Cited by 1,859Circadian rhythm and melatoninSleep and Work-Related FatigueEstrogen and related hormone effects

Resetting of circadian time in peripheral tissues by glucocorticoid signaling

Open access
Balsalobre, Aurélio, Brown, Steven A., Marcacci, Lysiane, Tronche, François, Kellendonk, Christoph, Reichardt, Holger M., Schütz, Günther, Schibler, Ueli·2000·Science

Abstract

In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.

Integrity signals

Registry

Crossref · 10.1126/science.289.5488.2344

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Peripheral clocks are synchronized to the SCN by a multitude of signals, including glucocorticoids, which can reset some peripheral clocks in the brain and body but not others.

    “These peripheral clocks are synchronized to the SCN by a multitude of signals, including glucocorticoids, which are able to “reset” some peripheral clocks in the brain and body (eg, liver), but not others.24”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [24]

  • Glucocorticoids are able to reset and synchronize the circadian clocks of peripheral tissues, including the liver, although the central pacemaker clock of the SCN does not respond to glucocorticoid.

    “Moreover, glucocorticoids are able to reset and synchronize the circadian clocks of peripheral tissues, including the liver, although the central pacemaker clock of the SCN does not respond to glucocorticoid.24”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [24]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U.
Affiliations
  • Département de Biologie Moléculaire, Sciences II, Université de Genève, 30 Quai Ernest Ansermet, CH-1211 Genève, Switzerland.
  • University of Geneva (CH)
  • Molecular Biology of the Cell, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Federal Republic of Germany.
  • German Cancer Research Center (DE)
Corresponding author
  • Kellendonk, Christoph
  • Schibler, Ueli
Venue
Science
Published
2000-09-29
Volume
289
Issue
5488
Pages
2344-2347
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2060925737
Cited by
1,859
References
20
Citations by year
2026: 65 · 2025: 62 · 2024: 87 · 2023: 76 · 2022: 89 · 2021: 90 · 2020: 91 · 2019: 79 · 2018: 79 · 2017: 87 · 2016: 86 · 2015: 83 · 2014: 79 · 2013: 89 · 2012: 71
FWCI
16.16
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
circadian clock, peripheral circadian oscillators, glucocorticoid signaling, dexamethasone, phase resetting, suprachiasmatic nucleus, circadian gene expression, liver, kidney, heart, fibroblasts
MeSH terms
Animals, Biological Clocks, Cell Line, Circadian Rhythm, Dexamethasone, DNA-Binding Proteins, Female, Gene Expression Regulation, Kidney, Liver, Male, Mice, Inbred Strains, Mutation, Myocardium, Neurons, Nuclear Proteins, Receptors, Glucocorticoid, Suprachiasmatic Nucleus, Transcription Factors, Signal Transduction, Cell Cycle Proteins, Mice, Rats, Period Circadian Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review