Circadian Mechanisms in Medicine

Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works

A circadian gene expression atlas in mammals: Implications for biology and medicine

Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works

Clock Mutants of Drosophila melanogaster

Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works

Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction

Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884 · see citing works

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853 · see citing works

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464 · see citing works

An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works

Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness.

Chang, A.-M., Aeschbach, D., Duffy, J. F., & Czeisler, C. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418490112 · Cited by 1,430 · see citing works

Molecular mechanisms and physiological importance of circadian rhythms

Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388 · see citing works

Positional Cloning of the Mouse Circadian Gene

King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

Fultz, N. E., Bonmassar, G., Setsompop, K., Stickgold, R. A., Rosen, B. R., Polimeni, J. R., & Lewis, L. D. (2019) · Science · doi:10.1126/science.aax5440 · Cited by 1,197 · see citing works

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

Hardin, P. E., Hall, J. C., & Rosbash, M. (1990) · Nature · doi:10.1038/343536a0 · Cited by 1,156 · see citing works

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works

Light as a central modulator of circadian rhythms, sleep and affect

LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001 · see citing works

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works

Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Wilkinson, M. J., Manoogian, E. N. C., Zadourian, A., Lo, H., Fakhouri, S., Shoghi, A., Wang, X., Fleischer, J. G., Navlakha, S., Panda, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.004 · Cited by 927 · see citing works

Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707 · see citing works

Circadian control of brain glymphatic and lymphatic fluid flow

Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18115-2 · Cited by 704 · see citing works

Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer

Lévi, F. A., Zidani, R., & Misset, J. L. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03358-8 · Cited by 702 · see citing works

Association between circadian rhythms and neurodegenerative diseases

Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 660 · see citing works

Suppression of Melatonin Secretion in Some Blind Patients by Exposure to Bright Light

Czeisler, C. A., Shanahan, T. L., Klerman, E. B., Martens, H., Brotman, D. J., Emens, J. S., Klein, T., & Rizzo, J. F. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501053320102 · Cited by 654 · see citing works

Circadian time signatures of fitness and disease

Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 616 · see citing works

Sex difference in the near-24-hour intrinsic period of the human circadian timing system

Duffy, J. F., Cain, S. W., Chang, A., Phillips, A. J. K., Münch, M. Y., Gronfier, C., Wyatt, J. K., Dijk, D., Wright, K. P., & Czeisler, C. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010666108 · Cited by 601 · see citing works

Meal timing regulates the human circadian system

Wehrens, S. M. T., Christou, S., Isherwood, C., Middleton, B., Gibbs, M. A., Archer, S. N., Skene, D. J., & Johnston, J. D. (2017) · Current Biology · doi:10.1016/j.cub.2017.04.059 · Cited by 596 · see citing works

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589 · see citing works

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons

LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577 · see citing works

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

Papagiannakopoulos, T., Bauer, M. R., Davidson, S. M., Heimann, M., Subbaraj, L., Bhutkar, A., Bartlebaugh, J., Vander Heiden, M. G., & Jacks, T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.001 · Cited by 557 · see citing works

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Lam, M. T. Y., Cho, H., Lesch, H. P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M. U., Kim, A. S., Kosaka, M., et al. (2013) · Nature · doi:10.1038/nature12209 · Cited by 548 · see citing works

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

Gibbs, J. E., Ince, L. M., Matthews, L. C., Mei, J., Bell, T., Yang, N., Saer, B., Begley, N., Poolman, T. M., Pariollaud, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3599 · Cited by 456 · see citing works

Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep

Van Cauter, E., Blackman, J. D., Roland, D., Spire, J. P., Refetoff, S., & Polonsky, K. S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115396 · Cited by 448 · see citing works

T H 17 Cell Differentiation Is Regulated by the Circadian Clock

Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S., & Hooper, L. V. (2013) · Science · doi:10.1126/science.1243884 · Cited by 445 · see citing works

Role of the circadian system in cardiovascular disease

Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works

Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

Peek, C. B., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M., Ramsey, K. M., & Bass, J. T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.010 · Cited by 415 · see citing works

Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder

Patke, A., Murphy, P. J., Onat, O. E., Krieger, A. C., Özçelik, T., Campbell, S. S., & Young, M. W. (2017) · Cell · doi:10.1016/j.cell.2017.03.027 · Cited by 381 · see citing works

Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 377 · see citing works

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Jeyaraj, D., Haldar, S. M., Wan, X., McCauley, M. D., Ripperger, J. A., Hu, K., Lu, Y., Eapen, B. L., Sharma, N., Ficker, E., et al. (2012) · Nature · doi:10.1038/nature10852 · Cited by 343 · see citing works

Antidepressant efficacy of agomelatine: meta-analysis of published and unpublished studies

Taylor, D. M., Sparshatt, A., Varma, S., & Olofinjana, O. (2014) · BMJ · doi:10.1136/bmj.g1888 · Cited by 336 · see citing works

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

Montaigne, D., Marechal, X., Modine, T., Coisne, A., Mouton, S., Fayad, G., Ninni, S., Klein, C., Ortmans, S., Seunes, C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32132-3 · Cited by 315 · see citing works

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

Altman, B. J., Hsieh, A. L., Sengupta, A., Krishnanaiah, S. Y., Stine, Z. E., Walton, Z. E., Gouw, A. M., Venkataraman, A., Li, B., Goraksha-Hicks, P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.003 · Cited by 273 · see citing works

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

Fang, B., Everett, L. J., Jager, J., Briggs, E. R., Armour, S. M., Feng, D., Roy, A., Gerhart‐Hines, Z., Sun, Z., & Lazar, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.022 · Cited by 262 · see citing works

Rotating Night-Shift Work and the Risk of Breast Cancer in the Nurses' Health Studies

Wegrzyn, L. R., Tamimi, R. M., Rosner, B. A., Brown, S. B., Stevens, R. G., Eliassen, A. H., Laden, F., Willett, W. C., Hankinson, S. E., & Schernhammer, E. S. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx140 · Cited by 258 · see citing works

BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output

Meredith, A. L., Wiler, S. W., Miller, B. H., Takahashi, J. S., Fodor, A. A., Ruby, N. F., & Aldrich, R. W. (2006) · Nature Neuroscience · doi:10.1038/nn1740 · Cited by 254 · see citing works

Control of skin cancer by the circadian rhythm

Gaddameedhi, S., Selby, C. P., Kaufmann, W. K., Smart, R. C., & Sancar, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115249108 · Cited by 234 · see citing works

Seasonal affective disorder and latitude: a review of the literature

Mersch, P. P. A., Middendorp, H. M., Bouhuys, A. L., Beersma, D. G. M., & van den Hoofdakker, R. H. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00097-4 · Cited by 234 · see citing works

A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability

Flourakis, M., Kula-Eversole, E., Hutchison, A. L., Han, T. H., Aranda, K., Moose, D. L., White, K. P., Dinner, A. R., Lear, B. C., Ren, D., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.036 · Cited by 217 · see citing works

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

Izumo, M., Pejchal, M., Schook, A. C., Lange, R. P., Walisser, J. A., Sato, T., Wang, X., Bradfield, C. A., & Takahashi, J. S. (2014) · eLife · doi:10.7554/elife.04617 · Cited by 180 · see citing works

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

Scheer, F. A. J. L., & Shea, S. A. (2014) · Blood · doi:10.1182/blood-2013-07-517060 · Cited by 172 · see citing works

Universal method for robust detection of circadian state from gene expression

Braun, R., Kath, W. L., Iwanaszko, M., Kula-Eversole, E., Abbott, S. M., Reid, K. J., Zee, P. C., & Allada, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800314115 · Cited by 168 · see citing works

Blood transcriptome based biomarkers for human circadian phase

Laing, E., Möller‐Levet, C. S., Poh, N., Santhi, N., Archer, S. N., & Dijk, D. (2017) · eLife · doi:10.7554/elife.20214 · Cited by 161 · see citing works

Circadian rhythm sleep disorders in the blind and their treatment with melatonin

Skene, D. J., & Arendt, J. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.013 · Cited by 157 · see citing works

The Coevolution of Blue-Light Photoreception and Circadian Rhythms

Gehring, W., & Rosbash, M. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-003-0038-8 · Cited by 132 · see citing works

Identification and functional characterization of melatonin Mel 1a receptors in pancreatic β cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

Kemp, D. M., Ubeda, M., & Habener, J. F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00064-3 · Cited by 122 · see citing works

Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expressionPreprint

Petrenko, V., Saini, C., Giovannoni, L., Gobet, C., Sage, D., Unser, M., Heddad-Masson, M., Gu, G., Bosco, D., Gachon, F., et al. (2017) · Genes & Development · doi:10.1101/gad.290379.116 · Cited by 105 · see citing works

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

Kriebs, A., Jordan, S. D., Soto, E., Henriksson, E., Sandate, C. R., Vaughan, M. E., Chan, A. B., Duglan, D., Papp, S. J., Huber, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704955114 · Cited by 105 · see citing works

Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis

Manfredini, R., Fabbian, F., Cappadona, R., Giorgi, A. D., Bravi, F., Carradori, T., Flacco, M. E., & Manzoli, L. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030404 · Cited by 92 · see citing works

Morning increase in the time of onset of sustained ventricular tachycardia

Twidale, N., Taylor, S., HEDDLE, W. F., Ayres, B. F., & Tonkin, A. M. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90881-3 · Cited by 84 · see citing works

Circadian regulation of membrane physiology in neural oscillators throughout the brain

Paul, J. R., Davis, J. A., Goode, L. K., Becker, B., Fusilier, A. R., Meador-Woodruff, A., & Gamble, K. L. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14343 · Cited by 80 · see citing works

Chronobiology of acute aortic rupture or dissection: A systematic review and a meta-analysis of the literature

Vitale, J., Manfredini, R., Gallerani, M., Mumoli, N., Eagle, K. A., Ageno, W., & Dentali, F. (2014) · Chronobiology International · doi:10.3109/07420528.2014.983604 · Cited by 79 · see citing works

Incidence of Myocardial Infarction With Shifts to and From Daylight Savings Time

Jiddou, M. R., Pica, M., Boura, J., Qu, L., & Franklin, B. A. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.11.010 · Cited by 72 · see citing works

Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder

Carr, O., Saunders, K. E. A., Tsanas, A., Bilderbeck, A. C., Palmius, N., Geddes, J. R., Foster, R., Goodwin, G. M., & De Vos, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19888-9 · Cited by 57 · see citing works

Circadian Variation of Cardiovascular Disease and Sympathetic Activity

Muller, J. E., Tofler, G. H., Willich, S. N., & Stone, P. H. (1987) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198700102-00032 · Cited by 56 · see citing works

Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis

Yates, N. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0030 · Cited by 50 · see citing works

The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis

Hand, L. E., Dickson, S. H., Freemont, A. J., Ray, D. W., & Gibbs, J. E. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1770-1 · Cited by 48 · see citing works

Circadian regulation of astrocyte function: implications for Alzheimer’s disease

McKee, C. A., Lananna, B. V., & Musiek, E. S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03314-y · Cited by 47 · see citing works

Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

Xu, F., Kula-Eversole, E., Iwanaszko, M., Hutchison, A. L., Dinner, A. R., & Allada, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.015 · Cited by 44 · see citing works

Circadian variation of endothelial cell function, red blood cell deformability and dehydro-thromboxane B2 in healthy volunteers

Bridges, A., McLaren, M., Saniabadi, A. R., Fisher, T. C., & Belch, J. J. F. (1991) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-199106000-00007 · Cited by 41 · see citing works

Measurable health effects associated with the daylight saving time shift

Zhang, H., Dahlén, T., Khan, A. A., Edgren, G., & Rzhetsky, A. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007927 · Cited by 39 · see citing works

Daylight Saving Time Transitions: Impact on Total Mortality

Poteser, M., & Moshammer, H. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051611 · Cited by 26 · see citing works

Traffic accident increase attributed to Daylight Saving Time doubled after Energy Policy Act

Martín‐Olalla, J. M. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.007 · Cited by 11 · see citing works

Pooled Population Pharmacokinetic Analysis of Phase I, II and III Studies of Linifanib in Cancer Patients

Salem, A. H., Koenig, D., & Carlson, D. M. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0121-2 · Cited by 10 · see citing works

Circadian disruption and human health

Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468 · see citing works

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Izumo, M., Xu, P., Wight‐Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 361 · see citing works

Circadian rhythms and disorders of the timing of sleep

Meyer, N., Harvey, A. G., Lockley, S. W., & Dijk, D.-J. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00877-7 · Cited by 346 · see citing works

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Zhao, Y., Xiong, W., Li, C., Zhao, R., Lu, H., Song, S., Zhou, Y., Hu, Y., Shi, B., & Ge, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01652-9 · Cited by 264 · see citing works

Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants

Burns, A. C., Saxena, R., Vetter, C., Phillips, A. J. K., Lane, J. M., & Cain, S. W. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.056 · Cited by 195 · see citing works

The translational neuroscience of sleep: A contextual framework

Grandner, M. A., & Fernandez, F. (2021) · Science · doi:10.1126/science.abj8188 · Cited by 197 · see citing works

Interconnections between circadian clocks and metabolism

Guan, D., & Lazar, M. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148278 · Cited by 166 · see citing works

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

Zhou, L., Zhang, Z., Nice, E. C., Huang, C., Zhang, W., & Tang, Y. C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01238-y · Cited by 156 · see citing works

Personalized nutrition therapy in critical care: 10 expert recommendations

Wischmeyer, P. E., Bear, D. E., Berger, M. M., Waele, E. D., Gunst, J., McClave, S. A., Prado, C. M. M., Puthucheary, Z., Ridley, E. J., den Berghe, G. V., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04539-x · Cited by 125 · see citing works

Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction

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Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement

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Associations between circadian disruption and cardiometabolic disease risk: A review

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Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience

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Effect of immunotherapy-infusion time of day on survival of patients with advanced cancers: a study-level meta-analysis

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Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

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Foundations of circadian medicine

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Keeping an eye on circadian time in clinical research and medicine

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Defining circadian disruption in neurodegenerative disorders

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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

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Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: a double-blind randomized controlled trial

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The circadian system, sleep, and the health/disease balance: a conceptual review

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The Circadian Syndrome Is a Significant and Stronger Predictor for Cardiovascular Disease than the Metabolic Syndrome—The NHANES Survey during 2005–2016

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Association between exposure to light at night (LAN) and sleep problems: A systematic review and meta-analysis of observational studies

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Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

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Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism

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Demographic characteristics associated with circadian rest-activity rhythm patterns: a cross-sectional study

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Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

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Circadian clock, carcinogenesis, chronochemotherapy connections

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Association Between Exposure to Outdoor Artificial Light at Night and Sleep Disorders Among Children in China

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Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals

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Wearables in Chronomedicine and Interpretation of Circadian Health

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The exposome of healthy and accelerated aging across 40 countries

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Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

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Thyroid and heart, a clinically relevant relationship

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Time to target the circadian clock for drug discovery

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The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic

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Tryptophan metabolism is a physiological integrator regulating circadian rhythms

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Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis

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ONECUT1 mutations and variants in diabetes

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Overall survival according to time-of-day of combined immuno-chemotherapy for advanced non-small cell lung cancer: a bicentric bicontinental study

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Melatonin, Clock Genes, and Mammalian Reproduction: What Is the Link?

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Prolonged hypothermic machine perfusion enables daytime liver transplantation – an IDEAL stage 2 prospective clinical trial

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Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

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Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research

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Circadian rhythms in cardiovascular (dys)function: approaches for future therapeutics

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Effects of surgery and general anaesthesia on sleep–wake timing: CLOCKS observational study

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Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients

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Interorgan rhythmicity as a feature of healthful metabolism

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Circadian Regulation of Gene Expression and Metabolism in the Liver

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The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression

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Daytime-restricted feeding enhances running endurance without prior exercise in mice

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Biorhythm-mimicking growth hormone patch

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Circadian rhythm of lipid metabolism

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Stroke in the Time of Circadian Medicine

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The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies

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The past, present, and future of chemotherapy with a focus on individualization of drug dosing

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Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer

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Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study

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The role of the circadian timing system on drug metabolism and detoxification: an update

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Sleep Disruption and Bone Health

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Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1

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Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression‐like behaviors

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Chronobiology and Chronotherapy in Inflammatory Joint Diseases

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The impact of sleep-corrected social jetlag on mental health, behavioral problems, and daytime sleepiness in adolescents

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Multi-omics profiling reveals rhythmic liver function shaped by meal timing

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The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

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Evaluation and Management of Sleep and Circadian Rhythm Disturbance in Cancer

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Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling

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The Relationship and Gender Disparity Between Thyroid Nodules and Metabolic Syndrome Components Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis

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Clock-modulated checkpoints in time-restricted eating

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Sleep and circadian rhythms during pregnancy, social disadvantage, and alterations in brain development in neonates

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Effect of time of day on outcomes in elective surgery: a systematic review

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Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology

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Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis

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Circadian Rhythms in Gastroenterology: The Biological Clock’s Impact on Gut Health

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Circadian Misalignment and Metabolic Disorders: A Story of Twisted Clocks

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Circadian Biology in Obstructive Sleep Apnea

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Disrupting circadian rhythms promotes cancer-induced inflammation in mice

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Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract Infection

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Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling

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A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients

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Circadian regulation of digestive and metabolic tissues

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Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism

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Hepatocyte SREBP signaling mediates clock communication within the liver

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Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models

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Time to eat reveals the hierarchy of peripheral clocks

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Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update

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The circadian clock is disrupted in pancreatic cancer

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Updated Perspectives on the Management of Sleep Disorders in the Intensive Care Unit

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Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

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