The DOI matches its Crossref record; 31 of the 33 references it cites were found in a registry or an index.
Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance
Open accessAbstract
The steady-state concept of Na(+) homeostasis, based on short-term investigations of responses to high salt intake, maintains that dietary Na(+) is rapidly eliminated into urine, thereby achieving constant total-body Na(+) and water content. We introduced the reverse experimental approach by fixing salt intake of men participating in space flight simulations at 12 g, 9 g, and 6 g/day for months and tested for the predicted constancy in urinary excretion and total-body Na(+) content. At constant salt intake, daily Na(+) excretion exhibited aldosterone-dependent, weekly (circaseptan) rhythms, resulting in periodic Na(+) storage. Changes in total-body Na(+) (±200-400 mmol) exhibited longer infradian rhythm periods (about monthly and longer period lengths) without parallel changes in body weight and extracellular water and were directly related to urinary aldosterone excretion and inversely to urinary cortisol, suggesting rhythmic hormonal control. Our findings define rhythmic Na(+) excretory and retention patterns independent of blood pressure or body water, which occur independent of salt intake.
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“primates including humans clearly possess hormonal cycles with monthly periodicity”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [89]
In the citing paper
“Recent data from human males who were kept isolated in a highly controlled environment indicates that such hormonal cycles are not limited to females, but can occur in males as well (89)”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [89]
Citations
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Background23 Na Magnetic Resonance Imaging of Tissue Sodium
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2 of the 33 references couldn’t be matched to a known paper.
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He, F. J., Tan, M., Ma, Y., & MacGregor, G. A. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.055 · Cited by 589
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Role of “Western Diet” in Inflammatory Autoimmune Diseases
Manzel, A., Müller, D. N., Hafler, D. A., Erdman, S. E., Linker, R. A., & Kleinewietfeld, M. (2013) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0404-6 · Cited by 477
Metadata
- Authors
- Rakova, N., Jüttner, K., Dahlmann, A., Schröder, A., Linz, P., Kopp, C., Rauh, M., Goller, U., Beck, L., Agureev, A., Vassilieva, G., Lenkova, L., Johannes, B., Wabel, P., Moissl, U., Vienken, J., Gerzer, R., Eckardt, K.-U., Müller, D. N., Kirsch, K., Morukov, B., Luft, F. C., & Titze, J.
- Affiliations
- Russian Academy of Sciences (RU)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- Fresenius Medical Care (Germany) (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Vanderbilt University (US)
- Corresponding author
- Titze, Jens
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 17
- Issue
- 1
- Pages
- 125-131
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1975967728
- Cited by
- 328
- References
- 33
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 28 · 2021: 37 · 2020: 25 · 2019: 37 · 2018: 25 · 2017: 38 · 2016: 25 · 2015: 33 · 2014: 23 · 2013: 12
- FWCI
- 28.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- elib (German Aerospace Center) (submittedVersion)
- Funders
- Bundesministerium für Wirtschaft und Technologie
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
- Keywords
- sodium homeostasis, infradian rhythms, circaseptan rhythm, sodium excretion, aldosterone, cortisol, salt restriction, extracellular water
- MeSH terms
- Adult, Aldosterone, Blood Pressure, Humans, Hydrocortisone, Ions, Male, Periodicity, Sodium, Sodium Chloride, Dietary, Space Simulation
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