The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility.
Open accessAbstract
Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its metabolic consequences remain uncertain. Here, we show that microglial inflammatory signaling determines the immunologic response of the MBH to dietary excess and regulates hypothalamic control of energy homeostasis in mice. Either pharmacologically depleting microglia or selectively restraining microglial NF-κB-dependent signaling sharply reduced microgliosis, an effect that includes prevention of MBH entry by bone-marrow-derived myeloid cells, and greatly limited diet-induced hyperphagia and weight gain. Conversely, forcing microglial activation through cell-specific deletion of the negative NF-κB regulator A20 induced spontaneous MBH microgliosis and cellular infiltration, reduced energy expenditure, and increased both food intake and weight gain even in absence of a dietary challenge. Thus, microglial inflammatory activation, stimulated by dietary excess, orchestrates a multicellular hypothalamic response that mediates obesity susceptibility, providing a mechanistic rationale for non-neuronal approaches to treat metabolic diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It has also been reported that genetic or pharmacologic treatments that increase microgliosis within the mediobasal hypothalamus are capable of inducing obesity even in the absence of dietary challenge (Valdearcos et al., 2017; Campolim et al., 2020).”
From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Valdearcos et al., 2017
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Recent studies have shown that both increased and decreased microglial inflammatory activity within the mediobasal hypothalamus can disrupt leptin/melanocortin related neuronal signaling, a pathway that is central to the regulation of energy balance (Gao et al., 2017; Valdearcos et al., 2017; Kim et al., 2019).”
From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Valdearcos et al., 2017
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Further, it has been demonstrated that reducing this dietary induced microgliosis can mitigate weight gain (Andre et al., 2017; Valdearcos et al., 2017; Kim et al., 2019).”
From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Valdearcos et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857
Self-citationNew tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
Self-citationIKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Cited by
Sorted by citations
Items 201–300 of 479
Downregulation of HIF complex in the hypothalamus exacerbates diet-induced obesity
Gaspar, J. M., Mendes, N. F., Corrêa‐da‐Silva, F., Júnior, J. C. D. L., Gaspar, R. S., Ropelle, E. R., ARAUJO, E. P. D., Carvalho, H. M., & Velloso, L. A. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.020 · Cited by 23
Giving a good start to a new life via maternal brain allostatic adaptations in pregnancy
Russell, J. A., & Brunton, P. J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.003 · Cited by 24
Cellular source of hypothalamic macrophage accumulation in diet-induced obesity
Lee, C. H., Shin, S. H., Kang, G. M., Kim, S., Kim, J., Yu, R., & Kim, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1607-0 · Cited by 25
Becetti, I., Bwenyi, E. L., de Araújo, I. E., Ard, J. D., Cryan, J. F., Farooqi, I. S., Ferrario, C. R., Gluck, M. E., Holsen, L. M., Kenny, P. J., et al. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.05.003 · Cited by 26
Drunen, R. V., Dai, Y., Wei, H., Fekry, B., Noori, S., Shivshankar, S., Bravo, R., Zhao, Z., Yoo, S. H., Justice, N. J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114380 · Cited by 24
Huang, H.-T., Chen, P. S., Kuo, Y., & Tzeng, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01837-x · Cited by 22
Coker, C. R., Keller, B. N., Arnold, A. C., & Silberman, Y. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601111 · Cited by 25
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome
Wang, W., Li, J., Cui, S., Li, J., Ye, X., Wang, Z., Zhang, T., Jiang, X. J., Kong, Y., Chen, X., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj7813 · Cited by 22
Obesity‐ and diet‐induced plasticity in systems that control eating and energy balance
Ferrario, C. R., Muenzberg, H., Rinaman, L., Betley, J. N., Borgland, S. L., Dus, M., Fadool, D. A., Medler, K. F., Morton, G. J., Sandoval, D. A., et al. (2024) · Obesity · doi:10.1002/oby.24060 · Cited by 24
Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice
So, S. W., Fleming, K. M., Duffy, C. M., Nixon, J. P., Bernlohr, D., & Butterick, T. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084354 · Cited by 21
Feng, M., Crowley, N. A., Patel, A., Guo, Y., Bugni, S. E., & Luscher, B. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.003 · Cited by 20
Poon, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.591559 · Cited by 20
Coker, C. R., White, M., Singal, A., Bingaman, S. S., Paul, A., Arnold, A. C., & Silberman, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.933706 · Cited by 20
Median eminence myelin continuously turns over in adult mice
Buller, S. A., Kohnke, S., Hansford, R., Shimizu, T., Richardson, W. D., & Blouet, C. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101690 · Cited by 20
Ullah, R., Shen, Y., Zhou, Y., & Fu, J. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155677 · Cited by 20
Obesity-induced neuronal senescence: Unraveling the pathophysiological links
Ghosh, P., Fontanella, R. A., Scisciola, L., Taktaz, F., Pesapane, A., Basilicata, M. G., Tortorella, G., Matacchione, G., Capuano, A., Vietri, M. T., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102533 · Cited by 22
Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice
Herrick, M. K., Favela, K. M., Simerly, R. B., Abumrad, N. N., & Bingham, N. C. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0057-y · Cited by 21
Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
Leon, S., Nadjar, A., & Quarta, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105243 · Cited by 22
SEWAYBRICKER, L. E., Kee, S., Melhorn, S. J., & Schur, E. A. (2021) · Obesity · doi:10.1002/oby.23286 · Cited by 20
SEWAYBRICKER, L. E., Melhorn, S. J., Askren, M. K., Webb, M. F., Tyagi, V., Leon, M. R. B. D., Grabowski, T. J., Seeley, W. W., & Schur, E. A. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0361-9 · Cited by 20
Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity
Henn, R. E., Guo, K., Elzinga, S. E., Noureldein, M. H., Mendelson, F. E., Hayes, J. M., Rigan, D. M., Savelieff, M. G., Hur, J., & Feldman, E. L. (2023) · iScience · doi:10.1016/j.isci.2023.106164 · Cited by 18
Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese mice
Moon, S., Park, Y., Jang, S., Kim, S., Song, D.-G., Shin, D.-C., & Lee, C. H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03244-y · Cited by 19
Sasaki, T., Numano, R., Yokota‐Hashimoto, H., Matsui, S., Kimura, N., Takeuchi, H., & Kitamura, T. (2018) · Molecular Brain · doi:10.1186/s13041-018-0372-9 · Cited by 19
An acute microglial metabolic response controls metabolism and improves memoryPreprint
Drougard, A., Ma, E. H., Wegert, V., Sheldon, R. D., Panzeri, I., Vatsa, N., Apostle, S., Fagnocchi, L., Schaf, J., Gossens, K., et al. (2023) · eLife · doi:10.7554/elife.87120 · Cited by 19
Loss of Microglial Insulin Receptor Leads to Sex-Dependent Metabolic Disorders in Obese Mice
Milanova, I. V., Korpel, N. L., Corrêa‐da‐Silva, F., Berends, E., Osman, S., la Fleur, S. E., Fliers, E., Kalsbeek, A., & Yi, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062933 · Cited by 18
Microglia in Central Control of Metabolism
Kim, J. D., Copperi, F., & Diano, S. (2023) · Physiology · doi:10.1152/physiol.00021.2023 · Cited by 21
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Okekawa, A., Wada, T., Onogi, Y., Takeda, Y., Miyazawa, Y., Sasahara, M., Tsuneki, H., & Sasaoka, T. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00793-z · Cited by 18
Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity
Razolli, D. S., Moura‐Assis, A., Bombassaro, B., & Velloso, L. A. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0451-8 · Cited by 18
Mapping of Microglial Brain Region, Sex and Age Heterogeneity in Obesity
Milanova, I. V., Corrêa‐da‐Silva, F., Kalsbeek, A., & Yi, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063141 · Cited by 19
Li, X., Cai, Y., Luo, J. M., Ding, J., Yao, G., Xiao, X., Tang, Y., & Liang, Z. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00732-5 · Cited by 18
Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling
Debarba, L. K., Jayarathne, H. S. M., Stilgenbauer, L., dos Santos, A. L. T., Koshko, L., Scofield, S., Sullivan, R. P., Mandal, A., Klueh, U., & Sadagurski, M. (2024) · Diabetes · doi:10.2337/db24-0110 · Cited by 17
Hypothalamic neuronal-glial crosstalk in metabolic disease
Nguyen, L. T., & Dodd, G. T. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00026-1 · Cited by 22
Bultinck, J., Yuan, S., Cantuti‐Castelvetri, L., Brosens, L., Bracke, D., Collins, J., Goethals, J., Christianson, C. A., Nuss, J. M., & Ogilvie, K. M. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102282 · Cited by 18
Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling
Ingraham, H. A., Herber, C. B., & Krause, W. C. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061121-035914 · Cited by 18
Hypothalamic Inflammation at a Crossroad of Somatic Diseases
Mravec, B., Horváthová, Ľ., & Černáčková, A. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0631-4 · Cited by 17
Nyamugenda, E., Trentzsch, M., Russell, S., Miles, T. K., Boysen, G., Phelan, K. D., & Baldini, G. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14662 · Cited by 18
Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation
Dey, S., Cui, Z., Gavrilova, O., Zhang, X., Gassmann, M., & Noguchi, C. T. (2020) · JCI Insight · doi:10.1172/jci.insight.134061 · Cited by 17
Yang, Q., Lei, G., & Liu, W. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.076 · Cited by 17
The timeline of neuronal and glial alterations in experimental obesity
Engel, D. F., & Velloso, L. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108983 · Cited by 21
Dietary fat: a potent microglial influencer
Ceasrine, A. M., & Bilbo, S. D. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.12.005 · Cited by 17
Jantsch, J., Rodrigues, F. D. S., Fraga, G. D. F., Eller, S. C. W. D. S., Silveira, A. K., Moreira, J. C. F., Giovenardi, M., & Guedes, R. P. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109371 · Cited by 17
Bombassaro, B., ARAUJO, E. P. D., & Velloso, L. A. (2024) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2024-0082 · Cited by 19
Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer’s disease
Weigel, T. K., Kulas, J. A., & Ferris, H. A. (2019) · Neuronal Signaling · doi:10.1042/ns20190068 · Cited by 16
Magnetic resonance assessment of the cerebral alterations associated with obesity development
Lizarbe, B., Campillo, B. W., Guadilla, I., López‐Larrubia, P., & Cerdán, S. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20941263 · Cited by 16
Cocozza, G., Garofalo, S., Morotti, M., Chece, G., Grimaldi, A., Lecce, M., Scavizzi, F., Menghini, R., Casagrande, V., Federici, M., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15665 · Cited by 16
Yan, L., & Li, J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.015 · Cited by 16
Macedo, F. P., dos Santos, L. S., Glezer, I., & da Cunha, F. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00342 · Cited by 17
Rong, X., Wei, F., Jiang, Y., Ma, Q., Wang, D., & Shen, J. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100736 · Cited by 15
GLP-1/GLP-1R axis: from metabolism (obesity and T2DM) to immunity
Kumar, V. (2025) · Open Biology · doi:10.1098/rsob.240303 · Cited by 17
Rasmussen, J. M., Thompson, P. M., Gyllenhammer, L. E., Lindsay, K. L., O’Connor, T. G., Koletzko, B. V., Entringer, S., Wadhwa, P. D., & Buß, C. (2022) · Obesity · doi:10.1002/oby.23452 · Cited by 15
Campillo, B. W., Galguera, D., Cerdán, S., López‐Larrubia, P., & Lizarbe, B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1025108 · Cited by 15
Guzmán‐Ruiz, M. A., Vargas, N. N. G., Carreto, R. J. R., González-Orozco, J. C., Torres-Hernández, B. A., Valle-Rodríguez, M., Guevara‐Guzmán, R., & Chavarría, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1392077 · Cited by 16
Becker, M., Kälin, S., Neubig, A. H., Lauber, M., Opaleva, D., Hipp, H., Salb, V. K., Ott, V. B., Legutko, B., Kälin, R. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57918-z · Cited by 17
Hankir, M. K., Rullmann, M., Seyfried, F., Preusser, S., Poppitz, S., Heba, S., Gousias, K., Hoyer, J., Schütz, T., Dietrich, A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131329 · Cited by 16
Mestre, Z., Bischoff‐Grethe, A., Wierenga, C. E., Jernigan, T. L., Eichen, D. M., Chang, L., Ernst, T., & Boutelle, K. N. (2020) · Obesity · doi:10.1002/oby.22841 · Cited by 16
Ngozi, Z., & Bolton, J. L. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.867217 · Cited by 16
Huang, H.-T., Chen, P., Chen, P. S., Chiu, W., Kuo, Y., & Tzeng, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.752771 · Cited by 14
Microglia mediate the early-life programming of adult glucose control
Valdearcos, M., McGrath, E. R., Mayfield, S. M. B., Jacuinde, M. G., Folick, A., Cheang, R. T., Li, R., Bachor, T. P., Lippert, R. N., Xu, A. W., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115409 · Cited by 14
Self-citationPeterson, T. C., Lechtenberg, K. J., Piening, B., Lucas, T. A., Wei, E., Chaı̈b, H., Dowdell, A. K., Snyder, M. P., & Buckwalter, M. S. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00826-9 · Cited by 13
César, H., Sertorio, M. N., de Souza, E. A., Jamar, G., Santamarina, A. B., Jucá, A., Casagrande, B. P., & Pisani, L. P. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02690-1 · Cited by 18
Rodrigues, E. L., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Pott, A., Santana, L. F., Hiane, P. A., do Nascimento, V. A., Bogo, D., & Freitas, K. D. C. (2023) · Nutrients · doi:10.3390/nu15071551 · Cited by 16
Suh, S. B., Lee, N., Kim, J., Kim, S., Jang, S., Park, J. K., Lee, K., Choi, S. Y., Kwon, H., & Lee, C. H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906717 · Cited by 13
The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis
Zhang, Y., Zhang, B., & Sun, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1378202 · Cited by 17
Rethinking the role of microglia in obesity
Cutugno, G., Kyriakidou, E., & Nadjar, A. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109951 · Cited by 13
Qiu, L., Ren, Y., Li, J., Li, M., Li, W., Qin, L., Ning, C., Zhang, J., & Gao, F. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.06.003 · Cited by 14
Extracellular vesicles released from microglia after palmitate exposure impact brain function
de Paula, G. C., Aldana, B. I., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03168-7 · Cited by 15
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
Pfuhlmann, K., Schriever, S. C., Legutko, B., Baumann, P., Harrison, L., Kabra, D. G., Baumgart, E. V., Tschöp, M. H., Garcia-Caceres, C., & Pfluger, P. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1076-x · Cited by 9
Rasmussen, J. M., Tuulari, J. J., Nolvi, S., Thompson, P. M., Merisaari, H., Lavonius, M., Karlsson, L., Entringer, S., Wadhwa, P. D., Karlsson, H., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02743-8 · Cited by 13
André, C., Catania, C., Rémus-Borel, J., Ladevèze, E., Leste-Lasserre, T., Mazier, W., Binder, E., Gonzales, D., Clark, S., Guzmán-Quevedo, O., et al. (2018) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2018.03.014 · Cited by 11
Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
Nyamugenda, E., Griffin, H., Russell, S., Cooney, K. A., Kowalczyk, N. S., Islam, I., Phelan, K. D., & Baldini, G. (2020) · iScience · doi:10.1016/j.isci.2020.101114 · Cited by 14
Microglia limit lesion expansion and promote functional recovery after spinal cord injury in micePreprint
Brennan, F. H., Hall, J. C. E., Guan, Z., & Popovich, P. G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/410258 · Cited by 13
Meneyrol, K., Estévez‐Salguero, Á., González‐García, I., Guitton, J., Taouis, M., Benomar, Y., Magnan, C., López, M., & Stunff, H. L. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154846 · Cited by 12
Emerging role of hypothalamus in the metabolic regulation in the offspring of maternal obesity
Zhang, J., Li, S., Luo, X., & Zhang, C. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1094616 · Cited by 12
Li, Y., & Shao, X. (2025) · Journal of Health Population and Nutrition · doi:10.1186/s41043-025-00981-5 · Cited by 11
Rosin, J. M., & Kurrasch, D. M. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00443.2017 · Cited by 12
Metabolic Regulation of Hypoxia-Inducible Factors in Hypothalamus
Du, D., Zhang, Y., Zhu, C., Chen, H., & Sun, J. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.650284 · Cited by 12
Microgliosis: a double‐edged sword in the control of food intake
Salvi, J., Andreoletti, P., Audinat, É., Balland, É., Fradj, S. B., Cherkaoui‐Malki, M., Heurtaux, T., Liénard, F., Nédélec, E., Rovère, C., et al. (2022) · FEBS Journal · doi:10.1111/febs.16583 · Cited by 16
Toniazzo, A. P., Arcego, D. M., Lazzaretti, C., Mota, C. D. S., Schnorr, C. E., Pettenuzzo, L. F., Krolow, R., Moreira, J. C. F., & Dalmaz, C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.008 · Cited by 12
High-Fat Diets and LXRs Expression in Rat Liver and Hypothalamus
Rey, M., Kruse, M. S., Huamán, R. N. M., & Coirini, H. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00692-6 · Cited by 12
Hironao, K.-Y., Ashida, H., & Yamashita, Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1006132 · Cited by 11
Deng, Y., Yi, X., Gong, Y., Zhou, L., Xie, D., Wang, J., Liu, Z., Zhang, Y., & Wu, W. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119385 · Cited by 11
Fico, B. G., Maharaj, A., Pena, G. S., & Huang, C. (2023) · Biology · doi:10.3390/biology12060865 · Cited by 16
Prostaglandin E 2 activates melanin-concentrating hormone neurons to drive diet-induced obesity
Fang, L. Z., Linehan, V., Licursi, M., Alberto, C. O., Power, J. L., Parsons, M. P., & Hirasawa, M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302809120 · Cited by 11
Lu, T., Ding, L., Zheng, X., Li, Y., Wei, W., Liu, W., Tao, J., & Xue, X. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03592-5 · Cited by 12
Pané, A., Videla, L., Calvet-Mirabent, À., Viaplana, J., Vaqué‐Alcázar, L., Ibarzábal, A., Aranha, M. R., Pegueroles, J., Moize, V. L., Vidal, J., et al. (2024) · Diabetes Care · doi:10.2337/dc23-2213 · Cited by 12
Chung, J., Jernigan, J. E., Menees, K. B., & Lee, J. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1374298 · Cited by 12
Long‐term reprogramming of primed microglia after moderate inhibition of CSF1R signaling
León‐Rodríguez, A., Grondona, J. M., Marín‐Wong, S., López‐Aranda, M. F., & López-Ávalos, M. D. (2024) · Glia · doi:10.1002/glia.24627 · Cited by 13
Perdaens, O., & Pesch, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312637 · Cited by 12
Effects of multiple cycles of weight loss and regain on the body weight regulatory system in rats
Rosenbaum, J. L., Frayo, R. S., Melhorn, S. J., Cummings, D. E., & Schur, E. A. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2019 · Cited by 13
Martins, I. C. A., Contieri, L. S., do Amaral, C. L., COSTA, S. O., Souza, A. C. P., Ignácio-Souza, L. M., Milanski, M., Torsoni, A. S., & Torsoni, M. A. (2021) · Mediators of Inflammation · doi:10.1155/2021/5526940 · Cited by 12
Chen, X., Huang, L., Cui, L., Xiao, Z., Xiong, X., & Chen, C. (2022) · The Journal of Physiology · doi:10.1113/jp283259 · Cited by 11
So, S. W., Nixon, J. P., Bernlohr, D., & Butterick, T. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043381 · Cited by 11
Kim, J., Kwon, Y., Kim, C.-S., Tu, T. H., Kim, B., Joe, Y., Chung, H., Goto, T., Kawada, T., Park, T., et al. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12426 · Cited by 11
Delahaye‐Duriez, A., Dufour, A., Bokobza, C., Gressèns, P., & Steenwinckel, J. V. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab049 · Cited by 13
Fioravante, M., Bombassaro, B., Ramalho, A. F. S., de Moura, R. F., Haddad-Tóvolli, R., Solon, C., Dragano, N. R. V., Vettorazzi, J. F., Gaspar, R. S., Ropelle, E. R., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.001 · Cited by 11
The influence of parental high-fat high-sugar diet on the gut-brain axis in male offspring
César, H., Nascimento Sertorio, M., Santamarina, A., Alves de Souza, E., Valles Mennitti, L., Jamar, G., Jucá, A., Picin Casagrande, B., Estadela, D., & Pellegrini Pisani, L. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111706 · Cited by 10
NAD+ oscillation and hypothalamic neuronal functions
Tokizane, K., & Imai, S. (2021) · Faculty Reviews · doi:10.12703/r/10-42 · Cited by 10
TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice
Jia, L., Chen, Z., Pan, T. S., Xia, Y., He, J., Jahangir, A., Wei, X., Liu, W., Shi, R., Huang, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169438 · Cited by 12
Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative
Bandala, C., Cárdenas‐Rodríguez, N., Reyes-Long, S., Cortes-Altamirano, J. L., Garciadiego-Cázares, D., Lara‐Padilla, E., Ibáñez-Cervantes, G., Mancilla-Ramı́rez, J., Gómez‐Manzo, S., & Alfaro-Rodríguez, A. (2022) · Antioxidants · doi:10.3390/antiox11101972 · Cited by 12
Preserving immune homeostasis with A20
Razani, B., Malynn, B. A., & Ma, A. I. (2020) · Advances in immunology · doi:10.1016/bs.ai.2020.10.001 · Cited by 9
Metadata
- Authors
- Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., Gerritse, I., Fasnacht, R., Barres, B. A., Thaler, J. P., & Koliwad, S. K.
- Affiliations
- University of Washington (US)
- University of California, San Francisco (US)
- Stanford Medicine (US)
- Corresponding author
- Thaler, Joshua P.
- Koliwad, Suneil K.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 26
- Issue
- 1
- Pages
- 185-197.e3
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5569901
- OpenAlex
- W2727793071
- Cited by
- 477
- References
- 58
- Citations by year
- 2026: 38 · 2025: 50 · 2024: 69 · 2023: 49 · 2022: 49 · 2021: 59 · 2020: 53 · 2019: 65 · 2018: 39 · 2017: 6
- FWCI
- 22.20
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-06-05)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Diabetes Association (1-14-ACE-51)
- NIDDK (K08 DK088872, T32 DK7247-37, F32 DK108473-01, R01 DK103175-02)
- UCSF Diabetes Family Fund
- Nutrition Obesity Research Centers (DK098722)
- University of Washington (DK035816)
- Diabetes Research Center (DK017047)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- microglia, microglial activation, mediobasal hypothalamus, dietary excess, obesity susceptibility, NF-κB signaling, A20, energy homeostasis, hyperphagia, weight gain, myeloid cell infiltration, energy expenditure, diet-induced obesity
- MeSH terms
- Animals, Appetite Regulation, Energy Metabolism, Hyperphagia, Hypothalamus, Inflammation, Male, Mice, Inbred C57BL, Obesity, Signal Transduction, NF-kappa B, Microglia, Myeloid Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
