The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production
Open accessAbstract
Proper control of hepatic glucose production is central to whole body glucose homeostasis and its disruption plays a major role in diabetes. Here we demonstrate that, although established as an intracellular lipid chaperone, aP2 is in fact actively secreted from adipocytes to regulate liver glucose metabolism. Fasting and lipolysisrelated signals regulate secretion of aP2 from adipocytes, and circulating aP2 levels are markedly elevated in mouse and human obesity. Recombinant aP2 stimulates glucose production and gluconeogenic activity in primary hepatocytes in vitro and in lean mice in vivo. In contrast, neutralization of secreted aP2 reduces glucose production and corrects the diabetic phenotype of obese mice. Hyperinsulinemiceuglycemic and pancreatic clamp studies demonstrated actions of aP2 in liver upon aP2 administration or neutralization. We conclude that aP2 is a novel adipokine linking adipocytes to hepatic glucose production and that neutralizing secreted aP2 may represent an effective therapeutic strategy for diabetes.
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Cites
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“In addition, adipose tissue is also an important endocrine organ responsible for systemic metabolic regulation (Rosen and Spiegelman, 2006).”
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Furuhashi, M., & Hotamisligil, G. S. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2589 · Cited by 1,785
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25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men<subtitle>A Prospective Study</subtitle>
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Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
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Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
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Cited by
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
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Metabolic functions of FABPs—mechanisms and therapeutic implications
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Adipocytokines in Obesity and Metabolic Disease
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The endocrine function of adipose tissues in health and cardiometabolic disease
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Metadata
- Authors
- Cao, H., Sekiya, M., Ertunc, M. E., Burak, M. F., Mayers, J. R., White, A., Inouye, K., Rickey, L. M., Ercal, B. C., Furuhashi, M., Tuncman, G., & Hotamisligil, G. S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 17
- Issue
- 5
- Pages
- 768-778
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2002789245
- Cited by
- 274
- References
- 38
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production. https://app.cochat.ai/papers/10.1016/j.cmet.2013.04.012
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- Cao, H., Sekiya, M., Ertunc, M. E., Burak, M. F., Mayers, J. R., White, A., Inouye, K., Rickey, L. M., Ercal, B. C., Furuhashi, M., Tuncman, G., & Hotamisligil, G. S. (2013). Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.04.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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