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Metabolic Pitfalls of CNS Cre-Based Technology
Open accessAbstract
Nestin-Cre mice have a significant metabolic phenotype that is hard to discern from current literature. Indeed, the Cre-lox system has numerous problems that can affect physiological parameters, and these are missed when the correct control strains are not used. Despite the increasing use of the Cre-lox system, these issues were not visible to the scientific community previously and may have affected published work. This makes it important to highlight the issues and raise awareness of the pitfalls of the Cre-lox system. Therefore, this perspective will discuss the impact of CNS and peripheral "off-target" Cre recombination on metabolic systems and describe the development of new approaches to obviate the difficulties.
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“However, these studies were confounded by the fact that ap2-Cre transgenic mice also express Cre recombinase in nonadipose tissues, including in the CNS (47).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [47]
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Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578
Genetic transformation of mouse embryos by microinjection of purified DNA.
Gordon, J. W., Scangos, G. A., Plotkin, D. J., Barbosa, J. A., & Ruddle, F. H. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7380 · Cited by 1,425
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896
Branda, C., & Dymecki, S. M. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00399-x · Cited by 876
Bacteriophage P1 site-specific recombination
Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 813
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Sai, K., Morioka, S., Takaesu, G., Muthusamy, N., Ghashghaei, H. T., Hanafusa, H., Matsumoto, K., & Ninomiya‐Tsuji, J. (2016) · Journal of Cell Science · doi:10.1242/jcs.180505 · Cited by 15
Hoffmann, H. M., Larder, R., Lee, J. S., Hu, R. J., Trang, C., Devries, B. M., Clark, D. D., & Mellon, P. L. (2019) · Neuroendocrinology · doi:10.1159/000497791 · Cited by 15
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Wasinski, F., Teixeira, P. D. S., List, E. O., Kopchick, J. J., & Donato, J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136402 · Cited by 12
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McLeod, V. M., Cuic, B., Chiam, M. D. F., Lau, C. L., & Turner, B. J. (2020) · genesis · doi:10.1002/dvg.23390 · Cited by 12
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Teitelman, G., & Kedees, M. H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.615484 · Cited by 13
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Duyne, G. D. V. (2015) · ASM Press eBooks · doi:10.1128/9781555819217.ch5 · Cited by 10
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Tomas, D., McLeod, V. M., Chiam, M. D. F., Wanniarachchillage, N., Boon, W. C., & Turner, B. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-88415-0 · Cited by 9
Alia, A. O., Jeon, S., Popović, J., Salvo, M. A., Sadleir, K. R., Vassar, R. J., & Cuddy, L. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-26671-4 · Cited by 9
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Li, S., Wang, J., Andersen, J. V., Aldana, B. I., Zhang, B. X., Prochownik, E. V., & Rosenberg, P. A. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16205 · Cited by 7
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Deng, H., Ge, H., Dubey, C., Losmanová, T., Medová, M., Konstantinidou, G., Mutlu, S. M., Birrer, F., Brodie, T. M., Stroka, D., et al. (2023) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03542-z · Cited by 7
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Nakashiba, T., Sugiyama, T., Iwano, S., Iwama, M., Yoshiki, A., Miyawaki, A., & Abe, K. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101369 · Cited by 4
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Lesciotto, K. M., Tomlinson, L., Leonard, S., & Richtsmeier, J. T. (2022) · Developmental Dynamics · doi:10.1002/dvdy.458 · Cited by 4
Maimaiti, S., Koshida, R., Ojima, M., Kulathunga, K., Oishi, H., & Takahashi, S. (2019) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0182 · Cited by 4
Dorà, N. J., Manuel, M. N., Kleinjan, D., Price, D. J., Collinson, J. M., Hill, R. E., & West, J. D. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3812-9 · Cited by 4
Ganglioside deficiency in hypothalamic POMC neurons promotes body weight gain
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Ishida, K., Tatsumi, K., Minamigawa, Y., Mori, K., Matsumaru, D., Nagase, H., Kanda, Y., Takuma, K., & Nakanishi, T. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115332 · Cited by 3
Grycel, K., Larsen, N. Y., Feng, Y., Qvortrup, K., Jensen, P. H., Fayyaz, M., Madsen, M. G., Midtgaard, J., Xu, Z., Hasselholt, S., et al. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103882 · Cited by 3
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Milicevic, K. D., Abreu, A. C., Chandran, G., Zhu, Y. M. D., Hu, X., Ivanova, V. O., Jami, M., Simon, B., Fernández, I., Yan, R., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-47370-4 · Cited by 1
Duan, C.-H., Liu, P., Sun, X. X., Ma, W.-H., Pang, J.-Y., ZHANG, Z., Li, X. Z., Jiao, L., Du, H., Teng, Z., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75063-z · Cited by 1
Jayasimhan, A., Ellis, D., Ziegler, A. I., & Slattery, R. M. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.01.001 · Cited by 1
Vinod, V., & Boudina, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00018-8 · Cited by 1
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Heeley, N. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.18622 · Cited by 1
Desor, F., Hajj, A. E., Herzine, A., Djelti, F., Bombail, V., Denis, I., Oster, T., Malaplate, C., Lanhers, M., Yen, F. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.582228 · Cited by 1
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de Groot, M. H. M., Castorena, C. M., Kumar, V., Mohawk, J. A., Ahmed, N. I., & Takahashi, J. S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/163378
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Couto, G. C. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2019.tde-17062019-165021
The role of protein tyrosine phosphatase 1b in the central regulation of energy homeostasis
Tsou, R. C. (2014) · Scholarly Commons (University of Pennsylvania)
Charron, F., & Yam, P. T. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737316694.793572169
Weiner, J. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737316694.793574115
Participação da via da STAT3 em neurônios POMC do hipotálamo na homeostase energética
Volpi, R. E. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2020.tde-30092022-095827
Balthazart, J. (2023) · Wiley eBooks · doi:10.1002/9781394236633.refs
Participação da via da PI3K em neurônios SF1 do hipotálamo na homeostase energética
de Jesus, A. A. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2023.tde-08022024-155611
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Molinaro, A., Mazzoli, A., Gaudi, A. U., Gupta, A. C., Silva, V. R. R., Ramel, D., Laffargue, M., Ruud, J., Becattini, B., & Solinas, G. (2024) · iScience · doi:10.1016/j.isci.2024.111562
Mlc2v-Cre induces germline recombination in a sex-biased manner
Aslani, T., Abid, R., Jeyaratnam, R., Liang, W., & Kim, K.-H. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00122.2025
Knockdown of Mct1 in the arcuate nucleus increases food-anticipatory activity in mice
Martini, T., & Albrecht, U. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1642386
Vaillant, J., Pal, S., Müller, J., Wittmann, A., Yiadom, A. B., Sievers, P., Zimmer, P., Schoof, M., Schelb, F., Hofmann, N., et al. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf251
Kalomoiri, M., Sorini, C., Vos, S. V. T., Camargo, A., Tsalikou, A., Krstic, A., Prakash, C. R., Svenningsson, P., Needhamsen, M., Kakhki, M. P., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.26.708277
Rôle du transporteur plasmique des monoamines (PMAT) dans le système nerveux central
Amin, S. R. (2017) · theses.fr (ABES) · doi:10.70675/f562837bz937fz402eza824z24af264eaf90
Lin, H. V., Gaidarov, I., Militello, G., & Hunt, K. W. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102381
Metadata
- Authors
- Harno, E., Cottrell, E. C., & White, A.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- White, Anne
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 18
- Issue
- 1
- Pages
- 21-28
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2093032500
- Cited by
- 200
- References
- 64
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 17 · 2021: 13 · 2020: 21 · 2019: 25 · 2018: 18 · 2017: 20 · 2016: 16 · 2015: 18 · 2014: 12 · 2013: 5
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- AstraZeneca
- National Institute for Health and Care Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- Cre-loxP system, central nervous system, metabolic phenotypes, control strains, conditional gene targeting
- MeSH terms
- Animals, Central Nervous System, DNA Nucleotidyltransferases, Protein-Lysine 6-Oxidase, Mice, Transgenic, Recombination, Genetic, Extracellular Matrix Proteins, Mice, Knockout, Gene Targeting, Integrases, Models, Animal, Mice, Nestin
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