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A Smooth Muscle-Like Origin for Beige Adipocytes
Open accessAbstract
SUMMARY Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole body energy expenditure. Using a selective translational profiling approach, we present a comprehensive molecular description of brown and beige gene expression in vivo. This UCP1-TRAP dataset demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown adipocytes. In vivo fate mapping demonstrates that at least a subset of beige cells arise from a smooth muscle-like origin. Finally, ectopic expression of PRDM16 converts bona fide vascular smooth muscle cells into Ucp1-positive adipocytes in vitro. These results establish a portrait of brown and beige adipocyte gene expression in vivo and identify a previously unrecognized origin for beige cells.
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Cites
Brown Adipose Tissue: Function and Physiological Significance
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
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Self-citationFunctional Brown Adipose Tissue in Healthy Adults
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InfluentialSelf-citationBrown and beige fat: Development, function and therapeutic potential
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Cited by
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575
Obesity, Adipose Tissue and Vascular Dysfunction
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Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis, L., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 687
Identification of a mesenchymal progenitor cell hierarchy in adipose tissue
Merrick, D., Sakers, A., Irgebay, Z., Okada, C., Calvert, C., Morley, M. P., Percec, I., & Seale, P. (2019) · Science · doi:10.1126/science.aav2501 · Cited by 664
The Common and Distinct Features of Brown and Beige Adipocytes
Ikeda, K., Maretich, P., & Kajimura, S. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.01.001 · Cited by 543
Metadata
- Authors
- Long, J. Z., Svensson, K. J., Tsai, L., Zeng, X., Roh, H. C., Kong, X., Rao, R. R., Lou, J., Lokurkar, I., Baur, W., Castellot, J. J., Rosen, E. D., & Spiegelman, B. M.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 19
- Issue
- 5
- Pages
- 810-820
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2020346259
- Cited by
- 461
- References
- 50
- FWCI
- 30.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Long, J. Z., Svensson, K. J., Tsai, L., Zeng, X., Roh, H. C., Kong, X., Rao, R. R., Lou, J., Lokurkar, I., Baur, W., Castellot, J. J., Rosen, E. D., & Spiegelman, B. M. (2014). A Smooth Muscle-Like Origin for Beige Adipocytes. Cell Metabolism. https://doi.org/10.1016/j.cmet.2014.03.025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
