The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells
Open accessAbstract
Summary The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor. Hence, we hypothesized that ectopic MYC expression perturbs the clock by deregulating E-box-driven components of the circadian network in cancer cells. We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBα to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB. REV-ERBα expression predicts poor clinical outcome for N-MYC-driven human neuroblastomas that have diminished BMAL1 expression, and reexpression of ectopic BMAL1 in neuroblastoma cell lines suppresses their clonogenicity. Further, ectopic MYC profoundly alters oscillation of glucose metabolism and perturbs glutaminolysis. Our results demonstrate an unsuspected link between oncogenic transformation and circadian and metabolic dysrhythmia, which we surmise to be advantageous for cancer.
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Self-citationCircadian integration of metabolism and energetics
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Self-citationCircadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis
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Research works printed but not linked: 1
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Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
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Bass, J., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 607
Self-citationCircadian Rhythm Disruption Promotes Lung Tumorigenesis
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“Recent work has demonstrated that c-Myc dampens circadian oscillations by opposing BMAL1 transcriptional oscillations and disrupting homeostatic glucose and glutamine oscillations (Altman et al., 2015).”
InfluentialCircadian Mechanisms in Medicine
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Metadata
- Authors
- Altman, B. J., Hsieh, A. L., Sengupta, A., Krishnanaiah, S. Y., Stine, Z. E., Walton, Z. E., Gouw, A. M., Venkataraman, A., Li, B., Goraksha-Hicks, P., Diskin, S. J., Bellovin, D. I., Simon, M. C., Rathmell, J. C., Lazar, M. A., Maris, J. M., Felsher, D. W., Hogenesch, J. B., Weljie, A. M., & Dang, C. V.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 22
- Issue
- 6
- Pages
- 1009-1019
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1895114046
- Cited by
- 274
- References
- 48
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
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- Altman, B. J., Hsieh, A. L., Sengupta, A., Krishnanaiah, S. Y., Stine, Z. E., Walton, Z. E., Gouw, A. M., Venkataraman, A., Li, B., Goraksha-Hicks, P., Diskin, S. J., Bellovin, D. I., Simon, M. C., Rathmell, J. C., Lazar, M. A., Maris, J. M., Felsher, D. W., Hogenesch, J. B., Weljie, A. M., & Dang, C. V. (2015). MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metabolism. https://doi.org/10.1016/j.cmet.2015.09.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
