The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner
Open accessAbstract
AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to improved intestinal homeostasis during aging and extended lifespan. Neuronal upregulation of the autophagy-specific protein kinase Atg1 is both necessary and sufficient to induce these intertissue effects during aging and to prolong the lifespan. Furthermore, upregulation of AMPK in the adult intestine induces autophagy both cell autonomously and non-cell-autonomously in the brain, slows systemic aging, and prolongs the lifespan. We show that the organism-wide response to tissue-specific AMPK/Atg1 activation is linked to reduced insulin-like peptide levels in the brain and a systemic increase in 4E-BP expression. Together, these results reveal that localized activation of AMPK and/or Atg1 in key tissues can slow aging in a non-cell-autonomous manner.
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1 retracted
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Cited by
Biological Functions of Autophagy Genes: A Disease Perspective
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Autophagy in healthy aging and disease
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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
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Autophagy as a promoter of longevity: insights from model organisms
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Self-citationSleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
Metadata
- Authors
- Ulgherait, M., Rana, A., Rera, M., Graniel, J., & Walker, D. W.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 8
- Issue
- 6
- Pages
- 1767-1780
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2006776535
- Cited by
- 306
- References
- 56
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ulgherait, M., Rana, A., Rera, M., Graniel, J., & Walker, D. W. (2014). AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Reports. https://doi.org/10.1016/j.celrep.2014.08.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
