The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction
Open accessAbstract
Estrogens regulate body weight and reproduction primarily through actions on estrogen receptor-α (ERα). However, ERα-expressing cells mediating these effects are not identified. We demonstrate that brain-specific deletion of ERα in female mice causes abdominal obesity stemming from both hyperphagia and hypometabolism. Hypometabolism and abdominal obesity, but not hyperphagia, are recapitulated in female mice lacking ERα in hypothalamic steroidogenic factor-1 (SF1) neurons. In contrast, deletion of ERα in hypothalamic pro-opiomelanocortin (POMC) neurons leads to hyperphagia, without directly influencing energy expenditure or fat distribution. Further, simultaneous deletion of ERα from both SF1 and POMC neurons causes hypometabolism, hyperphagia, and increased visceral adiposity. Additionally, female mice lacking ERα in SF1 neurons develop anovulation and infertility, while POMC-specific deletion of ERα inhibits negative feedback regulation of estrogens and impairs fertility in females. These results indicate that estrogens act on distinct hypothalamic ERα neurons to regulate different aspects of energy homeostasis and reproduction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Estrogens directly act on POMC neurons and regulate their cellular activity.”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [88]
In the citing paper
“While ERα is abundantly expressed in the rodent brain in VMN and ARC, PVN, and the medial preoptic area, ERβ is found in the same hypothalamic nuclei, but ERβ expression is significantly lower relative to ERα [88, 91].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [88]
In the citing paper
“Indeed, deletion of ER in POMC neurons in mice leads to hyperphagia without directly influencing energy expenditure or adipose tissue distribution [88].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [88]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
The Emergence of the Metabolic Syndrome with Menopause
Carr, M. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030242 · Cited by 1,449
Increased adipose tissue in male and female estrogen receptor-α knockout mice
Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282
Transcriptional Control of Brown Fat Determination by PRDM16
Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174
Regulation of Kiss1 gene expression in the brain of the female mouse
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Self-citationWintermantel, T. M., Campbell, R. E., Porteous, R. W., Bock, D., Gröne, H., Todman, M. G., Korach, K. S., Greiner, E. F., Pérez, C. A., Schütz, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.023 · Cited by 598
Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin
Clegg, D. J., Brown, L. M., Woods, S. C., & Benoit, S. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1339 · Cited by 552
Self-citationAbsence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones
Shivers, B. D., Harlan, R. E., Morrell, J. I., & Pfaff, D. W. (1983) · Nature · doi:10.1038/304345a0 · Cited by 531
Cited by
Sorted by citations
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329
Self-citationSex differences in human adipose tissues – the biology of pear shape
Karastergiou, K., Smith, S. R., Greenberg, A. S., & Fried, S. K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-13 · Cited by 1,109
Sex differences in metabolic regulation and diabetes susceptibility
Tramunt, B., Smati, S., Grandgeorge, N., Lenfant, F., Arnal, J.-F., Montagner, A., & Gourdy, P. (2020) · Diabetologia · doi:10.1007/s00125-019-05040-3 · Cited by 923
The sexual dimorphism of obesity
Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919
Self-citationEstrogen deficiency and the origin of obesity during menopause
Lizcano, F., & Guzmán, G. (2014) · BioMed Research International · doi:10.1155/2014/757461 · Cited by 586
Neural circuit mechanisms of social behavior
Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527
Sex differences in lipid and lipoprotein metabolism
Palmisano, B. T., Zhu, L., Eckel, R. H., & Stafford, J. M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.008 · Cited by 551
Self-citationSex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513
Cooke, P. S., Nanjappa, M. K., Ko, C. J., Prins, G. S., & Hess, R. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00018.2016 · Cited by 489
Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
de Morentin, P. B. M., González‐García, I., Martins, L., Lage, R., Fernández-Mallo, D., Martínez‐Sánchez, N., Ruíz-Pino, F., Liu, J. T., Morgan, D. A., Pinilla, L., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.031 · Cited by 455
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407
Sex-Specific Differences in Lipid and Glucose Metabolism
Varlamov, O., Bethea, C. L., & Roberts, C. T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00241 · Cited by 429
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
Stener‐Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa010 · Cited by 391
Mauvais-Jarvis, F., Manson, J. E., Stevenson, J. C., & Fonseca, V. A. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1146 · Cited by 341
Hamilton, K. J., Hewitt, S. C., Arao, Y., & Korach, K. S. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.005 · Cited by 370
Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., Han, G., Newell‐Fugate, A. E., Tian, Y., Majeti, R., et al. (2018) · Diabetes · doi:10.2337/db18-0638 · Cited by 353
Self-citationTargeted estrogen delivery reverses the metabolic syndrome
Finan, B., Yang, B. S., Ottaway, N., Stemmer, K., Müller, T. D., Yi, C., Habegger, K. M., Schriever, S. C., García‐Cáceres, C., Kabra, D. G., et al. (2012) · Nature Medicine · doi:10.1038/nm.3009 · Cited by 333
Hypothalamic AMPK: a canonical regulator of whole-body energy balance
López, M., Nogueiras, R., Tena‐Sempere, M., & Diéguez, C. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.67 · Cited by 318
Reproduction, Fat Metabolism, and Life Span: What Is the Connection?
Hansen, M., Flatt, T., & Aguilaniu, H. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.003 · Cited by 312
Genetic Basis for Sex Differences in Obesity and Lipid Metabolism
Link, J. C., & Reue, K. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064827 · Cited by 306
Multimodal analysis of cell types in a hypothalamic node controlling social behavior
Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.020 · Cited by 259
Ribas, V., Drew, B. G., Zhou, Z., Phun, J., Kalajian, N. Y., Soleymani, T., Daraei, P., Widjaja, K., Wanagat, J., de Aguiar Vallim, T. Q., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3815 · Cited by 259
Metabolic regulation of kisspeptin — the link between energy balance and reproduction
Navarro, V. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0363-7 · Cited by 240
Martínez‐Sánchez, N., Seoane‐Collazo, P., Contreras, C., Varela, L., Villarroya, J., Rial‐Pensado, E., Buqué, X., Aurrekoetxea, I., Delgado, T. C., Vázquez‐Martínez, R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.014 · Cited by 238
Body composition and cardiometabolic health across the menopause transition
Marlatt, K. L., Pitynski, D., Gavin, K. M., Moreau, K. L., Melanson, E. L., Santoro, N. F., & Kohrt, W. M. (2021) · Obesity · doi:10.1002/oby.23289 · Cited by 261
Impact of estrogens in males and androgens in females
Hammes, S. R., & Levin, E. R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125755 · Cited by 250
Fontana, R., & Torre, S. D. (2016) · Nutrients · doi:10.3390/nu8020087 · Cited by 234
Extra-gonadal sites of estrogen biosynthesis and function
Barakat, R., Oakley, O., Kim, H., Jin, J., & Ko, C. J. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.9.141 · Cited by 215
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice
Kübeck, R., Bonet-Ripoll, C., Hoffmann, C., Walker, A., Müller, V. M., Schüppel, V. L., Lagkouvardos, I., Scholz, B., Engel, K.-H., Daniel, H., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.001 · Cited by 211
Mittelman-Smith, M. A., Williams, H., Krajewski, S. J., McMullen, N. T., & Rance, N. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211517109 · Cited by 211
The endocrinology of food intake
Begg, D. P., & Woods, S. C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.136 · Cited by 214
Brown Adipose Tissue—A Translational Perspective
Carpentier, A. C., Blondin, D. P., Haman, F., & Richard, D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac015 · Cited by 218
Mittelman-Smith, M. A., Williams, H., Krajewski, S. J., Lai, J. Y., Ciofi, P., McMullen, N. T., & Rance, N. E. (2012) · Endocrinology · doi:10.1210/en.2012-1045 · Cited by 197
POMC neuronal heterogeneity in energy balance and beyond: an integrated view
Quarta, C., Claret, M., Zeltser, L. M., Williams, K. W., Yeo, G. S. H., Tschöp, M. H., Diano, S., Brüning, J. C., & Cota, D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00345-3 · Cited by 194
Moore, A. M., Coolen, L. M., Porter, D. T., Goodman, R. L., & Lehman, M. N. (2018) · Endocrinology · doi:10.1210/en.2018-00389 · Cited by 190
Buso, G., Depairon, M., Tomson, D., Raffoul, W., Vettor, R., & Mazzolai, L. (2019) · Obesity · doi:10.1002/oby.22597 · Cited by 208
Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα
Morselli, E., Fuente-Martín, E., Finan, B., Kim, M. H., Frank, A. P., García‐Cáceres, C., Navas, C. R., Gordillo, R., Neinast, M. D., Kalainayakan, S. P., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.025 · Cited by 194
Self-citationMembrane-Localized Estrogen Receptor α Is Required for Normal Organ Development and Function
Pedram, A., Razandi, M., Lewis, M. T., Hammes, S. R., & Levin, E. R. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.04.016 · Cited by 183
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R. D., Lara-Lince, F., Meek, T. H., Shi, X., Damian, V. M., Hồng, N. T., Matsen, M. E., et al. (2017) · Nature Communications · doi:10.1038/ncomms14556 · Cited by 175
The regulation of adipose tissue health by estrogens
Steiner, B. M., & Berry, D. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889923 · Cited by 171
Pathophysiological dilemmas of lipedema
Szél, E., Kemény, L. V., Groma, G., & Szolnoky, G. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.08.011 · Cited by 174
Brain regulation of energy balance and body weight
Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168
Dubois, S. L., Acosta‐Martínez, M., DeJoseph, M. R., Wolfe, A., Radovick, S., Boehm, U., Urban, J. H., & Levine, J. E. (2014) · Endocrinology · doi:10.1210/en.2014-1851 · Cited by 167
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Contreras, C., González, F., Fernø, J., Diéguez, C., Rahmouni, K., Nogueiras, R., & López, M. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.919727 · Cited by 167
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Brown and Beige Adipose Tissues in Health and Disease
Rui, L. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170001 · Cited by 186
Energy metabolism and fertility—a balance preserved for female health
Torre, S. D., Benedusi, V., Fontana, R., & Maggi, A. C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.203 · Cited by 162
Correa, S. M., Newstrom, D. W., Warne, J. P., Flandin, P., Cheung, C. C., Lin-Moore, A. T., Pierce, A. A., Xu, A. W., Rubenstein, J. L. R., & Ingraham, H. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.011 · Cited by 158
Estrogen as a key regulator of energy homeostasis and metabolic health
Mahboobifard, F., Pourgholami, M. H., Jorjani, M., Dargahi, L., Amiri, M., Sadeghi, S., & Tehrani, F. R. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113808 · Cited by 154
Meinsohn, M.-C., Smith, O. E., Bertolin, K., & Murphy, B. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00019.2018 · Cited by 146
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143
Sex differences in metabolism and cardiometabolic disorders
Krishnan, K. C., Mehrabian, M., & Lusis, A. J. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000536 · Cited by 153
Endocrine role of bone in the regulation of energy metabolism
Zhou, R., Guo, Q., Xiao, Y., Guo, Q., Huang, Y., Li, C., & Luo, X. (2021) · Bone Research · doi:10.1038/s41413-021-00142-4 · Cited by 157
Neuroendocrine Control of the Ovarian Cycle of the Rat
Levine, J. E. (2015) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-0-12-397175-3.00026-0 · Cited by 140
Qiu, S., Vazquez, J. T., Boulger, E., Liu, H., Xue, P., Hussain, M. A., & Wolfe, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-01937-4 · Cited by 135
Estrogens and the control of energy homeostasis: a brain perspective
López, M., & Tena‐Sempere, M. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.06.003 · Cited by 136
Central nervous control of energy and glucose balance: focus on the central melanocortin system
Xu, Y., Elmquist, J. K., & Fukuda, M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06248.x · Cited by 135
Self-citationEstrogen-sensitive medial preoptic area neurons coordinate torpor in mice
Zhang, Z., Reis, F. M., He, Y., Park, J. W., DiVittorio, J. R., Sivakumar, N., van Veen, J. E., Maesta‐Pereira, S., Shum, M., Nichols, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20050-1 · Cited by 144
Self-citationEstrogens stimulate serotonin neurons to inhibit binge-like eating in mice
Cao, X., Xu, P., Oyola, M. G., Xia, Y., Yan, X., Saito, K., Zou, F., Wang, C., Yang, Y., Hinton, A. O., Jr., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74726 · Cited by 131
Self-citationChoi, Y., Fujikawa, T., Lee, J., Reuter, A. L., & Kim, K. W. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00071 · Cited by 130
Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv309 · Cited by 119
Self-citationA Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
Martins, L., Seoane-Collazo, P., Contreras, C., González-García, I., Martínez-Sánchez, N., González, F., Zalvide, J., Gallego, R., Diéguez, C., Nogueiras, R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.045 · Cited by 154
The role of hypothalamic estrogen receptors in metabolic regulation
Frank, A., Brown, L. M., & Clegg, D. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.002 · Cited by 128
“expenditure, as well as increased visceral adiposity in the perigonadal depot (Xu et al., 2011).”
Self-citationContribution of specific ceramides to obesity-associated metabolic diseases
Hammerschmidt, P., & Brüning, J. C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04401-3 · Cited by 133
Oestrogen engages brain MC4R signalling to drive physical activity in female mice
Krause, W. C., Rodríguez, R., Gegenhuber, B., Matharu, N. K., Rodriguez, A. N., Padilla-Roger, A. M., Toma, K., Herber, C. B., Correa, S. M., Duan, X., et al. (2021) · Nature · doi:10.1038/s41586-021-04010-3 · Cited by 133
Kisspeptin and energy balance in reproduction
Bond, J. P. D., & Smith, J. T. (2013) · Reproduction · doi:10.1530/rep-13-0509 · Cited by 130
Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors
Clegg, D. J., Hevener, A. L., Moreau, K. L., Morselli, E., Criollo, A., Pelt, R. E. V., & Vieira‐Potter, V. J. (2017) · Endocrinology · doi:10.1210/en.2016-1677 · Cited by 126
Self-citationEstradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice
Litwak, S. A., Wilson, J. L., Chen, W., Garcia-Rudaz, C., Khaksari, M., Cowley, M. A., & Enriori, P. J. (2014) · Endocrinology · doi:10.1210/en.2014-1342 · Cited by 115
Obesity: A neuroimmunometabolic perspective
Larabee, C. M., Neely, O. C., & Domingos, A. I. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0283-6 · Cited by 123
Central regulation of energy metabolism by estrogens
Xu, Y., & López, M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.012 · Cited by 124
Self-citationHandgraaf, S., Riant, É., Fabre, A., Waget, A., Burcelin, R., Lière, P., Krust, A., Chambon, P., Arnal, J., & Gourdy, P. (2013) · Diabetes · doi:10.2337/db13-0282 · Cited by 124
Cheong, R. Y., Czieselsky, K., Porteous, R., & Herbison, A. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1776-15.2015 · Cited by 114
Minireview: The Year in Review of Estrogen Regulation of Metabolism
Clegg, D. J. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1284 · Cited by 114
Self-citationMembrane Estrogen Receptor Regulation of Hypothalamic Function
Micevych, P. E., & Kelly, M. J. (2012) · Neuroendocrinology · doi:10.1159/000338400 · Cited by 112
Menopause-associated risk of cardiovascular disease
Anagnostis, P. G., Lambrinoudaki, I. V., Stevenson, J. C., & Goulis, D. G. (2022) · Endocrine Connections · doi:10.1530/ec-21-0537 · Cited by 126
When do we eat? Ingestive behavior, survival, and reproductive success
Schneider, J. E., Wise, J. D., Benton, N. A., Brozek, J. M., & Keen‐Rhinehart, E. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.07.005 · Cited by 109
Yonezawa, R., Wada, T., Matsumoto, N., Morita, M., Sawakawa, K., Ishii, Y., Sasahara, M., Tsuneki, H., Saito, S., & Sasaoka, T. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00638.2011 · Cited by 108
Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome
Hevener, A. L., Clegg, D. J., & Mauvais-Jarvis, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.020 · Cited by 112
Self-citationThe hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 109
Self-citationHypothalamus and thermogenesis: Heating the BAT, browning the WAT
Contreras, C., Nogueiras, R., Diéguez, C., Medina‐Gómez, G., & López, M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.002 · Cited by 104
Shift in Kiss1 Cell Activity Requires Estrogen Receptor α
Frazão, R., Cravo, R. M., Donato, J., Ratra, D. V., Clegg, D. J., Elmquist, J. K., Zigman, J. M., Williams, K. W., & Elias, C. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1610-12.2013 · Cited by 101
Self-citationAblation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Xi, D., Gandhi, N. M., Lai, M., & Kublaoui, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036453 · Cited by 100
Viskaitis, P., Irvine, E. E., Smith, M. A., Choudhury, A. I., Alvarez‐Curto, E., Glegola, J. A., Hardy, D. G., Pedroni, S. M. A., Pessoa, M. R. P., Fernando, A. B. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.089 · Cited by 93
Estrogen receptor–α in medial amygdala neurons regulates body weight
Xu, P., Cao, X., He, Y., Zhu, L., Yang, Y., Saito, K., Wang, C., Yan, X., Hinton, A. O., Jr., Zou, F., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80941 · Cited by 97
Self-citationCharacterization of the metabolic differences between male and female C57BL/6 mice
de Souza, G. O., Wasinski, F., & Donato, J. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120636 · Cited by 103
Zhuang, P., Shou, Q., Lu, Y., Wang, G., Qiu, J., Wang, J., He, L., Chen, J., Jiao, J., & Zhang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.003 · Cited by 94
Regulation of Body Composition and Bioenergetics by Estrogens
Pelt, R. E. V., Gavin, K. M., & Kohrt, W. M. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.05.011 · Cited by 100
Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress
González‐García, I., Contreras, C., Estévez‐Salguero, Á., Ruíz-Pino, F., Colsh, B., Pensado, I., Liñares‐Pose, L., Rial‐Pensado, E., de Morentin, P. B. M., Fernø, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.038 · Cited by 94
van Veen, J. E., Kammel, L. G., Bunda, P., Shum, M., Reid, M., Massa, M. G., Arneson, D. V., Park, J. W., Zhang, Z., Joseph, A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0189-6 · Cited by 93
Zuloaga, D. G., Heck, A., Guzman, R. M. D., & Handa, R. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00319-2 · Cited by 99
Herber, C. B., Krause, W. C., Wang, L., Bayrer, J. R., Li, A., Schmitz, M. T., Fields, A. J., Ford, B., Zhang, Z., Reid, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08046-4 · Cited by 86
Western-style diet, sex steroids and metabolism
Varlamov, O. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.025 · Cited by 91
Neuroendocrine control of appetite and metabolism
Yoo, E.-S., Yu, J., & Sohn, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00597-9 · Cited by 92
Estrogen, astrocytes and the neuroendocrine control of metabolism
Fuente-Martín, E., García‐Cáceres, C., Morselli, E., Clegg, D. J., Chowen, J. A., Finan, B., Brinton, R. D., & Tschöp, M. H. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9263-7 · Cited by 91
Self-citationSteroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
Yang, Y., van der Klaauw, A. A., Zhu, L., Cacciottolo, T. M., He, Y., Stadler, L. K. J., Wang, C., Xu, P., Saito, K., Hinton, A. O., Jr., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08737-6 · Cited by 85
Self-citationLinoleic acid rescues microglia inflammation triggered by saturated fatty acid
Tu, T. H., Kim, H., Yang, S., Kim, J. K., & Kim, J. G. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.047 · Cited by 84
Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance
He, Y., Xu, P., Wang, C., Xia, Y., Yu, M., Yang, Y., Yu, K., Cai, X., Qu, N., Saito, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15982-7 · Cited by 84
Self-citationAcyl Coenzyme A Thioesterase 7 Regulates Neuronal Fatty Acid Metabolism To Prevent Neurotoxicity
Ellis, J. M., Wong, G. W., & Wolfgang, M. J. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01548-12 · Cited by 85
Metadata
- Authors
- Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., Khan, S. A., Elias, C. F., Elmquist, J. K., & Clegg, D. J.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Clegg, Deborah J.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 14
- Issue
- 4
- Pages
- 453-465
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3235745
- OpenAlex
- W2013865699
- Cited by
- 597
- References
- 43
- Citations by year
- 2026: 19 · 2025: 34 · 2024: 35 · 2023: 36 · 2022: 38 · 2021: 48 · 2020: 42 · 2019: 56 · 2018: 45 · 2017: 54 · 2016: 48 · 2015: 39 · 2014: 36 · 2013: 36 · 2012: 27
- FWCI
- 14.74
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-05-07)
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 655 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK073689, DK088220, HD061539, P30 DK079638-03, PL1 DK081182, PO1DK088761, R00DK085330, R01DK071320, R01DK088423, R01DK093587, R37DK53301, RL1 DK081185, UL1 RR024923)
- American Diabetes Association
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- estrogen receptor alpha, hypothalamic neurons, energy homeostasis, reproduction, abdominal obesity, hyperphagia, hypometabolism, proopiomelanocortin neurons, anovulation, infertility, estrogen negative feedback, visceral fat, female fertility
- MeSH terms
- Animals, Energy Metabolism, Estradiol, Female, Hyperphagia, Hypothalamus, Infertility, Female, Male, Neurons, Obesity, Pro-Opiomelanocortin, Mice, Knockout, Estrogen Receptor alpha, Mice, Steroidogenic Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
