Metformin Action: Concentrations Matter

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Madiraju, A. K., Erion, D. M., Rahimi, Y., Zhang, X.-M., Braddock, D. T., Albright, R. A., Prigaro, B. J., Wood, J. L., Bhanot, S., MacDonald, M. J., et al. (2014) · Nature · doi:10.1038/nature13270 · Cited by 1,284

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181

Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., & Gerich, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508313330903 · Cited by 1,148

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Miller, R., Chu, Q., Xie, J., Foretz, M., Viollet, B., & Birnbaum, M. J. (2013) · Nature · doi:10.1038/nature11808 · Cited by 845

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773

Metformin pathways: pharmacokinetics and pharmacodynamics

Gong, L., Goswami, S., Giacomini, K. M., Altman, R. B., & Klein, T. E. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283559b22 · Cited by 495

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

Silamiķele, L., Silamiķelis, I., Ustinova, M., Kalniņa, Z., Elbere, I., Petrovska, R., Kalniņa, I., & Kloviņš, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.626359 · Cited by 63

Metformin as a Potential Agent in the Treatment of Multiple Sclerosis

Dziedzic, A., Saluk, J., Miller, E. D., & Bijak, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175957 · Cited by 62

Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes

Mu, X., Xiang, Z., Xu, Y., He, J., Lu, J., Chen, Y., Wang, X., Tu, C. R., Zhang, Y., Zhang, W., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00894-x · Cited by 61

Metformin: A Dual-Role Player in Cancer Treatment and Prevention

Galal, M. A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S. S., & Aljada, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074083 · Cited by 73

Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advancedin vitrotesting

Koepsell, H. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1915284 · Cited by 58

Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes

Hozumi, K., Sugawara, K., Ishihara, T., Ishihara, N., & Ogawa, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-27689-y · Cited by 62

Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies

Amengual-Cladera, E., Morla-Barcelo, P. M., Morán-Costoya, A., Valle, A., Pons, D. G., Sastre‐Serra, J., Roca, P., & Nadal‐Serrano, M. (2024) · Biology · doi:10.3390/biology13050302 · Cited by 74

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

Zhang, X., Milito, A. D., Olofsson, A. M., Gullbo, J., D’Arcy, P., & Linder, S. T. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126020 · Cited by 56

Hepatoprotective activity of metformin: A new mission for an old drug?

Iranshahy, M., Rezaee, R., & Karimi, G. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.004 · Cited by 58

The Relationship between Diabetes Mellitus and Gastric Cancer and the Potential Benefits of Metformin: An Extensive Review of the Literature

Tseng, C. (2021) · Biomolecules · doi:10.3390/biom11071022 · Cited by 55

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Pěnčík, J., Philippe, C., Schlederer, M., Atas, E., Pecoraro, M., Grund‐Gröschke, S., Li, W., Tracz, A., Heidegger, I. M., Lagger, S., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01825-8 · Cited by 53

Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer

Johnson, J. M., Lai, S. Y., Cotzia, P., Cognetti, D. M., Luginbuhl, A., Pribitkin, E. A., Zhan, T., Mollaee, M., Domingo‐Vidal, M., Chen, Y., et al. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.025 · Cited by 55

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

Magno, L. D., Manni, S., Pastena, F. D., Coni, S., Macone, A., Cairoli, S., Sambucci, M., Infante, P., Moretti, M., Petroni, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.024 · Cited by 56

The effects of metformin in the treatment of osteoarthritis: Current perspectives

Song, Y., Wu, Z., & Zhao, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.952560 · Cited by 55

Metformin: A Possible Option in Cancer Chemotherapy

Ugwueze, C. V., Ogamba, O. J., Young, E. E., Onyenekwe, B. M., & Ezeokpo, B. C. (2020) · Analytical Cellular Pathology · doi:10.1155/2020/7180923 · Cited by 52

Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones

Karademir, D., Todorova, V., Ebner, L. J. A., Samardzija, M., & Grimm, C. (2022) · BMC Biology · doi:10.1186/s12915-022-01280-9 · Cited by 50

Molecular mechanisms of action of metformin: latest advances and therapeutic implications

Zhu, H., Jia, Z., Li, Y. R., & Danelisen, I. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01051-y · Cited by 59

Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate

Lewis, A., Miller, J. J. J. J., McCallum, C., Rider, O. J., Neubauer, S., Heather, L. C., & Tyler, D. J. (2016) · Diabetes · doi:10.2337/db16-0804 · Cited by 50

Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease

Triggle, C. R., Ding, H., Marei, I., Anderson, T. J., & Hollenberg, M. D. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0677 · Cited by 49

Knocking on GDF15’s door for the treatment of type 2 diabetes mellitus

Aguilar-Recarte, D., Barroso, E., Palomer, X., Wahli, W., & Vázquez‐Carrera, M. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.08.004 · Cited by 51

Promising use of metformin in treating neurological disorders: biomarker-guided therapies

Loan, A., Syal, C., Lui, M., He, L., & Wang, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385286 · Cited by 50

Regulation of organelle function by metformin

Kim, J., & You, Y. (2017) · IUBMB Life · doi:10.1002/iub.1633 · Cited by 50

Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice

Wei, X., Yang, D., Zhang, B., Fan, X., Du, H., Zhu, R., Sun, X., Zhao, M., & Gu, N. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156815 · Cited by 48

Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia

Top, W. M. C., Kooy, A., & Stehouwer, C. D. A. (2022) · Pharmaceuticals · doi:10.3390/ph15030312 · Cited by 51

Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening

Luo, Z., Wang, B., Luo, F., Guo, Y., Jiang, N., Wei, J., Wang, X., Tseng, Y., Chen, J., Zhao, B. T., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03034-y · Cited by 50

Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells

Amable, G., Martínez-León, E., Picco, M. E., Siervi, N. D., Davio, C. A., Rozengurt, E., & Rey, O. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.05.004 · Cited by 47

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

Stein, B. D., Calzolari, D., Hellberg, K., Hu, Y., He, L., Hung, C., Toyama, E. Q., Ross, D. S., Lillemeier, B. F., Cantley, L. C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.117 · Cited by 44

Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Zake, D. M., Kurlovičs, J., Zaharenko, L., Komašilovs, V., Kloviņš, J., & Stalidzāns, E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249594 · Cited by 50

Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: Starving tumors

Wokoun, U., Hellriegel, M., Emons, G., & Gründker, C. (2017) · Oncology Reports · doi:10.3892/or.2017.5491 · Cited by 45

Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway

Lei, Y., Gong, L., Tan, F., Liu, Y., Li, S., Shen, H., Zhu, M. P., Cai, W., Xu, F., Hou, B., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.029 · Cited by 45

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion

Chen, Y., Fujuan, Q., Yu, B., Chen, Y., Zuo, F., Zhu, X., Nandakumar, K. S., & Xiao, C. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.05.008 · Cited by 47

Metformin promotes mitophagy in mononuclear cells: a potential in vitro model for unraveling metformin's mechanism of action

Bhansali, S., Bhansali, A., & Dhawan, V. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14141 · Cited by 45

Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy

Chen, L., Liao, F., Jiang, Z., Zhang, C., Wang, Z., Luo, P., Jiang, Q., Wu, J., Wang, Q., Luo, M., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15149 · Cited by 45

Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption

de Mey, S., Jiang, H., Corbet, C., Wang, H., Dufait, I., Ka, L. L., Bastien, E., Verovski, V. N., Gevaert, T., Féron, O., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01073 · Cited by 45

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Zhou, X. E., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Xu, H. E., & Melcher, K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004883 · Cited by 44

Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A

Zhang, L., Lu, L., Zhong, X., Yue, Y., Hong, Y., Li, Y., & Li, Y. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.03.006 · Cited by 44

PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy

Shariq, M., Khan, M. F., Raj, R., Ahsan, N., & Kumar, P. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02411-7 · Cited by 42

Dose-Response Metabolomics To Understand Biochemical Mechanisms and Off-Target Drug Effects with the TOXcms Software

Yao, C.-H., Wang, L., Stancliffe, E., Sindelar, M., Cho, K., Yin, W., Wang, Y., & Patti, G. J. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03811 · Cited by 43

Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes

Onken, B., Sedore, C. A., Coleman-Hulbert, A. L., Hall, D., Johnson, E., Jones, E. G., Banse, S. A., Huynh, P., Guo, S., Xue, J., et al. (2021) · Aging Cell · doi:10.1111/acel.13488 · Cited by 46

Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

Schommers, P., Thurau, A., Bultmann-Mellin, I., Guschlbauer, M., Klatt, A. R., Rozman, J., Klingenspor, M., de Angelis, M. H., Alber, J., Gründemann, D., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.05.002 · Cited by 42

Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient

Nantsupawat, T., Wongcharoen, W., Chattipakorn, S. C., & Chattipakorn, N. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01176-4 · Cited by 41

Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?

Shoshan‐Barmatz, V., Anand, U., Crystal, E. N., Carlo, M. D., & Shteinfer‐Kuzmine, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730048 · Cited by 42

A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects

Aguilar-Recarte, D., Barroso, E., Zhang, M., Rada, P., Pizarro‐Delgado, J., Peña, L., Palomer, X., Valverde, Á. M., Wahli, W., & Vázquez‐Carrera, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106578 · Cited by 47

Spatial control of AMPK signaling at subcellular compartments

Chauhan, A. S., Li, Z., & Gan, B. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1727840 · Cited by 41

Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma

Singh, A., Gu, J. J., Zhang, Q., Torka, P., Sundaram, S., Mavis, C. K., & Hernandez‐Ilizaliturri, F. J. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00213-w · Cited by 40

Metformin: Metabolic Rewiring Faces Tumor Heterogeneity

Cioce, M., Pulito, C., Strano, S., Blandino, G., & Fazio, V. M. (2020) · Cells · doi:10.3390/cells9112439 · Cited by 41

Metformin Reverses the Enhanced Myocardial SR/ER–Mitochondria Interaction and Impaired Complex I-Driven Respiration in Dystrophin-Deficient Mice

Angebault, C., Panel, M., Lacôte, M., Rieusset, J., Lacampagne, A., & Fauconnier, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.609493 · Cited by 40

AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration

Miyagishima, K. J., Sharma, R., Nimmagadda, M., Clore-Gronenborn, K., Qureshy, Z., Ortolan, D., Bose, D., Farnoodian, M., Zhang, C., Fausey, A., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02872-x · Cited by 43

Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury

Kaur, S., Auger, C., & Jeschke, M. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.599576 · Cited by 39

PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging

Petrocelli, J. J., & Drummond, M. J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17228650 · Cited by 39

Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney

Miguel, V., Rey, C., Tituaña, J., Sirera, B., Alcalde‐Estévez, E., Herrero, J. I., Ranz, I., Fernández, L., Castillo, C., Sevilla, L. F. V., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102957 · Cited by 38

Metformin and tenovin‐6 synergistically induces apoptosis through LKB1‐independent SIRT1 down‐regulation in non‐small cell lung cancer cells

Lee, B. B., Kim, Y., Kim, D., Cho, E. Y., Han, J., Kim, H. K., Shim, Y. M., & Kim, D. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14194 · Cited by 38

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway

Chen, C., Wang, H., Geng, X., Zhang, D., Zhu, Z., Zhang, G., & Hou, J. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02043-2 · Cited by 39

Metformin Represses Glucose Starvation Induced Autophagic Response in Microvascular Endothelial Cells and Promotes Cell Death

Samuel, S. M., Ghosh, S., Majeed, Y., Arunachalam, G., Emara, M. M., Ding, H., & Triggle, C. R. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.001 · Cited by 37

AMPK inhibits liver gluconeogenesis: fact or fiction?

Johanns, M., Hue, L., & Rider, M. H. (2023) · Biochemical Journal · doi:10.1042/bcj20220582 · Cited by 46

Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux

He, X. M., Chen, X., Wang, L., Wang, W., Liang, Q., Yi, L., Wang, Y., & Gao, Q. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.024 · Cited by 37

Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease

Guitton-Sert, L., Gao, Y., & Masson, J. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.11.010 · Cited by 36

The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance

Aguilar-Recarte, D., Palomer, X., Wahli, W., & Vázquez‐Carrera, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168555 · Cited by 40

Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium

Li, Y., Gappy, S. S., Liu, X., Sassalos, T. M., Zhou, T., Hsu, A., Zhang, A., Edwards, P. A., Gao, H., & Qiao, X. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268451 · Cited by 40

Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways

Sarmento‐Cabral, A., L‐López, F., Gahete, M. D., Castano, J. P., & Luque, R. M. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0493 · Cited by 35

H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses

Deng, J., Mueller, M., Geng, T., Shen, Y., Liu, Y., Hou, P., Ramillapalli, R., Taylor, H. S., Paidas, M. J., & Huang, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.392 · Cited by 35

Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease

Song, X., Tsakiridis, E. E., Steinberg, G. R., & Pei, Y. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109704 · Cited by 36

MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer

Crowell, P. D., Giafaglione, J. M., Jones, A. E., Nunley, N. M., Hashimoto, T., Delcourt, A. M. L., Petcherski, A., Agrawal, R., Bernard, M. J., Diaz, J. A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113221 · Cited by 35

Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells

Tai, Y., Li, L., Peng, X., Zhu, J.-X., Mao, X.-H., Qin, N., Ma, M., Huo, R., Bai, Y., & Dong, D. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.07.010 · Cited by 34

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

Moonira, T., Chachra, S. S., Ford, B. E., Marín, S., Alshawi, A., Adam-Primus, N. S., Arden, C., Al‐Oanzi, Z. H., Foretz, M., Viollet, B., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012533 · Cited by 35

Low glucose enhanced metformin’s inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p

Ma, M., Ma, C., Li, P., Ma, C., Ping, F., Li, W., Xu, L., Zhang, H., Sun, Q., & Li, Y. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1796036 · Cited by 34

The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

Hohnholt, M. C., Blumrich, E., Waagepetersen, H. S., & Dringen, R. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24050 · Cited by 34

Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression

Erices, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, M. L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15348 · Cited by 33

An update on mode of action of metformin in modulation of meta-inflammation and inflammaging

Khodadadi, M., Jafari-Gharabaghlou, D., & Zarghami, N. (2022) · Pharmacological Reports · doi:10.1007/s43440-021-00334-z · Cited by 34

Sodium–glucose cotransporter inhibition in polycystic kidney disease: fact or fiction

Afşar, B., Afşar, R. E., Demiray, A., Altay, S., Korkmaz, H., Yıldız, A., Covic, A. C., Ortíz, A., & Kanbay, M. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac029 · Cited by 35

Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity

Kaplowitz, N., Win, S., Than, T. A., Liu, Z., & Dara, L. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.050 · Cited by 32

Platelets and endothelial dysfunction in gestational diabetes mellitus

Valero, P., Cornejo, M., Fuentes, G., Wehinger, S., Toledo, F., van der Beek, E. M., Sobrevía, L., & Moore‐Carrasco, R. (2023) · Acta Physiologica · doi:10.1111/apha.13940 · Cited by 34

Liver and Metformin: Lessons of a fructose diet in mice

Karise, I., Ornellas, F., Barbosa‐da‐Silva, S., Matsuura, C., del Sol, M., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2017) · Biochimie Open · doi:10.1016/j.biopen.2017.01.002 · Cited by 31

Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity

Chhunchha, B., Kubo, E., & Singh, D. P. (2022) · Cells · doi:10.3390/cells11193021 · Cited by 31

Concentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells

Ravera, S., Cossu, V., Tappino, B., Nicchia, E., Dufour, C., Cavani, S., Sciutto, A., Bolognesi, C., Columbaro, M., Degan, P., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26085 · Cited by 30

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties

Dasgupta, A., Trucco, M. M., Rainusso, N. C., Bernardi, R. J., Shuck, R. L., Kurenbekova, L., Loeb, D. M., & Yustein, J. T. (2017) · Oncotarget · doi:10.18632/oncotarget.20467 · Cited by 33

The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin

Kopel, J. J., Higuchi, K., Ristić, B., Sato, T., Ramachandran, S., & Ganapathy, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-65621-w · Cited by 30

Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease

Gupta, S., Ozimek-Kulik, J. E., & Phillips, J. K. (2021) · Genes · doi:10.3390/genes12111762 · Cited by 35

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Šalovská, B., Gao, E., Müller‐Dott, S., Li, W., Cordon, C. C., Wang, S., Dugourd, A. J. F., Rosenberger, G., Sáez-Rodríguez, J., & Liu, Y. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1179 · Cited by 31

Metformin inhibits IgE‐ and aryl hydrocarbon receptor‐mediated mast cell activation in vitro and in vivo

Wang, H., & Huang, S. (2018) · European Journal of Immunology · doi:10.1002/eji.201847706 · Cited by 30

Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery

Li, S., Han, D. G., Zhang, Y., Xie, X., Ke, R., Zhu, Y., Liu, L., Song, Y., Yang, L., & Li, M. (2016) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.897505 · Cited by 29

Direct assessment of renal mitochondrial redox state using hyperpolarized 13C‐acetoacetate

von Morze, C., Ohliger, M. A., Marco‐Rius, I., Wilson, D. M., Flavell, R. R., Pearce, D., Vigneron, D. B., Kurhanewicz, J. V., & Wang, Z. J. (2018) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27054 · Cited by 32

Of mice and men: Is there a future for metformin in the treatment of hepatic steatosis?

Green, C., Marjot, T., Tomlinson, J., & Hodson, L. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13592 · Cited by 29

An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis

Markowicz-Piasecka, M., Sadkowska, A., Huttunen, K. M., Podsiedlik, M., Mikiciuk‐Olasik, E., & Sikora, J. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172984 · Cited by 31

Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective

Torres, W., Nava, M., Galbán, N., Gómez, Y., Morillo, V., Rojas, M., Cano, C., Chacín, M., D’Marco, L., Herazo-Beltrán, Y., et al. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200716161610 · Cited by 28

Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Chen, Y., Ma, H., Dasheng, Z., Zhao, G., Wang, L., Fu, X., & Chen, W. (2017) · PPAR Research · doi:10.1155/2017/8360919 · Cited by 29

Opposite effects of a glucokinase activator and metformin on glucose‐regulated gene expression in hepatocytes

Al‐Oanzi, Z. H., Fountana, S., Moonira, T., Tudhope, S. J., Petrie, J. L., Alshawi, A., Patman, G., Arden, C., Reeves, H. L., & Agius, L. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12910 · Cited by 29

Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris

Cummings, B. M., Needoba, J. A., & Peterson, T. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207041 · Cited by 29

Sulfenamide and Sulfonamide Derivatives of Metformin – A New Option to Improve Endothelial Function and Plasma Haemostasis

Markowicz-Piasecka, M., Huttunen, K. M., Broncel, M., & Sikora, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-43083-z · Cited by 27

Metformin: (future) best friend of the radiation oncologist?

Chevalier, B., Pasquier, D., Lartigau, E. F., Chargari, C., Schernberg, A., Jannin, A., Mirabel, X., Vantyghem, M., & Escande, A. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.06.030 · Cited by 27

Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer

Kong, Y., Zhang, Y., Mao, F., Zhang, Z., Li, Z., Wang, R., Liu, J., & Liu, X. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0874 · Cited by 27

Frontiers in Anti-Cancer Drug Discovery: Challenges and Perspectives of Metformin as Anti-Angiogenic Add-On Therapy in Glioblastoma

Guarnaccia, L., Navone, S. E., Masseroli, M. M., Balsamo, M., Caroli, M., Valtorta, S., Moresco, R. M., Campanella, R., Garzia, E., Riboni, L., et al. (2021) · Cancers · doi:10.3390/cancers14010112 · Cited by 30

Metformin combats high glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells via inhibition of the NPR3-mediated MAPK pathway

Zhang, Y., Liu, F., Li, Z.-B., He, X., Li, X., Wu, R., Sun, H., Ge, S., Chen, F., & An, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02992-z · Cited by 29

Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

Gerthofer, V., Kreutz, M. P., Renner, K., Jachnik, B., Dettmer, K., Oefner, P. J., Riemenschneider, M. J., Proescholdt, M. A., Vollmann‐Zwerenz, A., Hau, P., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092586 · Cited by 28

Metformin Suppresses Development of the Echinococcus multilocularis Larval Stage by Targeting the TOR Pathway

Loos, J. A., Dávila, V. A., Brehm, K., & Cumino, A. C. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01808-19 · Cited by 26

Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy

Wang, F., Sun, H., Zuo, B., Shi, K., Zhang, X., Zhang, C., & Sun, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-95827-5 · Cited by 25

The Hormetic Effect of Metformin: “Less Is More”?

Panfoli, I., Puddu, A., Bertola, N., Ravera, S., & Maggi, D. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126297 · Cited by 29

New Aspects of Diabetes Research and Therapeutic Development

Satin, L. S., Soleimanpour, S. A., & Walker, E. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000160 · Cited by 30

Metformin Alleviates Neuroinflammation Following Intracerebral Hemorrhage in Mice by Regulating Microglia/Macrophage Phenotype in a Gut Microbiota-Dependent Manner

Xiaobo, Y., Fu, X., Wu, X., Tang, W., Xu, L., Hu, L., Xu, C., Zhou, H., Zhou, G., Li, J., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.789471 · Cited by 26

Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes

Anwardeen, N. R., Naja, K., & Elrayess, M. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1506767 · Cited by 29

Cette metformine, si connue. Si méconnue pour ses taux thérapeutiques…

Kajbaf, F., & Lalau, J. (2016) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(16)30155-9

Therapeutic vs. Suprapharmacological Metformin Concentrations: Different Effects on Energy Metabolism and Mitochondrial Function in Skeletal Muscle Cells in vitro

Pavlović, K., Jakovljevic, N. K., Isakovic, A. M., Ivanovic, T., Marković, I., & Lalic, N. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930308 · Cited by 30

Vol de glucose par le fœtus !

A., F. (2016) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(16)30124-9

Metformin: A Case Study in the Meaning of Serum Concentrations

Ochs, R. S. (2014) · Journal of Molecular Pharmaceutics & Organic Process Research · doi:10.4172/2329-9053.1000e111 · Cited by 2

La leptine : Le retour !

A., F. (2016) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(16)30129-8