The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Open accessAbstract
Summary Brown fat defends against hypothermia and obesity through thermogenesis mediated by mitochondrial UCP1. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here we report the cloning of “beige” cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we show that deposits of brown fat previously observed in adult humans are composed of beige adipose cells. These data illustrate a new cell type with therapeutic potential in mouse and human.
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Citations
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Self-citationCold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Self-citationFunctional Brown Adipose Tissue in Healthy Adults
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Self-citationPRDM16 controls a brown fat/skeletal muscle switch
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“The ‘‘brown-like’’ cells within white adipose depots are not derived from the myf-5 lineage and have been called ‘‘beige’’ or ‘‘brite’’ cells (Ishibashi and Seale, 2010; Petrovic et al., 2010; Seale et al., 2008).”
BackgroundSelf-citationMuscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
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“Other polypeptide hormones that brown white adipose tissues in rodents, such as FGF21 (Fisher et al., 2012) and ANP (Bordicchia et al.”
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Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
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Cited by
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Self-citationBrown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440
Self-citationFTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Claussnitzer, M., Dankel, S. N., Kim, K.-H., Quon, G., Meuleman, W., Haugen, C., Glunk, V., Sousa, I. S., Beaudry, J. L., Puviindran, V., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1502214 · Cited by 1,332
Metadata
- Authors
- Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A.-H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerbäck, S., Schrauwen, P., & Spiegelman, B. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 150
- Issue
- 2
- Pages
- 366-376
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2027753197
- Cited by
- 3,319
- References
- 12
- FWCI
- 135.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A.-H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerbäck, S., Schrauwen, P., & Spiegelman, B. M. (2012). Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human. Cell. https://doi.org/10.1016/j.cell.2012.05.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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