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One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

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Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade

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Tracing Metabolic Fate of Mitochondrial Glycine Cleavage System Derived Formate In Vitro and In Vivo

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Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy

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Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity

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Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach

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Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1

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Drugging cancer metabolism: Expectations vs. reality

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Acidity induces durable enhancement of Treg cell suppressive functions for tumor immune evasion

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Mitochondrial folate metabolism–mediated α-linolenic acid exhaustion masks liver fibrosis resolution

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Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments

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Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer

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The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors

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Isotope-Assisted Metabolic Flux Analysis: A Powerful Technique to Gain New Insights into the Human Metabolome in Health and Disease

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Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer

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Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes

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Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling

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Folate Metabolism in Hepatocellular Carcinoma. What Do We Know So Far?

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Upregulation of MTHFD2 is associated with PD‑L1 activation in bladder cancer via the PI3K/AKT pathway

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HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression

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A Transfer Hydrogenation Approach to Activity-Based Sensing of Formate in Living Cells

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Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

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Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses

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Rewired Metabolism of Amino Acids and Its Roles in Glioma Pathology

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Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

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Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution

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Mitochondrial One-Carbon Metabolism and Alzheimer’s Disease

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Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

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Weanling Offspring of Dams Maintained on Serine‐Deficient Diet Are Vulnerable to Oxidative Stress

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Traditional and novel tools to probe the mitochondrial metabolism in health and disease

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Amino acids metabolism: a potential target for cancer treatment

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Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes

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A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

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Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut

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A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production

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Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases

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Modulation of the de novo purine nucleotide pathway as a therapeutic strategy in mitochondrial myopathy

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Effects of maternal gestational diet, with or without methionine, on muscle transcriptome of Bos indicus-influenced beef calves following a vaccine-induced immunological challenge

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Integrative analysis of metabolomics and proteomics unravels purine metabolism dysregulation in the SOD1G93A mouse model of amyotrophic lateral sclerosis

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Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability

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Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

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Identification of key candidate genes for colorectal cancer by bioinformatics analysis

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Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice

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Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver

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Methyl Group Metabolism in Differentiation, Aging, and Cancer

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G2 arrest primes hematopoietic stem cells for megakaryopoiesis

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Rat liver folate metabolism can provide an independent functioning of associated metabolic pathways

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Tracing insights into human metabolism using chemical engineering approaches

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Exploring Metabolic and Gut Microbiome Responses to Paraquat Administration in Male Wistar Rats: Implications for Oxidative Stress

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Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates

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Engineered Biomimetic Nanovesicles Synergistically Remodel Folate-Nucleotide and γ-Aminobutyric Acid Metabolism to Overcome Sunitinib-Resistant Renal Cell Carcinoma

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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

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Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH

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Identification of three new compounds that directly target human serine hydroxymethyltransferase 2

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Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

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Inflammation, mitochondrial metabolism and nutrition: the multi-faceted progression of non-alcoholic fatty liver disease to hepatocellular carcinoma

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SHMT as a Potential Therapeutic Target for Renal Cell Carcinoma

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Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo

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3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis

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Metabolic Analysis at the Nanoscale with Multi‐Isotope Imaging Mass Spectrometry (MIMS)

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Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

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Stable Isotope Tracing Metabolomics to Investigate the Metabolic Activity of Bioactive Compounds for Cancer Prevention and Treatment

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Engineered hematopoietic and immune cells derived from human pluripotent stem cells

Chang, Y., Hummel, S. N., Jung, J., Jin, G., Deng, Q., & Bao, X. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.08.006 · Cited by 11

The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process

Majumder, A., Bano, S., & Nayak, K. B. (2024) · Biomolecules · doi:10.3390/biom14111387 · Cited by 11

Methylosystem for Cancer Sieging Strategy

Tatekawa, S., Ofusa, K., Chijimatsu, R., Vecchione, A. M., Tamari, K., Ogawa, K., & Ishii, H. (2021) · Cancers · doi:10.3390/cancers13205088 · Cited by 10

NRF2-driven redox metabolism takes center stage in cancer metabolism from an outside-in perspective

Choi, E.-J., & Jeon, S. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01224-3 · Cited by 10

The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis

Tait-Mulder, J., Hodge, K., Sumpton, D. P., Zanivan, S. R., & Vázquez, A. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00228-3 · Cited by 11

MTHFD1L knockdown diminished cells growth in papillary thyroid cancer

Yi, D., Yilihamu, Y., Jiang, C., Wang, R., Lu, X., Sang, J., & Su, L. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101869 · Cited by 10

Improved redox homeostasis owing to the up-regulation of one-carbon metabolism and related pathways is crucial for yeast heterosis at high temperaturePreprint

Song, L., Shi, J., Duan, S., Han, D., Li, K., Zhang, R., He, P., Han, P., Wang, Q., & Bai, F. (2021) · Genome Research · doi:10.1101/gr.262055.120 · Cited by 10

The oncogenic control of nucleotide synthesis

Vidal-Cruchez, O., & Ben‐Sahra, I. (2026) · Oncogenesis · doi:10.1038/s41389-026-00608-2 · Cited by 11

Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells

Haitzmann, T., Schindlmaier, K., Frech, T., Mondal, A., Bubalo, V., Konrad, B., Bluemel, G., Stiegler, P., Lackner, S., Hrzenjak, A., et al. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00337-3 · Cited by 11

Tumor Metabolism: A New Field for the Treatment of Glioma

Chai, X., Zhang, Y., Zhang, W., Feng, K., Jiang, Y., Zhu, A., Chen, X., Di, L., & Wang, R. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00287 · Cited by 10

MTHFD2: A significant mitochondrial metabolic enzyme and a novel target for anticancer therapy

Liu, S., Wang, X., Zhao, L., Zhang, L., & Song, Y. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104372 · Cited by 10

Advances in highly active one-carbon metabolism in cancer diagnosis, treatment and drug resistance: A systematic review

Liu, S., Wang, Z., Lv, D., & Zhao, Y.-X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1063305 · Cited by 9

More than a powerplant: the influence of mitochondrial transfer on the epigenome

Patananan, A. N., Sercel, A. J., & Teitell, M. A. (2017) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.11.006 · Cited by 11

Isotope tracing assisted metabolic profiling: Application to understanding HSP60 silencing mediated tumor progression

Tang, H., Teng, R., Zhao, X., Wang, X., Xu, L., Deng, H., & Liu, X. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.09.067 · Cited by 10

Developmental and Transcriptomal Responses to Seasonal Dietary Shifts in the CactophilicDrosophila mojavensisof North America

Mateus, R. P., Nazario-Yepiz, N. O., Ibarra‐Laclette, E., Laclette, M. R. L., & Markow, T. A. (2018) · Journal of Heredity · doi:10.1093/jhered/esy056 · Cited by 10

Ketogenic Diet Consumption Inhibited Mitochondrial One-Carbon Metabolism

Hsu, F.-Y., Liou, J.-Y., Tang, F., Sou, N., Peng, J.-H., & Chiang, E. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073650 · Cited by 10

Probing Folate-Responsive and Stage-Sensitive Metabolomics and Transcriptional Co-Expression Network Markers to Predict Prognosis of Non-Small Cell Lung Cancer Patients

Lin, Y., Chen, Y.-C., Chen, T.-E., Cheng, M., Lynn, K., Shah, P., Chen, J., & Huang, R.-F. S. (2022) · Nutrients · doi:10.3390/nu15010003 · Cited by 9

Apollo-NADP + reveals in vivo adaptation of NADPH/NADP + metabolism in electrically activated pancreatic β cells

Bui, C. V., Boswell, C. W., Ciruna, B. G., & Rocheleau, J. V. (2023) · Science Advances · doi:10.1126/sciadv.adi8317 · Cited by 9

Outcomes of folic acid esterification upon the properties of hydrophilic phenothiazinium dyes: New photosensitizers for antimicrobial photodynamic therapy

Stoean, B., Lupan, I., Cristea, C., Silion, M., Silaghi‐Dumitrescu, L., Silaghi-Dumitrescu, R. L., & Găină, L. (2024) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2024.115500 · Cited by 9

Complexity of subcellular metabolism: strategies for compartment-specific profiling

More, T. H., & Hiller, K. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102711 · Cited by 9

CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

Shao, M., Pan, Q., Tan, H., Wu, J., Lee, H. W., Huber, A. D., Wright, W. C., Cho, J., Yu, J., Peng, J., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101079 · Cited by 8

Recent advances in CRISPR-Cas systems for colorectal cancer research and therapeutics

Sokhangouy, S. K., Alizadeh, F. L., Lotfi, M., Sharif, S., Ashouri, A., Yoosefi, Y., Qomi, S. B., & Abbaszadegan, M. R. (2024) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2024.2388777 · Cited by 8

Metallothionein as a biomarker of aquatic contamination in fish: An in silico and in vitro approach using zebrafish as experimental model organism

da Luz, J. Z., Gorshkov, V., Miranda, R. R., de Souza, T. L., Rodrigues‐Ribeiro, L., Duan, X., Huang, Y., Ribeiro, C. A. D. O., Xu, E. G., Kjeldsen, F., et al. (2025) · Chemosphere · doi:10.1016/j.chemosphere.2025.144316 · Cited by 8

Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis

Flickinger, K. M., Fritz, C. M., Huggler, K. S., Wade, G., Chang, G. R., Fox, K. C., Simcox, J., & Cantor, J. R. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01272-3 · Cited by 9

The oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity

Jiao, Z., Zhang, M., Ning, J., Yao, H., Yan, X., Wu, Z., Wu, D., Liu, Y., Zhang, M., Wang, L., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412854122 · Cited by 8

Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

Lee, W. D., Pirona, A. C., Sarvin, B. A., Stern, A., Nevo‐Dinur, K., Besser, E., Sarvin, N., Lagziel, S., Mukha, D., Raz, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.002 · Cited by 67

Abstract A14: Role of mitochondrial folate metabolism in cancer cell growth and proliferation

Ducker, G. S., Esposito, M., Kang, Y., & Rabinowitz, J. D. (2016) · Molecular Cancer Research · doi:10.1158/1557-3125.metca15-a14

Abstract 4709: Compartmental flexibility in mammalian folate metabolism

Ducker, G. S., Chen, L., Teng, X., & Rabinowitz, J. D. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-4709

Abstract 232: Pharmacological and genetic dissection of one carbon pathway provides novel insights into generation, transformation and utilization of one carbon units

Suri, V., Mainolfi, N., Friedman, A. A., Moyer, M. P., Ducker, G., Rabinowitz, J. D., & Manfredi, M. G. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-232

Emerging concepts on one-carbon metabolism as a unique and actionable vulnerability in cancer

Schneider, M. J., Hou, Z., & Matherly, L. H. (2026) · ASPET Discovery · doi:10.1016/j.aspetd.2026.100029