Cited by 430Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

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Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

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Zarse, Kim, Schmeisser, Sebastian, Groth, Marco, Priebe, Steffen, Beuster, Gregor, Kuhlow, Doreen, Guthke, Reinhard, Platzer, Matthias, Kahn, C. Ronald, Ristow, Michael·2012·Cell Metabolism

DOI 10.1016/j.cmet.2012.02.013PMC PMC4844853

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Abstract

Impaired insulin and IGF-1 signaling (iIIS) in C. elegans daf-2 mutants extends life span more than 2-fold. Constitutively, iIIS increases mitochondrial activity and reduces reactive oxygen species (ROS) levels. By contrast, acute impairment of daf-2 in adult C. elegans reduces glucose uptake and transiently increases ROS. Consistent with the concept of mitohormesis, this ROS signal causes an adaptive response by inducing ROS defense enzymes (SOD, catalase), culminating in ultimately reduced ROS levels despite increased mitochondrial activity. Inhibition of this ROS signal by antioxidants reduces iIIS-mediated longevity by up to 60%. Induction of the ROS signal requires AAK-2 (AMPK), while PMK-1 (p38) and SKN-1 (NRF-2) are needed for the retrograde response. IIIS upregulates mitochondrial L-proline catabolism, and impairment of the latter impairs the life span-extending capacity of iIIS while L-proline supplementation extends C. elegans life span. Taken together, iIIS promotes L-proline metabolism to generate a ROS signal for the adaptive induction of endogenous stress defense to extend life span.

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Authors: Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M.
Affiliations: Joslin Diabetes Center (US)
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Friedrich Schiller University Jena (DE)
German Institute of Human Nutrition (DE)
Corresponding author: Ristow, Michael
ORCID: Zarse, Kim
Schmeisser, Sebastian
Groth, Marco
Platzer, Matthias
Kahn, C. Ronald
Ristow, Michael
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2012-04
Volume: 15
Issue: 4
Pages: 451-465
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2012.02.013
PMC: PMC4844853
OpenAlex: W2027977649
Cited by: 430
References: 73
Citations by year: 2026: 13 · 2025: 20 · 2024: 28 · 2023: 17 · 2022: 28 · 2021: 36 · 2020: 26 · 2019: 31 · 2018: 27 · 2017: 31 · 2016: 40 · 2015: 41 · 2014: 50 · 2013: 28 · 2012: 12
FWCI: 13.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 472 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Center for Research Resources
University of Minnesota
Deutsche Forschungsgemeinschaft (RI 1976/3-1)
Bundesministerium für Bildung und Forschung (0315581, DK31036, DK33201)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: insulin/IGF-1 signaling, lifespan extension, reactive oxygen species, mitohormesis, daf-2, AMPK, p38 MAPK, SKN-1, antioxidant defense, antioxidants, glucose uptake, Caenorhabditis elegans, longevity
MeSH terms: Animals, Antioxidants, Glucose, Insulin, Insulin-Like Growth Factor I, Longevity, Mitochondria, Proline, Stress, Physiological, Signal Transduction, Caenorhabditis elegans, Reactive Oxygen Species, Gene Expression Profiling, Models, Animal, Caenorhabditis elegans Proteins, Mice, Transcriptome

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Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

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