Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

Zarse, Kim, Schmeisser, Sebastian, Groth, Marco, Priebe, Steffen, Beuster, Gregor, Kuhlow, Doreen, Guthke, Reinhard, Platzer, Matthias +2 more·2012·Cell Metabolism

Cited by (430)

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    Shiva Marthandan, Stefan Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter H. Hemmerich, Stephan Diekmann · 2015 · Immunity & Ageing
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    Sameh A. Abdelnour, Wael A. Khalil, Norhan E. Khalifa, Fatma Mohamed Ameen Khalil, Mahmoud A. E. Hassan · 2024 · Animal Reproduction Science
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    David Dolivo, Sarah J. Hernandez, Tanja Dominko · 2016 · BioEssays
  34. rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction
    Jiao Li, Xiaodong Cui, Zhuanhua Wang, Yuying Li · 2015 · Experimental Gerontology
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    Shanshan Chu, Xiangxiang Li, Ning Sun, Falin He, Zhihan Cui, Yuze Li, Rutao Liu · 2021 · The Science of The Total Environment
  36. dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster
    Rhoda K.A. Stefanatos, Ashwin Sriram, Essi Kiviranta, Aravind K. Mohan, Victòria Ayala, Howard Trevor Jacobs, Reinald Pamplona, Alberto Sanz · 2012 · Cell Cycle
  37. Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide
    Paolo Ettore Porporato, Pierre Sonveaux · 2014 · Molecular & Cellular Oncology
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    Beatrice Tassone, Stefania Saoncella, Francesco Neri, Ugo Ala, Davide Brusa, Mark A. Magnuson, Paolo Provero, Salvatore Oliviero, Chiara Riganti, Enzo Calautti · 2017 · Cell Death and Differentiation
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    Zhifan Mao, Wenwen Liu, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu, Jian Li · 2021 · Acta Pharmaceutica Sinica B
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  42. Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration
    Kostoula Troulinaki, Daniele Bano · 2012 · Frontiers in Genetics
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  52. Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue
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  53. Role/s of ‘Antioxidant’ Enzymes in Ageing
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  70. Large‐scale genetic screens identify BET ‐1 as a cytoskeleton regulator promoting actin function and life span
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  71. Measuring the Effect of Chemicals on the Growth and Reproduction of Caenorhabditis elegans
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  72. Cytoskeleton of cortical astrocytes as a target to proline through oxidative stress mechanisms
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  73. Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts
    Jagoda Adamczyk, Anna Deręgowska, Marek Skoneczny, Adrianna Skoneczna, Aleksandra Kwiatkowska, Leszek Potocki, Ewa Rawska, Sylwia Pabian, Jakub Kaplan, Anna Lewińska et al. · 2016 · Oncotarget
  74. Exposure to sixty minutes of hyperoxia upregulates myocardial humanins in patients with coronary artery disease - a pilot study.
    Inga Karu, Peeter Tähepôld, Arno Ruusalepp, Ene Reimann, Sulev Kõks, Joel Starkopf · 2015 · PubMed
  75. Sexual Preferences in Nutrient Utilization Regulate Oxygen Consumption and Reactive Oxygen Species Generation in Schistosoma mansoni: Potential Implications for Parasite Redox Biology
    Matheus Oliveira, Juliana B. R. Corrêa Soares, Marcus Fernandes de Oliveira · 2016 · PLoS ONE
  76. FGT‐1‐mediated glucose uptake is defective in insulin/IGF‐like signaling mutants in Caenorhabditis elegans
    Shun Kitaoka, Anthony D. Morielli, Feng‐Qi Zhao · 2016 · FEBS Open Bio
  77. Endogenous metabolites promote stress resistance through induction of mitohormesis
    Fabian Fischer, Michael Ristow · 2020 · EMBO Reports
  78. Metabolomic Investigation of Ultraviolet Ray-Inactivated White Spot Syndrome Virus-Induced Trained Immunity in Marsupenaeus japonicus
    Shaoqing Zang, Li-Xia Lv, Chen‐Fei Liu, Peng Zhang, Cang Li, Jin‐Xing Wang · 2022 · Frontiers in Immunology
  79. RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis
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  80. Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7
    Patricia Mármol, Favio Ariel Krapacher, Carlos F. Ibáñez · 2020 · eLife
  81. Combined addition of L-carnitine and L-proline improves cryopreservation of dairy goat semen
    Jianglin Zhao, Peng Meng, Miaomiao Jin, Xianghai Ma, Hongwei Ma, Hanwen Yang, Yanzhi Chen, Junyu Zhang, Yong Zhang, Yan Luo et al. · 2023 · Animal Reproduction Science
  82. AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension
    Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Yan‐Hui Liu, Jianfeng Wu, Yan Chen, Jinye Xiong, Li-Feng Cui, Mingxia Zhu et al. · 2024 · Cell Research
  83. The deep end of the metabolite pool: influences on epigenetic regulatory mechanisms in cancer
    Kendra K. S. Nordgren, Andrew J. Skildum · 2014 · European Journal of Clinical Investigation
  84. WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress
    Zhaofa Xu, Yiman Hu, Yajun Deng, Yutao Chen, Hanqi Hua, Siyu Huang, Qian Nie, Qian Pan, K. Dengke, Long Ma · 2018 · G3 Genes Genomes Genetics
  85. Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans
    Rachele Sangaletti, Massimo D’Amico, Jeff Grant, David Della‐Morte, Laura K. Bianchi · 2017 · PLoS Genetics
  86. Levels and location are crucial in determining the effect of ROS on lifespan
    Jeremy M. Van Raamsdonk · 2015 · Worm
  87. The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan in C. elegans Worms
    Paloma García-Casas, Jessica Arias-del-Val, Pilar Álvarez-Illera, Aneta Wojnicz, Cristóbal de los Rı́os, Rosalba I. Fonteríz, Mayte Montero, Javier Álvarez · 2019 · Frontiers in Aging Neuroscience
  88. Interplay between redox and protein homeostasis
    Diogo R. Feleciano, Kristin Arnsburg, Janine Kirstein · 2016 · Worm
  89. Enhanced synthesis of poly gamma glutamic acid by increasing the intracellular reactive oxygen species in the Bacillus licheniformis Δ1-pyrroline-5-carboxylate dehydrogenase gene ycgN-deficient strain
    Bichan Li, Dongbo Cai, Shiying Hu, Anting Zhu, Zhili He, Shouwen Chen · 2018 · Applied Microbiology and Biotechnology
  90. Yin and Yang of mitochondrial ROS in Drosophila
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  91. Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla
    Paméla Dakik, Younes Medkour, Karamat Mohammad, Vladimir I. Titorenko · 2019 · Frontiers in Physiology
  92. Measurement of the membrane elasticity of red blood cell with osmotic pressure by optical tweezers.
    Jianguang Wu, Yinmei Li, Di Lu, Zhong Liu, Zhengdong Cheng, Liqun He · 2009 · PubMed
  93. Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts
    Manoj K. Gupta, Adrian Kee Keong Teo, Tata Nageswara Rao, Shweta Bhatt, André Kleinridders, Jun Shirakawa, Tomozumi Takatani, Jiang Yong Hu, Dario F. De Jesus, Rebecca Windmueller et al. · 2015 · Stem Cells Translational Medicine
  94. Age-related changes of physiological performance and survivorship of bank voles selected for high aerobic capacity
    Agata M. Rudolf, Maciej Jan Dańko, Edyta Teresa Sadowska, Geoffrey Dheyongera, Paweł Koteja · 2017 · Experimental Gerontology
  95. Sestrin2 is a central regulator of mitochondrial stress responses in disease and aging
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  97. Alternative Mitochondrial Fuel Extends Life Span
    Elizabeth A. Schroeder, Gerald S. Shadel · 2012 · Cell Metabolism
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  99. Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease
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  100. Mechanisms of mitophagy: putting the powerhouse into the doghouse
    Joel S. Riley, Stephen W. G. Tait · 2016 · Biological Chemistry