β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
Open accessAbstract
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise. Muscle PGC-1α transgenic expression and exercise both increase the expression of thermogenic genes within white adipose. How the PGC-1α-mediated response to exercise in muscle conveys signals to other tissues remains incompletely defined. We employed a metabolomic approach to examine metabolites secreted from myocytes with forced expression of PGC-1α, and identified β-aminoisobutyric acid (BAIBA) as a small molecule myokine. BAIBA increases the expression of brown adipocyte-specific genes in white adipocytes and β-oxidation in hepatocytes both in vitro and in vivo through a PPARα-mediated mechanism, induces a brown adipose-like phenotype in human pluripotent stem cells, and improves glucose homeostasis in mice. In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors. BAIBA may thus contribute to exercise-induced protection from metabolic diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BAIBA are natural metabolites of thymine and valine secreted primarily by myocytes during physical exercise.
“β-aminoisobutyric acid (BAIBA) are natural metabolites of thymine and valine secreted primarily by myocytes during the practice of physical exercise (Roberts et al., 2014).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Roberts et al., 2014
The Discussion (page unavailable) says BAIBA can be generated from valine and identifies it as an exercise-triggered myokine; the Results show BAIBA secretion by cultured muscle cells and increased muscle and plasma levels after exercise. Our copy does not identify thymine as a precursor or establish that myocytes are its primary source during exercise; the Discussion notes that BAIBA may also increase in other tissues. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe increase of PGC1α observed during physical exercise results in a concomitant increase in BAIBA serum levels.
“The increase of PGC1α observed during physical exercise results in a concomitant increase in BAIBA serum levels.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Roberts et al., 2014
The Results section reports higher plasma BAIBA after exercise training in mice and humans, and higher plasma BAIBA in mice with forced muscle PGC-1α expression. These findings support the proposed link, but the paper does not establish that the rise in PGC-1α during exercise causes the observed rise in circulating BAIBA. Page numbers were not available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredβ-aminoisobutyric acid (BAIBA) attenuates insulin resistance, improves glucose tolerance, and promotes browning of white adipose tissue and hepatic β-oxidation.
“For example, β‐aminoisobutyric acid (BAIBA), a novel exercise‐induced muscle factor, attenuates insulin resistance, improves glucose tolerance, and promotes the browning of white adipose tissue (WAT) and hepatic β‐oxidation (Roberts et al, 2014; Jung et al, 2015).”
From Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation (2020) · cites this paper as Roberts et al, 2014
The Results report that BAIBA improved glucose tolerance in treated mice, while the Discussion reports BAIBA-induced browning of white adipose tissue and increased hepatic β-oxidation. The Results also show an inverse association between plasma BAIBA and an insulin-resistance measure in humans, but do not show that BAIBA treatment attenuates insulin resistance. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTwo studies have reported increased circulating levels of BAIBA following aerobic exercise, e.g., cycling for 1 h at 40% maximal power output or after 20 weeks of 30-50 min cycling sessions at 55-75% VO2 max in healthy young men.
“two studies have reported increased circulating levels of BAIBA following aerobic exercise, e.g., cycling for 1 h at 40% maximal power output [106] or after 20 weeks of 30–50 min cycling sessions at 55–75% VO2 max [104] in healthy young men.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [104]
The Results section reports a 17% increase in plasma BAIBA among 80 HERITAGE participants after 20 weeks of training. Experimental Procedures describes cycling sessions that progressed from 30 minutes at 55% VO2max to 50 minutes at 75% VO2max. The paper does not identify the 80 participants as healthy young men; it describes the broader study as enrolling previously sedentary people aged 16–65. The separate one-hour cycling example is attached to citation [106], not this source. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe myokines irisin and BAIBA directly induce WAT browning both in vitro and in vivo by upregulating genes involved in mitochondrial biogenesis, FAO, oxidative phosphorylation, and thermogenesis.
“The myokines irisin [57] and BAIBA [104] have been described to directly induce WAT “browning” both in vitro and in vivo, by upregulating genes involved in mitochondrial biogenesis, FAO, oxidative phosphorylation, and thermogenesis (1).”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [104]
The Discussion and Results (page numbers unavailable) report that BAIBA induces a browning gene program in white adipose tissue in vitro and in vivo, including thermogenic genes UCP-1 and CIDEA. The paper reports fatty-acid β-oxidation gene upregulation in the liver, not as part of WAT browning, and does not establish upregulation of an oxidative-phosphorylation gene program in WAT. Irisin has a separate citation in the citing sentence and is not the part attributed to this paper. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Fat mass loss associated with increased total energy expenditure was observed with BAIBA.
“Fat mass loss associated with increased total energy expenditure was also observed [104].”
A trend toward a negative correlation between BAIBA and BMI was shown, while another study reported no increase.
“A trend toward a negative correlation between BAIBA and BMI [104] was shown, while another study reported no increase [107].”
PGC-1α upregulates the WAT browning myokines FNDC5-irisin, METRNL, and BAIBA.
“which is known to upregulate the WAT browning myokines FNDC5-irisin [57], METRNL [274], and BAIBA [104].”
BAIBA and FGF21 increase hepatic β-oxidation.
“For instance, BAIBA [104] and FGF21 [160] have been shown to increase hepatic β-oxidation (6)”
Physical exercise increases BAIBA production by the body.
“in addition to demonstrating that physical exercise increases its production by the body.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Roberts et al., 2014
In vitro, when BAIBA was cultivated with primary cells from subcutaneous adipose tissue, there was upregulation of brown and beige adipocyte markers such as UCP1 and CIDEA.
“In the same study, in vitro, when BAIBA was cultivated with primary cells from subcutaneous adipose tissue (scAT), there was an up regulation of brown and beige adipocytes marker, such as UCP1 and CIDEA.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Roberts et al., 2014
Whether exercise can brown WAT in humans, especially through an irisin-mediated pathway, remains controversial.
“Thus, whether exercise can brown WAT in humans, especially through an irisin-mediated pathway, remains controversial55,83,84,90.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [55]
In humans, circulating BAIBA increases with chronic training and inversely correlates with insulin resistance.
“In humans, circulating levels of β-aminoisobutyric acid (BAIBA) increased with chronic training55 and inversely correlated with insulin resistance55.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [55]
In wild-type mice, BAIBA treatment reduced insulin resistance and suppressed inflammation.
“In wild-type mice, BAIBA treatment reduced insulin resistance and suppressed inflammation55.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [55]
The myokine BAIBA can brown white adipose tissue to improve glucose homeostasis, as shown in a mouse model.
“Using a mouse model, this paper demonstrated that a myokine, BAIBA, can ‘brown’ WAT to improve glucose homeostasis.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
Self-citationBeige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,299 · see citing works
Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165 · see citing works
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143 · see citing works
Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.012 · Cited by 2,662 · see citing works
Self-citationThe mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Self-citationBrown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works
Self-citationmPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,182 · see citing works
Self-citationPeroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works
Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263 · see citing works
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works
Transcriptional Control of Brown Fat Determination by PRDM16
Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works
Branched-Chain Amino Acid Metabolism
Harper, A. E., Miller, R. H., & Block, K. P. (1984) · Annual Review of Nutrition · doi:10.1146/annurev.nu.04.070184.002205 · Cited by 1,011 · see citing works
Production and purification of lentiviral vectors
Tiscórnia, G., Singer, O., & Verma, I. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.37 · Cited by 998 · see citing works
Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia
Bröer, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00018.2006 · Cited by 961 · see citing works
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
Stadtfeld, M., Maherali, N., Breault, D. T., & Hochedlinger, K. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.02.001 · Cited by 823 · see citing works
Plasma Amino Acid Levels and Insulin Secretion in Obesity
Felig, P., Marliss, E., & Cahill, G. F. (1969) · New England Journal of Medicine · doi:10.1056/nejm196910092811503 · Cited by 812 · see citing works
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 799 · see citing works
Branched-Chain Amino Acid Metabolism
Yudkoff, M. (1999) · Cited by 763 · see citing works
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724 · see citing works
Roberts, L. D., Souza, A. L., Gerszten, R. E., & Clish, C. B. (2012) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb3002s98 · Cited by 714 · see citing works
Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature · doi:10.1038/nature08262 · Cited by 703 · see citing works
Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665 · see citing works
Michael, L. F., Wu, Z., Cheatham, R. B., Puigserver, P., Adelmant, G., Lehman, J. J., Kelly, D. P., & Spiegelman, B. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061035098 · Cited by 663 · see citing works
Activation of PPARγ Coactivator-1 Through Transcription Factor Docking
Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. W., & Spiegelman, B. M. (1999) · Science · doi:10.1126/science.286.5443.1368 · Cited by 596 · see citing works
Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 560 · see citing works
Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works
St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works
Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ
Frontini, A., & Cinti, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.004 · Cited by 458 · see citing works
Brandt, J. M., Djouadi, F., & Kelly, D. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23786 · Cited by 456 · see citing works
2-Aminoadipic acid is a biomarker for diabetes risk
Wang, T. J., Ngo, D., Psychogios, N., Dejam, A., Larson, M. G., Vasan, R. S., Ghorbani, A., O’Sullivan, J., Cheng, S. C., Rhee, E. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64801 · Cited by 450 · see citing works
Shimomura, Y., Murakami, T., Nakai, N., Nagasaki, M., & Harris, R. A. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.6.1583s · Cited by 405 · see citing works
Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 380 · see citing works
Calvo, J. A., Daniels, T. G., Wang, X., Paul, A., Lin, J., Spiegelman, B. M., Stevenson, S. C., & Rangwala, S. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01231.2007 · Cited by 377 · see citing works
Wright, H. M., Clish, C. B., Mikami, T., Hauser, S., Yanagi, K., Hiramatsu, R., Serhan, C. N., & Spiegelman, B. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1873 · Cited by 368 · see citing works
Distinct Transcriptional Profiles of Adipogenesisin Vivo and in Vitro
Soukas, A. A., Socci, N. D., Saatkamp, B. D., Novelli, S. E., & Friedman, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104421200 · Cited by 368 · see citing works
Ishibashi, J., & Seale, P. (2010) · Science · doi:10.1126/science.1190816 · Cited by 344 · see citing works
The HERITAGE family study. Aims, design, and measurement protocol.
Bouchard, C., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Gagnon, J. (1995) · PubMed · Cited by 331 · see citing works
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
Rhee, E. P., Ho, J. E., Chen, M., Shen, D., Cheng, S. C., Larson, M. G., Ghorbani, A., Shi, X. D., Helenius, I. T., O’Donnell, C. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.013 · Cited by 318 · see citing works
Wu, J., Ruas, J. L., Estall, J. L., Rasbach, K. A., Choi, J. H., Ye, L., Boström, P., Tyra, H. M., Crawford, R. W., Campbell, K. P., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.003 · Cited by 312 · see citing works
In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
Viscomi, C. F., Bottani, E., Civiletto, G., Cerutti, R., Moggio, M. G., Fagiolari, G., Schon, E. A., Lamperti, C., & Zeviani, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.011 · Cited by 291 · see citing works
Aims, design, and measurement protocol
BOUCHARD, C., LEON, A. S., RAO, D. C., SKINNER, J. S., WlLMORE, J. H., & GAGNON, J. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199505000-00015 · Cited by 271 · see citing works
Self-citationProgramming human pluripotent stem cells into white and brown adipocytes
Ahfeldt, T., Schinzel, R. T., Lee, Y., Hendrickson, D. G., Kaplan, A. N., Lum, D. H., Camahort, R., Xia, F., Shay, J., Rhee, E. P., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2411 · Cited by 248 · see citing works
A genome-wide association study of metabolic traits in human urine
Suhre, K., Wallaschofski, H., Raffler, J., Friedrich, N., Haring, R., Michael, K., Wasner, C., Krebs, A., Kronenberg, F., Chang, D., et al. (2011) · Nature Genetics · doi:10.1038/ng.837 · Cited by 246 · see citing works
PGC-1α-mediated adaptations in skeletal muscle
Olesen, J., Kiilerich, K., & Pilegaard, H. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0834-0 · Cited by 244 · see citing works
GWAF: an R package for genome-wide association analyses with family data
Chen, M.-H., & Yang, Q. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp710 · Cited by 208 · see citing works
Exercise and adrenaline increase PGC‐1α mRNA expression in rat adipose tissue
Sutherland, L., Bomhof, M. R., Capozzi, L., Basaraba, S. A. U., & Wright, D. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165464 · Cited by 201 · see citing works
Xu, X., Ying, Z., Cai, M., Xu, Z., Li, Y., Jiang, S. Y., Tzan, K., Wang, A., Parthasarathy, S., He, G., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2010 · Cited by 200 · see citing works
Rabøl, R., Petersen, K. F., Dufour, S., Flannery, C. A., & Shulman, G. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110105108 · Cited by 195 · see citing works
Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F., & Patsch, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37142-x · Cited by 191 · see citing works
Xue, B., Coulter, A. A., Rim, J. S., Koza, R. A., & Kozak, L. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8311-8322.2005 · Cited by 179 · see citing works
Rector, R. S., Uptergrove, G. M., Morris, E. M., Borengasser, S. J., Laughlin, M. H., Booth, F. W., Thyfault, J. P., & Ibdah, J. A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00510.2010 · Cited by 152 · see citing works
PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
Rasbach, K. A., Gupta, R. K., Ruas, J. L., Wu, J., Naseri, E., Estall, J. L., & Spiegelman, B. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016089107 · Cited by 142 · see citing works
Optimized production and concentration of lentiviral vectors containing large inserts
Al‐Yacoub, N., Romanowska, M., Haritonova, N., et al. (2007) · The Journal of Gene Medicine · doi:10.1002/jgm.1052 · Cited by 135 · see citing works
Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation.
Guerra, C. E., Koza, R. A., Walsh, K., Kurtz, D. M., Wood, P. A., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4532 · Cited by 131 · see citing works
Branched-Chain Amino Acid Catabolism in Exercise and Liver Disease
Shimomura, Y., Honda, T., Shiraki, M., Murakami, T., Sato, J., Kobayashi, H., Mawatari, K., Obayashi, M., & Harris, R. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.250s · Cited by 128 · see citing works
Prosperi, M., Rosen‐Zvi, M., Altmann, A., Zazzi, M., Giambenedetto, S. D., Kaiser, R., Schülter, E., Struck, D., Sloot, P. M. A., van de Vijver, D. A. M. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013753 · Cited by 124 · see citing works
β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency
Begriche, K., Massart, J., Abbey‐Toby, A., Igoudjil, A., Lettéron, P., & Fromenty, B. (2008) · Obesity · doi:10.1038/oby.2008.337 · Cited by 99 · see citing works
Leskinen, T., Rinnankoski-Tuikka, R., Rintala, M., Seppänen-Laakso, T., Pöllänen, E., Alen, M., Sipilä, S., Kaprio, J., Kovanen, V., Rahkila, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012609 · Cited by 75 · see citing works
Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice
Melnyk, A. A., Harper, M., & Himms‐Hagen, J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.4.r1088 · Cited by 52 · see citing works
Schulz, N., Himmelbauer, H., Rath, M., van Weeghel, M., Houten, S. M., Kulik, W., Suhre, K., Scherneck, S., Vogel, H., Kluge, R., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1547 · Cited by 47 · see citing works
Note, R., Maisonneuve, C., Lettéron, P., Peytavin, G., Djouadi, F., Igoudjil, A., Guimont, M.-C., Biour, M., Pessayre, D., & Fromenty, B. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.11.3384-3392.2003 · Cited by 44 · see citing works
Maisonneuve, C., Igoudjil, A., Begriche, K., Lettéron, P., Guimont, M.-C., Bastin, J., Laigneau, J., Pessayre, D., & Fromenty, B. (2004) · Antiviral Therapy · doi:10.1177/135965350400900513 · Cited by 43 · see citing works
Oh, K. S., Kim, M. K., Lee, J., Kim, M., Nam, Y. S., Ham, J. E., Shin, S. S., Lee, C. M., & Yoon, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.182 · Cited by 31 · see citing works
NPs — heart hormones that regulate brown fat?
Whittle, A. J., & Vidal‐Puig, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62595 · Cited by 29 · see citing works
Aoi, W., Naito, Y., Hang, L. P., Uchiyama, K., Akagiri, S., Mizushima, K., & Yoshikawa, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.097 · Cited by 28 · see citing works
Efficient Culturing and Genetic Manipulation of Human Pluripotent Stem Cells
Schinzel, R., Ahfeldt, T., Lau, F., Lee, Y.-K., Cowley, A., Shen, T., Peters, D., Lum, D. H., & Cowan, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027495 · Cited by 27 · see citing works
Multiple roles of PPARα in brown adipose tissue under constitutive and cold conditions
Komatsu, M., Tong, Y., Li, Y., Nakajima, T., Li, G., Hu, R., Sugiyama, E., Kamijo, Y., Tanaka, N., Hara, A., et al. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01368.x · Cited by 22 · see citing works
Liu, M., Russell, R. L., Beigelman, L. N., Handschumacher, R. E., & Pizzorno, G. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.1.g206 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Lin J Wu H Tarr PT Zhang CY Wu ZD Boss O Michael LF Puigserver P Isotani E Olson EN Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres Nature 2002b 418 797 801 12181572
Cited by
Sorted by citations
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226 · see citing works
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works
Brown and Beige Fat: Physiological Roles beyond Heat Generation
Kajimura, S., Spiegelman, B. M., & Seale, P. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.007 · Cited by 1,004 · see citing works
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803 · see citing works
PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD
Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778 · see citing works
Metabolomics and Metabolic Diseases: Where Do We Stand?
Newgard, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.018 · Cited by 756 · see citing works
Neinast, M. D., Murashige, D., & Arany, Z. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114455 · Cited by 727 · see citing works
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 689 · see citing works
Metabolites as regulators of insulin sensitivity and metabolism
Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 680 · see citing works
Jang, C., Oh, S. F., Wada, S., Rowe, G. C., Liu, L., Chan, M. C., Rhee, J., Hoshino, A., Kim, B., Ibrahim, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4057 · Cited by 589 · see citing works
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Neinast, M. D., Jang, C., Hui, S. T., Murashige, D., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.013 · Cited by 500 · see citing works
Immune Regulation of Metabolic Homeostasis in Health and Disease
Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 498 · see citing works
Crane, J., Palanivel, R., Mottillo, E., Bujak, A. L., Wang, H.-Q., Ford, R., Collins, A., Blümer, R., Fullerton, M., Yabut, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3766 · Cited by 462 · see citing works
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works
Evans, M., Cogan, K. E., & Egan, B. (2017) · The Journal of Physiology · doi:10.1113/jp273185 · Cited by 414 · see citing works
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
Hoffmann, C., & Weigert, C. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029793 · Cited by 393 · see citing works
Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works
“β-aminoisobutyric acid (BAIBA) are natural metabolites of thymine and valine secreted primarily by myocytes during Frontiers in Physiology | www.frontiersin.org 11 September 2018 | Volume 9 | Article 1307 the practice of physical exercise (Roberts et al., 2014).”
BackgroundRuiz‐Ojeda, F. J., Rupérez, A. I., Gómez‐Llorente, C., Gil, Á., & Aguilera, C. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071040 · Cited by 380 · see citing works
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations
Stanford, K. I., Middelbeek, R. J. W., & Goodyear, L. J. (2015) · Diabetes · doi:10.2337/db15-0227 · Cited by 342 · see citing works
Muscle as a “Mediator” of Systemic Metabolism
Baskin, K. K., Winders, B. R., & Olson, E. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.021 · Cited by 333 · see citing works
An exercise-inducible metabolite that suppresses feeding and obesity
Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S.-H., Lyu, X., Zushin, P.-J. H., et al. (2022) · Nature · doi:10.1038/s41586-022-04828-5 · Cited by 331 · see citing works
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
Agudelo, L. Z., Ferreira, D. M. S., Červenka, I., Bryzgalova, G., Dadvar, S., Jannig, P. R., Pettersson-Klein, A. T., Lakshmikanth, T., Sustarsic, E. G., Porsmyr‐Palmertz, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.004 · Cited by 303 · see citing works
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street
White, P. J., McGarrah, R. W., Herman, M. A., Bain, J. R., Shah, S. H., & Newgard, C. B. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101261 · Cited by 291 · see citing works
Rodrı́guez, A., Ezquerro, S., Méndez-Giménez, L., Becerril, S., & Frühbeck, G. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2015 · Cited by 281 · see citing works
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Inter-organ cross-talk in metabolic syndrome
Priest, C., & Tontonoz, P. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0145-5 · Cited by 279 · see citing works
The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications
Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279 · see citing works
Endocrine Crosstalk Between Skeletal Muscle and the Brain
Delezie, J., & Handschin, C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00698 · Cited by 270 · see citing works
Myokines: The endocrine coupling of skeletal muscle and bone
Gomarasca, M., Banfi, G., & Lombardi, G. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.010 · Cited by 274 · see citing works
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274 · see citing works
Regulation of Skeletal Muscle Function by Amino Acids
Kamei, Y., Hatazawa, Y., Uchitomi, R., Yoshimura, R., & Miura, S. (2020) · Nutrients · doi:10.3390/nu12010261 · Cited by 254 · see citing works
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 251 · see citing works
The role of exercise-induced myokines in regulating metabolism
Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242 · see citing works
Convertible visceral fat as a therapeutic target to curb obesity
Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 232 · see citing works
Use it or lose it to age: A review of bone and muscle communication
Bonewald, L. F. (2018) · Bone · doi:10.1016/j.bone.2018.11.002 · Cited by 229 · see citing works
Induction of Adipose Tissue Browning as a Strategy to Combat Obesity
Kuryłowicz, A., & Puzianowska-Kuźnicka, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176241 · Cited by 219 · see citing works
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
Osataphan, S. A., Macchi, C., Singhal, G., CHIMENE-WEISS, J. I., Sales, V., Kozuka, C., Dreyfuss, J. M., Pan, H., Tangcharoenpaisan, Y., Morningstar, J. E., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123130 · Cited by 229 · see citing works
Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
Kong, X., Yao, T. S., Zhou, P., Kazak, L., Tenen, D. E., Lyubetskaya, A., Dawes, B. A., Tsai, L. T.-Y., Kahn, B. B., Spiegelman, B. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.004 · Cited by 226 · see citing works
Human Brown Adipose Tissue: What We Have Learned So Far
Betz, M. J., & Enerbäck, S. (2015) · Diabetes · doi:10.2337/db15-0146 · Cited by 223 · see citing works
Jeremic, N., Chaturvedi, P., & Tyagi, S. C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25450 · Cited by 211 · see citing works
Machado, S. A., Pasquarelli-do-Nascimento, G., da Silva, D. S., Farias, G. R., Santos, I. D. O., Baptista, L. B., & Magalhães, K. G. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00694-0 · Cited by 229 · see citing works
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor
Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.041 · Cited by 219 · see citing works
Interorgan Communication Pathways in Physiology: Focus on Drosophila
Droujinine, I. A., & Perrimon, N. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-122024 · Cited by 205 · see citing works
Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes
Kaisanlahti, A., & Glumoff, T. (2018) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-018-0658-5 · Cited by 213 · see citing works
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210 · see citing works
Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 204 · see citing works
The hitchhiker’s guide to PGC-1α isoform structure and biological functions
Martínez-Redondo, V., Pettersson, A. T., & Ruas, J. (2015) · Diabetologia · doi:10.1007/s00125-015-3671-z · Cited by 191 · see citing works
Crosstalk between adipokines and myokines in fat browning
Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works
Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review
Montanari, T., Pošćić, N., & Colitti, M. (2017) · Obesity Reviews · doi:10.1111/obr.12520 · Cited by 189 · see citing works
A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Gøbel, R. J., Kristensen, M., Valles‐Colomer, M., Vieira‐Silva, S., Ibrügger, S., Lind, M. V., Mærkedahl, R. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07019-x · Cited by 189 · see citing works
Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue
Mika, A., Macaluso, F., Barone, R., Felice, V. D., & Śledziński, T. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00026 · Cited by 182 · see citing works
Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans
Morville, T. H., Sahl, R. E., Möritz, T., Helge, J. W., & Clemmensen, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108554 · Cited by 179 · see citing works
The evolving view of thermogenic adipocytes — ontogeny, niche and function
Shamsi, F., Wang, C.-H., & Tseng, Y.-H. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00562-6 · Cited by 154 · see citing works
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 187 · see citing works
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154 · see citing works
Myokines mediate the cross talk between skeletal muscle and other organs
Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162 · see citing works
Li, Y., Fromme, T., Schweizer, S., Schöttl, T., & Klingenspor, M. (2014) · EMBO Reports · doi:10.15252/embr.201438775 · Cited by 159 · see citing works
Whitehead, A., Krause, F. N., Moran, A., MacCannell, A. D. V., Scragg, J. L., McNally, B. D., Boateng, E. A., Murfitt, S. A., Virtue, S., Wright, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22272-3 · Cited by 161 · see citing works
Metabolic communication during exercise
Murphy, R. M., Watt, M. J., & Febbraio, M. A. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0258-x · Cited by 158 · see citing works
Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen
Lu, L., & Tian, L. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0116 · Cited by 154 · see citing works
The circulating metabolome of human starvation
Steinhauser, M. L., Olenchock, B. A., O’Keefe, J., Lun, M., Pierce, K. A., Lee, H., Pantano, L., Klibanski, A., Shulman, G. I., Clish, C. B., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.121434 · Cited by 152 · see citing works
Kloock, S., Ziegler, C. G., & Dischinger, U. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108549 · Cited by 147 · see citing works
Jung, T. W., Hwang, H.-J., Hong, H. C., Yoo, H. J., Baik, S. H., & Choi, K. M. (2015) · Diabetologia · doi:10.1007/s00125-015-3663-z · Cited by 145 · see citing works
Roberts, L. D., Ashmore, T., Kotwica, A. O., Murfitt, S. A., Fernandez, B. O., Feelisch, M., Murray, A. J., & Griffin, J. L. (2014) · Diabetes · doi:10.2337/db14-0496 · Cited by 145 · see citing works
Renal metabolism and hypertension
Tian, Z., & Liang, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21301-5 · Cited by 145 · see citing works
Barquissau, V., Beuzelin, D., Pisani, D. F., Béranger, G. E., Mairal, A., Montagner, A., Roussel, B., Tavernier, G., Marques, M.-A., Moro, C., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.03.002 · Cited by 141 · see citing works
Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk
Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 143 · see citing works
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes
O’Sullivan, J., Morningstar, J. E., Yang, Q., Zheng, B., Gao, Y. L., Jeanfavre, S., Scott, J. M., Fernandez, C., Zheng, H., O’Connor, S., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci95995 · Cited by 136 · see citing works
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling
Shimizu, N., Maruyama, T., Yoshikawa, N., Matsumiya, R., Ma, Y., Ito, N., Tasaka, Y., Souta-Kuribara, A., Miyata, K., Oike, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms7693 · Cited by 138 · see citing works
Ghesmati, Z., Rashid, M., Fayezi, S., Gieseler, F., Alizadeh, E., & Darabi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09850-0 · Cited by 139 · see citing works
Jung, T. W., Park, H. S., Choi, G. H., Kim, D., & Lee, T. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0431-7 · Cited by 137 · see citing works
The search for exercise factors in humans
Catoire, M., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-263699 · Cited by 137 · see citing works
Impaired proteostasis during skeletal muscle aging
Fernando, R., Drescher, C., Nowotny, K., Grune, T., & Castro, J. P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.037 · Cited by 134 · see citing works
Exercise regulation of adipose tissue
Stanford, K. I., & Goodyear, L. J. (2016) · Adipocyte · doi:10.1080/21623945.2016.1191307 · Cited by 133 · see citing works
Martin, K. S., Azzolini, M., & Ruas, J. L. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00580.2019 · Cited by 126 · see citing works
Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives
Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works
Sánchez‐Delgado, G., Martínez‐Téllez, B., Olza, J., Aguilera, C. M., Labayen, I., Ortega, F. B., Chillón, P., Fernandez-Reguera, C., Alcántara, J. M. A., Martinez-Avila, W. D., et al. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.11.004 · Cited by 128 · see citing works
Biswas, D., Duffley, L., & Pulinilkunnil, T. (2019) · The FASEB Journal · doi:10.1096/fj.201802842rr · Cited by 124 · see citing works
Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance
Balakrishnan, R., & Thurmond, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094636 · Cited by 131 · see citing works
Systemic Nutrient and Stress Signaling via Myokines and Myometabolites
Rai, M., & Demontis, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105305 · Cited by 123 · see citing works
Bone and Muscle Crosstalk in Aging
He, C., He, W., Hou, J., Chen, K., Huang, M., Yang, M., Luo, X., & Li, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.585644 · Cited by 128 · see citing works
Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism
Tanianskii, D. A., Jarzebska, N., Birkenfeld, A. L., O’Sullivan, J. F., & Rodionov, R. N. (2019) · Nutrients · doi:10.3390/nu11030524 · Cited by 121 · see citing works
Exercise-induced adaptations to white and brown adipose tissue
Lehnig, A. C., & Stanford, K. I. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.161570 · Cited by 121 · see citing works
Engineered skeletal muscles for disease modeling and drug discovery
Wang, J., Khodabukus, A., Rao, L., VanDusen, K. W., Abutaleb, N. O., & Bursac, N. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119416 · Cited by 117 · see citing works
Kwon, J. H., Moon, K. M., & Min, K.-W. (2020) · Healthcare · doi:10.3390/healthcare8040378 · Cited by 116 · see citing works
Role of Exercise in the Activation of Brown Adipose Tissue
Sánchez‐Delgado, G., Martínez‐Téllez, B., Olza, J., Aguilera, C. M., Gil, Á., & Ruiz, J. R. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000437173 · Cited by 114 · see citing works
Muscle-Adipose Tissue Cross TalkPreprint
Stanford, K. I., & Goodyear, L. J. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029801 · Cited by 116 · see citing works
Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes
Mu, Q., Fang, X., Li, X., Zhao, D., Mo, F., Jiang, G., Yu, N., Zhang, Y., Guo, Y., Fu, M., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.064 · Cited by 114 · see citing works
Contreras, C., González‐García, I., Seoane‐Collazo, P., Martínez‐Sánchez, N., Liñares‐Pose, L., Rial‐Pensado, E., Fernø, J., Tena‐Sempere, M., Casals, N., Diéguez, C., et al. (2016) · Diabetes · doi:10.2337/db15-1547 · Cited by 110 · see citing works
Myokines in metabolic homeostasis and diabetes
Eckel, J. (2019) · Diabetologia · doi:10.1007/s00125-019-4927-9 · Cited by 107 · see citing works
Shi, C.-X., Zhao, M.-X., Shu, X.-D., Xiong, X.-Q., Wang, J.-J., Gao, X.-Y., Chen, Q., Li, Y.-H., Kang, Y.-M., & Zhu, G.-Q. (2016) · Scientific Reports · doi:10.1038/srep21924 · Cited by 108 · see citing works
HDAC11 suppresses the thermogenic program of adipose tissue via BRD2
Bagchi, R. A., Ferguson, B. S., Stratton, M. S., Hu, T., Cavasin, M. A., Sun, L., Lin, Y.-H., Liu, D., Londono, P., Song, K., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120159 · Cited by 110 · see citing works
Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans
Thyagarajan, B., & Foster, M. T. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0016 · Cited by 106 · see citing works
Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
Singh, R., Barrios, A., Dirakvand, G., & Pervin, S. (2021) · Cells · doi:10.3390/cells10113030 · Cited by 109 · see citing works
The Beige Adipocyte as a Therapy for Metabolic Diseases
Lizcano, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205058 · Cited by 106 · see citing works
New therapeutic approaches for the treatment of obesity
Saltiel, A. R. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad1811 · Cited by 100 · see citing works
Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence
Bilski, J., Mazur-Biały, A. I., Brzozowski, B., Magierowski, M., Zahradnik-Bilska, J., Wójcik-Grzybek, D., Magierowska, K., Kwiecień, S., Mach, T., & Brzozowski, T. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.04.009 · Cited by 95 · see citing works
The Muscle Metabolome Differs between Healthy and Frail Older Adults
Fazelzadeh, P., Hangelbroek, R., Tieland, M., de Groot, C. P. G. M., Verdijk, L. B., van Loon, L. J. C., Smilde, A. K., Alves, R. D. A. M., Vervoort, J. J. M., Müller, M. M., et al. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00840 · Cited by 94 · see citing works
Vargas‐Castillo, A., Fuentes‐Romero, R., Rodríguez-López, L. A., Torres, N., & Tovar, A. R. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.10.002 · Cited by 94 · see citing works
- Authors
- Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., Chen, M.-H., Ramachandran, V. S., Larson, M. G., Bouchard, C., Rankinen, T., Souza, A. L., Clish, C. B., Wang, T. J., Estall, J. L., Soukas, A. A., Cowan, C. A., Spiegelman, B. M., & Gerszten, R. E.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Karolinska Institutet (SE)
- Boston University (US)
- Pennington Biomedical Research Center (US)
- Montreal Clinical Research Institute (CA)
- Corresponding author
- Gerszten, Robert E.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 96-108
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4017355
- OpenAlex
- W1974559463
- Cited by
- 643
- References
- 62
- Citations by year
- 2026: 49 · 2025: 46 · 2024: 57 · 2023: 62 · 2022: 65 · 2021: 51 · 2020: 55 · 2019: 59 · 2018: 50 · 2017: 34 · 2016: 51 · 2015: 42 · 2014: 21
- FWCI
- 32.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195, R01HL098280, N01-HC-025195, R01HL045670)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK095384, R01DK031405, DK-31405, R37DK031405, R01DK081572)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- beta-aminoisobutyric acid, myokines, PGC-1α, brown adipose tissue browning, white adipose tissue, hepatic beta-oxidation, PPARα, physical activity, glucose homeostasis, cardiometabolic risk factors
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Aminoisobutyric Acids, Animals, Adipose Tissue, Brown, Cardiovascular Diseases, Cell Differentiation, Gene Expression Regulation, Glucose Tolerance Test, Humans, Liver, Metabolic Diseases, Organ Specificity, Oxidation-Reduction, Phenotype, Physical Conditioning, Animal, Risk Factors, Transcription Factors, Transcription, Genetic, Weight Gain, Exercise, PPAR alpha, Mice, Adipose Tissue, White, Adipocytes, Brown, Adipocytes, White, Induced Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
