Metabolic Pitfalls of CNS Cre-Based Technology

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

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Generalized lacZ expression with the ROSA26 Cre reporter strain

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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

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Genetic transformation of mouse embryos by microinjection of purified DNA.

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Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

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Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

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Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

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Talking about a Revolution

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Bacteriophage P1 site-specific recombination

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Immune responses to gene therapy vectors: influence on vector function and effector mechanisms

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Neuronal PTP1B regulates body weight, adiposity and leptin action

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Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

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Fate mapping Nkx2.1‐lineage cells in the mouse telencephalon

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Introduction of a rabbit β-globin gene into the mouse germ line

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Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

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Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

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Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

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Epithelial-Specific Cre/lox Recombination in the Developing Kidney and Genitourinary Tract

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Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

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Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

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Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types.

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Mammalian genomes contain active recombinase recognition sites

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Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice

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RIP-Cre Revisited, Evidence for Impairments of Pancreatic β-Cell Function

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Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo

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Sonic Hedgehog Signaling Confers Ventral Telencephalic Progenitors with Distinct Cortical Interneuron Fates

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Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice

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Adeno-associated virus effectively mediates conditional gene modification in the brain

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Pancreas-specific Cre driver lines and considerations for their prudent use

Magnuson, M., & Osipovich, A. B. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.011 · Cited by 188 · see citing works

Nestin‐Cre transgenic mouse line Nes‐Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite‐derived tissues

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Conditional gene targeting on the pure C57BL/6 genetic background

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CaMKII?-cre transgene expression and recombination patterns in the mouse brain

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Conditional transgenic technologies.

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High Levels of Cre Expression in Neuronal Progenitors Cause Defects in Brain Development Leading to Microencephaly and Hydrocephaly

Forni, P. E., Scuoppo, C., Imayoshi, I., Taulli, R., Dastrù, W., Sala, V., Betz, U. A. K., Muzzi, P., Martinuzzi, D., Vercelli, A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2815-06.2006 · Cited by 167 · see citing works

Nestin expression in pancreatic exocrine cell lineages.

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Cre activity causes widespread apoptosis and lethal anemia during embryonic development

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The advent of AAV9 expands applications for brain and spinal cord gene delivery

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Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice

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Defining POMC Neurons Using Transgenic Reagents: Impact of Transient Pomc Expression in Diverse Immature Neuronal Populations

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Deficiency of corpus callosum varies with strain and supplier of the mice

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Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes

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A Nestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors

Liang, H., Hippenmeyer, S., & Ghashghaei, H. T. (2012) · Biology Open · doi:10.1242/bio.20122287 · Cited by 107 · see citing works

Brain expression of Cre recombinase driven by pancreas‐specific promoters

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Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors

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Ectopic recombination in the central and peripheral nervous system by aP2/FABP4‐Cre mice: Implications for metabolism research

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Genetically manipulated mice: a powerful tool with unsuspected caveats

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The 5'-flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice.

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Synapsin I Cre transgene expression in male mice produces germline recombination in progeny

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A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods

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The optogenetic (r)evolution

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Nestin-Cre Mice Are Affected by Hypopituitarism, Which Is Not Due to Significant Activity of the Transgene in the Pituitary Gland

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Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance

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A chemical-genetic approach for precise spatio-temporal control of cellular signaling

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Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine KrasG12D-Induced Skin Carcinogenesis In Vivo

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Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

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Conditional deletion of histone deacetylase‐4 in the central nervous system has no major effect on brain architecture or neuronal viability

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A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice

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Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line

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Hypoxia‐inducible factor 1 activation from adipose protein 2‐cre mediated knockout of von hippel‐lindau gene leads to embryonic lethality

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Molecular biology and biotechnology

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Rat Synapsin 1 Promoter Mediated Transgene Expression in Testicular Cell Types

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A pink mouse reports the switch from red to green fluorescence upon Cre-mediated recombination

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Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, K. K., Delibegović, M., Xue, B., Görgün, C. Z., Hotamışlıgil, G. S., Neel, B. G., & Kahn, B. B. (2010) · Nature Medicine · doi:10.1038/nm0210-237b · Cited by 2 · see citing works

Nestin-expressing progenitor cells: function, identity and therapeutic implications

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A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

Wu, R., Li, A., Sun, B., Sun, J.-G., Zhang, J., Zhang, T., Chen, Y., Xiao, Y., Gao, Y., Zhang, Q., et al. (2019) · Cell Research · doi:10.1038/s41422-018-0113-8 · Cited by 366 · see citing works

FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms

BonDurant, L. D., Ameka, M., Naber, M. C., Markan, K. R., Idiga, S. O., Acevedo, M. R., Walsh, S. A., Ornitz, D. M., & Potthoff, M. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.005 · Cited by 330 · see citing works

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Zhang, Q., Delessa, C. T., Augustin, R., Bakhti, M., Colldén, G., Drucker, D. J., Feuchtinger, A., Caceres, C. G., Grandl, G., Harger, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.015 · Cited by 322 · see citing works

Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

Furigo, I. C., Teixeira, P. D. S., de Souza, G. O., Couto, G. C. L., Romero, G. G., Perelló, M., Frazão, R., Elias, L. L. K., Metzger, M., List, E. O., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08607-1 · Cited by 229 · see citing works

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

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Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

Yagishita, Y., Fukutomi, T., Sugawara, A., Kawamura, H., Takahashi, T., Pi, J., Uruno, A., & Yamamoto, M. P. (2013) · Diabetes · doi:10.2337/db13-0909 · Cited by 205 · see citing works

Pancreas-specific Cre driver lines and considerations for their prudent use

Magnuson, M., & Osipovich, A. B. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.011 · Cited by 188 · see citing works

Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway

Kubota, T., Kubota, N., & Kadowaki, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.004 · Cited by 169 · see citing works

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

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Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

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Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic

Pugach, E. K., Richmond, P. A., Azofeifa, J. G., Dowell, R. D., & Leinwand, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.06.019 · Cited by 119 · see citing works

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

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Autophagy in Adipose Tissue Physiology and Pathophysiology

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Considerations and guidelines for mouse metabolic phenotyping in diabetes research

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Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

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Behavioral phenotyping of Nestin-Cre mice: Implications for genetic mouse models of psychiatric disorders

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Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure

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Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons

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Leptin-Responsive GABAergic Neurons Regulate Fertility through Pathways That Result in Reduced Kisspeptinergic Tone

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Deficiency of Autophagy in Dendritic Cells Protects against Experimental Autoimmune Encephalomyelitis

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Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

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Cre Recombinase

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Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

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Altered Baseline and Nicotine-Mediated Behavioral and Cholinergic Profiles in ChAT-Cre Mouse Lines

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Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice

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Central growth hormone action regulates metabolism during pregnancy

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Cre-dependent DNA recombination activates a STING-dependent innate immune response

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ASIC1A in neurons is critical for fear‐related behaviors

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DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

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Central FGF21 production regulates memory but not peripheral metabolism

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Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation

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FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology

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Dnmt1, Dnmt3a and Dnmt3b cooperate in photoreceptor and outer plexiform layer development in the mammalian retina

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Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration

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STAT3 Regulates Mouse Neural Progenitor Proliferation and Differentiation by Promoting Mitochondrial Metabolism

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Brain JNK and metabolic disease

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Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus

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Hemizygous Le-Cre Transgenic Mice Have Severe Eye Abnormalities on Some Genetic Backgrounds in the Absence of LoxP Sites

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Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

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Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice

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Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

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Neuronal deficiency ofARV1causes an autosomal recessive epileptic encephalopathy

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Central growth hormone signaling is not required for the timing of puberty

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Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice

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Rodent Models for the Analysis of Tissue Clock Function in Metabolic Rhythms Research

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The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior

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Germline recombination by conditional gene targeting with Parvalbumin-Cre lines

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Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens

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The evolution of the axonal transport toolkit

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Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis

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Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

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11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

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Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory

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Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation

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Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

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De Novo ARID1B mutations cause growth delay associated with aberrant Wnt/β–catenin signaling

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The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin

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Increased GH Secretion and Body Growth in Mice Carrying Ablation of IGF-1 Receptor in GH-releasing Hormone Cells

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The role of non-neuronal cells in hypogonadotropic hypogonadism

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Canine Adenovirus 2: A Natural Choice for Brain Circuit Dissection

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Podocyte-specific expression of Cre recombinase promotes glomerular basement membrane thickening

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NMDA receptor in vasopressin 1b neurons is not required for short-term social memory, object memory or aggression

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Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases

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Reduced insulin signaling in neurons induces sex-specific health benefits

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Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype

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Brain patterning perturbations following PTEN loss

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Nkx2.2:Cre knock‐in mouse line: A novel tool for pancreas‐ and CNS‐specific gene deletion

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Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis

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Androgen and estrogen actions on male physical activity: a story beyond muscle

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A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns

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Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning

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Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine

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The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury

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Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner

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Cre-Recombinase Dependent Germline Deletion of a Conditional Allele in the Rgs9cre Mouse Line

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Disordered autonomic function during exposure to moderate heat or exercise in a mouse model of Dravet syndrome

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Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice

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Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions

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Nestin-Cre Mouse Lines: A User Guide for CNS Genetics

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Pitfalls of PCR-Based Strategy for Genotyping Cre-Loxp Mice

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