The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Open accessAbstract
Summary Immune cells function in diverse metabolic environments. Tissues with low glucose and high lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require immune responses to be more pro-tolerant avoiding unwanted reactions against self-antigens or commensal bacteria. T-regulatory cells (Treg) maintain peripheral tolerance, but how Treg function in low glucose lactate rich environments is unknown. We report that the Treg transcription factor Foxp3 reprograms T cell metabolism by suppressing Myc and glycolysis, enhancing oxidative phosphorylation, and increasing nicotinamide adenine dinucleotide oxidation. These adaptations allow Treg a metabolic advantage in low glucose, lactate rich environments; resisting lactate mediated suppression of T cell function and proliferation. This metabolic phenotype may explain how Tregs promote peripheral immune tolerance during tissue injury, but also how cancer cells evade immune destruction in the tumor microenvironment. Understanding Treg metabolism may therefore lead to novel approaches for selective immune modulation in cancer and autoimmune diseases.
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Citations
Cites
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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
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Cited by
Macrophages and metabolism in the tumor microenvironment
Vitale, I., Manic, G., Coussens, L. M., Kroemer, G., & Galluzzi, L. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.001 · Cited by 1,837
Bile acid metabolites control TH17 and Treg cell differentiation
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Lactate metabolism in human health and disease
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Self-citationThe updated landscape of tumor microenvironment and drug repurposing
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Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
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Metadata
- Authors
- Angelin, A., Gil-de-Gómez, L., Dahiya, S., Jiao, J., Guo, L., Levine, M. H., Wang, Z., Quinn, W. J., Kopinski, P. K., Wang, L., Akimova, T., Liu, Y., Bhatti, T. R., Han, R., Laskin, B. L., Baur, J. A., Blair, I. A., Wallace, D. C., Hancock, W. W., & Beier, U. H.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 25
- Issue
- 6
- Pages
- 1282-1293.e7
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2607103422
- Cited by
- 1,246
- References
- 63
- FWCI
- 30.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Angelin, A., Gil-de-Gómez, L., Dahiya, S., Jiao, J., Guo, L., Levine, M. H., Wang, Z., Quinn, W. J., Kopinski, P. K., Wang, L., Akimova, T., Liu, Y., Bhatti, T. R., Han, R., Laskin, B. L., Baur, J. A., Blair, I. A., Wallace, D. C., Hancock, W. W., & Beier, U. H. (2017). Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metabolism. https://doi.org/10.1016/j.cmet.2016.12.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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