Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Open accessAbstract
In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.
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Peripheral clocks are synchronized to the SCN by a multitude of signals, including glucocorticoids, which can reset some peripheral clocks in the brain and body but not others.
“These peripheral clocks are synchronized to the SCN by a multitude of signals, including glucocorticoids, which are able to “reset” some peripheral clocks in the brain and body (eg, liver), but not others.24”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [24]
Glucocorticoids are able to reset and synchronize the circadian clocks of peripheral tissues, including the liver, although the central pacemaker clock of the SCN does not respond to glucocorticoid.
“Moreover, glucocorticoids are able to reset and synchronize the circadian clocks of peripheral tissues, including the liver, although the central pacemaker clock of the SCN does not respond to glucocorticoid.24”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [24]
Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works
Self-citationResetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works
Neural regulation of circadian rhythms.
Rusak, B., & Zucker, I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.449 · Cited by 1,402 · see citing works
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81638-4 · Cited by 968 · see citing works
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912 · see citing works
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works
A Functional analysis of circadian pacemakers in nocturnal rodents
Daan, S., & Pittendrigh, C. S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417857 · Cited by 683 · see citing works
Light-Dependent Sequestration of TIMELESS by CRYPTOCHROME
Ceriani, M. F., Darlington, T. K., Staknis, D., Más, P., Petti, A. A., Weitz, C. J., & Kay, S. A. (1999) · Science · doi:10.1126/science.285.5427.553 · Cited by 565 · see citing works
Light acts directly on organs and cells in culture to set the vertebrate circadian clock
Whitmore, D., Foulkes, N. S., & Sassone‐Corsi, P. (2000) · Nature · doi:10.1038/35003589 · Cited by 481 · see citing works
Cycling vrille Expression Is Required for a Functional Drosophila Clock
Blau, J., & Young, M. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81554-8 · Cited by 439 · see citing works
Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators
Whitmore, D., Foulkes, N. S., Strähle, U., & Sassone‐Corsi, P. (1998) · Nature Neuroscience · doi:10.1038/3703 · Cited by 357 · see citing works
Lopez‐Molina, L., Conquet, F., Dubois‐Dauphin, M., & Schibler, U. (1997) · The EMBO Journal · doi:10.1093/emboj/16.22.6762 · Cited by 300 · see citing works
Self-citationGenetic dissection of glucocorticoid receptor function in mice
Tronche, F., Kellendonk, C., Reichardt, H. M., & Schütz, G. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80007-5 · Cited by 180 · see citing works
Self-citationCaMKII?-cre transgene expression and recombination patterns in the mouse brain
Dragatsis, I., & Zeitlin, S. O. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 171 · see citing works
Rosenfeld, P., Eekelen, J. A. M. V., Levine, S. D., & de Kloet, E. R. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90207-6 · Cited by 171 · see citing works
Rhythms of Drosophila period gene expression in culture
Emery, I. F., Noveral, J., Jamison, C. F., & Siwicki, K. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4092 · Cited by 133 · see citing works
Ontogeny of corticosteroid receptors in the brain
Rosenfeld, P., van Eekelen, J. A. M., Levine, S. D., & de Kloet, E. R. (1993) · Cellular and Molecular Neurobiology · doi:10.1007/bf00711575 · Cited by 121 · see citing works
The ins and outs of circadian timekeeping
Brown, S. A., & Schibler, U. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00009-x · Cited by 78 · see citing works
Self-citationHastings, M. H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00350-2 · Cited by 43 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works
Self-citationDamiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works
Self-citationCentral and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265 · see citing works
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Molecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216 · see citing works
The Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004 · see citing works
Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works
Timing to perfection: the biology of central and peripheral circadian clocks
Albrecht, U. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.006 · Cited by 915 · see citing works
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works
Glucocorticoid receptor signaling in health and disease
Kadmiel, M., & Cidlowski, J. A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.07.003 · Cited by 849 · see citing works
A circadian clock in macrophages controls inflammatory immune responses
Keller, M., Mazuch, J., Abraham, U., Eom, G. D., Herzog, E. D., Volk, H.-D., Kramer, A., & Maier, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906361106 · Cited by 843 · see citing works
Molecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738 · see citing works
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681 · see citing works
The circadian clock: pacemaker and tumour suppressor
Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678 · see citing works
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works
Self-citationCrosstalk between components of circadian and metabolic cycles in mammals
Asher, G., & Schibler, U. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.006 · Cited by 601 · see citing works
Self-citationCrosstalk between metabolism and circadian clocks
Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598 · see citing works
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589 · see citing works
Reddy, T. E., Pauli, F., Sprouse, R. O., Neff, N. F., Newberry, K. M., Garabedian, M. J., & Myers, R. M. (2009) · Genome Research · doi:10.1101/gr.097022.109 · Cited by 543 · see citing works
Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works
Oster, H., Damerow, S., Kiessling, S., Jakubcakova, V., Abraham, D., Tian, J., Hoffmann, M. W., & Eichele, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.002 · Cited by 528 · see citing works
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547 · see citing works
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548 · see citing works
Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523 · see citing works
Metabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works
Glucocorticoids and the circadian clock
Dickmeis, T. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0415 · Cited by 494 · see citing works
The coming out of the brain mineralocorticoid receptor
Joëls, M., Karst, H., DeRijk, R., & de Kloet, E. R. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.10.005 · Cited by 481 · see citing works
Psychobiological allostasis: resistance, resilience and vulnerability
Karatsoreos, I. N., & McEwen, B. S. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.005 · Cited by 458 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431 · see citing works
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So, A. Y.-L., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909733106 · Cited by 431 · see citing works
Circadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426 · see citing works
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403 · see citing works
Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis
Kalsbeek, A., van der Spek, R., Lei, J., Endert, E., Buijs, R. M., & Fliers, E. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.042 · Cited by 380 · see citing works
Circadian disruption in cancer: A neuroendocrine-immune pathway from stress to disease?
Sephton, S., & Spiegel, D. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00078-3 · Cited by 377 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
Schmutz, I., Ripperger, J. A., Baeriswyl-Aebischer, S., & Albrecht, U. (2010) · Genes & Development · doi:10.1101/gad.564110 · Cited by 361 · see citing works
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348 · see citing works
Circadian control of glucose metabolism
Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338 · see citing works
Sleep Deprivation and Circadian Disruption
McEwen, B. S., & Karatsoreos, I. N. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.007 · Cited by 338 · see citing works
Impact of the human circadian system, exercise, and their interaction on cardiovascular function
Scheer, F. A. J. L., Hu, K., Evoniuk, H., Kelly, E. E., Malhotra, A., Hilton, M. F., & Shea, S. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006749107 · Cited by 332 · see citing works
Modified-release hydrocortisone to provide circadian cortisol profiles
Debono, M., Ghobadi, C., Rostami-Hodjegan, A., Huatan, H., Campbell, M. J., Newell-Price, J., Darzy, K., Merke, D. P., Arlt, W., & Ross, R. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2380 · Cited by 322 · see citing works
Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
Crosby, P., Hamnett, R., Putker, M., Hoyle, N. P., Reed, M., Karam, C. J., Maywood, E. S., Stangherlin, A., Chesham, J. E., Hayter, E. A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.017 · Cited by 309 · see citing works
Psychophysiological Reactivity: Mechanisms and Pathways to Cardiovascular Disease
Lovallo, W. R., & Gerin, W. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000033128.44101.c1 · Cited by 302 · see citing works
Circadian rhythm of adrenal glucocorticoid: its regulation and clinical implications
Chung, S., Son, G. H., & Kim, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.003 · Cited by 305 · see citing works
Exploring phylogeny to find the function of sleep
Anafi, R. C., Kayser, M. S., & Raizen, D. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0098-9 · Cited by 259 · see citing works
Circadian Clocks and Metabolism
Marcheva, B., Ramsey, K. M., Peek, C. B., Affinati, A., Maury, E., & Bass, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25950-0_6 · Cited by 282 · see citing works
Clocks, metabolism, and the epigenome
Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271 · see citing works
“The central clock can entrain the peripheral clocks through neuronal and hormonal signals, as well as body temperature, aligning all clocks with the external light/dark cycle (Balsalobre et al., 2000; Brown et al., 2002; reviewed in Dibner et al., 2010).”
Karatsoreos, I. N., Bhagat, S. M., Bowles, N. P., Weil, Z. M., Pfaff, D. W., & McEwen, B. S. (2010) · Endocrinology · doi:10.1210/en.2009-1436 · Cited by 260 · see citing works
Morris, C. J., Purvis, T. E., Mistretta, J., & Scheer, F. A. J. L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3924 · Cited by 262 · see citing works
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251 · see citing works
Circadian clocks: setting time by food
Mendoza, J. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01510.x · Cited by 257 · see citing works
Review: Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy
Chan, S., & Debono, M. (2010) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018810380214 · Cited by 243 · see citing works
Circadian timing of metabolism in animal models and humans
Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237 · see citing works
Self-citationCircadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235 · see citing works
Impact of nutrients on circadian rhythmicity
Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221 · see citing works
Circadian eating and sleeping patterns in the night eating syndrome
O'Reardon, J. P., Ringel, B. L., Dinges, D. F., Allison, K. C., Rogers, N. L., Martino, N. S., & Stunkard, A. J. (2004) · Obesity Research · doi:10.1038/oby.2004.222 · Cited by 223 · see citing works
Gumz, M. L., Stow, L. R., Lynch, I. J., Greenlee, M. M., Rudin, A., Cain, B. D., Weaver, D. R., & Wingo, C. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36908 · Cited by 216 · see citing works
Bray, M. S., & Young, M. E. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00277.x · Cited by 213 · see citing works
Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211 · see citing works
The mammalian circadian clock and its entrainment by stress and exercise
Tahara, Y., Aoyama, S., & Shibata, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0450-7 · Cited by 198 · see citing works
Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191 · see citing works
Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions
Nicolaides, N. C., Charmandari, E., Chrousos, G. P., & Kino, T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12464 · Cited by 183 · see citing works
Evidence for a biological dawn and dusk in the human circadian timing system
Wehr, T. A., Aeschbach, D., & Duncan, W. C. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00937.x · Cited by 182 · see citing works
Endocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170 · see citing works
Reddy, T. E., Gertz, J., Crawford, G. E., Garabedian, M. J., & Myers, R. M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00062-12 · Cited by 149 · see citing works
Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity
Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013) · Cell · doi:10.1016/j.cell.2012.12.027 · Cited by 160 · see citing works
Self-citationPhysiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158 · see citing works
Circadian Rhythms, Aging, and Life Span in Mammals
Froy, O. (2011) · Physiology · doi:10.1152/physiol.00012.2011 · Cited by 156 · see citing works
Indication of circadian oscillations in the rat pancreas
Mühlbauer, E., Wolgast, S., Finckh, U., Peschke, D., & Peschke, E. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00322-9 · Cited by 147 · see citing works
Circadian Clocks Are Resounding in Peripheral Tissues
Ptitsyn, A. A., Zvonic, S., Conrad, S. A., Scott, L. K., Mynatt, R. L., & Gimble, J. M. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020016 · Cited by 145 · see citing works
The circadian clock and glucocorticoids – interactions across many time scales
Dickmeis, T., Weger, B. D., & Weger, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.012 · Cited by 144 · see citing works
Conway‐Campbell, B. L., Sarabdjitsingh, R. A., McKenna, M. A., Pooley, J. R., Kershaw, Y. M., Meijer, O. C., De Kloet, E. R., & Lightman, S. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02051.x · Cited by 137 · see citing works
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Son, G. H., Chung, S., & Kim, K. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.003 · Cited by 136 · see citing works
Husse, J., Leliavski, A., Tsang, A. H., Oster, H., & Eichele, G. (2014) · The FASEB Journal · doi:10.1096/fj.14-256594 · Cited by 133 · see citing works
Circadian disruption and SCN control of energy metabolism
Kalsbeek, A., Scheer, F. A., Perreau-Lenz, S., La Fleur, S. E., Yi, C.-X., Fliers, E., & Buijs, R. M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.021 · Cited by 133 · see citing works
Young, M. E., & Bray, M. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.010 · Cited by 129 · see citing works
A role for clock genes in sleep homeostasis
Franken, P. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.05.002 · Cited by 125 · see citing works
The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity
Lockett, J., Inder, W. J., & Clifton, V. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae008 · Cited by 135 · see citing works
Mammalian circadian systems: Organization and modern life challenges
Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117 · see citing works
The role of circadian rhythmicity in reproduction
Kennaway, D. J. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmh054 · Cited by 120 · see citing works
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
Aguilar-Arnal, L., Katada, S., Orozco-Solis, R., & Sassone-Corsi, P. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2990 · Cited by 117 · see citing works
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115 · see citing works
Assessment of circadian function in fibroblasts of patients with bipolar disorder
Yang, S., Van Dongen, H. P. A., Wang, K., Berrettini, W., & Bućan, M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.10 · Cited by 113 · see citing works
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., & Franken, P. (2013) · SLEEP · doi:10.5665/sleep.2440 · Cited by 94 · see citing works
Kolber, B. J., Wieczorek, L., & Muglia, L. J. (2008) · Stress · doi:10.1080/10253890701821081 · Cited by 106 · see citing works
Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock
Kemler, D., Wolff, C. A., & Esser, K. A. (2020) · The Journal of Physiology · doi:10.1113/jp279779 · Cited by 87 · see citing works
The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle
Perrin, J. S., Segall, L. A., Harbour, V. L., Woodside, B., & Amir, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601310103 · Cited by 88 · see citing works
Uncoupling of social zeitgebers and diurnal cortisol secretion in clinical depression
Stetler, C., Dickerson, S. S., & Miller, G. E. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.03.003 · Cited by 88 · see citing works
24-h activity rhythm and sleep in depressed outpatients
Hori, H., Koga, N., Hidese, S., Nagashima, A., Kim, Y., Higuchi, T., & Kunugi, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.022 · Cited by 78 · see citing works
Encoding and decoding mechanisms of pulsatile hormone secretion
Walker, J. J., Terry, J. R., Tsaneva‐Atanasova, K., Armstrong, S. P., McArdle, C. A., & Lightman, S. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02087.x · Cited by 78 · see citing works
Hoyt, K. R., & Obrietan, K. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00537-9 · Cited by 77 · see citing works
Haraszti, R. Á., Purebl, G., Salavecz, G., Poole, L., Dockray, S., & Steptoe, A. (2014) · Chronobiology International · doi:10.3109/07420528.2014.911188 · Cited by 72 · see citing works
Hasan, S., Santhi, N., Lazar, A. S., Slak, A., Lo, J., von Schantz, M., Archer, S. N., Johnston, J. D., & Dijk, D. (2012) · The FASEB Journal · doi:10.1096/fj.11-201699 · Cited by 68 · see citing works
- Authors
- Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U.
- Affiliations
- Département de Biologie Moléculaire, Sciences II, Université de Genève, 30 Quai Ernest Ansermet, CH-1211 Genève, Switzerland.
- University of Geneva (CH)
- Molecular Biology of the Cell, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Federal Republic of Germany.
- German Cancer Research Center (DE)
- Corresponding author
- Kellendonk, Christoph
- Schibler, Ueli
- Venue
- Science
- Published
- 2000-09-29
- Volume
- 289
- Issue
- 5488
- Pages
- 2344-2347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060925737
- Cited by
- 1,859
- References
- 20
- Citations by year
- 2026: 65 · 2025: 62 · 2024: 87 · 2023: 76 · 2022: 89 · 2021: 90 · 2020: 91 · 2019: 79 · 2018: 79 · 2017: 87 · 2016: 86 · 2015: 83 · 2014: 79 · 2013: 89 · 2012: 71
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- circadian clock, peripheral circadian oscillators, glucocorticoid signaling, dexamethasone, phase resetting, suprachiasmatic nucleus, circadian gene expression, liver, kidney, heart, fibroblasts
- MeSH terms
- Animals, Biological Clocks, Cell Line, Circadian Rhythm, Dexamethasone, DNA-Binding Proteins, Female, Gene Expression Regulation, Kidney, Liver, Male, Mice, Inbred Strains, Mutation, Myocardium, Neurons, Nuclear Proteins, Receptors, Glucocorticoid, Suprachiasmatic Nucleus, Transcription Factors, Signal Transduction, Cell Cycle Proteins, Mice, Rats, Period Circadian Proteins
About these checks
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