The influence of skeletal muscle on systemic aging and lifespan

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

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Muscles, exercise and obesity: skeletal muscle as a secretory organ

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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

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Wasting as independent risk factor for mortality in chronic heart failure

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Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

Hwangbo, D., Gersham, B., Tu, M., Palmer, M., & Tatar, M. (2004) · Nature · doi:10.1038/nature02549 · Cited by 954 · see citing works

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

Zhou, X., Wang, J. L., Lu, J., Song, Y., Kwak, K. S., Jiao, Q., Rosenfeld, R., Chen, Q., Boone, T. C., Simonet, W. S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.011 · Cited by 941 · see citing works

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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Induction of Cachexia in Mice by Systemically Administered Myostatin

Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P. A., Esquela‐Kerscher, A., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., & Lee, S. (2002) · Science · doi:10.1126/science.1069525 · Cited by 908 · see citing works

Skeletal Muscle Strength as a Predictor of All-Cause Mortality in Healthy Men

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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

Libina, N., Berman, J. R., & Kenyon, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00889-4 · Cited by 820 · see citing works

REGULATION OF MUSCLE MASS BY MYOSTATIN

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Association between muscular strength and mortality in men: prospective cohort study

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Genetic Analysis of Tissue Aging in <i>Caenorhabditis elegans</i> : A Role for Heat-Shock Factor and Bacterial Proliferation

Garigan, D., Hsu, A.-L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Genetics · doi:10.1093/genetics/161.3.1101 · Cited by 803 · see citing works

Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running

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Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.

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FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656 · see citing works

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

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The Q System: A Repressible Binary System for Transgene Expression, Lineage Tracing, and Mosaic Analysis

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JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling

Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 537 · see citing works

Interleukin-6 and Diabetes

Kristiansen, O. P., & Mandrup-Poulsen, T. R. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s114 · Cited by 525 · see citing works

Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works

Smad2 and 3 transcription factors control muscle mass in adulthood

Sartori, R., Milan, G., Patron, M., Mammucari, C., Blaauw, B., Abraham, R., & Sandri, M. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00104.2009 · Cited by 517 · see citing works

Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content

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Inhibition of myostatin in adult mice increases skeletal muscle mass and strength

Whittemore, L.-A., Song, K., Li, X., Aghajanian, J. D., Davies, M. V., Girgenrath, S., Hill, J. J., Jalenak, M., Kelley, P. E., Knight, A., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02953-4 · Cited by 503 · see citing works

Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in

Gargano, J. W., MARTIN, I., Bhandari, P., & Grotewiel, M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.02.005 · Cited by 494 · see citing works

Penetration of interleukin-6 across the murine blood-brain barrier

Banks, W. A., Kastin, A. J., & Gutierrez, E. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90933-4 · Cited by 485 · see citing works

Untitled work

Nair (2005) · doi:10.1093/ajcn/81.5.953 · Cited by 469 · see citing works

Lack of myostatin results in excessive muscle growth but impaired force generation

Amthor, H., Macharia, R., Navarrete, R., Schuelke, M., Brown, S., Otto, A., Voït, T., Francesco Muntoni, A., Vrbovà, G., Partridge, T. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604893104 · Cited by 425 · see citing works

FGF21 is an Akt‐regulated myokine

Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works

Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis

Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336834 · Cited by 406 · see citing works

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity

Guo, T., Jou, W., Chanturiya, T., Portas, J., Gavrilova, O., & McPherron, A. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004937 · Cited by 402 · see citing works

Dietary restriction in Drosophila

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Endocrine regulation of ageing

Russell, S. J., & Kahn, C. R. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2234 · Cited by 356 · see citing works

A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

Aoi, W., Naito, Y., Takagi, T., Tanimura, Y., Takanami, Y., Kawai, Y., Sakuma, K., Hang, L. P., Mizushima, K., Hirai, Y., et al. (2013) · Gut · doi:10.1136/gutjnl-2011-300776 · Cited by 347 · see citing works

Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism

Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338 · see citing works

Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works

Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309 · see citing works

Dynamics of the skeletal muscle secretome during myoblast differentiation

Henningsen, J., Rigbolt, K. T. G., Blagoev, B., Pedersen, B. K., & Kratchmarova, I. (2010) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m110.002113 · Cited by 303 · see citing works

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

Wang, Y., Michikawa, Y., Mallidis, C., Bai, Y., Woodhouse, L. J., Yarasheski, K. E., Miller, C. A., Askanas, V., Engel, W. K., Bhasin, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061013598 · Cited by 272 · see citing works

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

Haidet, A. M., Rizo, L., Handy, C. R., Umapathi, P., Eagle, A., Shilling, C., Boué, D. R., Martin, P. T., Sahenk, Z., Mendell, J. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709144105 · Cited by 267 · see citing works

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

Grumati, P., Coletto, L., Schiavinato, A., Castagnaro, S., Bertaggia, E., Sandri, M., & Bonaldo, P. (2011) · Autophagy · doi:10.4161/auto.7.12.17877 · Cited by 267 · see citing works

Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth

Hojman, P., Dethlefsen, C., Brandt, C., Hansen, J., Pedersen, L., & Pedersen, B. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00520.2010 · Cited by 259 · cited 2× · see citing works

Physical Exercise Protects Against Alzheimer's Disease in 3xTg-AD Mice

García‐Mesa, Y., López, J. C., Giménez‐Llort, L., Revilla, S., Guerra, R., Gruart, A., LaFerla, F. M., Cristòfol, R. M., Delgado-Garcia, J. M., & Sanfeliu, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101635 · Cited by 253 · see citing works

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

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Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

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Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects

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Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse

Hakimi, P., Yang, J., Casadesús, G., Massillon, D., Tolentino‐Silva, F., Nye, C. K., Cabrera, M. E., Hagen, D., Utter, C. B., Baghdy, Y., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706127200 · Cited by 200 · see citing works

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

Stenesen, D., Suh, J. M., Seo, J. H., Yu, K., Lee, K., Kim, J.-S., Min, K., & Graff, J. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.006 · Cited by 192 · see citing works

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans

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Musclin, a novel skeletal muscle-derived secretory factor

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Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training

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Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice

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Physical activity and fitness

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Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

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Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

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LIF is a contraction-induced myokine stimulating human myocyte proliferation

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Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance

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Regulation of muscle atrophy in aging and disease

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Prolonged absence of myostatin reduces sarcopenia

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Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism.

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Exercise Increases Average Longevity of Female Rats Despite Increased Food Intake and No Growth Retardation

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Metabolic Functions of Myostatin and GDF11

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Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation

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Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency

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Effects of myostatin deletion in aging mice

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Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins

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Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease

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Specific age related signatures in Drosophila body parts transcriptome

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Born to Run

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IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice

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Differential patterns of apoptosis in response to aging in <i>Drosophila</i>

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Myostatin expression in age and denervation-induced skeletal muscle atrophy.

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Flight Activity, Mortality Rates, and Lipoxidative Damage in Drosophila

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A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila

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FGF21: a novel prospect for the treatment of metabolic diseases.

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Dissociation between functional senescence and oxidative stress resistance in Drosophila

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Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

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Born to run; the story of the PEPCK-Cmus mouse

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Age‐Related Modifications in Circulating IL‐15 Levels in Humans

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Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

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