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Cited by 531

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

Open access
Cawthorn, William P., Scheller, Erica L., Learman, Brian S., Parlee, Sebastian D., Simon, Becky R., Mori, Hiroyuki, Ning, Xiaomin, Bree, Adam J., Schell, Benjamin, Broome, David T., Soliman, Sandra S., DelProposto, Jenifer L., Lumeng, Carey N., Mitra, Aditi, Pandit, Sandeep V., Gallagher, Katherine A., Miller, Joshua D., Krishnan, Venkatesh, Hui, Susanta K., Bredella, Miriam A., Fazeli, Pouneh K., Klibanski, Anne, Horowitz, Mark C., Rosen, Clifford J., MacDougald, Ormond A.·2014·Cell Metabolism
DOI 10.1016/j.cmet.2014.06.003
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Abstract

SUMMARY The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated if MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than from WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR, despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR, and perhaps in other adverse states.

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Metadata

Authors
Cawthorn, W. P., Scheller, E. L., Learman, B. S., Parlee, S. D., Simon, B. R., Mori, H., Ning, X., Bree, A. J., Schell, B., Broome, D. T., Soliman, S. S., DelProposto, J. L., Lumeng, C. N., Mitra, A., Pandit, S. V., Gallagher, K. A., Miller, J. D., Krishnan, V., Hui, S. K., Bredella, M. A., Fazeli, P. K., Klibanski, A., Horowitz, M. C., Rosen, C. J., & MacDougald, O. A.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2014-08
Volume
20
Issue
2
Pages
368-375
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2014.06.003
OpenAlex
W2100012264
Cited by
531
References
32
FWCI
23.71
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction. https://app.cochat.ai/papers/10.1016/j.cmet.2014.06.003
The paper
Cawthorn, W. P., Scheller, E. L., Learman, B. S., Parlee, S. D., Simon, B. R., Mori, H., Ning, X., Bree, A. J., Schell, B., Broome, D. T., Soliman, S. S., DelProposto, J. L., Lumeng, C. N., Mitra, A., Pandit, S. V., Gallagher, K. A., Miller, J. D., Krishnan, V., Hui, S. K., . . . MacDougald, O. A. (2014). Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction. Cell Metabolism. https://doi.org/10.1016/j.cmet.2014.06.003

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.