Cited by 43Pancreatic function and diabetesMitochondrial Function and PathologyDiabetes Treatment and Management

β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?

Open access
Knudsen, Jakob G., Rorsman, Patrik·2019·Cell Metabolism

Abstract

Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.

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Crossref · 10.1016/j.cmet.2018.12.015

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Authors
Knudsen, J. G., & Rorsman, P.
Affiliations
Churchill Hospital (GB)
Corresponding author
Rorsman, Patrik
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2019-01
Volume
29
Issue
1
Pages
1-2
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2910125310
Cited by
42
References
13
Citations by year
2024: 2 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 1
FWCI
8.43
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
type 2 diabetes, beta-cell dysfunction, hyperglycemia, mitochondrial ion channels, plasma membrane, insulin secretion, diabetes progression, energy depletion
MeSH terms
Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Mitochondria, Insulin-Secreting Cells, Voltage-Dependent Anion Channel 1

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