoprotein lipase deficient mice

Wang, H., Wang, Y., Taussig, M. D., & Eckel, R. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.013 · Cited by 6

The loss of ERE-dependent ERα signaling potentiates the effects of maternal high-fat diet on energy homeostasis in female offspring fed an obesogenic diet

Roepke, T. A., Yasrebi, A., Villalobos, A., Krumm, E. A., Yang, J., & Mamounis, K. J. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000515 · Cited by 6

Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause

Prakapenka, A. V., Peña, V., Strouse, I. M., Northup-Smith, S. N., Schrier, A. R., Ahmed, K., Bimonte‐Nelson, H. A., & Sirianni, R. W. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121225 · Cited by 6

Associations between metabolic score for visceral fat and adult lung functions from NHANES 2007–2012

Zhou, J., You, L., Zhou, X. H., & Li, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1436652 · Cited by 5

Hypothalamic actions of estrogens in the regulation of energy and glucose homeostasis

González‐García, I., & Xu, Y. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09994-1 · Cited by 6

Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential

Mak, K. W. Y., Mustafa, A. F., & Belsham, D. D. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00409-5 · Cited by 5

Glucose transporter-2 regulation of VMN GABA neuron metabolic sensor and transmitter gene expression

Roy, S. C., Sapkota, S., Pasula, M. B., Katakam, S., Shrestha, R., & Briski, K. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-64708-y · Cited by 5

Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats

Scott, A., Paulson, A., Prill, C., Kermoade, K., Newell, B., Eckenwiler, E. A., Lemos, J. C., & Richard, J. M. (2025) · eNeuro · doi:10.1523/eneuro.0245-24.2025 · Cited by 4

Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females

Zhang, N., Yu, M., Zhao, Q., Feng, B. C., Deng, Y., Bean, J. C., Liu, Q., Eappen, B. P., He, Y., Conde, K., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102108 · Cited by 7

Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet

Mela, V., Piscitelli, F., Llorente‐Berzal, A., Chowen, J. A., Silvestri, C., Viveros, M., & Marzo, V. D. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0558-0 · Cited by 5

Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat

Bahtiar, A., Setyowati, H. T., Mahanani, R. R., Wati, A., Arsianti, A., & Fadilah, F. (2021) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_324_20 · Cited by 5

Insulin Resistance in Obesity

Yang, W., Guo, J. Z., & Guo, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_28 · Cited by 5

Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence

Lawton, S. B. R., Wagner, V. A., Nakagawa, P., Segar, J. L., Sigmund, C. D., Morselli, L. L., & Grobe, J. L. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.20524 · Cited by 5

Sex-specific Effects of α2δ-1 in the Ventromedial Hypothalamus of Female Mice Controlling Glucose and Lipid Balance

Felsted, J. A., Meng, A., Ameroso, D., & Rios, M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa068 · Cited by 6

The role of IDO1-mediated Tryptophan/Kynurenine metabolism and its association with estrogen level in PTSD within SPS mouse model

Zhang, L., Wang, F.-H., Wang, X.-M., Zhang, X., Yu, X.-F., & Bao, Y.-X. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.02.015 · Cited by 4

Beyond BMI: The Janus-like effect of muscle versus fat on midlife women’s health

Yong, E., Wong, B. W. X., & Tan, D. Y. Z. (2025) · Annals of the Academy of Medicine Singapore · doi:10.47102//annals-acadmedsg.2024278 · Cited by 4

Sexual dimorphism in the development and function of the melanocortin system

Claret, M., & Haddad-Tóvolli, R. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09983-4 · Cited by 6

Estrogen Receptor-α Knockout Mice

Antonson, P., Humire, P., & Gustafsson, J.-Α. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3127-9_33 · Cited by 4

The Metabolic Benefits of Menopausal Hormone Therapy Are Not Mediated by Improved Nutritional Habits. The OsteoLaus Cohort

Papadakis, G. E., Hans, D. B., Rodríguez, E. G., Vollenweider, P., Waeber, G., Marques-Vidal, P. M., & Lamy, O. (2019) · Nutrients · doi:10.3390/nu11081930 · Cited by 4

Development of the Hypothalamus

Tobet, S. A., & McClellan, K. (2013) · Colloquium Series on The Developing Brain · doi:10.4199/c00079ed1v01y201303dbr010 · Cited by 4

Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys

Kraynak, M., Colman, R. J., Flowers, M. T., Abbott, D. H., & Levine, J. E. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0156-4 · Cited by 4

Age and sex variation in visceral adipose tissue

Panchu, P., Bahuleyan, B., Babu, R., & Vijayan, V. (2019) · International Journal of Advances in Medicine · doi:10.18203/2349-3933.ijam20190113 · Cited by 5

Control of Liver Gene Expression by Sex Steroids and Growth Hormone Interplay

Fernández‐Pérez, L., de Mirecki-Garrido, M., Recio, C., & Guerra, B. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86611 · Cited by 4

Animal Models for Manipulation of Thermogenesis

Fuller‐Jackson, J., Clarke, I. J., & Henry, B. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00012-7 · Cited by 4

Influence of exogenous and endogenous estrogen on thermoregulatory responses to mild heat and the interaction with light and dark phases

Marui, S., Masuda, Y., Kato, I., & Nagashima, K. (2020) · The Journal of Physiological Sciences · doi:10.1186/s12576-020-00782-x · Cited by 4

Brain Regulation of Feeding and Energy Homeostasis

Myers, M. G., Olson, D. P., Low, M. J., & Elias, C. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_22 · Cited by 5

Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys

Kraynak, M., Willging, M. M., Kuehlmann, A. L., Kapoor, A., Flowers, M. T., Colman, R. J., Levine, J. E., & Abbott, D. H. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac063 · Cited by 4

Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice

Semple, E. A., Harberson, M. T., Xu, B., Rashleigh, R., Cartwright, T. L., Braun, J. J., Custer, A. C., Liu, C., & Hill, J. W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.983670 · Cited by 4

Brain Regulation of Feeding and Energy Homeostasis

Affinati, A. H., Elias, C. F., Olson, D. P., & Myers, M. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_22 · Cited by 4

HYPOTHesizing about central comBAT against obesity

González‐García, I., Milbank, E., Martínez-Ordóñez, A., Diéguez, C., López, M., & Contreras, C. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00719-y · Cited by 5

Perinatal 17α-ethinylestradiol exposure affects formalin-induced responses in middle-aged male (but not female) rats

Ceccarelli, I., Fiorenzani, P., Della Seta, D., & Aloisi, A. M. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.001 · Cited by 4

Sex/Gender Differences in Obesity

Kwon, H. (2024) · Springer eBooks · doi:10.1007/978-981-97-0130-8_14 · Cited by 3

The stem bark decoction of Myrianthus arboreus P. Beauv. (Cecropiaceae) shows anti-uterine leiomyoma effects in Wistar rat

Ateba, S. B., Mbella, L. F. C. E., Nyobe, J. C. N., Awounfack, C. F., Voutsop, C. J. N., Atsama, P. M., Nana, B. C., Loe, G. E., Dongmo, A. B., & Njamen, D. (2025) · Reproduction and Fertility · doi:10.1530/raf-25-0037 · Cited by 3

Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice

Saito, K., Dickey, J. E., Rodeghiero, S. R., Toth, B. A., Kelly, M. J., Deng, Y., Singh, U., Deng, G., Jiang, J., & Cui, H. (2022) · Endocrinology · doi:10.1210/endocr/bqac160 · Cited by 3

Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network

Zhang, S., Jia, S., Li, X., Hu, R.-R., Luo, Z., Wang, J., & Xi, H. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2424443 · Cited by 3

A history of cranial radiotherapy is associated with a higher visceral to subcutaneous fat ratio in men with pituitary insufficiency

Borgers, A. J., Alkemade, A., Venema, H. W., Fliers, E., & Bisschop, P. H. L. T. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-1023 · Cited by 3

Hormone Therapy and Replacement in Cancer and Aging-related Diseases

Rangel, L. B. A., Kirubamani, H., Silva, I. V., & Junior, P. C. M. L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77810 · Cited by 3

Estrogen Receptor Beta Mediates the Dipsogenic Effect of Estradiol in Ovariectomized Female Rats

Santollo, J., & Edwards, A. A. (2023) · Neuroendocrinology · doi:10.1159/000530962 · Cited by 3

Nutrition and Reproduction

Santoro, N. F., Polotsky, A. J., Rieder, J., & Kondapalli, L. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00018-4 · Cited by 3

Size, site, and signaling: Three attributes of estrogen receptors

Sachdeva, G., Desouza, J., Gadkar, S., & Jagtap, D. D. (2019) · Biomedical Research Journal · doi:10.4103/bmrj.bmrj_24_19 · Cited by 3

Sex steroids and growth hormone interactions

Fernández‐Pérez, L., de Mirecki-Garrido, M., Guerra, B., Díaz, M. L., & Díaz-Chico, J. C. (2016) · Endocrinología y Nutrición (English Edition) · doi:10.1016/j.endoen.2016.04.006 · Cited by 3

Deficiency of neuronal LGR4 increases energy expenditure and inhibits food intake via hypothalamic leptin signaling

Zhang, L., Li, Y., Gao, W., Li, Z., Wu, T., Lang, C., Rui, L., & Zhang, W. (2025) · EMBO Reports · doi:10.1038/s44319-025-00398-5 · Cited by 2

Amygdala aromatase controls food intake, reward, and thermoregulation

Marić, I., Richard, J. E., Taing, L., Byun, S., López‐Ferreras, L., Qiu, Y., & Skibicka, K. P. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102202 · Cited by 2

Developmental reprogramming in melanocortin neurons modulates diet-induced obesity in mice

Xu, B., LI, L., Chen, M., Wu, Z., Chen, X., Swati, Wan, R., Almeida, A. G., Wyler, S. C., & Liu, C. (2026) · Neuron · doi:10.1016/j.neuron.2025.12.022 · Cited by 2

Sex-specific differences in mediobasal hypothalamus in response to nutritional states

Bean, J. C., Jian, J., Lu, T., Liu, H., Conde, K. M., Threat, D. A., Jossy, S. V., Burt, M. E., Cheng, J., Deng, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69239-w · Cited by 2

Ablation of microglial estrogen receptor alpha predisposes male mice to diet-induced obesity

Velasco, I., Frey, J. M., Baglaev, V., JAFARI, T. Z., Huang, T., Schwie, S., Santiago, O. D., Fasnacht, R. D., Thaler, J. P., & Dorfman, M. D. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156689 · Cited by 2

The pathogenic role of androgen excess in PCOS

Pignatelli, D., Pereira, S. S., & Kandaraki, E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823045-9.00017-1 · Cited by 4

Central Feminization of Obese Male Mice Reduces Metabolic Syndrome

Blackmore, K. A., & Young, C. N. (2022) · Brain Sciences · doi:10.3390/brainsci12101324 · Cited by 4

Transient loss of satiety effects of leptin in middle‐aged male mice

Aung, Z. K., Ladyman, S. R., & Brown, R. S. E. (2024) · Journal of Neuroendocrinology · doi:10.1111/jne.13386 · Cited by 2

The potential protective effects of curcumin on the diabetic ovary: Experimental and molecular approaches.

Tüfekci̇, K. K., Altun, G., Kipanyula, M. J., & Kaplan, S. (2025) · PubMed · doi:10.14670/hh-18-866 · Cited by 2

It's ALL in the Hypothalamus! Sex, Reproduction, and Obesity.

Xu, Y., Nedungadiuli, T., Gent, L. M., Elias, C. F., Elmquist, J. K., & Clegg, D. J. (2012) · Biology of Reproduction · doi:10.1093/biolreprod/87.s1.34

Adult Neurogenesis in the Female Mouse Hypothalamus: Estradiol and High-Fat Diet Alter the Generation of Newborn Neurons Expressing Estrogen Receptor α

Bless, E., Yang, J., Acharya, K. D., Nettles, S. A., Vassoler, F. M., Byrnes, E. M., & Tetel, M. (2016) · eNeuro · doi:10.1523/eneuro.0027-16.2016 · Cited by 33

Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome

Musatov, S. A., Chen, W. W., Pfaff, D. W., Mobbs, C. V., Yang, X.-J., Clegg, D. J., Kaplitt, M. G., & Ogawa, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610787104 · Cited by 521

‘Estrogen receptors in obesity and their signaling pathways’

Chakraborty, T. R., & Chakraborty, S. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.6.a988-a

Sexually Differentiated Neuron Populations in the Ventromedial Hypothalamus Contribute to Sex-Specific Regulation of Energy Balance

Kammel, L. G. (2019) · eScholarship (California Digital Library)