Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.

Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849

Differential expression analysis for sequence count data

Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581

Health benefits of physical activity: the evidence

Warburton, D. E. R. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051351 · Cited by 8,007

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

Signal transduction by reactive oxygen species

Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109

Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis elegans

Cai, H., Rasulova, M., Vandemeulebroucke, L., Meagher, L., Vlaeminck, C., Dhondt, I., & Braeckman, B. P. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx013 · Cited by 13

Photodynamic treatment increases the lifespan and oxidative stress resistance of Caenorhabditis elegans

Nguyen, U. T. T., Youn, E., Le, T. A. N., Ha, N. M., Tran, S. H., Lee, S., Cha, J. W., Park, J., Kwon, H. C., & Kang, K. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.05.023 · Cited by 11

Shaping longevity early in life: developmental ROS and H3K4me3 set the clock

Oleson, B. J., Bazopoulou, D., & Jakob, U. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1986317 · Cited by 12

18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes

Kirkwood, J. S., Miranda, C. L., Bobe, G., Maier, C. S., & Stevens, J. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157118 · Cited by 11

Superoxide Dismutase (SOD) Genes and Aging in Drosophila

Tower, J. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-18326-8_3 · Cited by 11

Leveraging mitochondrial stress to improve healthy aging

Gorgori-González, A., Soto-Rodriguez, S., Tamayo-Torres, E., García-Domínguez, E., Sebastiá, V., Gambini, J., González, G. O., & Gómez‐Cabrera, M. C. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.10.003 · Cited by 13

Systems Biology Approaches in Aging Research

Chauhan, A., Liebal, U. W., Vera, J., Baltrusch, S., Junghanß, C., Tiedge, M., Fuellen, G., Olaf Wolkenhauer, A., & Köhling, R. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000364981 · Cited by 9

Mitochondria Inspire a Lifestyle

Krämer, P., & Bressan, P. (2019) · Advances in anatomy, embryology and cell biology · doi:10.1007/102_2018_5 · Cited by 10

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons

Guan, L., Zhan, Z., Yang, Y., Miao, Y., Huang, X., & Ding, M. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008704 · Cited by 10

Blumea laciniata protected Hep G2 cells and Caenorhabditis elegans against acrylamide-induced toxicity via insulin/IGF-1 signaling pathway

Zhou, L., Luo, S., Wang, X., Zhou, Y., Zhang, Y., Zhu, S., Chen, T., Feng, S., Yuan, M., & Ding, C. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112667 · Cited by 10

Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging

Shadel, G. S., & New Haven, C. 0.-8. (2014) · Microbial Cell · doi:10.15698/mic2014.05.143 · Cited by 10

An evidence-based approach to identify aging-related genes in Caenorhabditis elegans

Callahan, A., Cifuentes, J. J., & Dumontier, M. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0469-4 · Cited by 10

Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan

Grigolon, G., Araldi, E., Erni, R., Wu, J. Y., Thomas, C., Fortezza, M. L., Laube, B., Pöhlmann, D., Stoffel, M., Zarse, K., et al. (2022) · RePEc: Research Papers in Economics · doi:10.3929/ethz-b-000524798 · Cited by 12

Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies

Putman, A. K., Contreras, G. A., & Mottillo, E. P. (2023) · Antioxidants · doi:10.3390/antiox12010196 · Cited by 10

Activation of protein arginine methyltransferase 1 and subsequent extension of moth lifespan is effected by the ROS/JNK/CREB signaling axis

Zhang, X., Li, W., & Xu, W. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102950 · Cited by 9

A Morinda Officinalis Extracellular Vesicles‐Encapsulated Redox Homeostasis Modulatory Hydrogel Promotes Growth Plate Injury Repair by Regulating the Oxidative Stress Microenvironment

Li, J., Li, G., Guan, P., Tong, R., Feng, H., Ang, K., Kong, Z., Zhu, Z., Liu, C., Li, C., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202417743 · Cited by 9

The excessive response: a preparation for harder conditions

Ren, Y., & Zhang, C. (2017) · Protein & Cell · doi:10.1007/s13238-017-0454-y · Cited by 9

Design, synthesis and biological evaluation of novel nitric oxide donors with antioxidative activity

Liang, J., Zhang, P., Yang, H., Zhang, Y., Yao, T., Liu, K., Wang, Y., Zhang, X., & Qin, X. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114331 · Cited by 9

Could caveolae be acting as warnings of mitochondrial ageing?

Caravia, L. G., Dudău, M., Gherghiceanu, M., Tănase, C., & Enciu, A. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.04.003 · Cited by 10

Rapid and Nondestructive Detection of Proline in Serum Using Near‐Infrared Spectroscopy and Partial Least Squares

Zhu, K., Zhang, S., Yue, K., Zuo, Y., Niu, Y., Wu, Q., & Pan, W. (2022) · Journal of Analytical Methods in Chemistry · doi:10.1155/2022/4610140 · Cited by 9

l-Proline uptake in Saccharomyces cerevisiae mitochondria can contribute to bioenergetics during nutrient stress as alternative mitochondrial fuel

Pallotta, M. L. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1415-0 · Cited by 9

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans

Riedinger, C., Mendler, M., Schlotterer, A., Fleming, T. H., Okun, J. G., Hammes, H., Herzig, S., & Nawroth, P. P. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.805879 · Cited by 9

Biphasic Dose–Response Induced by PCB150 and PCB180 in HeLa Cells and Potential Molecular Mechanisms

Zehra, A., Hashmi, M. Z., Khan, A. M., Malik, T., & Abbas, Z. (2020) · Dose-Response · doi:10.1177/1559325820910040 · Cited by 10

Effects of proline on growth performance, protein synthesis and cold resistance in white shrimp (Litopenaeus vannamei)

Zou, D., Yang, M. J., Chen, Z., Lin, P., Li, Y., Liu, X., Tan, B., & Ye, C. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.06.002 · Cited by 8

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant

Traa, A., González, A. A. T., & Raamsdonk, J. M. V. (2024) · GeroScience · doi:10.1007/s11357-024-01276-z · Cited by 12

Subcellular Redox Signaling

Zhu, L., Lu, Y., Zhang, J., & Hu, Q. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_25 · Cited by 9

Mitochondria, Oxidative Stress, Cancer, and Aging

Pecorini, S., Gibellini, L., Biasi, S. D., Bianchini, E., Nasi, M., Cossarizza, A., & Pinti, M. (2020) · Springer eBooks · doi:10.1007/978-3-319-57415-8_80 · Cited by 8

Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

Hedges, C. P., Pham, T., Shetty, B., Masson, S. W. C., Hickey, A. J., Shepherd, P. R., & Merry, T. L. (2020) · Bioscience Reports · doi:10.1042/bsr20201128 · Cited by 8

The past-tense debate

Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8

Oxidative Stress

Braeckman, B. P., Back, P., & Matthijssens, F. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_10 · Cited by 8

Reduced Expression Level of the Cyclic Adenosine Monophosphate Response Element–Binding Protein Contributes to Lung Aging

Rolewska, P., Simm, A., Silber, R., & Bartling, B. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0057oc · Cited by 11

Intelligent responsive PVA hydrogel loaded with composite MXene nanozyme enables efficient myocardial infarction repair by disrupting the oxidative stress–inflammation cascade

Tong, J., Sun, D., Sun, J., Zhang, J., Chen, M., Liu, X., Zhang, R., Zhang, F., Zheng, C., Wei, Y., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102556 · Cited by 7

Mitochondria directly interact with the nuclear pore complex

Menendez-Montes, I., Marín‐Vicente, C., Mukherjee, S., Ahmed, M. S., Gomez, M. J., Anene-Nzelu, C. G., Lee, C. J. M., Koslowski, S., Solmonson, A., Tassin, T., et al. (2026) · Nature · doi:10.1038/s41586-026-10588-3 · Cited by 8

Mitochondrial targets exploration of epigallocatechin gallate and theaflavin in regards to differences in stress protection under different temperatures

Zhang, M., Li, B., & Tian, J. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109400 · Cited by 8

Glucose Load Following Prolonged Fasting Increases Oxidative Stress– Linked Response in Individuals With Diabetic Complications

von Rauchhaupt, E., Rodemer, C., Kliemank, E., Bulkescher, R., Campos, M., Kopf, S., Fleming, T., Herzig, S., Nawroth, P. P., Szendroedi, J., et al. (2024) · Diabetes Care · doi:10.2337/dc24-0209 · Cited by 7

3D Network exploration and visualisation for lifespan data

Hühne, R., Kessler, V., Fürstberger, A., Werle, S. D., Platzer, M., Sühnel, J., Lausser, L. M., & Kestler, H. A. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2393-x · Cited by 7

C. elegans protein interaction network analysis probes RNAi validated pro-longevity effect of nhr-6, a human homolog of tumor suppressor Nr4a1

Akhoon, B. A., Gupta, S. K., Tiwari, S., Rathor, L., Pant, A., Singh, N., Gupta, S. K., Dandekar, T., & Pandey, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-51649-0 · Cited by 7

Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging

Escudero, B., Lucas, D., Albo, C., Dhup, S., Bacher, J. W., Sánchez, A., Fernández, M., Rivera, J., Carmona, R. M., Fuster, E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093074 · Cited by 7

5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans

Ahmadi, M., & Roy, R. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_15 · Cited by 8

Hormesis in Health and Disease: Molecular Mechanisms

Meiliana, A., & Wijaya, A. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i4.1315 · Cited by 6

Redox Balance, Mitohormesis, and Organ Stress in Type 2 Diabetes Mellitus: Mechanistic Insights and the Therapeutic Role of SGLT2 Inhibitors

Otoda, T., Aihara, K., & Takayama, T. (2025) · Diabetology · doi:10.3390/diabetology6100111 · Cited by 7

The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction

Cornwell, A., Zhang, Y., Thondamal, M., Johnson, D. W., Thakar, J., & Samuelson, A. V. (2024) · GeroScience · doi:10.1007/s11357-024-01197-x · Cited by 6

β-fructofuranosidase regulation in silkworm silk gland development: Implications for silk gland morphogenesis and silk production

Sun, B., Zhang, H., Chen, C., Yan, J., Hong, J., Xu, J., Chen, K., & Sun, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138309 · Cited by 6

A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo

Dakhovnik, A., Mantovani, M., Knufinke, M., Brügger, V., Pramono, I. E., Statzer, C., Saravi, B., Demidenko, O., Budovskaya, Y. V., Rümmelein, C. B., et al. (2025) · npj Aging · doi:10.1038/s41514-025-00280-7 · Cited by 5

Multi‐Omics Analysis Reveals Photodynamic Therapy Ameliorating Skin Photoaging by Improving Cellular Senescence Through Mitohormesis‐Mediated Reduction of Citrate Content

Yan, Y., Chang, Q., Wu, Y., Zhao, Y., Yan, G., Cao, Z., Zhang, H., Wang, X., Zeng, Q., & Wang, P. (2025) · Aging Cell · doi:10.1111/acel.70328 · Cited by 5

Macauba ( Acrocomia aculeata ) pulp oil reduces fat accumulation and enhances the lifespan of Caenorhabditis elegans at low temperatures via fat‐1‐ and fat‐7 ‐dependent pathway

Ana, C. T. S., Ju, J., de Barros, F. A. R., & Kim, K. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17224 · Cited by 5

A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans

Admasu, T. D., Barardo, D., Ng, L. F., Batchu, K. C., Cazenave‐Gassiot, A., Wenk, M. R., & Gruber, J. (2021) · GeroScience · doi:10.1007/s11357-021-00374-6 · Cited by 6

The role of protein kinase R in placental inflammation, mtUPR and apoptosis

Kolaç, U. K., Dönmez, G., Karayel, R., & Yalçın, A. (2023) · Placenta · doi:10.1016/j.placenta.2023.07.007 · Cited by 5

Superoxide signal orchestrates tetrathiomolybdate-induced longevity via ARGK-1 in Caenorhabditis elegans

Zhou, Y., Zhang, M., Lu, S., Liu, L., Duan, Z., Wei, F., & Li, G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.014 · Cited by 5

Zein nanoparticles extend lifespan in C. elegans and SAMP8 mice

Martínez‐López, A. L., Reboredo, C., González-Navarro, C. J., Solas, M., Puerta, E., Ramírez, M. J., Vizmanos, J. L., & Irache, J. M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124798 · Cited by 4

Metabolic shifts in murine inner ears mimicking erythrocytes and plasma reveal diagnostics and early predictors for age-related hearing loss

Guo, Q., Li, Z., Luo, C., Chen, C., Long, X., Wang, Y., Qiang, Q., Fang, Y., Liu, W., Zhang, Y., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113285 · Cited by 4

An emerging role for cysteine-mediated redox signaling in aging

Jin, M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103852 · Cited by 6

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism

Chen, P. X., Zhang, L., Wu, X., Liang, Z., Hao, X., Zhu, Q., Liu, Y., Zheng, J., Zhang, Q., Yang, Q., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01452-9 · Cited by 4

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

Chivite, Í., Monelli, E., Munar-Gelabert, M., Gómez-Valadés, A. G., Alvarado-Diaz, A., Pozo, M., Varela, L. C., Ramírez, S., Haddad-Tóvolli, R., Toledo, M., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.01.012 · Cited by 6

The hallmarks of protein and amino acid restriction in aging and longevity

Knopf, B. A., & Lamming, D. W. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100079 · Cited by 4

Intestine-specific disruption of mitochondrial superoxide dismutase extends longevity

Liontis, T., Senchuk, M. M., Zhu, S., Jacob‐Tomas, S., Anglas, U., Traa, A., Soo, S. K., & Raamsdonk, J. M. V. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.032 · Cited by 4

Synthetic mitochondria as therapeutics against systemic aging: a hypothesis

Tang, B. L. (2014) · Cell Biology International · doi:10.1002/cbin.10362 · Cited by 4

Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels

Bresilla, D., Tawfik, I., Hirtl, M., Gabrijelčič, S., Ostaku, J., Mossegger, F., Wurzer, L., Lederer, S., Kalinová, K., Malle, E., et al. (2025) · Aging Cell · doi:10.1111/acel.70247 · Cited by 4

Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice

Sun, X., Liu, S., Cai, J., Yang, M., Li, C., Tan, M., & He, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065999 · Cited by 4

Antioxidant activity and protective effect of hydroxy derivatives of chalcones for sterlet (Acipenser ruthenus, Linnaeus, 1758) sperm

Osipova, V. P., Kolyada, M. N., Polovinkina, M. A., Kolumbet, A. D., Ponomareva, E. N., & Великородов, А. В. (2025) · Cryobiology · doi:10.1016/j.cryobiol.2024.105193 · Cited by 3

Mitochondrial modulators

Naumova, N., Koliada, A. K., Kuzub, N., & Vaiserman, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00012-6 · Cited by 3

Role of Oxidative Stress in Aging

Knoefler, D., Tienson, H. L., & Jakob, U. (2013) · Springer eBooks · doi:10.1007/978-94-007-5787-5_14 · Cited by 3

Aging: The Blurry Line between Life and Death

Liu, J. C., & Finkel, T. (2014) · Current Biology · doi:10.1016/j.cub.2014.05.057 · Cited by 4

Mitochondrial theory of skeletal muscle ageing –new facts, new doubts

Słodki, S., & Bogucka, J. (2019) · Journal of Veterinary Research · doi:10.2478/jvetres-2019-0015 · Cited by 4

Molecular Targets and Novel Therapeutics to Target Oxidative Stress in Cardiovascular Diseases

Dhawan, V., Bakshi, C., & Rather, R. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_4 · Cited by 3

Fasting requires Peroxiredoxin 2 and Peroxiredoxin 6 to coordinate redox dependent mitochondrial and lipid remodelling in Caenorhabditis elegans

Li, P., Zheng, Y., Casas-Martinez, J. C., Xia, Q., Miranda‐Vizuete, A., Goljanek‐Whysall, K., & McDonagh, B. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104231 · Cited by 3

Preliminary study of low-dose photodynamic therapy on the oxidative stress response of Cutibacterium acnes

He, S.-X., Huang, X., Zou, T., Wang, Q., Wang, Y., Cheng, S., Liu, G., Ye, J., & Liu, W. (2023) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2023.103854 · Cited by 2

Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in C. elegans

Zhang, H., Lan, H.-Q., Wang, M., Wang, C., Wei, L.-G., & Xu, C. (2024) · Metabolites · doi:10.3390/metabo14120716 · Cited by 2

Cellular lifespan and senescence: a complex balance between multiple cellular pathways

Dolivo, D., Hernandez, S. J., & Dominko, T. (2015) · Inside the Cell · doi:10.1002/icl3.1036 · Cited by 3

From pathogen to a commensal: modification of the Microbacterium nematophilum-C. elegans interaction during chronic infection by the absence of host insulin signalling

Gravato-Nobre, M. J., Hodgkin, J., & Ligoxygakis, P. (2020) · Biology Open · doi:10.1242/bio.053504 · Cited by 2

An insulin, AMPK, and steroid hormone-mediated metabolic switch regulates the transition between growth and diapause in C. elegansPreprint

Penkov, S., Raghuraman, B. K., Erkut, C., Oertel, J., Galli, R., Ackerman, E. J. M., Vorkel, D., Verbavatz, J., Koch, E., Fahmy, K., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/323956 · Cited by 2

Royalactin induces copious longevity via increased translation and proteasome activity in C . elegansPreprint

Detienne, G., de Walle, P. V., Haes, W. D., Cockx, B., Braeckman, B. P., Schoofs, L., & Temmerman, L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/421818 · Cited by 2

Mapping Drosophila insulin receptor structure to the regulation of aging through analysis of amino acid substitutionsPreprint

Yamamoto, R., Palmer, M., Koski, H., Curtis-Joseph, N., & Tatar, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.30.180505 · Cited by 2

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutantPreprint

Traa, A., & Raamsdonk, J. M. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.07.579360 · Cited by 2

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts

Shen, L., & Karner, C. M. (2022) · Journal of Visualized Experiments · doi:10.3791/62995 · Cited by 2

Accumulation of proline in vegetative organs of Triticum aestivum (Poaceae) under drought conditions in the early phases of development: a meta-analysis of data

Kolupaev, Y. E., Shkliarevskyi, M. A., & Intego Group, 8. M. S. (2025) · Ukrainian Botanical Journal · doi:10.15407/ukrbotj82.04.277 · Cited by 1

The 1 –Cys peroxiredoxin, PRDX-6, suppresses an NHR-49-dependent pro-survival response, including the Flavin monooxygenase, FMO-2, that protects against fungal and bacterial infection

Button, E. L., Dwyer, E., Lewis, J. B., Mortensen, M. S., McDonald, E., Butler, E., Pearson, F., Tang, A. E., Watts, J. L., & Veal, E. A. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103992 · Cited by 2

Proline metabolism supports the hepatocellular carcinoma cell survival by mitigating ROS generation under nutrient starvation

Mo, J., Liu, Z., Fu, J., 葛起超, Qu, Y., Ge, N., & Liu, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153392 · Cited by 1

Nematode gut microbiota confers cadmium tolerance through microbial-dependent activation of detoxification and innate immune pathways

Zheng, F., Gao, J., Han, X., Kang, S. K., Zhou, T., Zhu, D., Neilson, R., Zhang, Z., & Chen, B. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.05.035 · Cited by 1

The lifespan and healthspan extending effects of ellagic acid in Caenorhabditis elegans require an intact insulin/IGF-1 signaling pathway

Xu, L., Li, J., Li, A., Chen, J., Wang, L., Shan, Y., & Cheng, X. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1811330 · Cited by 1

Facilitative glucose transporter and its regulation by insulin/IGF-like signaling in Caenorhabditis elegans

Kitaoka, S. (2015) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1

Assignment of Orthologous Genes by Utilization of Multiple Databases - The Orthology Package in R

Priebe, S., & Menzel, U. (2013) · International Conference on Bioinformatics Models, Methods and Algorithms (BIOINFORMATICS) · doi:10.5220/0004193201050110 · Cited by 1

Dimethylsulfoniopropionate (DMSP) Increases Longevity and Mitochondrial Function in Caenorhabditis elegans: Implications for the Role of the Global Sulfur Cycle in Terrestrial Ecosystems

Li, H., Ji, P., Cao, Y., Cui, Z., Gao, J., Wang, H., Lin, C., Wang, Y., & Wang, X. (2024) · Environment & Health · doi:10.1021/envhealth.3c00208 · Cited by 1

Widespread changes in gene expression accompany body size evolution in nematodes

Woodruff, G., Willis, J. H., Johnson, E., & Phillips, P. C. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae110 · Cited by 1

Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina

Xue, Y., Xue, B., & Zhang, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169111 · Cited by 1

Analysis of the role of tryptophan-kynurenine pathway in the life span control in Drosophila melanogaster

Gorenskaya, O. V., & Navrotskaya, V. (2019) · Faktori eksperimental noi evolucii organizmiv · doi:10.7124/feeo.v25.1135 · Cited by 4

Impact of Caenorhabditis elegans in Cancer Drug Resistance Development

Shanmugam, G., Kannan, S., & Senthilkumar, K. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_16 · Cited by 1

Introduction and reconciliation of the ROS and aging paradoxesPreprint

Ren, Y., & Zhang, C. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1710.10391 · Cited by 1

Friend or Foe

Annis, S., Safdar, A., Biala, E., Saleem, A., Li, H., Gandhi, P., Fleischmann, Z., Castaneda‐Sceppa, C., Tilly, J. L., Woods, D. C., et al. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch31 · Cited by 1

Mitohormetic effects of rotenone drastically depend on agePreprint

Baumgart, M., Ugolini, M., Groth, M., Platzer, M., & Cellerino, A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/528547 · Cited by 1

Mitochondria Inspire a LifestylePreprint

Krämer, P., & Bressan, P. (2018) · doi:10.31234/osf.io/t49eg · Cited by 2

Proline Maintains the Proliferation of Hepatocellular Carcinoma Cells by Decreasing Intracellular Oxidative Stress and Reducing Autophagy During Acute Nutrient StressPreprint

Liu, Z., Li, X., Ge, Q., Yang, F., Sun, S., & Ge, N. (2023) · Research Square · doi:10.21203/rs.3.rs-2777810/v1 · Cited by 1

Sequestration of oxidative is necessary but not sufficient enough to conclude dopaminergic neuroprotective efficacy of curcumin: Insights from ALSS Drosophila Parkinson’s disease modelPreprint

Phom, L., Modi, P., Das, A., & Yenisetti, S. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.19.613867 · Cited by 1

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans

Rudich, Z. D., Guan, J., González, A. A. T., Booth, G. F., Soo, S. K., Anglas, U., Mistry, M., Senchuk, M. M., & Raamsdonk, J. M. V. (2026) · eLife · doi:10.7554/elife.112139 · Cited by 1

The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · DSpace@MIT (Massachusetts Institute of Technology)

A prolinemia como um fator de severidade na infecção causada pelo Trypanosoma cruzi.

Rocha, S. C. (2016) · doi:10.11606/t.42.2016.tde-14032016-104826

Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of

Monteoliva, M. I., Rizzi, Y. S., Cecchini, N. M., Hajirezaei, M., & Álvarez, M. E. (2014)

Integration of Metabolic Signals

Lynn, D. A., & Curran, S. P. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_17

Genomics and Epigenomics of Common Human Metabolic and Heart Disease

Multhaup, M. (2015)

Regulation of In Vivo Mitochondrial Energetics by Oxidative Stress throughout Life: A Multi-Modal Spectroscopy Approach

Siegel, M. P. (2012) · ResearchWorks at the University of Washington (University of Washington)

Alternative Mitochondrial Fuel Extends Life Span

Schroeder, E. A., & Shadel, G. S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.011 · Cited by 12

Lifespan extension in Caenorhabditis elegans insulin/IGF-1 signalling mutants is supported by non-vertebrate physiological traits

Braeckman, B. P., & Dhondt, I. (2017) · Nematology · doi:10.1163/15685411-00003060 · Cited by 4

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

Feng, J., Bussière, F., & Hekimi, S. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00071-5 · Cited by 675

Having the Nerve to Go On

(2000) · Science Signaling · doi:10.1126/scisignal.532000tw9

Combined Downregulation of Insulin and Mitochondrial Signaling Leads to Synergistic Life- and Healthspan Extension in Caenorhabditis Elegans

Emans, S. W., Sthur, N., DiPaola, S., Nathwani, Z., & Soukas, A. A. (2025) · Innovation in Aging · doi:10.1093/geroni/igaf122.968