Cited by 680Liver Disease Diagnosis and TreatmentMitochondrial Function and PathologyDiet, Metabolism, and Disease

The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

Open access

Sunny, Nishanth E., Parks, Elizabeth J., Browning, Jeffrey D., Burgess, Shawn C.·2011·Cell Metabolism

DOI 10.1016/j.cmet.2011.11.004PMC PMC3658280

Open this paper in CoChat — free account Open PDF

Abstract

Approximately one-third of the U.S. population has nonalcoholic fatty liver disease (NAFLD), a condition closely associated with insulin resistance and increased risk of liver injury. Dysregulated mitochondrial metabolism is central in these disorders, but the manner and degree of dysregulation are disputed. This study tested whether humans with NAFLD have abnormal in vivo hepatic mitochondrial metabolism. Subjects with low (3.0%) and high (17%) intrahepatic triglyceride (IHTG) were studied using (2)H and (13)C tracers to evaluate systemic lipolysis, hepatic glucose production, and mitochondrial pathways (TCA cycle, anaplerosis, and ketogenesis). Individuals with NAFLD had 50% higher rates of lipolysis and 30% higher rates of gluconeogenesis. There was a positive correlation between IHTG content and both mitochondrial oxidative and anaplerotic fluxes. These data indicate that mitochondrial oxidative metabolism is ~2-fold greater in those with NAFLD, providing a potential link between IHTG content, oxidative stress, and liver damage.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2011.11.004

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Self-citation
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Self-citation
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,166
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
Self-citation

Flagged first, then by citations

Show all 47 references

1 of the 47 references couldn’t be matched to a known paper.

Sorted by citations

Mechanisms for Insulin Resistance: Common Threads and Missing Links
Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294
Energy Metabolism in the Liver
Rui, L. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130024 · Cited by 2,401
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics
Puchalska, P., & Crawford, P. A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.022 · Cited by 1,682
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,170
Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.049 · Cited by 1,069
Self-citation
Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis
Koliaki, C., Szendroedi, J., Kaul, K., Jelenik, T., Nowotny, P., Jankowiak, F., Herder, C., Carstensen, M., Krausch, M., Knoefel, W. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.004 · Cited by 1,032
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
Lebeaupin, C., Vallée, D., Hazari, Y., Hetz, C. A., Chevet, É., & Bailly‐Maitre, B. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.008 · Cited by 971
Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications
Cusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 940
Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R. A., Bugianesi, E., & Gastaldelli, A. (2013) · Nutrients · doi:10.3390/nu5051544 · Cited by 849
Nonalcoholic Fatty Liver Disease, Hepatic Insulin Resistance, and Type 2 Diabetes
Birkenfeld, A. L., & Shulman, G. I. (2013) · Hepatology · doi:10.1002/hep.26672 · Cited by 752
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631
Molecular pathways of nonalcoholic fatty liver disease development and progression
Bessone, F., Razori, M. V., & Roma, M. G. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2947-0 · Cited by 664
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615
Understanding cachexia as a cancer metabolism syndrome
Porporato, P. E. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.3 · Cited by 562
Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease
Khan, R. S., Bril, F., Cusi, K. J., & Newsome, P. N. (2018) · Hepatology · doi:10.1002/hep.30429 · Cited by 552
Non-alcoholic fatty liver disease and diabetes
Hazlehurst, J., Woods, C. P., Marjot, T., Cobbold, J., & Tomlinson, J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.01.001 · Cited by 541
Mammalian iron metabolism and its control by iron regulatory proteins
Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.010 · Cited by 493
Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH
Pierantonelli, I., & Svegliati‐Baroni, G. (2018) · Transplantation · doi:10.1097/tp.0000000000002480 · Cited by 473
From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
Gastaldelli, A., & Cusi, K. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.07.002 · Cited by 455
Role of Insulin Resistance in MAFLD
Sakurai, Y., Kubota, N., Yamauchi, T., & Kadowaki, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084156 · Cited by 448
How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?
Geng, Y., Faber, K. N., de Meijer, V. E., Blokzijl, H., & Moshage, H. J. (2021) · Hepatology International · doi:10.1007/s12072-020-10121-2 · Cited by 465
Mitochondrial alterations in fatty liver diseases
Fromenty, B., & Roden, M. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.09.020 · Cited by 448
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
Leamy, A. K., Egnatchik, R. A., & Young, J. D. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.10.004 · Cited by 424
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m023382 · Cited by 407
Self-citation
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver
Satapati, S., Kucejová, B., Duarte, J. A. G., Fletcher, J. A., Reynolds, L., Sunny, N. E., He, T., Nair, L. A., Livingston, K. A., Fu, X., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82204 · Cited by 403
Self-citation
Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease
Haas, J. T., Francque, S., & Staels, B. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105331 · Cited by 411
SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase
Laurent, G., German, N. J., Saha, A. K., de Boer, V. C. J., Davies, M. N., Koves, T. R., Dephoure, N., Fischer, F. F., Boanca, G., Vaitheesvaran, B., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.012 · Cited by 399
Understanding metabolic regulation and its influence on cell physiology
Metallo, C. M., & Vander Heiden, M. G. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.018 · Cited by 367
GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease
Loomba, R., Kayali, Z., Noureddin, M., Ruane, P., Lawitz, E. J., Bennett, M., Wang, L., Harting, E., Tarrant, J. M., McColgan, B. J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.027 · Cited by 340
Resolving the paradox of hepatic insulin resistance
Santoleri, D., & Titchenell, P. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.016 · Cited by 336
“Indeed, there is a significant correlation between rates of gluconeogenesis and the extent of liver fat in NAFLD patients.(10) Therefore, during the progression of insulin resistance, insulin fails to suppress HGP yet continues to drive excess lipid synthesis, leading to the sequela of NAFLD, hyperglycemia, and hypert…”
Background
Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression
Wang, R., Li, B., Lam, S. M., & Shui, G. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.11.009 · Cited by 346
Pathogenesis and Prevention of Hepatic Steatosis.
Nassir, F., Rector, R. S., Hammoud, G. M., & Ibdah, J. A. (2015) · PubMed Central · Cited by 317
Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies
Sunny, N. E., Bril, F., & Cusi, K. J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.11.006 · Cited by 327
Self-citation
Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance
Jornayvaz, F. R., & Shulman, G. I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.005 · Cited by 331
The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state
Hodson, L., & Gunn, P. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0256-9 · Cited by 321
Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis
Apostolopoulou, M., Gordillo, R., Koliaki, C., Gancheva, S., Jelenik, T., De Filippo, E., Herder, C., Markgraf, D., Jankowiak, F., Esposito, I., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1318 · Cited by 284
Hepatic glucose and lipid metabolism
Jones, J. G. (2016) · Diabetologia · doi:10.1007/s00125-016-3940-5 · Cited by 308
Metabolic and Signaling Roles of Ketone Bodies in Health and Disease
Puchalska, P., & Crawford, P. A. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111120-111518 · Cited by 304
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
Yki-Järvinen, H., Luukkonen, P. K., Hodson, L., & Moore, J. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00472-y · Cited by 294
Hepatic Selective Insulin Resistance at the Intersection of Insulin Signaling and Metabolic Dysfunction-Associated Steatotic Liver Disease
Bo, T., Gao, L., Yao, Z., Shao, S., Wang, X., Proud, C. G., & Zhao, J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.006 · Cited by 293
Free radical biology for medicine: learning from nonalcoholic fatty liver disease
Serviddio, G., Bellanti, F., & Vendemiale, G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.174 · Cited by 272
Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis
Yu, S., Meng, S., Xiang, M., & Ma, H. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101257 · Cited by 277
Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease
Svegliati‐Baroni, G., Pierantonelli, I., Torquato, P., Marinelli, R., Ferreri, C., Chatgilialoglu, C., Bartolini, D., & Galli, F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.029 · Cited by 255
Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis
Lee, K., Wu, P.-S., & Lin, H. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0237 · Cited by 269
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246
Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD
Moore, M. P., Cunningham, R. P., Meers, G. M.-E., Johnson, S. A., Wheeler, A. A., Ganga, R., Spencer, N., Pitt, J. B., Diaz‐Arias, A. A., Swi, A. I. A., et al. (2022) · Hepatology · doi:10.1002/hep.32324 · Cited by 247
Self-citation
Mitochondria in non-alcoholic fatty liver disease
Simões, I. C. M., Fontes, A., Pinton, P., Zischka, H., & Wieckowski, M. R. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.12.019 · Cited by 234
Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo
Williams, K., Shackel, N. A., Gorrell, M. D., McLennan, S. V., & Twigg, S. M. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1009 · Cited by 235
Developmental origins of NAFLD: a womb with a clue
Wesolowski, S. R., Kasmi, K. C. E., Jonscher, K. R., & Friedman, J. E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.160 · Cited by 239
Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
Liu, M., Jin, L., Sun, S.-J., Liu, P., Feng, X., Cheng, Z., Liu, W., Guan, K., Shi, Y., Yuan, H., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0070-6 · Cited by 217
Endoplasmic reticulum proteostasis in hepatic steatosis
Baiceanu, A., Mesdom, P., Lagouge, M., & Foufelle, F. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.124 · Cited by 216
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia
Cotter, D. G., Erçal, B., Huang, X., Leid, J. M., d’Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J., & Crawford, P. A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76388 · Cited by 211
Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver
Fletcher, J. A., Deja, S., Satapati, S., Fu, X., Burgess, S. C., & Browning, J. D. (2019) · JCI Insight · doi:10.1172/jci.insight.127737 · Cited by 200
Self-citation
Interorgan Metabolic Crosstalk in Human Insulin Resistance
Gancheva, S., Jeleník, T., Álvarez-Hernández, E., & Roden, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00015.2017 · Cited by 194
Hepatic Steatosis as a Marker of Metabolic Dysfunction
Fabbrini, E., & Magkos, F. (2015) · Nutrients · doi:10.3390/nu7064995 · Cited by 192
Ins and outs of the TCA cycle: the central role of anaplerosis
Inigo, M., Deja, S., & Burgess, S. C. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120420-025558 · Cited by 189
Diet and exercise in NAFLD/NASH: Beyond the obvious
Semmler, G., Datz, C., Reiberger, T., & Trauner, M. (2021) · Liver International · doi:10.1111/liv.15024 · Cited by 187
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)—relationship to newly identified mitochondrial pyruvate carrier proteins
Colca, J. R., McDonald, W. G., Cavey, G. S., Cole, S. L., Holewa, D. D., Brightwell-Conrad, A. S., Wolfe, C. L., Wheeler, J. S., Coulter, K. R., Kilkuskie, P. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061551 · Cited by 171
Metabolically healthy and unhealthy obese – the 2013 S tock C onference report
Samocha‐Bonet, D., Dixit, V. D., Kahn, C. R., Leibel, R. L., Lin, X., Nieuwdorp, M., Pietiläinen, K. H., RABASA-LHORET, R. P. R., Roden, M., Scherer, P. E., et al. (2014) · Obesity Reviews · doi:10.1111/obr.12199 · Cited by 176
Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus
Koliaki, C. C., & Roden, M. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050656 · Cited by 170
Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk
Ciaula, A. D., Baj, J., Garruti, G., Celano, G., Angelis, M. D., Wang, H. H., Palo, D. M. D., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082648 · Cited by 166
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity
Patterson, R. E., Kalavalapalli, S., Williams, C. M., Nautiyal, M., Mathew, J. T., Martinez, J., Reinhard, M. K., McDougall, D. J., Rocca, J. R., Yost, R. A., et al. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00492.2015 · Cited by 161
Self-citation
Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes
Egnatchik, R. A., Leamy, A. K., Noguchi, Y., Shiota, M., & Young, J. D. (2014) · Metabolism · doi:10.1016/j.metabol.2013.10.009 · Cited by 161
Hepatic Fatty Acid Trafficking: Multiple Forks in the Road
Mashek, D. G. (2013) · Advances in Nutrition · doi:10.3945/an.113.004648 · Cited by 167
ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
Egnatchik, R. A., Leamy, A. K., Jacobson, D. A., Shiota, M., & Young, J. D. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.004 · Cited by 161
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship
Karkucińska‐Więckowska, A., Simões, I. C. M., Kalinowski, P., Lebiedzińska, M., Zieniewicz, K., Milkiewicz, P., Górska‐Ponikowska, M., Pinton, P., Malik, A. N., Krawczyk, M. J., et al. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13622 · Cited by 172
Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches
Lomonaco, R., Sunny, N. E., Bril, F., & Cusi, K. J. (2013) · Drugs · doi:10.1007/s40265-012-0004-0 · Cited by 159
Self-citation
Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
Kumashiro, N., Beddow, S. A., Vatner, D. F., Majumdar, S. K., Cantley, J. L., Guebre‐Egziabher, F., Fat, I., Guigni, B. A., Jurczak, M. J., Birkenfeld, A. L., et al. (2013) · Diabetes · doi:10.2337/db12-1311 · Cited by 157
Nonalcoholic Fatty Liver Disease
Bril, F., & Cusi, K. J. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.06.005 · Cited by 158
Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes
Lomonaco, R., Bril, F., Portillo-Sánchez, P., Ortiz‐Lopez, C., Orsak, B., Biernacki, D., Lo, M. C., Suman, A., Weber, M. H., & Cusi, K. J. (2016) · Diabetes Care · doi:10.2337/dc15-1876 · Cited by 151
Targeting hepatic Glutaminase 1 ameliorates Non-Alcoholic Steatohepatitis by restoring Very-Low Density Lipoproteins triglyceride assembly
Simón, J., Núñez-García, M., Fernández-Tussy, P., Barbier-Torres, L., Fernández-Ramos, D., Gómez-Santos, B., Buqué, X., Lopitz-Otsoa, F., Goikoetxea-Usandizaga, N., Serrano-Maciá, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.013 · Cited by 141
Characterising metabolically healthy obesity in weight-discordant monozygotic twins
Naukkarinen, J., Heinonen, S., Hakkarainen, A., Lundbom, J., Vuolteenaho, K., Saarinen, L., Hautaniemi, S., Rodrı́guez, A., Frühbeck, G., Pajunen, P., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3066-y · Cited by 146
Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism
Tang, G., Xu, Y., Zhang, C., Wang, N., Li, H., & Feng, Y. (2021) · Antioxidants · doi:10.3390/antiox10071076 · Cited by 150
Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options
Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., & Ciaula, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115640 · Cited by 167
Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Mayneris‐Perxachs, J., Cardellini, M., Hoyles, L., Latorre, J., Davato, F., Moreno‐Navarrete, J. M., Arnoriaga‐Rodríguez, M., Sérino, M., Abbott, J., Barton, R. H., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01052-7 · Cited by 145
Treatment of patients with type 2 diabetes and non-alcoholic fatty liver disease: current approaches and future directions
Cusi, K. J. (2016) · Diabetologia · doi:10.1007/s00125-016-3952-1 · Cited by 141
Lipid metabolism in MASLD and MASH: From mechanism to the clinic
Carli, F., Della Pepa, G., Sabatini, S., Vidal Puig, A., & Gastaldelli, A. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101185 · Cited by 147
Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease
Koliaki, C. C., & Roden, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.002 · Cited by 140
Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis
Bellanti, F., Villani, R., Facciorusso, A., Vendemiale, G., & Serviddio, G. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.023 · Cited by 136
Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?
Ciaula, A. D., Passarella, S., Shanmugam, H., Noviello, M., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105375 · Cited by 142
Hepatic glucose metabolism in the steatotic liver
Scoditti, E., Sabatini, S., Carli, F., & Gastaldelli, A. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00888-8 · Cited by 134
Influence of Dietary Macronutrients on Liver Fat Accumulation and Metabolism
Parry, S. A., & Hodson, L. (2017) · Journal of Investigative Medicine · doi:10.1136/jim-2017-000524 · Cited by 141
Sirtuins and nonalcoholic fatty liver disease
Nassir, F., & Ibdah, J. A. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10084 · Cited by 128
Physiology and pathophysiology of liver lipid metabolism
Ponziani, F. R., Pecere, S., Gasbarrini, A., & Ojetti, V. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1056156 · Cited by 133
CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism
Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. M., & Wong, G. W. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00102.2013 · Cited by 123
Phytochemical gallic acid alleviates nonalcoholic fatty liver disease via AMPK-ACC-PPARa axis through dual regulation of lipid metabolism and mitochondrial function
Zhang, J., Zhang, W., Yang, L. H., Zhao, W., Liu, Z., Wang, E., & Wang, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154589 · Cited by 131
Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease
Chen, Z., Yu, Y., Cai, J., & Li, H. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.006 · Cited by 127
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
Asif, S., Kim, R. Y., Fatica, T., Sim, J., Zhao, X., Oh, Y., Denoncourt, A. M., Cheung, A., Downey, M., Mulvihill, E. E., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101494 · Cited by 122
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
Sookoian, S. C., Castaño, G. O., Scian, R., Gianotti, T. F., Dopazo, H., Rohr, C., Gaj, G., Martino, J. S., Sevic, I., Flichman, D. M., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.118695 · Cited by 121
Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells
Gu, L., Ding, X., Wang, Y., Gu, M., Zhang, J., Yan, S., Li, N., Song, Z., Yin, J., Lu, L., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.31781 · Cited by 124
Pharmacological advances in mitochondrial therapy
Singh, A., Faccenda, D., & Campanella, M. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103244 · Cited by 128
Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non‐alcoholic steatohepatitis ( NASH )?
Tariq, Z., Green, C., & Hodson, L. (2014) · Liver International · doi:10.1111/liv.12523 · Cited by 122
Molecular insights into the role of mitochondria in non-alcoholic fatty liver disease
Lee, J., Park, J.-S., & Roh, Y. S. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01178-1 · Cited by 121
Non-alcoholic Fatty Liver Disease as a Canonical Example of Metabolic Inflammatory-Based Liver Disease Showing a Sex-Specific Prevalence: Relevance of Estrogen Signaling
Torre, S. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572490 · Cited by 125
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Hyötyläinen, T., Jerby‐Arnon, L., Petäjä, E. M., Mattila, I. M., Jäntti, S. E., Auvinen, P., Gastaldelli, A., Yki‐Järvinen, H., Ruppin, E., & Orešič, M. (2016) · Nature Communications · doi:10.1038/ncomms9994 · Cited by 114
Metabolic Changes of Hepatocytes in NAFLD
Lu, Q., Tian, X., Wu, H., Huang, J., Li, M., Mei, Z., Zhou, L., Xie, H., & Zheng, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.710420 · Cited by 118
Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity
Jiang, J., Zhang, G., Zheng, J.-Y., Sun, J., & Ding, S.-B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876550 · Cited by 117
Nonalcoholic Fatty Liver Disease in Latinos
Saab, S., Manne, V., Nieto, J. M., Schwimmer, J. B., & Chalasani, N. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.05.001 · Cited by 117
Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine
Noureddin, M., Mato, J. M., & Lu, S. C.-L. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215579161 · Cited by 116

Authors: Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Browning, Jeffrey D.
Burgess, Shawn C.
ORCID: Sunny, Nishanth E.
Parks, Elizabeth J.
Burgess, Shawn C.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2011-12
Volume: 14
Issue: 6
Pages: 804-810
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2011.11.004
PMC: PMC3658280
OpenAlex: W1985236262
Cited by: 672
References: 47
Citations by year: 2026: 41 · 2025: 60 · 2024: 43 · 2023: 58 · 2022: 55 · 2021: 62 · 2020: 52 · 2019: 54 · 2018: 43 · 2017: 33 · 2016: 50 · 2015: 43 · 2014: 29 · 2013: 28 · 2012: 20
FWCI: 18.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 630 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Texas Southwestern Medical Center
Georgia Clinical and Translational Science Alliance (UL1RR024982)
National Institutes of Health (1tl1dk081181-01, UL1TR000451)
National Institute of Diabetes and Digestive and Kidney Diseases (TL1-DK081181, P01DK058398, PL1DK081182, PL1DK081183, RL1DK081187, K23DK074396, R01DK087977, RL9DK081180, R01DK078184)
National Institute of Dental and Craniofacial Research (UL1DE019584)
National Center for Research Resources (UL1RR024982, UL1RR024923, P20RR020691)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: non-alcoholic fatty liver disease, TCA cycle, gluconeogenesis, anaplerosis, ketogenesis, intrahepatic triglyceride, lipolysis, hepatic glucose production, insulin resistance, oxidative stress, liver injury
MeSH terms: Adult, Black or African American, Carbon Isotopes, Citric Acid Cycle, Deuterium, Fatty Liver, Female, Gluconeogenesis, Glucose, Hispanic or Latino, Humans, Lipolysis, Liver, Male, Middle Aged, Mitochondria, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks