The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance
Open accessAbstract
Summary Resveratrol has been reported to improve metabolic function in metabolically-abnormal rodents and humans, but has not been studied in non-obese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in non-obese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation increased plasma resveratrol concentration, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically-labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, Sirt1, Nampt, and Pgc-1α, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in non-obese, postmenopausal women with normal glucose tolerance.
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Resveratrol improves health and survival of mice on a high-calorie diet
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972
Self-citationNutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.035 · Cited by 950
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Spermidine in health and disease
Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154
Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.005 · Cited by 886
“…clamp procedure conducted in conjunction with infusion of stable isotopically labeled tracers) and an increase in both systemic and adipose tissue markers of inflammation (compared with a group of lean adults that we studied previously) (Yoshino et al., 2012) (Table S1 and Figure S3).”
InfluentialSelf-citationInterventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592
“Resveratrol has had mixed efficacy, in that its insulin-sensitizing effects (Ghanim et al. , 2011; Smoliga et al. , 2011) and DR-like phenotypes have been observed in elderly and obese humans (Timmers et al. , 2011), but not in nonobese subjects with normal glucose tolerance (Yoshino et al. , 2012).”
Self-citationMuraki, I., Imamura, F., Manson, J. E., Hu, F. B., Willett, W. C., van Dam, R. M., & Sun, Q. (2013) · BMJ · doi:10.1136/bmj.f5001 · Cited by 544
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 532
Metadata
- Authors
- Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S.-I., Schechtman, K. B., Gu, C., Kunz, I., Fanelli, F. R., Patterson, B. W., & Klein, S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 16
- Issue
- 5
- Pages
- 658-664
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1984225039
- Cited by
- 380
- References
- 7
- FWCI
- 19.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S.-I., Schechtman, K. B., Gu, C., Kunz, I., Fanelli, F. R., Patterson, B. W., & Klein, S. (2012). Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.09.015
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