β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?
Open accessAbstract
Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.
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- Authors
- Knudsen, J. G., & Rorsman, P.
- Affiliations
- Churchill Hospital (GB)
- Corresponding author
- Rorsman, Patrik
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 29
- Issue
- 1
- Pages
- 1-2
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2910125310
- Cited by
- 42
- References
- 13
- Citations by year
- 2024: 2 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 1
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 373 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, beta-cell dysfunction, hyperglycemia, mitochondrial ion channels, plasma membrane, insulin secretion, diabetes progression, energy depletion
- MeSH terms
- Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Mitochondria, Insulin-Secreting Cells, Voltage-Dependent Anion Channel 1
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