The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
Open accessAbstract
SUMMARY Because metabolites are hypothesized to play key roles as markers and effectors of cardio-metabolic diseases, recent studies have sought to annotate the genetic determinants of circulating metabolite levels. We report a genome-wide association study (GWAS) of 217 plasma metabolites, including >100 not measured in prior GWAS, in 2,076 participants of the Framingham Heart Study. For the majority of analytes, we find that estimated heritability explains >20% of inter-individual variation, and that variation attributable to heritable factors is greater than that attributable to clinical factors. Further, we identify 31 genetic loci associated with plasma metabolites, including 23 that have not previously been reported. Importantly, we include GWAS results for all surveyed metabolites, and demonstrate how this information highlights a role for AGXT2 in cholesterol ester and triacylglycerol metabolism. Thus, our study outlines the relative contributions of inherited and clinical factors on the plasma metabolome and provides a resource for metabolism research.
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Biological, clinical and population relevance of 95 loci for blood lipids
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Self-citationMetabolite profiles and the risk of developing diabetes
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Self-citationMultipoint Quantitative-Trait Linkage Analysis in General Pedigrees
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
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SLCO1B1 Variants and Statin-Induced Myopathy — A Genomewide Study
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InfluentialLarge-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
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Self-citationMaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
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Cited by
An atlas of genetic influences on human blood metabolites
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70-year legacy of the Framingham Heart Study
Andersson, C., Johnson, A. D., Benjamin, E. J., Levy, D., & Vasan, R. S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0202-5 · Cited by 305
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Metadata
- Authors
- Rhee, E. P., Ho, J. E., Chen, M.-H., Shen, D., Cheng, S., Larson, M. G., Ghorbani, A., Shi, X., Helenius, I. T., O’Donnell, C. J., Souza, A. L., Deik, A., Pierce, K. A., Bullock, K., Walford, G. A., Vasan, R. S., Florez, J. C., Clish, C., Yeh, J.-R. J., Wang, T. J., & Gerszten, R. E.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 18
- Issue
- 1
- Pages
- 130-143
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1993018723
- Cited by
- 321
- References
- 70
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rhee, E. P., Ho, J. E., Chen, M.-H., Shen, D., Cheng, S., Larson, M. G., Ghorbani, A., Shi, X., Helenius, I. T., O’Donnell, C. J., Souza, A. L., Deik, A., Pierce, K. A., Bullock, K., Walford, G. A., Vasan, R. S., Florez, J. C., Clish, C., Yeh, J.-R. J., . . . Gerszten, R. E. (2013). A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.06.013
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