Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
Open accessAbstract
Summary: Impaired insulin/ IGF 1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor ( IR ) in non‐neuronal tissues of adult mice on the lifespan. We induced hemizygous (Per IRKO +/− ) or homozygous (Per IRKO −/− ) disruption of the IR in peripheral tissue of 15‐weeks‐old mice using a tamoxifen‐inducible Cre transgenic mouse with only peripheral tissue expression, and subsequently monitored glucose metabolism, insulin signalling and spontaneous death rates over 4 years. Complete peripheral IR disruption resulted in a diabetic phenotype with increased blood glucose and plasma insulin levels in young mice. Although blood glucose levels returned to normal, and fat mass was reduced in aged Per IRKO −/− mice, their lifespan was reduced. By contrast, heterozygous disruption had no effect on lifespan. This was despite young male Per IRKO +/− mice showing reduced fat mass and mild increase in hepatic insulin sensitivity. In conflict with findings in metazoans like Caenorhabditis elegans and Drosophila melanogaster , our results suggest that heterozygous impairment of the insulin signalling limited to peripheral tissues of adult mice fails to extend lifespan despite increased systemic insulin sensitivity, while homozygous impairment shortens lifespan.
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The same metabolic phenotype was not observed when the insulin receptor was disrupted in liver, adipose, and muscle tissues of adult mice.
“Interestingly, the same phenotype was not observed when the insulin receptor was disrupted in liver, adipose and muscle tissues in adult mice29, denoting the complex role of the mammalian IIS pathway.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [29]
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Cites
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Self-citationDeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555 · see citing works
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854 · see citing works
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works
Self-citationIGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
Srere, P. A. (1969) · Methods in Enzymology · doi:10.1016/0076-6879(69)13005-0 · Cited by 2,005 · see citing works
Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works
The retardation of aging and disease by dietary restriction
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5101 · Cited by 1,477 · see citing works
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,348 · see citing works
Self-citationThe Endocrine Regulation of Aging by Insulin-like Signals
Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,327 · see citing works
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works
Self-citationSchulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209 · see citing works
Self-citationKulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148 · see citing works
Self-citationDwarf mice and the ageing process
Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works
Friedman, D. B., & Johnson, T. E. (1988) · Genetics · doi:10.1093/genetics/118.1.75 · Cited by 1,011 · see citing works
Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891 · see citing works
Lithgow, G. J., White, T. M., Melov, S., & Johnson, T. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7540 · Cited by 862 · see citing works
Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works
Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806 · see citing works
Self-citationWeindruch, R. H., & Walford, R. L. (1982) · Science · doi:10.1126/science.7063854 · Cited by 766 · see citing works
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703 · see citing works
Genetic analysis of ageing: role of oxidative damage and environmental stresses
Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 641 · see citing works
Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice <sup>1</sup>
Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611 · see citing works
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., José, P. A., Taylor, S. I., & Westphal, H. (1996) · Nature Genetics · doi:10.1038/ng0196-106 · Cited by 594 · see citing works
Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532 · see citing works
Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis
Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510 · see citing works
Timing Requirements for Insulin/IGF-1 Signaling in C. elegans
Dillin, A., Crawford, D. K., & Kenyon, C. J. (2002) · Science · doi:10.1126/science.1074240 · Cited by 467 · see citing works
Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.013 · Cited by 430 · see citing works
Self-citationHormonal regulation of hepatic glucose production in health and disease
Lin, H. V., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.003 · Cited by 429 · see citing works
Surgical removal of visceral fat reverses hepatic insulin resistance.
Barzilai, N., She, L., Liu, B. Q., Vuguin, P. M., Cohen, P., Wang, J., & Rossetti, L. (1999) · Diabetes · doi:10.2337/diabetes.48.1.94 · Cited by 373 · see citing works
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
Pawlikowska, L., Hu, D., Huntsman, S., Sung, A., Chu, C., Chen, J., Joyner, A. H., Schork, N. J., Hsueh, W., Reiner, A. P., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00493.x · Cited by 352 · see citing works
Central insulin action regulates peripheral glucose and fat metabolism in mice
Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 270 · see citing works
Self-citationCaloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
Barzilai, N., Banerjee, S., Hawkins, M. A., Chen, W., & Rossetti, L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci485 · Cited by 268 · see citing works
D-Glucosamine supplementation extends life span of nematodes and of ageing mice
Weimer, S., Priebs, J., Kuhlow, D., Groth, M., Priebe, S., Mansfeld, J., Merry, T. L., Dubuis, S., Laube, B., Pfeiffer, A. F. H., et al. (2014) · Nature Communications · doi:10.1038/ncomms4563 · Cited by 241 · see citing works
Self-citationVisceral adipose tissue modulates mammalian longevity
Muzumdar, R. H., Allison, D. B., Huffman, D. M., Ma, X., Atzmon, G., Einstein, F. H., Fishman, S., Poduval, A., McVei, T., Keith, S. W., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00391.x · Cited by 213 · see citing works
Influences of Aging and Dietary Restriction on Serum Thymosin l Levels in Mice
Weindruch, R., Naylor, P. H., Goldstein, A. L., & Walford, R. L. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.2.b40 · Cited by 207 · see citing works
Transgenic rescue of insulin receptor–deficient mice
Okamoto, H., Nakae, J., Kitamura, T., Park, B.-C., Dragatsis, I., & Accili, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421645 · Cited by 151 · see citing works
Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?
Bokov, A. F., Garg, N., Ikeno, Y., Thakur, S., Musi, N., DeFronzo, R. A., Zhang, N., Erickson, R. C., Gelfond, J., Hubbard, G. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026891 · Cited by 150 · see citing works
Katic, M., Kennedy, A. R., Leykin, I., Norris, A., McGettrick, A., Gesta, S., Russell, S. J., Bluher, M., Maratos‐Flier, E., & Kahn, C. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00346.x · Cited by 141 · see citing works
Self-citationLipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD
Softic, S., Boucher, J., Solheim, M. H., Fujisaka, S., Haering, M.-F., Homan, E. P., Winnay, J. N., Pérez‐Atayde, A. R., & Kahn, C. R. (2016) · Diabetes · doi:10.2337/db16-0213 · Cited by 129 · see citing works
Self-citationMartens, K., Bottelbergs, A., & Baes, M. I. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.061 · Cited by 100 · see citing works
Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice
Nojima, A., Yamashita, M., Yoshida, Y., Shimizu, I., Ichimiya, H., Kamimura, N., Kobayashi, Y., Ohta, S., Ishii, N., & Minamino, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069178 · Cited by 76 · see citing works
Merry, T. L., Tran, M., Stathopoulos, M., Wiede, F., Fam, B. C., Dodd, G. T., Clarke, I. J., Watt, M. J., Andrikopoulos, S., & Tiganis, T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5428 · Cited by 69 · see citing works
Self-citationCentral insulin action regulates peripheral glucose and fat metabolism in mice
Schinner, S. (2009) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(09)79310-2 · Cited by 48 · see citing works
Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity
Pomplun, D., Voigt, A., Schulz, T. J., Thierbach, R., Pfeiffer, A. F. H., & Ristow, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611631104 · Cited by 35 · see citing works
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
The aetiology and molecular landscape of insulin resistance
James, D. E., Stöckli, J., & Birnbaum, M. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00390-6 · Cited by 701 · see citing works
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Akbari, M., Kirkwood, T. B. L., & Bohr, V. A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100940 · Cited by 232 · see citing works
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Cignarelli, A., Genchi, V. A., Perrini, S., Natalicchio, A., Laviola, L., & Giorgino, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030759 · Cited by 222 · see citing works
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Statzer, C., Park, J. Y. C., & Ewald, C. (2023) · Aging and Disease · doi:10.14336/ad.2022.1116 · Cited by 75 · see citing works
Kazemi, A., Speakman, J. R., Soltani, S., & Djafarian, K. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.07.030 · Cited by 45 · see citing works
Reifsnyder, P. C., Flurkey, K., Doty, R. A., Calcutt, N. A., Koza, R. A., & Harrison, D. E. (2022) · Aging Cell · doi:10.1111/acel.13666 · Cited by 34 · see citing works
Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms
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Dakic, T. B., Jevdjovic, T. V., Vujovic, P. Z., & Mladenović, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126546 · Cited by 23 · see citing works
Hedges, C. P., Shetty, B., Broome, S. C., MacRae, C. L., Koutsifeli, P., Buckels, E. J., Macindoe, C., Boix, J., Tsiloulis, T., Matthews, B. G., et al. (2023) · Nature Aging · doi:10.1038/s43587-022-00349-y · Cited by 22 · see citing works
Self-citationMerry, T. L., Hedges, C. P., Masson, S. W. C., Laube, B., Pöhlmann, D., Wueest, S., Walsh, M. E., Arnold, M., Langhans, W., Konrad, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15623-z · Cited by 21 · see citing works
Self-citationReduced insulin signaling in neurons induces sex-specific health benefits
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Watanabe, K., Wilmanski, T. M., Baloni, P., Robinson, M., Garcia, G. G., Hoopmann, M. R., Midha, M. K., Baxter, D. H., Maes, M., Morrone, S. R., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05128-y · Cited by 20 · see citing works
Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., Mitchell, S. J., Zarse, K., Carreira, E. M., & Ristow, M. (2023) · Nature Communications · doi:10.1038/s41467-023-43672-7 · Cited by 20 · see citing works
Self-citationChanges of Signaling Pathways in Hypothalamic Neurons with Aging
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Bin, P., Zhu, C., Liu, S., Li, Z., Ren, W., & Zhu, G. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa028 · Cited by 16 · see citing works
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Hedges, C. P., Boix, J., Jaiswal, J. K., Shetty, B., Shepherd, P. R., & Merry, T. L. (2021) · Biomolecules · doi:10.3390/biom11020150 · Cited by 16 · see citing works
Self-citationMerry, T. L., MacRae, C. L., Pham, T., Hedges, C. P., & Ristow, M. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00426.2019 · Cited by 14 · see citing works
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Santo, E. E., Ribel‐Madsen, R., Stroeken, P. J. M., de Boer, V. C. J., Hansen, N. S., Commandeur, M., Vaag, A. A., Versteeg, R., Paik, J., & Westerhout, E. M. (2023) · Aging Cell · doi:10.1111/acel.13763 · Cited by 9 · see citing works
Zhang, X., Wang, L., Wang, Y., He, L., Xu, D., Yan, E., Guo, J., Ma, C., Zhang, P., & Yin, J. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01389-y · Cited by 9 · see citing works
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Ge, G., Ren, J., Song, G., Li, Q., & Cui, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511994 · Cited by 8 · see citing works
Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8 · see citing works
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Singh, A., Ghai, N., & Bedi, P. M. S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104806 · Cited by 8 · see citing works
Yamamoto, R., Palmer, M., Koski, H., Curtis-Joseph, N., & Tatar, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.30.180505 · Cited by 2 · see citing works
Harake, S. N. A., Abedin, Y., Hatoum, F., Nassar, N. Z., Ali, A., Nassar, A., Kanaan, A., Bazzi, S. I., Azar, S. T., Harb, F., et al. (2024) · Adipocyte · doi:10.1080/21623945.2024.2403380 · Cited by 1 · see citing works
Reduced insulin signalling in neurons induces sex-specific health benefitsPreprint
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- Authors
- Merry, T. L., Kuhlow, D., Laube, B., Pöhlmann, D., Pfeiffer, A. F. H., Kahn, C. R., Ristow, M., & Zarse, K.
- Affiliations
- University of Auckland (NZ)
- German Institute of Human Nutrition (DE)
- ETH Zurich (CH)
- Joslin Diabetes Center (US)
- Corresponding author
- Ristow, Michael
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2017-05-22
- Volume
- 16
- Issue
- 4
- Pages
- 761-772
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC5506415
- OpenAlex
- W2618151420
- Cited by
- 30
- References
- 50
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 4 · 2017: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- Bundesministerium für Bildung und Forschung (BMBF 0315581)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF 31003A_156031)
- Novartis Foundation (14C149)
- National Institutes of Health (NIH R01 DK031036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- insulin signaling, insulin receptor, lifespan extension, diabetes mellitus, glucose metabolism, fat mass, hepatic insulin sensitivity, aging
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Heterozygote, Homozygote, Insulin, Longevity, Male, Mutation, Receptor, Insulin, Signal Transduction, Gene Expression, Mice, Knockout, Integrases, Mice
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