The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Anatomical, Physiological, and Functional Diversity of Adipose Tissue
Open accessAbstract
Adipose tissue depots can exist in close association with other organs, where they assume diverse, often ‘non-traditional’ functions. In stem cell-rich skin, bone marrow and mammary glands, adipocytes signal to and modulate organ regeneration and remodeling. Skin adipocytes and their progenitors signal to hair follicles, promoting epithelial stem cell quiescence and activation, respectively. Hair follicles signal back to adipocyte progenitors, inducing their expansion and regeneration, as in skin scars. In mammary glands and heart, adipocytes supply lipids to neighboring cells for nutritional and metabolic functions, respectively. Adipose depots adjacent to skeletal structures function to absorb mechanical shock. Adipose tissue near the surface of skin and intestine senses and responds to bacterial invasion, contributing to the body’s innate immune barrier. As the recognition for diverse adipose depot functions increase, novel therapeutic approaches centered on tissue-specific adipocytes are likely to emerge for a range of cancers and regenerative, infectious, and autoimmune disorders.
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Citations
Cites
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PRDM16 controls a brown fat/skeletal muscle switch
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“BAT develops embryonically, derived from Myf5- and Pax7-expressing precursor cells in the mesoderm that also give rise to skeletal muscle cells and a portion of white adipocytes (Lepper and Fan, 2010; Sanchez-Gurmaches et al., 2012; Seale et al., 2008; Wang and Seale, 2016).”
Human epicardial adipose tissue is a source of inflammatory mediators
Mazurek, T., Zhang, L., Zalewski, A., Mannion, J. D., Diehl, J. T., Arafat, H., Sarov-Blat, L., O’Brien, S., Keiper, E. A., Johnson, A. G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000099542.57313.c5 · Cited by 1,966 · cited 1×
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Cited by
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00471-8 · Cited by 527
Reassessing human adipose tissue
Cypess, A. M. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2032804 · Cited by 404
Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
Dilworth, L., Facey, A., & Omoruyi, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147644 · Cited by 382
Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
Lahiri, V., Hawkins, W. D., & Klionsky, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.003 · Cited by 282
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271
Metadata
- Authors
- Zwick, R. K., Guerrero-Juarez, C. F., Horsley, V., & Plikus, M. V.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 27
- Issue
- 1
- Pages
- 68-83
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2783249679
- Cited by
- 527
- References
- 169
- FWCI
- 21.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zwick, R. K., Guerrero-Juarez, C. F., Horsley, V., & Plikus, M. V. (2018). Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metabolism. https://doi.org/10.1016/j.cmet.2017.12.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
