Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs
Open accessAbstract
Targeted delivery of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) system to the receptor cells is essential for in vivo gene editing. Exosomes are intensively studied as a promising targeted drug delivery carrier recently, while limited by their low efficiency in encapsulating of large nucleic acids. Here, a kind of hybrid exosomes with liposomes is developed via simple incubation. Different from the original exosomes, the resultant hybrid nanoparticles efficiently encapsulate large plasmids, including the CRISPR–Cas9 expression vectors, similarly as the liposomes. Moreover, the resultant hybrid nanoparticles can be endocytosed by and express the encapsulated genes in the mesenchymal stem cells (MSCs), which cannot be transfected by the liposome alone. Taken together, the exosome–liposome hybrid nanoparticles can deliver CRISPR–Cas9 system in MSCs and thus be promising in in vivo gene manipulation.
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Exosome-liposome hybrid system can be engineered to efficiently deliver mRNA to cells.
“By associating mRNA with cationic liposomes and incubating these liposomes with exosomes, the exosome-liposome hybrid system can be engineered to efficiently deliver mRNA to cells [115].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [115]
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- Authors
- Lin, Y., Wu, J., Gu, W., Huang, Y., Tong, Z., Huang, L., & Tan, J.
- Affiliations
- Sun Yat-sen University (CN)
- Corresponding author
- Tan, Jiali
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2018-01-30
- Volume
- 5
- Issue
- 4
- Pages
- 1700611-1700611
- ISSN
- 2198-3844 (ISSN-L)
- PMC
- PMC5908366
- OpenAlex
- W2793760887
- Cited by
- 625
- References
- 43
- Citations by year
- 2026: 66 · 2025: 90 · 2024: 90 · 2023: 102 · 2022: 83 · 2021: 86 · 2020: 54 · 2019: 42 · 2018: 10
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Advanced Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81570803)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- CRISPR/Cas9 delivery, mesenchymal stem cells, exosomes, liposomes, in vivo gene editing, targeted gene delivery, endocytosis, nucleic acid delivery
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