The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus
Open accessAbstract
SUMMARY Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but the detailed mechanisms underlying its success are not fully understood. Here we show that MSCT rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically, we show that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 (Dnmt1) expression in MRL/lpr BMMSCs. This results in hypomethylation of the Notch1 promoter and activation of Notch signaling, in turn leading to impaired osteogenic differentiation. Furthermore, we show that exosomes, secreted due to MSCT, transfer Fas to recipient MRL/lpr BMMSCs to reduce intracellular levels of miR-29b, which results in recovery of Dnmt1-mediated Notch1 promoter hypomethylation and thereby improves MRL/lpr BMMSC function. Collectively our findings unravel the means by which MSCT rescues MRL/lpr BMMSC function through reuse of donor exosome-provided Fas to regulate the miR-29b/Dnmt1/Notch epigenetic cascade.
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Cites
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Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
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Cited by
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., & Wang, Y. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0023-5 · Cited by 1,223
Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs
Lin, Y., Wu, J., Gu, W., Huang, Y., Tong, Z., Huang, L., & Tan, J. (2018) · Advanced Science · doi:10.1002/advs.201700611 · Cited by 625
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Self-citationMSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
He, X., Dong, Z., Cao, Y., Wang, H., Liu, S., Liao, L., Jin, Y., Yuan, L., & Li, B. (2019) · Stem Cells International · doi:10.1155/2019/7132708 · Cited by 404
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Metadata
- Authors
- Liu, S., Liu, D., Chen, C., Hamamura, K., Moshaverinia, A., Yang, R., Liu, Y., Jin, Y., & Shi, S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 22
- Issue
- 4
- Pages
- 606-618
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1836448277
- Cited by
- 246
- References
- 7
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, S., Liu, D., Chen, C., Hamamura, K., Moshaverinia, A., Yang, R., Liu, Y., Jin, Y., & Shi, S. (2015). MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Cell Metabolism. https://doi.org/10.1016/j.cmet.2015.08.018
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