Setting the Tone: Reactive Oxygen Species and the Control of Appetitive Melanocortin Neurons
Open accessAbstract
The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior (Diano et al., 2011).
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Mitochondrial ROS have been put forward as a mediator in response to nutrient availability.
“Along with malonyl-CoA and LCFA-CoA, mitochondrial ROS have been put forward as a mediator in response to nutrient availability ([140](#B140))”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [140]
Cites
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Role of central melanocortin pathways in energy homeostasis
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Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works
- Authors
- Rochford, J. J., Myers, M. G., & Heisler, L. K.
- Affiliations
- University of Cambridge (GB)
- University of Michigan (US)
- Corresponding author
- Heisler, Lora K.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 14
- Issue
- 5
- Pages
- 573-574
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2009117015
- Cited by
- 5
- References
- 10
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- reactive oxygen species, appetite, energy balance, energy status, hypothalamic neurons, redox signaling, feeding behavior
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