The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster
Open accessAbstract
Summary Changes in fat content have been associated with dietary restriction (DR), but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shift their metabolism towards increasing both fatty acid synthesis and breakdown, which is required for various responses to DR. Inhibition of fatty acid synthesis or oxidation genes specifically in the muscle tissue inhibited lifespan extension upon DR. Furthermore, DR enhances spontaneous activity of flies which was found to be dependent on the enhanced fatty acid metabolism. This increase in activity was found to be at least partially required for the lifespan extension upon DR. Over-expression of adipokinetic hormone (dAKH), the functional ortholog of glucagon, enhances fat metabolism, spontaneous activity and lifespan. Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR.
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Skeletal muscle triglyceride levels are inversely related to insulin action
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Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
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Fat maintenance is a predictor of the murine lifespan response to dietary restriction
Liao, C., Rikke, B. A., Johnson, T. E., Gelfond, J. A. L., Diaz, V., & Nelson, J. F. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00702.x · Cited by 120 · cited 3×
“, 1984), the ability to maintain adipose tissue levels correlates with life-span extension upon caloric restriction in mice (Liao et al., 2011).”
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Kapahi, P., Kaeberlein, M., & Hansen, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.005 · Cited by 340
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The influence of skeletal muscle on systemic aging and lifespan
Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Aging Cell · doi:10.1111/acel.12126 · Cited by 238
Self-citationMechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
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Metadata
- Authors
- Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S., & Kapahi, P.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 16
- Issue
- 1
- Pages
- 97-103
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2048092161
- Cited by
- 168
- References
- 5
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S., & Kapahi, P. (2012). Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.06.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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