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Cited by 84Pancreatic function and diabetesDiabetes Treatment and ManagementGlycogen Storage Diseases and Myoclonus

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

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Ashcroft, Frances M., Rohm, Maria, Clark, Anne, Brereton, Melissa F.·2017·Cell Metabolism
DOI 10.1016/j.cmet.2017.05.014PMC PMC5890904
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Abstract

Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.

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  • The direct contribution of glucose to β-cell failure is described as glucotoxicity.

    “The direct contribution of glucose to β-cell failure is described as glucotoxicity [76].”

    From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [76]

  • Glucotoxicity is thought to result in β-cell apoptosis over time.

    “In addition, glucotoxicity is also thought to result in β-cell apoptosis over time [76].”

    From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [76]

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Cited by

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Authors
Ashcroft, F. M., Rohm, M., Clark, A., & Brereton, M. F.
Affiliations
  • University of Oxford (GB)
  • Churchill Hospital (GB)
Corresponding author
Ashcroft, Frances M.
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2017-07
Volume
26
Issue
1
Pages
17-23
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2017.05.014
PMC
PMC5890904
OpenAlex
W2727176663
Cited by
84
References
3
Citations by year
2026: 4 · 2025: 6 · 2024: 8 · 2023: 16 · 2022: 14 · 2021: 6 · 2020: 14 · 2019: 12 · 2018: 4
FWCI
1.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Oxford University Research Archive (ORA) (University of Oxford) (acceptedVersion, cc-by-nc-nd)
Funders
  • Novo Nordisk
  • Wellcome Trust (084655, 089795)
  • European Research Council (322620)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Keywords
type 2 diabetes, pancreatic beta cells, glycogen storage, glucotoxicity, beta-cell dysfunction, beta-cell death, glycogen metabolism, plasma glucose
MeSH terms
Animals, Blood Glucose, Diabetes Mellitus, Type 2, Glycogen, Glycogen Storage Disease, Humans, Signal Transduction, Insulin-Secreting Cells

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