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Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease
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Approximately one-third of the U.S. population has nonalcoholic fatty liver disease (NAFLD), a condition closely associated with insulin resistance and increased risk of liver injury. Dysregulated mitochondrial metabolism is central in these disorders, but the manner and degree of dysregulation are disputed. This study tested whether humans with NAFLD have abnormal in vivo hepatic mitochondrial metabolism. Subjects with low (3.0%) and high (17%) intrahepatic triglyceride (IHTG) were studied using (2)H and (13)C tracers to evaluate systemic lipolysis, hepatic glucose production, and mitochondrial pathways (TCA cycle, anaplerosis, and ketogenesis). Individuals with NAFLD had 50% higher rates of lipolysis and 30% higher rates of gluconeogenesis. There was a positive correlation between IHTG content and both mitochondrial oxidative and anaplerotic fluxes. These data indicate that mitochondrial oxidative metabolism is ~2-fold greater in those with NAFLD, providing a potential link between IHTG content, oxidative stress, and liver damage.
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“Interestingly, in work performed in humans with NAFLD, a rapid elevation of liver levels of triglycerides was observed and is associated with stimulation of mitochondrial oxidative function165, suggesting a compensatory stimulation of mitochondrial β-oxidation.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [165]
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“Potential mechanisms to explain the beneficial effects of targeting mitochondrial FAO could be the concomitant enhancement of hepatic ketone bodies, CO2, acid soluble products, ATP production, and endergonic processes (*e.g.,* gluconeogenesis) seen in previous publications ([38](#B38), [130](#B130), [158](#B158)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [158]
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Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Self-citationDonnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Self-citationThe Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,166
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
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Burgess, S. C., Merritt, M. E., Jones, J. G., Browning, J. D., Sherry, A. D., & Malloy, C. R. (2015) · Nature Medicine · doi:10.1038/nm.3789 · Cited by 15
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Fuller, K. N. Z., McCoin, C. S., Stierwalt, H. D., Allen, J., Gandhi, S., Perry, C. G. R., Jambal, P., Shankar, K., & Thyfault, J. P. (2022) · The Journal of Physiology · doi:10.1113/jp283733 · Cited by 17
He, T., Lykov, N., Luo, X., Wang, H., Du, Z., Chen, Z., Chen, S., Zhu, L., Zhao, Y., & Tzeng, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032053 · Cited by 15
Talari, N. K., Mattam, U., Kamińska, D., Sotomayor-Rodriguez, I., Rahman, A. P., Péterfy, M., Pajukanta, P., Pihlajamäki, J., & Krishnan, K. C. (2024) · iScience · doi:10.1016/j.isci.2024.109709 · Cited by 16
Alger, J. R., Sherry, A. D., & Malloy, C. R. (2018) · Current Metabolomics · doi:10.2174/2213235x07666181219115856 · Cited by 15
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Bae, M., Lee, Y., Pham, T. X., Hu, S., Park, Y., & Lee, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117926 · Cited by 13
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Uematsu, S., Ohno, S., Tanaka, K. Y., Hatano, A., Kokaji, T., Ito, Y., Kubota, H., Hironaka, K., Suzuki, Y., Matsumoto, M., et al. (2022) · iScience · doi:10.1016/j.isci.2022.103787 · Cited by 13
Johansen, M. L., Schou, M., Rasmussen, J., Rossignol, P., Holm, M. R., Chabanova, E., Dela, F., Faber, J. O., & Kistorp, C. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.11.003 · Cited by 14
Marco‐Rius, I., Wright, A. J., Hu, D., Savic, D., Miller, J. J. J. J., Timm, K. N., Tyler, D. J., Brindle, K. M., & Comment, A. (2020) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-020-00884-y · Cited by 14
Li, Y., Sun, W., Liu, H., & Ruan, X. Z. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101761 · Cited by 16
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Liu, S., Ji, Y., Wei, L., Zhang, Y., Zeng, L., Min, Y., Yin, D., Liu, K., Guan, C., Liu, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62731-9 · Cited by 13
Surugihalli, C., Farley, L. S., Beckford, R. C., Kamkrathok, B., Liu, H., Muralidaran, V., Patel, K., Porter, T. E., & Sunny, N. E. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.870451 · Cited by 13
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Song, S., Zheng, J., Zhao, D., Zheng, A., Zhu, Y., Xu, Q., & Liu, T. (2023) · Clinical Proteomics · doi:10.1186/s12014-023-09442-9 · Cited by 13
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Jones, J. G. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00020-7 · Cited by 14
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Acierno, C., Nevola, R., Rinaldi, L., Sasso, F. C., Adinolfi, L. E., & Caturano, A. (2025) · Livers · doi:10.3390/livers5020017 · Cited by 14
Botha, J., Magnussen, L. V., Nielsen, M. H., Nielsen, T. B., Højlund, K., Andersen, M., & Handberg, A. (2017) · Journal of Diabetes Research · doi:10.1155/2017/4257875 · Cited by 13
Daurio, N. A., Wang, S.-P., Chen, Y., Zhou, H., McLaren, D. G., Roddy, T. P., Johns, D. G., Milot, D. P., Kasumov, T., Erion, M. D., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.241091 · Cited by 13
Carreau, A., Jin, E. S., Garcia‐Reyes, Y., Rahat, H., Nadeau, K. J., Malloy, C. R., & Cree‐Green, M. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00047.2019 · Cited by 13
Lee, S., Bae, J., Jo, D. R., Lee, M., Lee, Y., Kang, E. S., Soo, B., & Lee, B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1124576 · Cited by 14
Common Genetic Variants and Nonalcoholic Fatty Liver Disease
Browning, J. D. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.05.013 · Cited by 13
Self-citationMartins, A. S. D. P., Campos, S. B. G., Goulart, M. O. F., Fabiana, & Moura, F. A. (2021) · Biocell · doi:10.32604/biocell.2021.014332 · Cited by 13
Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1
Peng, K., Wang, S., Liu, R., Zhou, L., Jeong, G. H., Jeong, I. H., Liu, X., Kiyokawa, H., Xue, B., Zhao, B., et al. (2023) · Biochemistry · doi:10.1021/acs.biochem.2c00624 · Cited by 12
The potential role of glucokinase activator SHP289-04 in anti-diabetes and hepatic protection
Lei, L., Liu, S., Li, Y., Song, H., He, L., Liu, Q., Sun, S., Li, Y., Feng, Z., & Shen, Z. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.02.036 · Cited by 12
Gallego‐Durán, R., Albillos, A., Ampuero, J., Arechederra, M., Bañares, R., Blas‐García, A., Berná, G., Caparrós, E., Delgado, T. C., Falcón‐Pérez, J. M., et al. (2022) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2022.02.005 · Cited by 13
Morales, M. D. C., Chang, C., Le, V. L., Huang, I., Tsai, I., Shih, H., & Huang, C. (2022) · Cells · doi:10.3390/cells11213425 · Cited by 12
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Boemeke, L., Raimundo, F. V., Bopp, M., Leonhardt, L. R., Fernandes, S. A., & Marroni, C. A. (2019) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.201900000-06 · Cited by 12
He, F., Wu, H., Zhao, F., Liu, X., Yang, Q., Zhou, S., Xu, T., Xu, J., Wang, S., & Zou, D. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107856 · Cited by 12
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Hall, L. G., Thyfault, J. P., & Johnson, J. D. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00472.2022 · Cited by 15
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da Silva, F. S. I., Bizerra, P. F. V., Mito, M. S., Constantin, R. P., Klosowski, E. M., de Souza, B. T. L., Menezes, P. V. M. D. C., Bueno, P. S. A., Nanami, L. F., Marchiosi, R., et al. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110054 · Cited by 11
Li, L., Zhang, T., Yang, L., Zhang, L., Wang, L., Liu, B., & Liu, K. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.07.038 · Cited by 11
Sihali-Beloui, O., Aroune, D., Benazouz, F., Hadji, A., El-Aoufi, S., & Marco, S. (2019) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2019.04.003 · Cited by 11
Skat‐Rørdam, J., Ipsen, D. H., Seemann, S. E., Latta, M. R., Lykkesfeldt, J., & Tveden‐Nyborg, P. (2021) · Biomedicines · doi:10.3390/biomedicines9091198 · Cited by 11
Fahlbusch, P., Nikolic, A., Hartwig, S., Jacob, S., Kettel, U., Koellmer, C., Al‐Hasani, H., Lehr, S., Müller‐Wieland, D., Knebel, B., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126873 · Cited by 11
Slow TCA flux implies low ATP production in tumorsPreprint
Bartman, C., Shen, Y., Lee, W. D., TeSlaa, T. A., Jankowski, C. S. R., Wang, L., Yang, L., Roichman, A., Bhatt, V. D., Lan, T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.04.463108 · Cited by 11
Stan, S. I., Biciuşcă, V., Clenciu, D., Mitrea, A., Boldeanu, M. V., Durand, P., & Dănoiu, S. (2023) · Medicine and Pharmacy Reports · doi:10.15386/mpr-2629 · Cited by 14
Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD
McLeod, M., Chang, M. C., Rushin, A., Ragavan, M., Mahar, R., Sharma, G. K., Badar, A., Giacalone, A., Glanz, M. E., Malut, V. R., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101714 · Cited by 12
Self-citationLuo, M., Luo, J., Kaminga, A. C., Wei, J., Dai, W., Zhong, Y., Xu, N., Li, X., Zhou, H., & Pan, X. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00706-w · Cited by 10
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Yu, Q., Ma, L., Norona, L. M., Dragovich, P. S., Wang, J., Wang, S., Chen, Y.-C., Khojasteh, S. C., Kenny, J. R., Dean, B. J., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01305 · Cited by 10
Grattagliano, I., Bonfrate, L., Lorusso, M. P., Castorani, L., de Bari, O., & Portincasa, P. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1875-1_12 · Cited by 10
Liver-Brain Axis in Sporadic Alzheimer’s Disease: Role of Ten Signature Genes in a Mouse Model
Jakhmola-Mani, R., Islam, A., & Katare, D. P. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666201209111006 · Cited by 10
Barboza, T. K., Susta, L., Linden, A. Z., Gardhouse, S. M., & Beaufrère, H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0274060 · Cited by 12
Zhang, D., Zheng, W. L., Li, X., Ge, L., Ye, N., Liu, Y., Li, A., Liu, X., Zhang, R., Cheng, J., et al. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00015 · Cited by 10
Kattapuram, N., Zhang, C., Muyyarikkandy, M. S., Surugihalli, C., Muralidaran, V., Gregory, T., & Sunny, N. E. (2021) · Metabolites · doi:10.3390/metabo11050272 · Cited by 10
Self-citationLoss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux
Franczak, E., Kugler, B. A., Salathe, S. F., Allen, J., Sardiu, M. E., McCoin, C. S., Hevener, A. L., Morris, E. M., & Thyfault, J. P. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00107.2025 · Cited by 9
Cui, H., Zhang, R., Huang, J., Kong, C., Yao, C., & Jin, Z. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.139652 · Cited by 10
Metabolic drivers of MASLD and MASH: from hormonal imbalance to fibrosis
Gastaldelli, A., Scoditti, E., & Macedo, M. P. (2026) · Diabetologia · doi:10.1007/s00125-026-06774-7 · Cited by 11
Somvanshi, P. R., Patel, A. K., Bhartiya, S., & Venkatesh, K. V. (2016) · RSC Advances · doi:10.1039/c5ra18128c · Cited by 9
Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics
Downes, D. P., Zhong, W., Zhang, J., Chen, B., Satapati, S., Metzger, D., Godinez, G. L., Lao, J. Z., Sheth, P. R., McLaren, D. G., et al. (2020) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00199 · Cited by 9
Cisd2 Preserves the Youthful Pattern of the Liver Proteome during Natural Aging of Mice
Huang, C., Huang, Y., Shen, Z., Lin, C., & Tsai, T. (2021) · Biomedicines · doi:10.3390/biomedicines9091229 · Cited by 9
Shao, L., Liu, J., Song, Y., Yang, W., Gong, L., Lyu, Z., Zhu, Q., Fu, J., Li, J., & Shi, J. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.12.014 · Cited by 10
Li, X., Gao, Y., Wang, Y., Wang, Y., & Wu, Q. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s398385 · Cited by 12
Wang, B., Li, F., Guo, J., Wang, C., Xu, D., & Li, C. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.7043 · Cited by 9
Syncytialization and prolonged exposure to palmitate impacts BeWo respiration
Easton, Z. J. W., Delhaes, F., Mathers, K. E., Zhao, L., Vanderboor, C., & Regnault, T. R. H. (2020) · Reproduction · doi:10.1530/rep-19-0433 · Cited by 8
Garcia‐Caraballo, S., Comhair, T. M., Dejong, C. H. C., Lamers, W. H., & Köhler, E. S. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001986 · Cited by 9
Das, A., De, A. J., Mohanty, T., & Aich, P. (2023) · Redox Experimental Medicine · doi:10.1530/rem-23-0016 · Cited by 10
Du, J., Shen, M., Chen, J., Yan, H., Xu, Z., Yang, X., Yang, B., Luo, P., Ding, K., Hu, Y., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1510080 · Cited by 9
Qiu, Y., Su, M., Xiao, X., Zhou, D., & Xie, L. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02900-5 · Cited by 8
Befroy, D. E., Kibbey, R. G., Perry, R. J., Petersen, K. F., Rothman, D. L., & Shulman, G. I. (2015) · Nature Medicine · doi:10.1038/nm.3790 · Cited by 8
Non-alcoholic fatty liver disease: more than just ectopic fat accumulation
Francisco Barrera, M., & George, J. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.06.002 · Cited by 8
Pathogenesis of NAFLD and NASH
Maher, J. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-20538-0_4 · Cited by 8
Carril, E., Valdecantos, M. P., Lanzón, B., Angulo, S., Valverde, Á. M., Godzień, J., & Rupérez, F. J. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.112958 · Cited by 8
Insulin-stimulated lipogenesis gets an epigenetic makeover
Manuel, C. R., & Haeusler, R. A. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137050 · Cited by 8
Zhang, T., Qi, Z., Wang, H., & Ding, S. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0840-3330 · Cited by 9
Where does liver fat go? A possible molecular link between fatty liver and diabetes
Kikuchi, A., & Takamura, T. (2016) · Journal of Diabetes Investigation · doi:10.1111/jdi.12573 · Cited by 8
Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome
dos Santos, B. G., Brisnovali, N. F., & Goedeke, L. (2024) · Biochemical Journal · doi:10.1042/bcj20240005 · Cited by 7
FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity
Panzitt, K., Jungwirth, E., Vosko, L. E., Madreiter‐Sokolowski, C. T., Madl, T., Tawfik, I., Habisch, H., Krstić, J., Prokesch, A., Karitnig, R., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adn4558 · Cited by 7
Effects of dietary fibres on gut microbial metabolites and liver lipid metabolism in growing pigs
Hu, Y., Chen, D., Yu, B., Yan, H., Zheng, P., Mao, X., Yu, J., He, J., Huang, Z., Luo, Y., et al. (2020) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13429 · Cited by 7
Anstey, C., & Russell, F. D. (2021) · Blood Purification · doi:10.1159/000513150 · Cited by 7
Chen, F., Yan, H., Guo, C. W., Zhu, H., Yi, J., Sun, X., & Yang, J. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmab096 · Cited by 7
Solís‐Muñoz, P., de la Flor‐Robledo, M., García‐Ruíz, I., Fernández-García, C. E., González‐Rodríguez, Á., Shah, N. K., Bataller, R. A., Heneghan, M. A., García‐Monzón, C., & Solis-Herruzo, J. A. (2023) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17434 · Cited by 7
Gerrard, S. D., Yonke, J. A., McMillan, R. P., Sunny, N. E., & El‐Kadi, S. W. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.01.023 · Cited by 7
Self-citationThe odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis
Comhair, T. M., Garcia‐Caraballo, S., Dejong, C. H. C., Lamers, W. H., & Köhler, E. S. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.11.005 · Cited by 7
Behn, C. D., Jin, E. S., Bubar, K. M., Malloy, C. R., Parks, E. J., & Cree‐Green, M. (2019) · Journal of Investigative Medicine · doi:10.1136/jim-2019-001109 · Cited by 7
Self-citationOjo, O. A., Adeyemo, T. R., Iyobhebhe, M. E., Adams, M. D., Asaleye, R. M., Evbuomwan, I. O., Abdurrahman, J., Maduakolam-Aniobi, T. C., Nwonuma, C. O., Odesanmi, O. E., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-77503-6 · Cited by 8
Park, J. M., Lin, S., Baxter, J. D., Harrison, C. E., Leary, J., Mozingo, C., Liticker, J., Malloy, C. R., & Jin, E. S. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156151 · Cited by 6
Chan, P., Cheung, P. H., Kang, X.-Z., Cheng, Y., Wong, C., Jin, D., & Chan, C. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.97008 · Cited by 6
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Pandey, S., Marwari, D., Mishra, J., Goel, A., Mishra, A. K., & Sinha, N. (2025) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.70017 · Cited by 6
Pradeau, M., Beaulieu, S., Paquet, V., Trottier, J., Verreault, M., Ferland, S., Barbier, O., & Carreau, A. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00346.2024 · Cited by 10
Carlsson, M., Frank, E., Màrmol, J. M., Ali, M. S., Raun, S. H., Battey, E., Andersen, N. R., Irazoki, A., Lund, C., Henríquez‐Olguín, C., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102261 · Cited by 6
Pasqua, L. G. D., Lotti, S., Trucchi, M., Palladini, G., Croce, A. C., Protopapa, F., Feletti, F., Kauschke, S. G., Sun, P., Vairetti, M., et al. (2026) · Antioxidants · doi:10.3390/antiox15010082 · Cited by 6
Harada, M., Adam, J., Covic, M., Ge, J., Brandmaier, S., Muschet, C., Huang, J., Han, S., Rommel, M., Rotter, M., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02288-x · Cited by 6
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Mallott, E. K., Kuthyar, S., Lee, W., Reiman, D. J., Jiang, H., Chitta, S., Waters, E. A., Layden, B. T., Sumagin, R., Manzanares, L. D., et al. (2024) · Microbial Genomics · doi:10.1099/mgen.0.001322 · Cited by 10
KAHL, S., Nowotny, B., Straßburger, K., Bierwagen, A., Klüppelholz, B., Hoffmann, B. H., Giani, G., Nowotny, P., Wallscheid, F., Hatziagelaki, E. E., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01773 · Cited by 6
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Carulli, L., Zanca, G., Schepis, F., & Villa, E. (2019) · Metabolites · doi:10.3390/metabo9020025 · Cited by 6
RetractedYu, E. A., Yu, T., Jones, D. P., Martorell, R., Ramírez‐Zea, M., & Stein, A. D. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa169 · Cited by 8
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Kim, I., Park, S., Kim, Y., Chang, Y., Choi, C. S., Suh, S., & Wolfe, R. R. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.406 · Cited by 6
Mullin, S. M., Kelly, A. J., Chathail, M. B. N., Norris, S., Shannon, C. E., & Roche, H. M. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100375 · Cited by 10
Bhattacharjee, P., Fadlaoui, A., Ryan, C. E., Carlson, C. B., Zhang, D., & Sunny, N. E. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.030 · Cited by 5
Self-citationRoumans, K. H. M., Veelen, A., Andriessen, C., Mevenkamp, J., Moonen‐Kornips, E., Veeraiah, P., Havekes, B., Peters, H. P. F., Lindeboom, L., Schrauwen, P., et al. (2023) · Obesity · doi:10.1002/oby.23676 · Cited by 5
Bertinat, R., Holyoak, T., Gatica, R., Jara, N., González‐Chavarría, I., & Westermeier, F. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102112 · Cited by 5
Han, S., Xiang, X., Zhang, X., Ou, L., Liu, Q., Xu, X., Zhang, J., Hao, T., Du, J., Li, Y., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402628r · Cited by 5
Rahim, M., Bednarski, T. K., Hasenour, C. M., Banerjee, D. R., Trenary, I. A., & Young, J. D. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115591 · Cited by 5
Nam, S. Y., Jang, H., Kim, J. B., Lee, S. H., & Lee, Y. M. (2016) · Journal of the East Asian Society of Dietary Life · doi:10.17495/easdl.2016.6.26.3.278 · Cited by 5
Siboto, A., Akinnuga, A. M., Ismail, M. B., Booysen, I. N., Sibiya, N. H., Ngubane, P. S., & Khathi, A. (2022) · Diabetology · doi:10.3390/diabetology3040040 · Cited by 5
Adherence to low carbohydrate diets and non-alcoholic fatty liver disease: a case control study
Yaghoubi, F., Darand, M., Vasmehjani, A. A., Darabi, Z., Talenezhad, N., Mirzavandi, F., & Hosseinzadeh, M. (2022) · BMC Nutrition · doi:10.1186/s40795-022-00625-5 · Cited by 4
Weijler, A. M., Schmidinger, B., Kapiotis, S., Laggner, H., & Hermann, M. (2018) · Biochimie · doi:10.1016/j.biochi.2018.02.003 · Cited by 5
Metadata
- Authors
- Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Browning, Jeffrey D.
- Burgess, Shawn C.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 14
- Issue
- 6
- Pages
- 804-810
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3658280
- OpenAlex
- W1985236262
- Cited by
- 672
- References
- 47
- Citations by year
- 2026: 41 · 2025: 60 · 2024: 43 · 2023: 58 · 2022: 55 · 2021: 62 · 2020: 52 · 2019: 54 · 2018: 43 · 2017: 33 · 2016: 50 · 2015: 43 · 2014: 29 · 2013: 28 · 2012: 20
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Texas Southwestern Medical Center
- Georgia Clinical and Translational Science Alliance (UL1RR024982)
- National Institutes of Health (1tl1dk081181-01, UL1TR000451)
- National Institute of Diabetes and Digestive and Kidney Diseases (TL1-DK081181, P01DK058398, PL1DK081182, PL1DK081183, RL1DK081187, K23DK074396, R01DK087977, RL9DK081180, R01DK078184)
- National Institute of Dental and Craniofacial Research (UL1DE019584)
- National Center for Research Resources (UL1RR024982, UL1RR024923, P20RR020691)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- non-alcoholic fatty liver disease, TCA cycle, gluconeogenesis, anaplerosis, ketogenesis, intrahepatic triglyceride, lipolysis, hepatic glucose production, insulin resistance, oxidative stress, liver injury
- MeSH terms
- Adult, Black or African American, Carbon Isotopes, Citric Acid Cycle, Deuterium, Fatty Liver, Female, Gluconeogenesis, Glucose, Hispanic or Latino, Humans, Lipolysis, Liver, Male, Middle Aged, Mitochondria, Non-alcoholic Fatty Liver Disease
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