Cited by 448Metabolism, Diabetes, and CancerDiabetes Treatment and ManagementNatural Antidiabetic Agents Studies

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Metformin Action: Concentrations Matter

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He, Ling, Wondisford, Fredric E.·2015·Cell Metabolism

DOI 10.1016/j.cmet.2015.01.003

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Abstract

Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

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Authors: He, L., & Wondisford, F. E.
Affiliations: Johns Hopkins University (US)
Corresponding author: Wondisford, Fredric E.
ORCID: He, Ling
Wondisford, Fredric E.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2015-02
Volume: 21
Issue: 2
Pages: 159-162
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2015.01.003
OpenAlex: W2080654617
Cited by: 448
References: 18
Citations by year: 2026: 25 · 2025: 30 · 2024: 39 · 2023: 43 · 2022: 61 · 2021: 57 · 2020: 59 · 2019: 37 · 2018: 41 · 2017: 30 · 2016: 16 · 2015: 10
FWCI: 14.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: metformin, type 2 diabetes, mechanism of action, therapeutic drug concentrations, oral antidiabetic drugs, pharmacokinetics
MeSH terms: Animals, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Humans, Metformin

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Metformin Action: Concentrations Matter

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